LOCUS       NM_031321               5210 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus slit guidance ligand 3 (Slit3), mRNA.
ACCESSION   NM_031321 XM_346391
VERSION     NM_031321.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5210)
  AUTHORS   Hu,Q., Wu,C., Yu,J., Luo,J. and Peng,X.
  TITLE     Angelica sinensis polysaccharide improves rheumatoid arthritis by
            modifying the expression of intestinal Cldn5, Slit3 and Rgs18
            through gut microbiota
  JOURNAL   Int J Biol Macromol 209 (Pt A), 153-161 (2022)
   PUBMED   35318077
  REMARK    GeneRIF: Angelica sinensis polysaccharide improves rheumatoid
            arthritis by modifying the expression of intestinal Cldn5, Slit3
            and Rgs18 through gut microbiota.
REFERENCE   2  (bases 1 to 5210)
  AUTHORS   Takahashi,T., Friedmacher,F., Zimmer,J. and Puri,P.
  TITLE     Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in
            the developing diaphragmatic vasculature of nitrofen-induced
            congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (6), 1035-1039 (2017)
   PUBMED   28363469
  REMARK    GeneRIF: Relative mRNA expression of Ndst1 and Slit3 was
            significantly decreased in pleuroperitoneal folds, developing
            diaphragms and fully muscularized diaphragms, and endothelial cells
            within the diaphragmatic vasculature of nitrofen-exposed fetuses
            compared to controls.
REFERENCE   3  (bases 1 to 5210)
  AUTHORS   Mommersteeg,M.T., Yeh,M.L., Parnavelas,J.G. and Andrews,W.D.
  TITLE     Disrupted Slit-Robo signalling results in membranous ventricular
            septum defects and bicuspid aortic valves
  JOURNAL   Cardiovasc Res 106 (1), 55-66 (2015)
   PUBMED   25691540
REFERENCE   4  (bases 1 to 5210)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 5210)
  AUTHORS   Doi,T., Hajduk,P. and Puri,P.
  TITLE     Upregulation of Slit-2 and Slit-3 gene expressions in the
            nitrofen-induced hypoplastic lung
  JOURNAL   J Pediatr Surg 44 (11), 2092-2095 (2009)
   PUBMED   19944214
REFERENCE   6  (bases 1 to 5210)
  AUTHORS   Marillat,V., Cases,O., Nguyen-Ba-Charvet,K.T., Tessier-Lavigne,M.,
            Sotelo,C. and Chedotal,A.
  TITLE     Spatiotemporal expression patterns of slit and robo genes in the
            rat brain
  JOURNAL   J Comp Neurol 442 (2), 130-155 (2002)
   PUBMED   11754167
REFERENCE   7  (bases 1 to 5210)
  AUTHORS   Patel,K., Nash,J.A., Itoh,A., Liu,Z., Sundaresan,V. and Pini,A.
  TITLE     Slit proteins are not dominant chemorepellents for olfactory tract
            and spinal motor axons
  JOURNAL   Development 128 (24), 5031-5037 (2001)
   PUBMED   11748139
REFERENCE   8  (bases 1 to 5210)
  AUTHORS   Little,M.H., Wilkinson,L., Brown,D.L., Piper,M., Yamada,T. and
            Stow,J.L.
  TITLE     Dual trafficking of Slit3 to mitochondria and cell surface
            demonstrates novel localization for Slit protein
  JOURNAL   Am J Physiol Cell Physiol 281 (2), C486-C495 (2001)
   PUBMED   11443047
REFERENCE   9  (bases 1 to 5210)
  AUTHORS   Brose,K., Bland,K.S., Wang,K.H., Arnott,D., Henzel,W.,
            Goodman,C.S., Tessier-Lavigne,M. and Kidd,T.
