LOCUS       NM_019349               3796 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus STE20-like kinase (Slk), mRNA.
ACCESSION   NM_019349 XM_579435
VERSION     NM_019349.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Li,D., Ni,H., Rui,Q., Gao,R. and Chen,G.
  TITLE     Deletion of Mst1 attenuates neuronal loss and improves neurological
            impairment in a rat model of traumatic brain injury
  JOURNAL   Brain Res 1688, 15-21 (2018)
   PUBMED   29054447
  REMARK    GeneRIF: Study found that the phosphorylation level of Mammalian
            STE20-like kinase-1 (Mst1) in injured area was significantly
            increased after traumatic brain injury (TBI) in rat model of TBI.
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Fokin,A.I., Klementeva,T.S., Nadezhdina,E.S. and Burakov,A.V.
  TITLE     SLK/LOSK kinase regulates cell motility independently of
            microtubule organization and Golgi polarization
  JOURNAL   Cytoskeleton (Hoboken) 73 (2), 83-92 (2016)
   PUBMED   26818812
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Jaberi,A., Hooker,E., Guillemette,J., Papillon,J., Kristof,A.S. and
            Cybulsky,A.V.
  TITLE     Identification of Tpr and alpha-actinin-4 as two novel
            SLK-interacting proteins
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2539-2552 (2015)
   PUBMED   26094769
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Baron,K.D., Al-Zahrani,K., Conway,J., Labreche,C., Storbeck,C.J.,
            Visvader,J.E. and Sabourin,L.A.
  TITLE     Recruitment and activation of SLK at the leading edge of migrating
            cells requires Src family kinase activity and the LIM-only protein
            4
  JOURNAL   Biochim Biophys Acta 1853 (7), 1683-1692 (2015)
   PUBMED   25882817
  REMARK    Erratum:[Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2754]
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   Pike,A.C., Rellos,P., Niesen,F.H., Turnbull,A., Oliver,A.W.,
            Parker,S.A., Turk,B.E., Pearl,L.H. and Knapp,S.
  TITLE     Activation segment dimerization: a mechanism for kinase
            autophosphorylation of non-consensus sites
  JOURNAL   EMBO J 27 (4), 704-714 (2008)
   PUBMED   18239682
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Hao,W., Takano,T., Guillemette,J., Papillon,J., Ren,G. and
            Cybulsky,A.V.
  TITLE     Induction of apoptosis by the Ste20-like kinase SLK, a germinal
            center kinase that activates apoptosis signal-regulating kinase and
            p38
  JOURNAL   J Biol Chem 281 (6), 3075-3084 (2006)
   PUBMED   16316999
  REMARK    GeneRIF: SLK is an anoxia/recovery-dependent kinase that is
            activated via homodimerization and that signals via ASK1 and p38 to
            promote apoptosis
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Vitt,U., Gietzen,D., Stevens,K., Wingrove,J., Becha,S., Bulloch,S.,
            Burrill,J., Chawla,N., Chien,J., Crawford,M., Ison,C., Kearney,L.,
            Kwong,M., Park,J., Policky,J., Weiler,M., White,R., Xu,Y.,
            Daniels,S., Jacob,H., Jensen-Seaman,M.I., Lazar,J., Stuve,L. and
            Schmidt,J.
  TITLE     Identification of candidate disease genes by EST alignments,
            synteny, and expression and verification of Ensembl genes on rat
            chromosome 1q43-54
  JOURNAL   Genome Res 14 (4), 640-650 (2004)
   PUBMED   15060005
REFERENCE   9  (bases 1 to 3796)
  AUTHORS   Cybulsky,A.V., Takano,T., Papillon,J., Khadir,A., Bijian,K.,
            Chien,C.C., Alpers,C.E. and Rabb,H.
  TITLE     Renal expression and activity of the germinal center kinase SK2
  JOURNAL   Am J Physiol Renal Physiol 286 (1), F16-F25 (2004)
   PUBMED   12965890
  REMARK    GeneRIF: Stk2 is a renal epithelial protein kinase whose expression
            and activity are increased during development and recovery from
            acute renal failure (germinal center kinase SK2)
REFERENCE   10 (bases 1 to 3796)
  AUTHORS   Yue,C.C.
  TITLE     Novel putative protein kinase clones from a rat large granular
            lymphocyte tumor cell line
  JOURNAL   Mol Immunol 28 (4-5), 399-408 (1991)
   PUBMED   2062320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI136919.1, AB003357.1 and CK227996.1.
            
            On Mar 15, 2007 this sequence version replaced NM_019349.1.
