LOCUS       NM_053687               4857 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus schlafen family member 4 (Slfn4), transcript
            variant 1, mRNA.
ACCESSION   NM_053687
VERSION     NM_053687.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4857)
  AUTHORS   Mavrommatis,E., Arslan,A.D., Sassano,A., Hua,Y., Kroczynska,B. and
            Platanias,L.C.
  TITLE     Expression and regulatory effects of murine Schlafen (Slfn) genes
            in malignant melanoma and renal cell carcinoma
  JOURNAL   J Biol Chem 288 (46), 33006-33015 (2013)
   PUBMED   24089532
  REMARK    GeneRIF: Slfn2 and Slfn3 play essential roles in the control of
            mouse malignant melanoma cell proliferation and/or
            anchorage-independent growth
REFERENCE   2  (bases 1 to 4857)
  AUTHORS   Kovalenko,P.L., Yuan,L., Sun,K., Kunovska,L., Seregin,S.,
            Amalfitano,A. and Basson,M.D.
  TITLE     Regulation of epithelial differentiation in rat intestine by
            intraluminal delivery of an adenoviral vector or silencing RNA
            coding for Schlafen 3
  JOURNAL   PLoS One 8 (11), e79745 (2013)
   PUBMED   24244554
  REMARK    GeneRIF: Slfn3 is an important regulator of the rat intestinal
            epithelial phenotype, and may represent a novel common pathway for
            the regulation of intestinal epithelial differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4857)
  AUTHORS   Walsh,M.F., Hermann,R., Sun,K. and Basson,M.D.
  TITLE     Schlafen 3 changes during rat intestinal maturation
  JOURNAL   Am J Surg 204 (5), 598-601 (2012)
   PUBMED   22906252
  REMARK    GeneRIF: Intestinal Slfn3 expression was increased substantially
            after birth (2.1- +/- .5-fold) and on days 1 and 5 (P < .02). Slfn3
            was higher after birth in liver and lung but decreased sharply
            thereafter.
REFERENCE   4  (bases 1 to 4857)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 4857)
  AUTHORS   Oh,P.S., Patel,V.B., Sanders,M.A., Kanwar,S.S., Yu,Y., Nautiyal,J.,
            Patel,B.B. and Majumdar,A.P.
  TITLE     Schlafen-3 decreases cancer stem cell marker expression and
            autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer
            cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 301 (2), G347-G355 (2011)
   PUBMED   21596996
  REMARK    GeneRIF: our present data suggest that Slfn-3 inhibits multiple
            cancer stem cell characteristics of FOLFOX-resistant colon cancer
            stem-like cells.
REFERENCE   6  (bases 1 to 4857)
  AUTHORS   Patel,V.B., Yu,Y., Das,J.K., Patel,B.B. and Majumdar,A.P.
  TITLE     Schlafen-3: a novel regulator of intestinal differentiation
  JOURNAL   Biochem Biophys Res Commun 388 (4), 752-756 (2009)
   PUBMED   19703412
  REMARK    GeneRIF: Slfn-3 plays a critical role in regulating intestinal
            mucosal differentiation.
REFERENCE   7  (bases 1 to 4857)
  AUTHORS   Patel,B.B., Yu,Y., Du,J., Rishi,A.K., Sarkar,F.H., Tarca,A.L.,
            Wali,A. and Majumdar,A.P.
  TITLE     Schlafen 3, a novel gene, regulates colonic mucosal growth during
            aging
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 296 (4), G955-G962 (2009)
   PUBMED   19228883
  REMARK    GeneRIF: Schlafen 3, a novel negative regulator of growth, which is
            markedly downregulated in the colonic mucosa of the aged, may play
            a role in regulating colonic mucosal growth during aging.
REFERENCE   8  (bases 1 to 4857)
  AUTHORS   Boucherat,O., Franco-Montoya,M.L., Thibault,C., Incitti,R.,
            Chailley-Heu,B., Delacourt,C. and Bourbon,J.R.
