LOCUS       NM_022953               4968 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus slit guidance ligand 1 (Slit1), mRNA.
ACCESSION   NM_022953 XM_346580
VERSION     NM_022953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Ying,Z., Wu,J., Jiang,W., Zhang,G., Zhu,W., Li,X., Pang,X. and
            Liu,W.
  TITLE     Expression of Slit and Robo during remodeling of corticospinal
            tract in cervical spinal cord in middle cerebral artery occlusion
            rats
  JOURNAL   Mol Biol Rep 48 (12), 7831-7839 (2021)
   PUBMED   34652618
  REMARK    GeneRIF: Expression of Slit and Robo during remodeling of
            corticospinal tract in cervical spinal cord in middle cerebral
            artery occlusion rats.
REFERENCE   2  (bases 1 to 4968)
  AUTHORS   Zhang,H.Y., Zheng,L.F., Yi,X.N., Chen,Z.B., He,Z.P., Zhao,D.,
            Zhang,X.F. and Ma,Z.J.
  TITLE     Slit1 promotes regenerative neurite outgrowth of adult dorsal root
            ganglion neurons in vitro via binding to the Robo receptor
  JOURNAL   J Chem Neuroanat 39 (4), 256-261 (2010)
   PUBMED   20172023
  REMARK    GeneRIF: These findings indicate that Slit1/Robo2 signaling may
            have a role in regulating peripheral nerve regeneration.
REFERENCE   3  (bases 1 to 4968)
  AUTHORS   Fujiwara,T., Kubo,T., Koyama,Y., Tomita,K., Yano,K., Tohyama,M. and
            Hosokawa,K.
  TITLE     mRNA expression changes of slit proteins following peripheral nerve
            injury in the rat model
  JOURNAL   J Chem Neuroanat 36 (3-4), 170-176 (2008)
   PUBMED   18755265
  REMARK    GeneRIF: The difference in expression pattern of Slit family mRNA
            in the neurons during peripheral nerve regeneration suggests that
            it plays a different role in axonal regeneration after axotomy of
            peripheral nerves
REFERENCE   4  (bases 1 to 4968)
  AUTHORS   Lin,L. and Isacson,O.
  TITLE     Axonal growth regulation of fetal and embryonic stem cell-derived
            dopaminergic neurons by Netrin-1 and Slits
  JOURNAL   Stem Cells 24 (11), 2504-2513 (2006)
   PUBMED   16840550
REFERENCE   5  (bases 1 to 4968)
  AUTHORS   Thompson,H., Camand,O., Barker,D. and Erskine,L.
  TITLE     Slit proteins regulate distinct aspects of retinal ganglion cell
            axon guidance within dorsal and ventral retina
  JOURNAL   J Neurosci 26 (31), 8082-8091 (2006)
   PUBMED   16885222
REFERENCE   6  (bases 1 to 4968)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
REFERENCE   7  (bases 1 to 4968)
  AUTHORS   Liang,Y., Annan,R.S., Carr,S.A., Popp,S., Mevissen,M.,
            Margolis,R.K. and Margolis,R.U.
  TITLE     Mammalian homologues of the Drosophila slit protein are ligands of
            the heparan sulfate proteoglycan glypican-1 in brain
  JOURNAL   J Biol Chem 274 (25), 17885-17892 (1999)
   PUBMED   10364234
REFERENCE   8  (bases 1 to 4968)
  AUTHORS   Brose,K., Bland,K.S., Wang,K.H., Arnott,D., Henzel,W.,
            Goodman,C.S., Tessier-Lavigne,M. and Kidd,T.
  TITLE     Slit proteins bind Robo receptors and have an evolutionarily
            conserved role in repulsive axon guidance
  JOURNAL   Cell 96 (6), 795-806 (1999)
   PUBMED   10102268
REFERENCE   9  (bases 1 to 4968)
  AUTHORS   Itoh,A., Miyabayashi,T., Ohno,M. and Sakano,S.