  TITLE     Slit proteins bind Robo receptors and have an evolutionarily
            conserved role in repulsive axon guidance
  JOURNAL   Cell 96 (6), 795-806 (1999)
   PUBMED   10102268
REFERENCE   10 (bases 1 to 5210)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB011531.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346391.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5210
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /note="slit guidance ligand 3"
                     /db_xref="GeneID:83467"
                     /db_xref="RGD:69311"
     exon            1..488
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..4863
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /note="slit homolog 3 protein; slit-3; multiple epidermal
                     growth factor-like domains 5; multiple EGF-like domains
                     protein 5; multiple epidermal growth factor-like domains
                     protein 5"
                     /codon_start=1
                     /product="slit homolog 3 protein precursor"
                     /protein_id="NP_112611.1"
                     /db_xref="GeneID:83467"
                     /db_xref="RGD:69311"
                     /translation="MAPGRTGAGAAVRARLALALALASILSGPPAAACPTKCTCSAAS
                     VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFTGLKNLRVLHLEDNQVSVIER
                     GAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVK
                     NLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY
                     CDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNAN
                     SLSCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFIQYKKLK
                     RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKIN
                     CLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD
                     YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCPEK
                     CRCEGTIVDCSNQKLSRIPSHLPEYTTDLRLNDNDIAVLEATGIFKKLPNLRKINLSN
                     NRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSGLKTLMLRSNLISCVNNDT
                     FAGLSSVRLLSLYDNRITTISPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRKRR
                     IVSGNPRCQKPFFLKEIPIQDVAIQDFTCEGNEENSCQLSPRCPEQCTCVETVVRCSN
                     RGLHTLPKGMPKDVTELYLEGNHLTAVPKELSTFRQLTLIDLSNNSISMLTNHTFSNM
                     SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGI
                     NPLHCDCSLRWLSEWIKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIV
                     AKCNACLSSPCKNNGTCSQDPVEQYRCTCPYSYKGKDCTVPINTCVQNPCQHGGTCHL
                     SESHRDGFSCSCPLGFEGQRCEINPDDCEDNDCENSATCVDGINNYACVCPPNYTGEL
                     CDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSGKLCETDNDDCVAHKCRHGAQ
                     CVDAVNGYTCICPQGFSGLFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCP
                     PGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPL
                     ALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSL
                     GKLQKQPAVGINSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKA
                     LPPQSLGVSPGCKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEAQDPCLGHSCS
                     HGTCVATGNSYVCKCAEGYEGPLCDQKNDSANACSAFKCHHGQCHISDRGEPYCLCQP
                     GFSGNHCEQENPCLGEIVREAIRRQKDYASCATASKVPIMVCRGGCGSQCCQPIRSKR
                     RKYVFQCTDGSSFVEEVERHLECGCRECS"
     exon            489..560
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            561..632
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..704
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..776
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            777..848
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            849..920
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1084
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1226
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1298
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1370
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1442