  TITLE     Gene expression profiling in lung fibroblasts reveals new players
            in alveolarization
  JOURNAL   Physiol Genomics 32 (1), 128-141 (2007)
   PUBMED   17911382
REFERENCE   9  (bases 1 to 4857)
  AUTHORS   Shimizu,T., Kawakita,S., Li,Q.H., Fukuhara,S. and Fujisawa,J.
  TITLE     Human T-cell leukemia virus type 1 Tax protein stimulates the
            interferon-responsive enhancer element via NF-kappaB activity
  JOURNAL   FEBS Lett 539 (1-3), 73-77 (2003)
   PUBMED   12650929
REFERENCE   10 (bases 1 to 4857)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053687.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF168795.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000010.1  68492220-68492292
            74-154              JAXUCZ010000010.1  68492794-68492874
            155-224             JAXUCZ010000010.1  68500940-68501009
            225-2549            JAXUCZ010000010.1  68508874-68511198
            2550-2660           JAXUCZ010000010.1  68512527-68512637
            2661-4857           JAXUCZ010000010.1  68513477-68515673
FEATURES             Location/Qualifiers
     source          1..4857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..4857
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /note="schlafen family member 4"
                     /db_xref="GeneID:114247"
                     /db_xref="RGD:620455"
     exon            1..73
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
     exon            74..154
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
     exon            155..224
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
     exon            225..2549
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1538..3301
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /note="schlafen 3; schlafen 4"
                     /codon_start=1
                     /product="schlafen family member 4"
                     /protein_id="NP_446139.1"
                     /db_xref="GeneID:114247"
                     /db_xref="RGD:620455"
                     /translation="MSITVDQDTDYAELVLSIGEITLGEKTRKSMKDSQRRKREAKTF
                     QQAVCTLLNSGGGVAKARIKNQNYDFSRDGVGQDLENFLPHILDFPHEYLDFKQVKDY
                     FLMFVKAWKLKQKGPGITTLKTNLYIRSISSSIELKAVNAVKFLKSRKCSKGRSDSRL
                     SSPGTIVCNEVLNECLNLFNRDCFTCKEKFCFTKATHAEVKLTPKENILEILPQTVSS
                     FANADGGYLFIGLDGKTQEIIGFEAEKSDLVHLESEIEKCIRQLPVTHFCEEREKIKY
                     TCKFMEVHKPGAACSFVCALRVERFCCAVFAAEPESWHVEDSCVKRFTAEDWVKRQMD
                     GPACFSKQDKGPLQSSRLPHSPRSCCPDNPDALQQSAGLPVISGKVISSPEALCGKLF
                     STQEAHEQLLWAQLDSLPKGTLVVTKRWALDLPLQDKHGVILDTLHIPQDSLLTLHGF
                     VLGGEDLEDDSTLLRELGAELKGYYKQTAVTLKQTLANHGSYTEKIGIAIKITYLGHN
                     KAVSLYDSSSKIHYPTKYYLTTETAKNLEKALAEILGSRESFYSLPRQNCSDHFIFAF
                     FLSFSFLLVFLFWSWGLNPEP"
     exon            2550..2660
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..4857
                     /gene="Slfn4"