  TITLE     Cloning and expressions of three mammalian homologues of Drosophila
            slit suggest possible roles for Slit in the formation and
            maintenance of the nervous system
  JOURNAL   Brain Res Mol Brain Res 62 (2), 175-186 (1998)
   PUBMED   9813312
REFERENCE   10 (bases 1 to 4968)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB011530.1, EV772160.1 and BF410201.1.
            
            On Oct 17, 2007 this sequence version replaced NM_022953.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011530.1, AF133730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3860              AB011530.1         1-3860
            3861-4015           EV772160.1         261-415
            4016-4932           AB011530.1         4016-4932
            4933-4968           BF410201.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4968
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /note="slit guidance ligand 1"
                     /db_xref="GeneID:65047"
                     /db_xref="RGD:69307"
     exon            1..356
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..4755
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /note="slit homolog 1 protein; slit-1; multiple epidermal
                     growth factor-like domains 4; multiple EGF-like domains
                     protein 4; multiple epidermal growth factor-like domains
                     protein 4"
                     /codon_start=1
                     /product="slit homolog 1 protein precursor"
                     /protein_id="NP_075242.1"
                     /db_xref="GeneID:65047"
                     /db_xref="RGD:69307"
                     /translation="MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTT
                     VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVER
                     GAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLK
                     NLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF
                     CDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAAQVPACT
                     LSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK
                     LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANK
                     INCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWL
                     ADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECT
                     SDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSH
                     LKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNR
                     ISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWL
                     GDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECAC
                     LDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS
                     LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVT
                     SLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFEC
                     QGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNP
                     CGNGGTCHAQEGEDAGFTCSCPSGFEGLTCGMNTDDCVKHDCVNGGVCVDGIGNYTCQ
                     CPLQYTGRACEQLVDFCSPDLNPCQHEAQCVGTPEGPRCECVPGYTGDNCSKNQDDCK
                     DHQCQNGAQCVDEINSYACLCAEGYSGQLCEIPPAPRNSCEGTECQNGANCVDQGSRP
                     VCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNG
                     DNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGG
                     SPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNEL
                     QDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPC
                     HGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATRG
                     AHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGC
                     CQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAPCA"
     exon            357..428
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            429..500
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            501..572
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            573..644
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..716