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1586
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1750
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1901
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1976
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2120
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2264
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2428
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2561
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2630
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2702
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2774
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2846
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3010
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3135
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3233
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3373
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3467
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3605
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3846
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3847..3977
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4132
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            4133..4418
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4627
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..5210
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5210
                     /gene="Slit3"
                     /gene_synonym="Megf5"
                     /note="17 a nucleotides"
ORIGIN      
        1 cccagaccga atcctcacct ctgccggcca cccacaggga cccgagagcg ctccgtacct
       61 gggcaccgtg agtgatgcgc agcggggcag cgccagcccc acggatggag ctgctgccgc
      121 cgccgcccgg cgcgccccgc tccgcccgcg ccccgtgcgc ctgagcgccg cgcccgcccc
      181 tcctccgcgc caactccgcc gcccgccccc caggccgccc gcgcgcctcc tcgggctcct
      241 cgtgtcccgc cgcgccaagc agcctcctct gggtgctggc gcctgtacac catggccccc
      301 gggcggaccg gggccggcgc cgctgtgcgc gcccgcctgg cgctggcctt ggcgctggcg
      361 agcatcctga gcggaccccc cgctgctgcc tgccccacca agtgtacctg ctccgccgct
      421 agcgtggact gccacgggct gggcctgcgc gccgttcccc ggggcatccc ccgcaacgct
      481 gagcgccttg acctggacag aaataacatc accaggatca ccaaaatgga cttcaccggc
      541 ttgaagaatc tccgagtctt gcatctggaa gacaatcagg tcagcgtcat cgagagaggc
      601 gccttccagg atctgaagca gctggagcga ttacgtctga acaagaacaa gctccaggtc
      661 cttccagaat tacttttcca gagcacaccg aagctcacca gactagatct gagcgaaaac
      721 cagatccagg gcatcccgag gaaggcgttc aggggcgtca cgggcgtgaa gaacctgcaa
      781 ctggacaata accacatcag ctgcattgaa gatggagcct tccgagcgct gcgcgatttg
      841 gagatcctca cccttaacaa caacaacatc agccgtatcc tggtcaccag cttcaaccac
      901 atgccgaaga tccggaccct gcgtctccac tccaaccacc tgtactgtga ttgtcacttg
      961 gcctggctct cagactggct gcgacagcgg cggaccattg gccagttcac cctctgcatg
     1021 gcgcccgtgc acctgagagg cttcagtgta gcagacgtgc agaagaagga gtatgtgtgt
     1081 ccaggtcccc actcagaggc tccagcctgc aatgccaact ccctctcctg cccttctgcc
     1141 tgctcatgca gtaataacat tgtagactgc cgtgggaagg gactgactga gatccctgcc
     1201 aacctgccgg agggcatcgt ggaaatacgc ctagaacaga actccatcaa atccattcct
     1261 gcaggagctt tcatccagta caaaaaactg aagcgaatag acatcagcaa gaatcagata
     1321 tcggacattg ctccagatgc cttccagggc ctgaaatcac tcacgtcgct ggtgctctat
     1381 gggaacaaga tcacagagat tcccaaagga ctgtttgacg ggctggtgtc cctgcagctg
     1441 ctcctcctca atgccaacaa gatcaactgc ctgcgggtaa acaccttcca ggacctacag
     1501 aacctcaatc tgctctctct gtatgacaac aagttgcaga ctatcagcaa agggctcttt
     1561 gctccgctgc agtccatcca gaccctccac ttagctcaaa acccgtttgt ttgcgactgc
     1621 cacttgaagt ggttggccga ctacctccag gacaacccca ttgagacgag cggggcccgc
     1681 tgcagcagcc cacgccggct ggccaacaag cgcatcagcc agatcaaaag caagaagttc
     1741 cgctgctcag gctcggagga ttatcgcaac agattcagca gcgagtgctt catggaccta
     1801 gtgtgccccg agaagtgccg ttgtgagggc accattgtgg actgctccaa ccagaagctc
     1861 tcccgcatcc cgagccacct ccctgaatat accactgacc tgcgactgaa cgacaatgac
     1921 atcgctgtgc tggaggccac tgggatcttc aagaagttgc ccaacctgag gaaaataaac
