LOCUS       NM_001002024            4866 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 4C1 (Slco4c1), mRNA.
ACCESSION   NM_001002024
VERSION     NM_001002024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4866)
  AUTHORS   Kuo,K.L., Zhu,H., McNamara,P.J. and Leggas,M.
  TITLE     Localization and functional characterization of the rat Oatp4c1
            transporter in an in vitro cell system and rat tissues
  JOURNAL   PLoS One 7 (6), e39641 (2012)
   PUBMED   22768102
  REMARK    GeneRIF: These data definitively demonstrate the subcellular
            localization and histological location of Oatp4c1.
REFERENCE   2  (bases 1 to 4866)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4866)
  AUTHORS   Mikkaichi,T., Suzuki,T., Onogawa,T., Tanemoto,M., Mizutamari,H.,
            Okada,M., Chaki,T., Masuda,S., Tokui,T., Eto,N., Abe,M., Satoh,F.,
            Unno,M., Hishinuma,T., Inui,K., Ito,S., Goto,J. and Abe,T.
  TITLE     Isolation and characterization of a digoxin transporter and its rat
            homologue expressed in the kidney
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3569-3574 (2004)
   PUBMED   14993604
  REMARK    GeneRIF: isolation, cloning, and activity in the transport pathway
            of digoxin in the kidney (Oatp4c1)
REFERENCE   4  (bases 1 to 4866)
  AUTHORS   Choudhuri,S., Cherrington,N.J., Li,N. and Klaassen,C.D.
  TITLE     Constitutive expression of various xenobiotic and endobiotic
            transporter mRNAs in the choroid plexus of rats
  JOURNAL   Drug Metab Dispos 31 (11), 1337-1345 (2003)
   PUBMED   14570765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jun 4, 2021 this sequence version replaced NM_001002024.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454761.1, SRR26643287.23358.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               JAXUCZ010000009.1  104676094-104676462 c
            370-633             JAXUCZ010000009.1  104672370-104672633 c
            634-813             JAXUCZ010000009.1  104652725-104652904 c
            814-910             JAXUCZ010000009.1  104650665-104650761 c
            911-1032            JAXUCZ010000009.1  104649130-104649251 c
            1033-1151           JAXUCZ010000009.1  104647147-104647265 c
            1152-1296           JAXUCZ010000009.1  104645863-104646007 c
            1297-1492           JAXUCZ010000009.1  104645293-104645488 c
            1493-1646           JAXUCZ010000009.1  104640519-104640672 c
            1647-1837           JAXUCZ010000009.1  104637391-104637581 c
            1838-1902           JAXUCZ010000009.1  104632258-104632322 c
            1903-2040           JAXUCZ010000009.1  104630732-104630869 c
            2041-4866           JAXUCZ010000009.1  104624802-104627627 c
FEATURES             Location/Qualifiers
     source          1..4866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..4866
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /note="solute carrier organic anion transporter family,
                     member 4C1"
                     /db_xref="GeneID:432363"
                     /db_xref="RGD:1303048"
     exon            1..369
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2201
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /note="solute carrier family 21 member 20; Organic anion
                     transporter member 4C1; organic anion transporting
                     polypeptide 4C1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 4C1"
                     /protein_id="NP_001002024.2"
                     /db_xref="GeneID:432363"
                     /db_xref="RGD:1303048"
                     /translation="MQGSKGVENPAFVPSSPDTPRRASASPSQVEVSAVASRNQNGGS
                     QPRESEDPQKSTEPSPPSSTLPASDEPPGSQLSELEEGPCGWRNFHPQCLQRCNNPKG
                     FLLHYCLLALTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCVLSLFVSF