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            717..788
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            789..952
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1100
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1172
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1244
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1316
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1460
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1624
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1648
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1793
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1868
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2012
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2156
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2323
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2456
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2525
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2597
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2669
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2741
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2905
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3030
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3128
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3268
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3362
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3500
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3729
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3860
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4015
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4304
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..4516
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4952
                     /gene="Slit1"
                     /gene_synonym="MEGF4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggagcat ctaggtgcta ctcgagccgc aagggcgcat cgtacgatcc ccccggctct
       61 tcggtccctc ggtggggata gcacctggag atagccccgg acggggatgg tcagcggctg
      121 cggccgtctg acacacgagc gggacacggc gagggcacca tggcgctaac gccccagcgc
      181 gggtcctctt cggggttgag ccgaccagag ctgtggctgc tgctatgggc agccgcgtgg
      241 cgcctggggg ccacggcgtg ccccgccctc tgcacctgca ccggcactac agtggactgc
      301 cacggcacgg gtttgcaggc catccccaag aacatcccac ggaacaccga gcgcctggaa
      361 ctcaatggta acaatatcac tcggatccat aagaatgact ttgctgggct caagcagctt
      421 cgagtgttgc agctgatgga gaaccagatt ggagctgtgg aacggggagc ttttgatgac
      481 atgaaggagt tggagcggct acgactgaac cgcaaccagc tgcaagtgtt gcctgaacta
      541 ctgttccaga acaaccaggc tctgtccaga ctggacctga gtgagaattc tctccaggct
      601 gtgcccagaa aggctttccg aggagccaca gacctcaaaa atctacagct ggacaagaac
      661 cagatcagct gcatcgagga aggggccttc cgtgccctac ggggactgga ggttctgacc
      721 ctgaacaaca acaacatcac caccatccct gtgtccagtt tcaaccatat gcccaagctt
      781 cggaccttcc ggctgcactc caaccacctg ttctgtgact gtcacctggc ctggctctcg
      841 cagtggctga gacagaggcc caccatcggg ctcttcaccc agtgctctgg gcccgccagc
      901 cttcggggcc tcaatgtggc agaggtgcaa aagagtgagt tcagctgctc aggccagggg
      961 gaggctgcac aagtacctgc ctgcaccctc tcatccggtt cctgcccagc catgtgcagc
     1021 tgtagcaatg gcatcgtgga ctgccgtggc aaaggcctca ctgccatccc tgctaacctt
     1081 ccggagacga tgaccgagat ccgcctggag ctgaacggta tcaaatccat cccaccagga
     1141 gccttctctc cctacagaaa gctgcgcagg atagacctga gtaacaacca gattgctgag
     1201 attgcacccg atgccttcca aggcctccgc tccttgaatt ccctggtcct ctatggcaac
     1261 aagatcacag acttgccccg aggtgtattt ggaggcctgt acaccctcca gctgctgctt
     1321 ctgaatgcca acaagatcaa ctgcatccgg cctgatgcct tccaggacct gcagaacctc
     1381 tctctgctct ccctatatga caacaagatc cagagtctcg ccaagggcac cttcacctcc
     1441 ctgcgggcca tccagacact gcatctggcc cagaaccctt tcatctgtga ctgtaacctc
     1501 aagtggctgg cagacttctt acgtaccaac cccattgaga caactggggc ccgctgtgcc
     1561 agcccccggc gccttgccaa caagcgtatc gggcagatca aaagcaagaa gttccggtgc
     1621 tcagccaaag agcagtactt cattccaggg acggaggatt accacctgaa cagcgagtgt
     1681 acgagtgacg tggcctgtcc ccacaagtgc cgctgtgagg ccagtgtggt ggagtgctct