            
            Sequence Note: The sequence AB003357.1 is chimeric. Only the Slk
            sequence region was propagated into this RefSeq record.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AI136919.1         6-78
            74-3732             AB003357.1         44-3702
            3733-3796           CK227996.1         121-184
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3796
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /note="STE20-like kinase"
                     /db_xref="GeneID:54308"
                     /db_xref="RGD:3780"
     exon            1..318
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3780
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 2; STE20-related kinase;
                     STE20-related serine/threonine-protein kinase"
                     /codon_start=1
                     /product="STE20-like serine/threonine-protein kinase"
                     /protein_id="NP_062222.2"
                     /db_xref="GeneID:54308"
                     /db_xref="RGD:3780"
                     /translation="MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGA
                     FGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYEN
                     NLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGN
                     ILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADV
                     WSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKN
                     VDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDDDDETESALPIP
                     ANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEKPTPEGPEK
                     TVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPQLESQPDTEDQQTVDVNLVGEG
                     NDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKE
                     ADFQAIDNEVGFTKEETQEKLGKDDKTHKVVISDITSEVGTDEPPGDTQKSAEQSQDA
                     EGGAGEEAPEPAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTS
                     TSESTRATTEEPETDEVDQVSESNSIEELERLGVTGAEEQALGSKGEAATELDLEREE
                     NAQELPVKAEPQAPAASQASEPPPVLIPSINIHSENTENKGEMGALPKPETILPPEPE
                     NGKGNDTDSGTGSTVENSSSDLNLSISSFLSKTKDSGSVSLQETRRQKKTLKKTRKFI
                     VDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQKAQQQLNGKLQQQRE
                     QIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKEL
                     SKFQNMLRNRKKEEQEFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAR
                     EAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKN
                     RQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNER
                     MAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEW
                     REKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS"
     exon            319..483
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..532
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..682
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..755
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..950
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1032
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1161
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..2514
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2645
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2769
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2949
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3079
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3204
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3393
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3519
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3633
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3796
                     /gene="Slk"
                     /gene_synonym="SK2; Stk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgccccc ctccggggcc ggagccctgt cggcgccccg ccttctccgg ggagcgcccg
       61 gcgggagcgg cccggacccc gggctcgcgc gggagacgac gcgccacaaa ctttgccttt
      121 tattgttcct agccctttaa gtgcaagggg ctctgttggg ctggaaaaat gtccttcttc
      181 aatttccgta agatcttcaa gttggggagc gagaagaaga agaaacagta cgaacacgtg
      241 aagagagacc tgaaccccga ggagttttgg gagattatcg gagagctggg cgacggagcc
      301 tttgggaaag tgtataaggc ccagaataag gagaccaatg ttttagctgc tgcaaaggtg