                     FGERGHKPRWLAFASFMIGLGALVFSLPHFFSGRYELGTIFEDTCLTRNSTRCASSTS
                     LLSNYFYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYSMSILGPAIG
                     YVLGGQLLTMYIDVAMGQSSDLTEDDPRWLGAWWIGFLLAWLFAWSLIMPFSCFPKHL
                     PGTAKIQAGKTSQTHQNNSTSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLSTTS
                     EALVTTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCK
                     NTMKFALCTSGVALMLSFVFIYAKCENGPFAGVSESYNGTGEMGNLTAPCNANCNCLR
                     SYYYPLCGSDGVQYFSPCFAGCLNSVSNRKPKAYYNCSCIERKVDITSTAESPDFEAR
                     AGKCKTQCSNLPIFLGIFFITVIFTFMAGTPITVSILRCVNHRQRSLALGVQFMLLRL
                     LGTIPGPIIFGVTIDSTCVLWDINECGTKGACWIYDNIRMAHMLVAISVTCKVITIFF
                     NGLAIVLYKPPPPGTEVSFQSQNVVVSTITVEEDLNKIENEG"
     exon            370..633
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            634..813
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            814..910
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1032
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1151
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1296
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1492
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1646
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1837
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1902
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2040
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..4866
                     /gene="Slco4c1"
                     /gene_synonym="Oatp-H; Oatp-M1; Oatp4c1; Slc21A20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagtctag agaacctttc ttgaccatgc agggttccaa gggagtcgag aacccggcat
       61 tcgtcccttc cagcccagac accccacgcc gtgcgtctgc gtcgccttcc caggtggagg
      121 tctctgctgt ggcctccagg aatcagaatg ggggttcgca acctcgggaa tctgaagatc
      181 cccagaagtc aactgagcca tctcctcctt cttcgactct cccagcttct gatgagccgc
      241 cggggtcaca gctaagcgag cttgaggagg gaccttgcgg gtggaggaac ttccaccccc
      301 agtgtcttca gcgctgcaac aaccccaaag gttttctgct tcactactgt ctcttagccc
      361 taacgcaagg tattgtagta aatggcctag taaatattag catttccacc atcgagaagc
      421 gctatgaaat gaagagttcc ctgaccggcc tgatatcatc gagctacgac atctcctttt
      481 gcgtgttgtc tctgtttgtg tctttctttg gtgagagagg acacaaacct cgctggcttg
      541 cctttgcatc ctttatgatc ggactgggag cgctggtgtt ttctttacca cacttcttca
      601 gtgggagata tgaactggga accattttcg aagatacctg cttaacaagg aacagcacca
      661 gatgtgcttc ttcaacctct ctgctttcta actacttcta tgtctttgtc ctgggacaac
      721 tgttgctggg gactggagga actccgctct acaccctggg aacggccttc attgatgact
      781 ctgtacccac acacaaatct tctctatata tcggtattgg ctattctatg tcaatcctag
      841 gcccagccat tggctatgtg ttgggaggac agctgttgac aatgtacatt gatgttgcta
      901 tgggacaaag ttcagatctg actgaggatg atccccggtg gttgggggct tggtggattg
      961 gattcctttt agcttggctc tttgcttggt ctttgataat gcctttctcc tgttttccaa
     1021 agcatttacc agggacagca aaaattcaag ctggcaaaac ttcccagact catcaaaata
     1081 atagtacttc cttccaacat atggatgaaa attttgggaa aagtattaaa gattttccaa
     1141 ctgctgtgaa gaatttgatg aggaatacag tctttatatg tttagttcta tcaactactt
     1201 ctgaagcact agttaccacg ggatttgcca cgtttttacc taaatttata gaaaatcaat
     1261 ttggattgac atcgagcttt gcggcaacac ttggaggggc tgttttaatt cctggagctg
     1321 ctcttggtca aatcttaggt ggtgttcttg tttcaaaatt caaaatgaag tgtaaaaata
     1381 caatgaagtt tgcgttatgt acatctggag tagcacttat gctgagtttt gtatttattt
     1441 atgcaaaatg tgaaaatggg ccatttgctg gtgtgtctga atcatataat ggaacaggag
     1501 agatggggaa tctgactgca ccttgcaatg ccaattgcaa ttgtttgaga tcctattatt
     1561 acccactctg tggaagtgat ggagtccagt atttttctcc ctgctttgca ggttgtttaa
     1621 actcagtttc aaacaggaaa ccaaaggcat attataattg ttcctgtatt gaaaggaaag
     1681 tcgacatcac ttctactgca gaaagccctg attttgaagc aagggctgga aaatgtaaaa
     1741 ctcagtgttc aaacctgccc atatttctcg gcatcttctt catcactgtg atttttacct