                     /gene_synonym="Cdk107; Slfn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctggacaa aggaaaggcc aggaagccta ccagtgctct gagcttcagg gaacacagct
       61 tctgggacac agagaatctt gactccttgg cgtcctcata gctattctct cagagtacgg
      121 gctgttgaga acttggagac tctgaaagct tggggaggac acacaacctg aagttctctc
      181 ttttgaacac cctggacttc aagcaaccca gattccgagc caagaatctg aagtcggaca
      241 gagttgacga gttatctgaa ggacagatgg ctggaaacct cccacggttg gtggaagatg
      301 taaatccaca gacattcaca gagccctctg ttcagctcaa gtgtccaggg aatatttttc
      361 agggaggacg gcatgccaag ccaggaagct ggaaggattc acagcatata aaatggttgc
      421 ttttgtcata ctgggaagaa ctggaaagca gcatcaagac agacagaaga aacagagaaa
      481 gtgctagaat tttgaccgag tgttcctgaa cagtgctcaa atatgaaaat caaggttcca
      541 gagcatagaa gccataccag gagggagctg gagaatggag aacacccatg ttaaagcagg
      601 aaaggggcca ggctgtgcct cctggaaaat gcttttctga ccctgactgt caaccccaac
      661 aacttccaca taagaaaggg gaggggatgg tatcatagga cagaatcaga tgaagtgaac
      721 caagccagtc tcagaatgac aaatctcata ccatttcctc tcagttgtgg ttcttagagg
      781 gtatatatta cacatctgag aaaccgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
      841 tgtgtgtgtg tgtgtgtaaa acatgaaagt agagctgaat ttatctaagg gagcataagg
      901 gacagatggg gcggtggcct caaagacgtt ggacaggagt gcacactcag tgtacagcat
      961 taagttaaat gtccttttgt agggctacag tattggctca gagtgaggta tcttgttgct
     1021 cttatagaga atagggtcca attcctagca cttacatagg agcttacaag caccctattt
     1081 ccagcctcga gggatccaac aactcttcag accttcagtg gtatcacgca tctctgtgtc
     1141 acgcgtacat atatgcagac aaaacactca tacacataaa aatataaaat acataattag
     1201 gctaaaatat tttaaacttt cttgtaaaac acagtgccgt gaacgtagaa tgcatataca
     1261 caatgatgtt ttttaatcca aaatagaaga ggatcgtaca gtcatgactg aaaattagaa
     1321 aatttagtga gtgttcatta ttgtagtcag ttcaaaattg tcccaacagt ccctaaacaa
     1381 atatcacctc tgaccttctc acttgctcat ccacagcaac tcaaatggtt gtgctgtctg
     1441 gtaacgctgg cctctaactg gttaggtcct tctgtaatga ctgtttctgt cttgcaggaa
     1501 aggatttcat ctgggaagca gagacagtaa ctgcaaaatg agcatcactg tcgatcagga
     1561 cacagactac gctgaactgg ttctgtctat aggagaaatc acacttggag agaagaccag
     1621 gaaatcaatg aaagatagtc aacggagaaa aagagaggcc aaaactttcc aacaggctgt
     1681 atgtaccctg ttgaattctg gaggaggcgt ggccaaggct cgcattaaaa atcaaaacta
     1741 cgacttcagc cgagatggag taggacagga tttggaaaat ttcttacctc atatcctgga
     1801 ttttcctcat gaatacctag acttcaagca ggtcaaagac tactttctca tgtttgtgaa
     1861 agcatggaag ctgaaacaga aaggtccagg gatcaccacc ttgaaaacca acttgtacat
     1921 cagaagcatc tcatcctcaa ttgaactgaa agcagtcaat gcagtgaagt tcctcaaatc
     1981 caggaaatgt tctaaaggga gatcagattc cagactgagt tcacccggaa caatcgtctg
     2041 taatgaagta ctaaatgaat gtcttaactt gtttaacaga gactgtttta cctgtaaaga
     2101 gaaattctgt ttcactaaag ccacacatgc tgaagtaaaa ttgactccta aggaaaacat
     2161 tttagaaatc ctccctcaaa ctgtttcttc atttgcaaac gcggatgggg gatatttgtt
     2221 cattggtttg gatggcaaaa cccaggaaat tattggcttt gaagcagaga agagcgacct
     2281 tgtgcatcta gagagtgaaa tagaaaagtg catccgacag ctgcctgtca ctcacttctg
     2341 tgaggagagg gagaagatca agtacacgtg caaattcatg gaagtgcaca aacccggagc
