LOCUS       NM_001106060            3637 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus sarcolemma associated protein (Slmap), mRNA.
ACCESSION   NM_001106060 XM_001057214 XM_224579
VERSION     NM_001106060.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3637)
  AUTHORS   Nader,M., Alsolme,E., Alotaibi,S., Alsomali,R., Bakheet,D. and
            Dzimiri,N.
  TITLE     SLMAP-3 is downregulated in human dilated ventricles and its
            overexpression promotes cardiomyocyte response to adrenergic
            stimuli by increasing intracellular calcium
  JOURNAL   Can J Physiol Pharmacol 97 (7), 623-630 (2019)
   PUBMED   30856349
  REMARK    GeneRIF: SLMAP-3 is downregulated in human dilated ventricles and
            its overexpression promotes cardiomyocyte response to adrenergic
            stimuli by increasing intracellular calcium
REFERENCE   2  (bases 1 to 3637)
  AUTHORS   Lant,B., Yu,B., Goudreault,M., Holmyard,D., Knight,J.D., Xu,P.,
            Zhao,L., Chin,K., Wallace,E., Zhen,M., Gingras,A.C. and Derry,W.B.
  TITLE     CCM-3/STRIPAK promotes seamless tube extension through endocytic
            recycling
  JOURNAL   Nat Commun 6, 6449 (2015)
   PUBMED   25743393
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3637)
  AUTHORS   Ishikawa,T., Sato,A., Marcou,C.A., Tester,D.J., Ackerman,M.J.,
            Crotti,L., Schwartz,P.J., On,Y.K., Park,J.E., Nakamura,K.,
            Hiraoka,M., Nakazawa,K., Sakurada,H., Arimura,T., Makita,N. and
            Kimura,A.
  TITLE     A novel disease gene for Brugada syndrome: sarcolemmal
            membrane-associated protein gene mutations impair intracellular
            trafficking of hNav1.5
  JOURNAL   Circ Arrhythm Electrophysiol 5 (6), 1098-1107 (2012)
   PUBMED   23064965
REFERENCE   4  (bases 1 to 3637)
  AUTHORS   Wielowieyski,P.A., Sevinc,S., Guzzo,R., Salih,M., Wigle,J.T. and
            Tuana,B.S.
  TITLE     Alternative splicing, expression, and genomic structure of the 3'
            region of the gene encoding the sarcolemmal-associated proteins
            (SLAPs) defines a novel class of coiled-coil tail-anchored membrane
            proteins
  JOURNAL   J Biol Chem 275 (49), 38474-38481 (2000)
   PUBMED   10986292
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474067.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_224579.4, XM_001057214.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3637
                     /gene="Slmap"
                     /note="sarcolemma associated protein"
                     /db_xref="GeneID:290533"
                     /db_xref="RGD:1307674"
     exon            1..84
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1367
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     CDS             1170..3533
                     /gene="Slmap"
                     /codon_start=1
                     /product="sarcolemmal membrane-associated protein"
                     /protein_id="NP_001099530.1"
                     /db_xref="GeneID:290533"
                     /db_xref="RGD:1307674"
                     /translation="MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNA
                     TFDCKVLSRNHALVWFDHKTSKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDI
                     IQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSM
                     YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLE
                     VMGNQLQACSKNQTEDSLRKELVALQEDKHSYETTAKESLRRVLQEKIEVVRKLSEVE
                     RSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLSDKLKAAEGKQEEIQQK
                     GQAEKKELQAKIDDMEEKEQELQAKIEALQADNDFTNERLTALQEKLMVQGHLTKVVE
                     ESKLSKENQAKAKESDLSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQG
                     TQAETEAKQDTQHLRKELVEAQELARASKQKCFDLQALLEEERKAYRNQVEESAKQIQ
                     VLQVQLQRLHMDMENLQEEKDTEISSTRDKLLSAQDEILLLHQAAAKAVSERDTDFMS
                     LQEELKKVRAELEGWRKAASEYEEEIRSLQSTFQLRCQQCEVQQREEATRLQGELEKL
                     KKEWDVLENECRSLKKENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMTRKELEN
                     QMGSLKEQHLRDEADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSI
                     TDELKQCKDNLKLLREKGNNPSILQPVPAVFIGLFLAFLFWCFGPLW"
     exon            1368..1515
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1588
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1625
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1688
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1784
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1856
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1997
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2135
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2304
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2364
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2445
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2505
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2628
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2703
