LOCUS       NM_001013247             298 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus sarcolipin (Sln), mRNA.
ACCESSION   NM_001013247 XM_345940
VERSION     NM_001013247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Nelson,B.R., Makarewich,C.A., Anderson,D.M., Winders,B.R.,
            Troupes,C.D., Wu,F., Reese,A.L., McAnally,J.R., Chen,X.,
            Kavalali,E.T., Cannon,S.C., Houser,S.R., Bassel-Duby,R. and
            Olson,E.N.
  TITLE     A peptide encoded by a transcript annotated as long noncoding RNA
            enhances SERCA activity in muscle
  JOURNAL   Science 351 (6270), 271-275 (2016)
   PUBMED   26816378
REFERENCE   3  (bases 1 to 298)
  AUTHORS   Bal,N.C., Maurya,S.K., Sopariwala,D.H., Sahoo,S.K., Gupta,S.C.,
            Shaikh,S.A., Pant,M., Rowland,L.A., Bombardier,E.,
            Goonasekera,S.A., Tupling,A.R., Molkentin,J.D. and Periasamy,M.
  TITLE     Sarcolipin is a newly identified regulator of muscle-based
            thermogenesis in mammals
  JOURNAL   Nat Med 18 (10), 1575-1579 (2012)
   PUBMED   22961106
  REMARK    Erratum:[Nat Med. 2012 Dec;18(12):1857. Tupling, A Russell [added];
            Bombardier, Eric [added]]
REFERENCE   4  (bases 1 to 298)
  AUTHORS   Tupling,A.R., Bombardier,E., Gupta,S.C., Hussain,D., Vigna,C.,
            Bloemberg,D., Quadrilatero,J., Trivieri,M.G., Babu,G.J.,
            Backx,P.H., Periasamy,M., MacLennan,D.H. and Gramolini,A.O.
  TITLE     Enhanced Ca2+ transport and muscle relaxation in skeletal muscle
            from sarcolipin-null mice
  JOURNAL   Am J Physiol Cell Physiol 301 (4), C841-C849 (2011)
   PUBMED   21697544
REFERENCE   5  (bases 1 to 298)
  AUTHORS   Minamisawa,S., Uemura,N., Sato,Y., Yokoyama,U., Yamaguchi,T.,
            Inoue,K., Nakagome,M., Bai,Y., Hori,H., Shimizu,M., Mochizuki,S.
            and Ishikawa,Y.
  TITLE     Post-transcriptional downregulation of sarcolipin mRNA by
            triiodothyronine in the atrial myocardium
  JOURNAL   FEBS Lett 580 (9), 2247-2252 (2006)
   PUBMED   16566928
  REMARK    GeneRIF: The atrium-specific effect of thyroid hormone may occur in
            part through the regulation of atrial sarcolipin gene expression.
REFERENCE   6  (bases 1 to 298)
  AUTHORS   Shimura,M., Minamisawa,S., Yokoyama,U., Umemura,S. and Ishikawa,Y.
  TITLE     Mechanical stress-dependent transcriptional regulation of
            sarcolipin gene in the rodent atrium
  JOURNAL   Biochem Biophys Res Commun 334 (3), 861-866 (2005)
   PUBMED   16036219
  REMARK    GeneRIF: we generated right-sided pressure-overload models by
            monocrotaline administration in Wistar rats. Monocrotaline
            administration significantly decreased expression of sarcolipin,
            SERCA2a, & phospholamban mRNAs in right atrium than those in left
            atrium.
REFERENCE   7  (bases 1 to 298)
  AUTHORS   Vangheluwe,P., Schuermans,M., Zador,E., Waelkens,E., Raeymaekers,L.
            and Wuytack,F.
  TITLE     Sarcolipin and phospholamban mRNA and protein expression in cardiac
            and skeletal muscle of different species
  JOURNAL   Biochem J 389 (Pt 1), 151-159 (2005)
   PUBMED   15801907
  REMARK    GeneRIF: The expression of SLN and PLB mRNA and protein relative to
            SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal
            msucle of mouse, rat, rabbit and pig.
REFERENCE   8  (bases 1 to 298)
  AUTHORS   Mascioni,A., Karim,C., Barany,G., Thomas,D.D. and Veglia,G.
  TITLE     Structure and orientation of sarcolipin in lipid environments
  JOURNAL   Biochemistry 41 (2), 475-482 (2002)
   PUBMED   11781085
REFERENCE   9  (bases 1 to 298)
  AUTHORS   Odermatt,A., Becker,S., Khanna,V.K., Kurzydlowski,K., Leisner,E.,
            Pette,D. and MacLennan,D.H.
  TITLE     Sarcolipin regulates the activity of SERCA1, the fast-twitch
            skeletal muscle sarcoplasmic reticulum Ca2+-ATPase
  JOURNAL   J Biol Chem 273 (20), 12360-12369 (1998)
   PUBMED   9575189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY456000.1.
            
            On Mar 26, 2005 this sequence version replaced XM_345940.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY456000.1, BF420843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132283, SAMD00132295
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..298
                     /gene="Sln"
                     /note="sarcolipin"
                     /db_xref="GeneID:367086"
                     /db_xref="RGD:1305224"
     exon            1..23
                     /gene="Sln"
                     /inference="alignment:Splign:2.1.0"
     exon            24..298
                     /gene="Sln"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..193
                     /gene="Sln"
                     /codon_start=1
                     /product="sarcolipin"
                     /protein_id="NP_001013265.1"
                     /db_xref="GeneID:367086"
                     /db_xref="RGD:1305224"
                     /translation="MERSTQELFINFTVVLITVLLMWLLVRSYQY"
ORIGIN      
        1 ggtgtgtctt tgcttctctt caggacgtga agacgagcca gtgtccttgg tgtgcactca
       61 gaagtcctcc tggagttctc acccagacct tctgaagatg gagcggtcta cccaggagct
      121 gtttatcaac ttcacagttg tcctgatcac tgtgctcctc atgtggctcc tcgtgaggtc
      181 ctaccaatac tgaggggcca tgccacactc ccgggagtga ctgctgtgtg ccctgagctt
      241 ccactgctct gttgacatgg gatgctgctc ttggctcctc cagcacctct gattcaca
//