     1741 ggcctgaagc tctctaagat ccctgagcga atcccccagt ccacgactga gctacgactg
     1801 aacaacaatg agatttcaat cctagaggcc actgggttgt ttaagaagct ctcacatctg
     1861 aagaaaataa acctgagcaa caacaaggtg tcagagattg aagacgggac gtttgaaggc
     1921 gccacctccg tcagcgagct gcacctgacc gccaaccagc tggagtctgt cagaagcggc
     1981 atgttccggg gtctagatgg cttgcggacc ctgatgctga ggaacaaccg tatcagctgc
     2041 atccacaatg acagcttcac tgggctgcgt aacgtgcggc tcctgtctct ttacgacaac
     2101 cacatcacca ccatctcccc tggagccttc gacaccctcc aggccctgtc cacactaaac
     2161 ctcctggcca acccattcaa ctgcaactgc cagttggcct ggctggggga ctggcttcgg
     2221 aagaggaaaa ttgtgacagg gaaccctcgc tgtcagaacc cagacttcct gcggcagatt
     2281 cctctgcaag atgtggcctt ccctgacttc aggtgtgagg aaggccagga ggaggtgggc
     2341 tgcctgcccc gcccacagtg cccccaagag tgcgcctgcc tggacaccgt ggtccggtgt
     2401 agcaacaagc acctccaggc tctgcccaag ggcatcccca agaatgtcac agaactctac
     2461 ttggatggga accagttcac actggttccg ggacagctgt ctaccttcaa gtatctgcag
     2521 cttgtcgacc tgagcaacaa caagatcagc tccttaagca actcttcctt caccaacatg
     2581 agtcagctga ccacactgat cctcagctac aacgccctcc agtgcatccc ccctctggcc
     2641 ttccaaggac ttcgttcact gcgcttgctg tctttgcatg gcaatgatgt ctccaccctc
     2701 caagagggaa tctttgcaga cgtgacgtct ctgtctcacc tggccattgg tgccaacccc
     2761 ctgtactgcg actgccacct ccgatggctc tccagctggg tgaagactgg ctacaaggaa
     2821 cctggcattg cccgctgtgc tggaccccca gagatggagg gcaaactgtt gctcaccaca
     2881 cctgccaaga agtttgaatg ccaaggtccc cccagcctgg cggttcaggc caagtgtgat
     2941 ccctgcttgt ccagcccatg ccagaatcag ggcacttgtc acaatgaccc tcttgaggta
     3001 tacaggtgta cctgccccag tggctacaag ggccgaaact gtgaggtgtc tctggacagc
     3061 tgttccagca acccatgtgg aaatggggga acctgccatg cccaggaggg cgaggatgct
     3121 ggcttcacgt gctcctgtcc ttccggcttt gaagggctga cgtgtggaat gaacacagat
     3181 gattgtgtga agcacgactg tgtcaatggg ggtgtctgtg tggatggcat agggaattac
     3241 acatgtcagt gccccctgca gtacacagga agggcctgtg aacagctagt ggacttctgc
     3301 tctccggatc tgaacccatg tcagcatgag gcccaatgtg ttggcacccc agaggggccc
     3361 aggtgtgagt gtgtgccagg ctacacgggt gacaattgca gcaaaaacca ggacgactgc
     3421 aaggaccacc agtgtcagaa cggggctcag tgtgtggatg agatcaacag ctacgcctgt
     3481 ctctgtgctg agggctacag cggacagctc tgtgagatcc cacctgcccc caggaactcc
     3541 tgtgaaggga ctgagtgcca gaatggagcc aactgtgtag accagggcag ccggcccgta
     3601 tgccagtgcc taccaggctt tggaggtccc gaatgtgaga agttgctcag tgtcaacttt
     3661 gtggaccggg acacttacct gcagttcact gacctgcaga actggcctcg ggccaacatc
     3721 actcttcagg tctccacagc agaggacaat gggatcctcc tctacaatgg ggataatgac
     3781 cacattgcag ttgagctgta ccagggccat gtccgtgtta gctacgaccc aggcagctac
     3841 cccagctctg ctatctacag tgctgaaaca atcaacgatg ggcagttcca cacagttgag
     3901 ctggtgacct ttgaccagat ggtgaacctc tccattgatg gtggcagccc catgaccatg
     3961 gacaactttg gaaagcacta cacactcaac agtgaggccc ccctctatgt gggagggatg
     4021 cccgtggatg tgaactcagc tgccttccgc ctgtggcaga tcctcaatgg caccagcttc
     4081 cacggttgca tccggaatct atacatcaac aacgaactgc aggacttcac caagacacag
     4141 atgaagccgg gcgtggtgcc cggctgcgag ccctgccgaa aactctactg tctacatggc
     4201 atttgccagc ccaacgccac cccagggccc gtgtgccact gcgaggctgg ctgggggggc
     4261 ctgcactgtg accagccagt ggacggcccc tgccatggcc acaagtgtgt ccatgggaaa
     4321 tgcgtgcccc tcgatgcact tgcctacagc tgccaatgcc aggatggata ctcgggggct
     4381 ctgtgcaacc aggtcggggc tgtggcagag ccctgtgggg gcttacagtg cctgcatggt
     4441 cactgccagg cctcggccac cagaggggca cactgtgtgt gcagcccagg tttttcaggc
     4501 gagctgtgtg agcaagagtc cgagtgccgg ggggaccctg tccgggactt tcaccgggtc
     4561 cagaggggct atgccatctg ccagaccacg cgcccactgt catgggtgga atgccggggc
     4621 gcgtgcccgg gccagggctg ctgccagggc ctgcggctga agcggaggaa gctcaccttc
     4681 gagtgcagcg atgggacctc gtttgctgag gaggtggaga agcccaccaa gtgcggctgt
     4741 gccccgtgtg cgtaacgtgc gggtggcaca ctagcagctg ggctggggcg ggcatcacca
     4801 ggatagcgct tgggtcctgg tgggcgcggg gacactgagc tgcctttcca gcggactgca
     4861 ctgccagggc agaggagcaa ggcccgggtt gccaagccct ctcccaaagt gccttgcaca
     4921 gataggcgct taataaatat ttgttgaatg aaaaaaaaaa aaaaaaaa
//