     2401 tgcgtgttca ttcgtgtgtg cgctcagagt ggagagattc tgctgtgcag tgttcgctgc
     2461 agagcccgaa tcctggcacg tggaagacag ctgtgtgaag aggtttaccg cagaggactg
     2521 ggtgaaacgc cagatggatg gcccagcatg tttctccaag caagataaag gccctcttca
     2581 gtcaagccga ctgccacaca gtccccgtag ctgctgtcct gacaatcctg atgctcttca
     2641 gcagagtgct ggccttccag tgatatctgg aaaggtgata agctctccag aagccctctg
     2701 cgggaaactg ttctcaacac aggaagcgca tgagcagttg ctctgggcac agttggactc
     2761 gcttcctaaa ggaacgctgg tcgtcactaa gagatgggct ttggatctac ccttgcaaga
     2821 caagcacgga gtcatcttgg atacgcttca tattccccag gacagtctcc tgaccctgca
     2881 tggctttgtc ctgggaggtg aagacctgga ggatgacagc actcttctga gggaactagg
     2941 cgctgagtta aagggctatt ataaacaaac cgccgtaaca ctaaagcaga cgttggcaaa
     3001 ccatggtagt tacactgaga aaataggtat cgcgataaag ataacatact tgggtcataa
     3061 taaggcagtg tccctttatg attcaagctc gaaaatacac tatcccacaa aatattatct
     3121 gacaaccgag acagcaaaga acttagaaaa agctcttgct gaaatcttag ggagtcgtga
     3181 gtctttctac agtttaccta ggcaaaactg tagtgatcat tttatctttg cgttttttct
     3241 ttctttttct tttttacttg tttttctttt ttggagctgg ggactgaacc cagagccttg
     3301 aacttactag gcaagcgctc taccactgag ctaaatcccc tacccttatc tttgcgtttt
     3361 taaagacgtg atgttatata gtttactctt tgaagaatta tcctaactcc tgttcaaggc
     3421 tggctttgac ataaaagaaa aaatggtgta tggcacagtg atattttaca atatgtaggt
     3481 tcttcaattc tataaaaata cgaaaaatgt gacattgagc tttatagaaa taaaaccaat
     3541 tctggaaaag gaattggcca ttggagctgg cagtgacaag ctaagcatta agaacatgtc
     3601 cctgagccat gcacctggcc cctgcctttg attccagcac ctggaggaag gcagaacctc
     3661 ctggtctatg taagagttcc aggacagcca cagctatgca gtgagagcct ctctcaacat
     3721 ttgttaatta attagctaat taattaatta agaagtgttt ctcctcatct gcatagccat
     3781 tccttcttgc taatgaaatg catggtgcct ttaatgcaca ggagacactc ttcctagaga
     3841 agtcagtaaa gaaaatgttg aaatacatgg attaatatgg aaaagttttt gtcatggtgt
     3901 tactatccag ccttgtgtgt tattgttgtt aaatacttaa tttgtatgtg acaacctgag
     3961 gaaaggcttt ccacagaggc aaaggtcaga atatgtggag attaaatggc aaatgctcac
     4021 aacatcatgt actatataca agagatttcc agaaagatca aagagacatt gaaactgaat
     4081 acaattattt tctgtgagga gagtacattc tgtcttaaag gaagacattg tatctcttgg
     4141 atggaacaca gtccacaaat cctaggccat gctagcagtc tctatggggc tatgtatagc
     4201 aaggcatcta tttttctatt tgaaccctca tttcctacga ggtatcgata ataggatgtg
     4261 agatggtgat attgctcgtt taatcattga tgtgctgtat ttttcacgtt catattgttg
     4321 tgttgtttgt gctgtaaata acgcctgtaa aggtatttac agcattgggt tttcattaga
     4381 gtattactct ttatttgaga tgttggtatt tccttcataa agaaagaagt gtctttattg
     4441 tacatgtaca tttgtgaagg ataaactctc tcaacattcg gcccttagcg gctattgata
     4501 agcagtggta acctgttgtg acttttgata gagtttatca aaagaccggt tgcccttcac
     4561 gagaggtctg atgactgggc tatgagctgg gtgctcacag caaccaatcc tcttagccat
     4621 gttttctctt ttgatctatt tctttatcga tatgatttat ttttaaaatc tacatcgttt
     4681 ttcatctact ctgttctcag aactgtgttg ttatgaatat aattcttctg cttgtatctt
     4741 tctctgatga atcttcattg tctgacttgg ggagttctac ttaccaaacc ttggacgcca
     4801 aacaaatgtt ccactctttt aatatgtttc taaaataaat gatctttaca aaacatc
//