     1981 ttgagcaata ataggatcaa ggaggtgcgg gagggtgcgt ttgatggagc ggcaggcgtg
     2041 caggaactga tgctgacggg gaaccagctg gagaccatgc acggacgcat gttccggggc
     2101 ctcagcggcc tgaagacact gatgttaagg agcaacctga tcagctgcgt aaacaatgac
     2161 accttcgctg gcctaagctc tgtgagactg ctgtccctct atgacaatcg gatcaccacc
     2221 atcagccctg gagccttcac cacgctcgtc tccctgtcca ccataaacct cttgtctaac
     2281 cctttcaact gcaactgtca catggcctgg ctcggccggt ggctgaggaa acgccgcatc
     2341 gtaagcggga accccagatg tcagaagccc tttttcctca aggagattcc tatccaagat
     2401 gtggccatcc aggacttcac ctgtgaaggc aatgaagaga acagctgtca gctgagtcca
     2461 cgctgccccg agcagtgtac ctgtgtggag acagtggtgc gatgcagcaa caggggtctc
     2521 cacaccctcc ccaagggcat gccaaaggac gtgactgaac tgtacctgga aggaaatcat
     2581 ttaacggcgg tgcccaaaga attgtccacc ttccgacagc tgacactaat tgacctgagc
     2641 aacaacagca tcagtatgct gaccaatcac accttcagca acatgtccca cctctccaca
     2701 ctgatcctga gctacaaccg gctgagatgc atcccggtcc atgccttcaa cgggctaagg
     2761 tcactccgag tgctaaccct ccatggcaat gacatttcca gtgttcctga aggctccttc
     2821 aatgatctga cgtccctctc ccacctggcc ctgggaatca accctctcca ctgtgactgc
     2881 agtctgcgtt ggttatcaga gtggataaag gctgggtaca aggagcctgg cattgccaga
     2941 tgcagtagcc ccgagtccat ggcagacaga ctcctgctca ccacccccac ccacaggttc
     3001 cagtgcaaag ggccagtgga cattaacatc gtggccaagt gcaacgcctg cctctctagc
     3061 ccatgcaaga acaacggcac ttgcagccag gatccggtgg agcagtaccg ctgtacctgc
     3121 ccttacagct acaagggcaa ggactgcacc gtgcccatca acacctgcgt ccagaacccc
     3181 tgtcagcacg gaggcacctg tcacctcagt gagagccaca gagatgggtt cagctgctcc
     3241 tgccccctgg gctttgaggg acagcggtgt gagatcaacc cagatgactg tgaggataac
     3301 gactgtgaaa acagcgccac ctgtgtggac gggatcaaca actacgcatg cgtgtgcccg
     3361 ccgaactaca caggggagct gtgtgatgag gtgattgact actgcgtgcc cgagatgaac
     3421 ctctgtcagc acgaggccaa gtgcatctcc ctggacaaag gattcaggtg cgaatgtgtc
     3481 cctggctaca gtggaaagct gtgcgagaca gacaacgatg actgtgtggc tcacaagtgt
     3541 cgccacggag cccagtgtgt ggacgcggtc aatggctaca cgtgcatctg cccccagggc
     3601 ttcagcgggc tcttctgtga gcacccccca cccatggttc tgctacagac cagcccctgt
     3661 gaccagtacg agtgccagaa tggggcgcag tgcatcgtgg tacagcagga gcccacttgc
     3721 cgctgtcccc caggcttcgc tgggcccagg tgtgagaagc tcatcactgt gaatttcgtg
     3781 ggcaaggact cctatgtgga actggcctct gccaaggtcc ggccccaggc caacatctcc
     3841 ctgcaggtgg ccactgacaa ggacaacggc atccttcttt acaagggaga caacgacccc
     3901 ctggcactgg agctgtacca gggtcacgtg aggctggtgt atgacagcct gagctcccct
     3961 ccgaccacgg tgtacagtgt ggagacggtg aatgatggcc agtttcacag tgtggagctg
     4021 gtgatgctaa accagaccct gaacctggtg gtagacaaag gagcccccaa gagcctgggg
     4081 aagctccaga agcagccagc agtgggcatc aacagtcccc tctatcttgg aggcatcccc
     4141 acgtctacag gcctctcagc cttacgccag ggtgcagaca ggccgctggg cggcttccac
     4201 ggctgtatac acgaagtgcg catcaacaac gagttgcagg atttcaaagc cctcccaccc
     4261 cagtccctgg gggtctctcc cggctgcaaa tcctgcactg tgtgtcgtca cggcctgtgt
     4321 cgttccgtgg agaaggacag cgtagtgtgt gagtgccatc cgggatggac tggtccactg
     4381 tgtgatcagg aagcccagga cccctgcctt ggtcacagct gcagccatgg gacatgcgtg
     4441 gcgactggca actcatatgt gtgcaagtgt gccgagggct atgagggacc tttgtgtgac
     4501 cagaagaatg actctgccaa tgcctgctca gccttcaagt gccaccacgg gcagtgccac
     4561 atctcagatc gaggggagcc ctattgcctg tgccagcctg gcttcagtgg caatcactgt
     4621 gagcaagaga atccatgttt gggagagata gtccgtgaag ccatccgccg ccagaaagat
     4681 tatgcctcct gtgccacagc atccaaggtg cccatcatgg tatgccgcgg gggctgcggg
     4741 agccaatgct gccagccgat tcggagcaag cggcggaaat acgtcttcca gtgcactgac
     4801 ggctcctcgt tcgtggaaga ggtggagaga cacttggaat gtggctgtcg tgagtgttcc
     4861 tgagcccctc cccctctgcc gcccactcat cctccgcctt cgggactcca cgtggaacct
     4921 ctttgagatt cagaatgaag gagagaaagc ttggagacca agaggcaaaa gagagaatat
     4981 taagtatatt gtaaaataaa caaaaaaata gaacttattt ttattatgga aagtgactat
     5041 tttcatcttt tattatataa atatatcaca ccgtctgagt atatggacta tacagtgagt
     5101 tatttttacc aagttttgtt ttgtgttgtg tatttgttgt gtttttataa acagctgttt
     5161 aaaattttaa gacaaaaaaa aaacactaat aaaaatgttt taaacacaag
//