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..3024
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3142
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3314
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3449
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3539
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3637
                     /gene="Slmap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccttgaa aagggtgcgc gttcccgtag cggtggaccc ggtaggtttc agtcagagtc
       61 actatggcgg ccaacgctgg caaggtcgga aagtttcctg cctcgtccgc caccgcctga
      121 gcttgccgca ctggctgcga gtggaggagg ctgcggcgga cccagccccg gcctccaggc
      181 ctctccctcc acctcccggc cagcctccct cccccacacc gtcgtcctcc gggagctgcc
      241 agtccctgag atgcgaccct cgcgaggacg ctcctgaggg gaggtggccc atgtgctgag
      301 cagcagagcc cagagctcaa ggaaccaact tcccgccggc ccgggcgccc aagcctccct
      361 ggggtagctc ctcgctctgt ccgcaccggc ctgcagagcc gggtccccgc cctggtccgg
      421 ggacacccgc caggtgctcg ggactcgcga tccagggacc gcccgtatcc cggccgccct
      481 cccacgcctc cagcccggga tcgcagcctc ggctcacgct gggccgggga cccctgccac
      541 tcccgggcgg cctcggcgca gcagggcaat gcagcccggc ccggtggccc tctagccctc
      601 ctcgtcgtct gtccccgcac ctcttctcat ccccgaggcc cctgaggacc ggcggtggct
      661 gcccggaggt ccttcactcc tcttcctcgg gccccggagg accttcctgg ctgagccgag
      721 tcaaccctct tcatgctgca gtgccgcacc gtttccgcta ccgaagggga gaagtggccg
      781 ggatctcaaa caaaacacaa gaatttgtgt gtgactcatc tgctcggata cctcccgtcc
      841 ccaaactgtc ttccaggagt ttccttggcc gaagctgccc aatgtttgag ctttttcttc
      901 ctagggaaga tggactgaaa gctgctagtt ggggactttt tttggtcaag gagcctctgt
      961 attttaaagg aggtgatggg gcttgctctg gcttgtcttc ctgcccaatt gaagagttgt
     1021 tgatgttcac tggttatgct tagacaatgc acagtttgtt ttaatttaaa aattttgggg
     1081 ggataggggt gtaggcttgt gaagagcatt ccgaacctgg aggagctcct cgttatccct
     1141 ggtccagaca cccccccagc ctgtcctcga tgccgtcagc cttggccatc ttcacttgcc
     1201 gcccgaactc acacccgttt caggagcgac atgtctacct ggacgagccc atcaagatcg
     1261 gccgctcagt ggcacgctgt cgaccagcgc agaataatgc cacctttgac tgcaaagtgc
     1321 tgtcaaggaa ccatgctctc gtctggtttg atcacaagac gagcaagttt tacctccaag
     1381 acactaaaag tagtaatggt acctttataa atagccagag attgagtcga ggctctgaag
     1441 aaagtccacc atgcgaaatt ctttctggtg acattatcca gtttggggta gatgtgacag
     1501 agaacacacg gaaagttacc catgggtgta ttgtttccac aataaaactt tttctaccag
     1561 atggtatgga agcccgactc cgttcagatg tcatccatgc tccattaccg agtcctgtag
     1621 acaaagttgc tgctaacact ccaagtatgt actctcagga actgttccaa ctttctcagt
     1681 atctacagga ggccttacat cgggaacaga tgttggaaca gaagttagcc acacttcagc
     1741 ggctgctggc catcacccaa gaggcttcag atactagttg gcaggcttta atagatgaag
     1801 atagactctt atcacggtta gaagttatgg ggaaccagtt gcaggcatgc tccaaaaatc
     1861 aaacagaaga tagcttacgg aaggagctgg tagcgttgca ggaggataaa catagctatg
     1921 aaaccacagc caaagagtcc ctgaggcggg ttcttcagga gaaaattgaa gtggttagaa
     1981 aactctcaga agtggagcgg agtctgagta acactgaaga tgaatgtacc cacctgaggg
     2041 agatgaatga gcggactcag gaagagttga gagaattagc caataaatat aatggagcag
     2101 ttaatgaaat taaagattta tctgataaat taaaggcagc agagggaaaa caagaggaaa
     2161 tccagcagaa gggacaagct gagaagaaag aattacaggc taaaatcgat gacatggaag
     2221 aaaaagaaca agagctccag gcaaaaatag aagctttgca agctgataac gatttcacca
     2281 acgagaggct gacagcttta caagagaagc tgatggtcca ggggcatcta accaaagtgg
     2341 tggaggaatc caagctttcc aaagaaaacc aggcaaaagc aaaggaatct gacttatcag
     2401 atactctgag tccaagcaaa gaaaaaagca gcgacgacac tacagacgcc cagatggatg
     2461 agcaagacct gaatgaaccc ctggctaagg tgtctctgtt aaaagatgac ttacagggta
     2521 cccaggcaga aactgaggcc aaacaagaca ctcaacatct tcggaaagaa ttggtggaag
     2581 cccaggagct agctagagca agtaaacaaa aatgctttga ccttcaagct cttttggaag
     2641 aagaacgaaa agcctatcga aatcaagttg aggaatcagc taaacaaatc caggttcttc
     2701 aagtccagct gcagaggcta cacatggata tggagaatct ccaggaggaa aaggacactg
     2761 agatttctag cacgagagat aaattgctga gtgctcaaga tgagattttg ctccttcatc
     2821 aagcagcagc aaaggctgtg tctgagcggg acactgactt tatgtctttg caagaagagc
     2881 tcaagaaggt gagagcagag cttgagggct ggaggaaagc agcatctgag tatgaggagg
     2941 aaatcagaag tctgcagagc actttccaac ttagatgtca gcagtgtgaa gtccagcaaa
     3001 gagaggaggc cacaaggttg caaggtgaac tagagaagtt gaaaaaggaa tgggatgtac
     3061 tggaaaatga gtgccgttct ctgaaaaagg agaatgtgtt attgtcatca gaactgcagc
     3121 gacaagaaaa agaattgcac aattctcaga agcaaagttt ggagctcacg agtgacctca
     3181 gcatccttca aatgactagg aaagaactcg agaaccaaat gggatccttg aaagaacaac
     3241 accttcggga tgaagctgac ttaaaaactc ttctcagtaa ggctgaaaac caagccaagg
     3301 atgtacagaa agagtatgaa aagacacaga ctgtactctc tgaactgaag ttgaagtttg
     3361 aaatgactga gcaggaaaag caatcaatca cagatgagct caaacaatgt aaagacaacc
     3421 tgaagctgct gcgagagaaa ggaaataatc cctccatatt acaacctgtc ccagccgttt
     3481 tcatcggcct attcctggct ttcctgtttt ggtgtttcgg tccgttgtgg tagagaaaga
     3541 aaccctggcc ctggatgccc atggtggcgg ccctggttgc ggtgacagct atggtgctgt
     3601 atgtaccagg tctggccaga gcttctccat gacagtg
//