     1801 ttatggcagg tacccccata actgtgtcca tattaaggtg tgtcaatcac agacagcgat
     1861 ctctagcact gggagtgcag ttcatgcttc ttcggttgtt aggcacgata cctgggccaa
     1921 ttatatttgg cgtcacaata gacagcacgt gtgttctgtg ggacatcaat gaatgtggaa
     1981 caaagggggc gtgttggatc tatgataaca tcaggatggc gcatatgctg gtggctataa
     2041 gtgttacttg taaagtcatc accatattct tcaatggact tgcgatagtt ctctataaac
     2101 caccgccccc aggaacggag gtatcatttc aaagtcagaa tgtagttgtg tcgacgatta
     2161 cagtggagga ggacctcaac aaaatagaga acgaaggatg agaaagaaga ggatactgct
     2221 ttagaaaagt ggctccttcc tgtcagaaca aactgtgcca aggcaccatt gtcttgtccg
     2281 ggtacaccat ggcttaaaac ccatatttca gtggtcactg tctatgtaca gattcctatt
     2341 tttgttaaag tgaaaaacaa aagacaaact cagaacacaa caggcccacg cctttaaagt
     2401 tcaccaaaag cctcaaacca tacagattct tatttatttc cattttctac ctataaaatc
     2461 accacggggt aaacagaaca atggccaaca aaacatagtt aaaagtttat gctttaaaca
     2521 cagctatgca cacaaagtaa aacattagtt tttatttctt ttgctttttt tttcacatac
     2581 cccatacagc ccaggaagtc cggtagctaa agatgaccta gatgcctgat cctcctggac
     2641 ttacatctca tgtactgagg ttacaagcct gtgtcacccc cattggctcc cactgtcata
     2701 ttttcattct ttctttaact agttccacat taattttcat tgttgattgt ttgagcttat
     2761 ttgagaagtt tacagcacaa aaatgtaggc tggtgaaatt tatgtgatgg ttttggggac
     2821 tagttattta aaactcatgg aattaaaaga catctttaca gtgtaattag gttttatata
     2881 atatatcctc tctggcatat attttcatag aaaattccaa gctgatagaa ggtagggtaa
     2941 ttatcttttt tgtgtctcga taccctacag cctcagaact atcagcaaga agtacgcatt
     3001 ttcaactcag aataagaatt ctaggaggga atttgttaat gttgttgact tttaacacta
     3061 aaacgtacga ctgtgatagt attcctcaat tacatatttt cagagaaaag aaccagcttc
     3121 cataatgaaa agtgccaagt agacaagcca ggaggacata atgcactatt gataagcgtc
     3181 tatatatcaa ctactttata ttttatttta caaactaatc acctcgccca ttcatgatag
     3241 taacccaagt agagtttcat tgactagcca tcatgcattg cgattcaatg gaagttttaa
     3301 attcaatgat gcagttactg aaagcttgag tgtttccaac caccttatat ctcagtaact
     3361 aaattccatc tctgaaggtt cctgacgaag ttacttaaaa tactgaagga gtctgtcatt
     3421 gagcatcaac aaaaataatt tactattgtg aataccattt ctaattaata aaagtattac
     3481 agggctaagg atgtagctga gtgcaaattc taaatttgat gcccggtcct gaaaagaact
     3541 attctgttgt ttgttttttt gtttgttttt ttgtttgttt tttacaaatc aaatcttttc
     3601 ctttaattag cttccccagc cagccctccc acatctctat cacctatatt aactctttat
     3661 aagcttcgtg aatcagtttc tccctcaggg caacacaggc ccagaaaaaa gacctggaag
     3721 aaaattagaa ttagagacac tagaattcac agaatttaca tagctgtgcc tggtggtcat
     3781 ccatgtatgg tccatgactt cagaaacttt tgtaagccaa attcaagaaa gagggatgag
     3841 ctaggagtta gactcataag caccttcaat attcaatgag agaggacagt ctcaggaaac
     3901 agacctactt atctcaggaa cttacatact aaaaatcaat ttgaaagaat tcagccaaaa
     3961 ttcaggtatt tgggaggctg acacttctat catgcaaagg gatagtacaa gaaagatagg
     4021 gaaatccaca cgatacctcg ggggagaaaa tttctcctga ctttctgggc acattttaaa
     4081 tactgcgtcc attgcggcca aggggacgag aagacagcct ttctacaatc ccacgtgtgg
     4141 aagcatggca gtctgtgagg aggataagct aatgcaatcc tgagaagctt agtgatagaa
     4201 acacgaagtg agaacgagaa agaaaacaag ctatctgcac agacaaaagg gtatgtggcc
     4261 cctcagggag agaagtgaaa agtcccagac atgtctgtta aacaggtcag tagagaattg
     4321 ttattctaat agttagtggt catcaaatgg acgtcgtctt cactatactc agtttttcct
     4381 atctcacttt tttttttaac aaacgtgcaa atgaaaatgg ctaaaggaac cgataatttc
     4441 ggcacttgaa tatacatatt tagaaaggat accaacattt ggaatgaagt gaacacacta
     4501 ctgtaatcat cattcccatt tgtaaattca tgcagattac atgtgttggt atgctgcttt
     4561 tagaatatat tttcatgata tgtatttgcc agagcttata attattttaa aataacttgc
     4621 aggtgtacct gctgtaattt tgtacataat tgaatatatc ttaaaatttg taatattttg
     4681 attttcttaa ctgcgaaaaa taaaattata gtactctttc ttaaccatgg aagaactgta
     4741 tacatttgac tttgctatgt aaattggaag aaatataaat acaatgtagg cctattttct
     4801 ttgttgcaaa caactctgta aataattgat acatataatt tttattaaat cggaatattt
     4861 atatta
//