      361 attgacacca aatctgaaga agaacttgaa gattatatgg ttgagattga catattagca
      421 tcttgtgatc acccaaacat agtcaagctt ctagatgcct tctattatga gaacaatctt
      481 tggatcctca ttgaattttg tgcaggggga gcagtagatg ccgtgatgct tgaacttgag
      541 agaccattaa ctgagtccca aattcaagta gtttgcaagc agacattaga ggcgttgaat
      601 tacctacatg acaataaaat catccacaga gatctaaaag ctggcaatat tctctttacc
      661 ttagatggag acattaaatt agcggatttt ggagtgtcag ctaagaatac caggacaatt
      721 caaaggaggg attcatttat tggcacaccg tattggatgg ctcctgaagt cgtcatgtgt
      781 gagacatcga aggacagacc ctatgactac aaagcggacg tttggtccct gggaatcact
      841 ttaatagaaa tggctgagat agagccgcct catcatgagc taaacccaat gcgagtgctg
      901 ctgaaaatag caaagtcgga gccccccaca ctagcacagc catccagatg gtcttcaaat
      961 tttaaggact ttctaaagaa atgcttggaa aagaatgtgg atgcgcggtg gaccacatcc
     1021 cagctgttac agcatccctt tgttaccgtt gattccaaca aaccagtccg agaattgatt
     1081 gctgaggcga aggctgaagt aacagaagaa gttgaagatg gcaaagagga agatgacgat
     1141 gatgagacag agagtgctct gccaatacct gcgaataaac gcgcctcctc tgacctcagc
     1201 attgccagct ctgaggaaga taagctttca caaaatgctt gtattttgga atctgtgtca
     1261 gaaagaacag aacacaatac ttctggggat aaatttagca acaaagttct tagtgagaag
     1321 cctactcctg agggacctga gaagactgtg gatgtggatg ggcctgcaaa tgatgttaac
     1381 ttagaaactg tggctgaacc aaatgaccaa gcggtaggat tccatgagaa tgggagagag
     1441 aagaaaagac cccaactgga aagtcaacca gatacagaag accaacaaac tgtggatgtt
     1501 aatttagtcg gtgaaggaaa tgacagcaat atagtaattt tagaaacaaa cactgattgt
     1561 ctgaaaccag aggaagacag aaatgaagaa aaccaagaga taattgagaa taaacttaca
     1621 caatctgaag aaattaaaga tatacatatt caaacaatgg acttagtttc tcaagaaact
     1681 ggagaaaaag aggcagattt tcaggcaatt gacaatgaag ttgggtttac aaaggaagaa
     1741 acccaagaga aattgggaaa agatgataaa actcacaaag ttgtgatcag tgatataacc
     1801 agtgaggtgg gaacagacga gcctccaggt gatacccaga agtctgctga gcagagccag
     1861 gatgcagagg gtggggctgg ggaagaagcc ccggagcctg cccagacact aacagagaag
     1921 gccactgagg gccctgaggc tcatggtgct gaggaagagc ctcgtagtgg agagagagta
     1981 gaggataagc agctagagca gcagtctgca gtgtgtgaag gtgagggaca ggtaaccagc
     2041 acttcagaga gcacacgggc aaccacggag gaaccagaga ctgacgaagt tgaccaagtc
     2101 agcgagtcaa atagcattga ggaactagag agacttggag ttactggtgc tgaggaacag
     2161 gctctaggga gcaaagggga ggctgctacg gagctagatt tggagagaga agaaaatgca
     2221 caggaactgc cagttaaagc agagccccaa gctcctgcag catcgcaggc cagcgaacct
     2281 ccccctgtct taatacccag tattaatatt cattcggaaa acacagaaaa taaaggagaa
     2341 atgggtgctt tgccaaaacc tgaaaccata ctgccaccag agcctgaaaa tggaaaggga
     2401 aatgacacgg actcagggac tgggtccact gtggagaaca gcagcagtga cctgaacttg
     2461 tccatctcta gcttcctgag caaaaccaag gacagtggct cggtgtctct gcaggagaca
     2521 agaagacaga agaaaacatt gaagaaaaca cgtaaattta ttgttgatgg agtagaagtg
     2581 agtgtgacaa catcaaagat agttacagac agcgactcta aaaccgagga attgaggttt
     2641 ctcaggcgtc aggaacttcg agagctaagg cttctccaga aggaagagca gaaagcccag
     2701 cagcagctca acgggaaatt gcagcagcag cgcgagcaga tcttcaggcg ctttgagcag
     2761 gagatgctga gtaagaagcg acaatatgac caagaaattg agaatctaga gaagcagcag
     2821 aaacagacaa ttgaacgact agaacaagaa cacacaaacc gcctgagaga cgaagctaag
     2881 cgcatcaaag gagagcagga gaaggagctg tccaaattcc agaatatgct aagaaaccga
     2941 aagaaggagg aacaagaatt tgttcagaag caacagcaag agttagacgg cgctctgaaa
     3001 aagatcatcc agcagcagaa ggcagagttg gccaatattg agagagagtg cttgaataac
     3061 aagcagcagc tcctgagagc ccgagaagct gcaatttggg agcttgaaga acgacattta
     3121 caagaaaagc accagctgct taaacagcaa cttaaagatc agtatttcat acagagacat
     3181 cagctgctta aacgccatga gaaggaaaca gaacaaatgc agcgttacaa tcaacgactt
     3241 attgaagaat tgaagaacag acagactcag gaacgagcta gactgcccaa gattcagaga
     3301 agtgaagcca agacacgaat ggccatgttt aaaaaaagtt tgaggattaa ctcaacagct
     3361 acaccagacc aggaccgtga aaaaattaaa cagtttgctg cacaggaaga aaagagacag
     3421 aaaaatgaga gaatggctca gcatcaaaaa catgagagtc agatgcggga ccttcagttg
     3481 cagtgtgaag ccaacgtccg agagctgcac cagctgcaga atgaaaaatg ccacctgttg
     3541 gttgaacatg agactcagaa actgaaggag ttagatgagg agcacagcca agagctcaag
     3601 gagtggagag agaagctgag gcccaggaag aagacactgg aggaagagtt tgccaggaaa
     3661 cttcaggaac aggaagtgtt ctttaaaatg accggggagt ccgaatgcct caacccctca
     3721 gcgcagagcc ggatctccaa attctaccct attcccacct tacattccac tgggtcatag
     3781 cggcagcagt gtcctc
//
