LOCUS       NM_080786               4046 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 2b1 (Slco2b1), mRNA.
ACCESSION   NM_080786
VERSION     NM_080786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4046)
  AUTHORS   Kinzi,J., Hussner,J., Schafer,A.M., Treyer,A., Seibert,I.,
            Tillmann,A., Mueller,V., Gherardi,C., Vonwyl,C., Hamburger,M. and
            Meyer Zu Schwabedissen,H.E.
  TITLE     Influence of Slco2b1-knockout and SLCO2B1-humanization on
            coproporphyrin I and III levels in rats
  JOURNAL   Br J Pharmacol 181 (1), 36-53 (2024)
   PUBMED   37533302
  REMARK    GeneRIF: Influence of Slco2b1-knockout and SLCO2B1-humanization on
            coproporphyrin I and III levels in rats.
REFERENCE   2  (bases 1 to 4046)
  AUTHORS   Hussner,J., Foletti,A., Seibert,I., Fuchs,A., Schuler,E.,
            Malagnino,V., Grube,M. and Meyer Zu Schwabedissen,H.E.
  TITLE     Differences in transport function of the human and rat orthologue
            of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)
  JOURNAL   Drug Metab Pharmacokinet 41, 100418 (2021)
   PUBMED   34628357
  REMARK    GeneRIF: Differences in transport function of the human and rat
            orthologue of the Organic Anion Transporting Polypeptide 2B1
            (OATP2B1).
REFERENCE   3  (bases 1 to 4046)
  AUTHORS   Takeda,F., Oda,M., Terasaki,M., Kubota,A., Asada,K., Ichimura,Y.,
            Kojima,H. and Saitoh,H.
  TITLE     Downregulated expression of organic anion transporting polypeptide
            (Oatp) 2b1 in the small intestine of rats with acute kidney injury
  JOURNAL   Drug Metab Pharmacokinet 40, 100411 (2021)
   PUBMED   34284282
  REMARK    GeneRIF: Downregulated expression of organic anion transporting
            polypeptide (Oatp) 2b1 in the small intestine of rats with acute
            kidney injury.
REFERENCE   4  (bases 1 to 4046)
  AUTHORS   Fang,Z., Huang,J., Chen,J., Xu,S., Xiang,Z. and Hong,M.
  TITLE     Transmembrane Domain 1 of Human Organic Anion Transporting
            Polypeptide 2B1 Is Essential for Transporter Function and Stability
  JOURNAL   Mol Pharmacol 94 (2), 842-849 (2018)
   PUBMED   29871943
REFERENCE   5  (bases 1 to 4046)
  AUTHORS   Ferreira,C., Hagen,P., Stern,M., Hussner,J., Zimmermann,U.,
            Grube,M. and Meyer Zu Schwabedissen,H.E.
  TITLE     The scaffold protein PDZK1 modulates expression and function of the
            organic anion transporting polypeptide 2B1
  JOURNAL   Eur J Pharm Sci 120, 181-190 (2018)
   PUBMED   29752999
REFERENCE   6  (bases 1 to 4046)
  AUTHORS   Sakamoto,K., Mikami,H. and Kimura,J.
  TITLE     Involvement of organic anion transporting polypeptides in the
            toxicity of hydrophilic pravastatin and lipophilic fluvastatin in
            rat skeletal myofibres
  JOURNAL   Br J Pharmacol 154 (7), 1482-1490 (2008)
   PUBMED   18500364
  REMARK    GeneRIF: The statin transporters Oatp1a4 and Oatp2b1 are expressed
            in rat skeletal myofibres, but not in satellite cells, fibroblasts
            or in L6 myoblasts
REFERENCE   7  (bases 1 to 4046)
  AUTHORS   Ugele,B., Bahn,A. and Rex-Haffner,M.
  TITLE     Functional differences in steroid sulfate uptake of organic anion
            transporter 4 (OAT4) and organic anion transporting polypeptide 2B1
            (OATP2B1) in human placenta
  JOURNAL   J Steroid Biochem Mol Biol 111 (1-2), 1-6 (2008)
   PUBMED   18501590
REFERENCE   8  (bases 1 to 4046)
  AUTHORS   St-Pierre,M.V., Stallmach,T., Freimoser Grundschober,A.,
            Dufour,J.F., Serrano,M.A., Marin,J.J., Sugiyama,Y. and Meier,P.J.
  TITLE     Temporal expression profiles of organic anion transport proteins in
            placenta and fetal liver of the rat
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 287 (6), R1505-R1516 (2004)
   PUBMED   15345472
REFERENCE   9  (bases 1 to 4046)
  AUTHORS   Kobayashi,D., Nozawa,T., Imai,K., Nezu,J., Tsuji,A. and Tamai,I.
  TITLE     Involvement of human organic anion transporting polypeptide OATP-B
            (SLC21A9) in pH-dependent transport across intestinal apical
            membrane
  JOURNAL   J Pharmacol Exp Ther 306 (2), 703-708 (2003)
   PUBMED   12724351
REFERENCE   10 (bases 1 to 4046)
  AUTHORS   Nishio,T., Adachi,H., Nakagomi,R., Tokui,T., Sato,E., Tanemoto,M.,
            Fujiwara,K., Okabe,M., Onogawa,T., Suzuki,T., Nakai,D., Shiiba,K.,
            Suzuki,M., Ohtani,H., Kondo,Y., Unno,M., Ito,S., Iinuma,K.,
            Nunoki,K., Matsuno,S. and Abe,T.
  TITLE     Molecular identification of a rat novel organic anion transporter
            moat1, which transports prostaglandin D(2), leukotriene C(4), and
            taurocholate
  JOURNAL   Biochem Biophys Res Commun 275 (3), 831-838 (2000)
   PUBMED   10973807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 25, 2023 this sequence version replaced NM_080786.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169409.1, SRR26643288.3389.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000001.1  163407744-163408065 c
            323-459             JAXUCZ010000001.1  163404258-163404394 c
            460-597             JAXUCZ010000001.1  163402826-163402963 c
            598-760             JAXUCZ010000001.1  163401254-163401416 c
            761-991             JAXUCZ010000001.1  163398424-163398654 c
            992-1090            JAXUCZ010000001.1  163398008-163398106 c
            1091-1281           JAXUCZ010000001.1  163395232-163395422 c
            1282-1375           JAXUCZ010000001.1  163383822-163383915 c
            1376-1733           JAXUCZ010000001.1  163379847-163380204 c
            1734-1899           JAXUCZ010000001.1  163377759-163377924 c
            1900-2063           JAXUCZ010000001.1  163375424-163375587 c
            2064-2128           JAXUCZ010000001.1  163374511-163374575 c
            2129-2249           JAXUCZ010000001.1  163374099-163374219 c
            2250-4046           JAXUCZ010000001.1  163371410-163373206 c
FEATURES             Location/Qualifiers
     source          1..4046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..4046
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /note="solute carrier organic anion transporter family,
                     member 2b1"
                     /db_xref="GeneID:140860"
                     /db_xref="RGD:621391"
     exon            1..322
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            323..459
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2385
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /function="transports taurocholate, prostaglandins and
                     leukotriene C4"
                     /note="organic anion transporter moatp1; solute carrier
                     family 21 member 9; multispecific organic anion
                     transporter 1; solute carrier family 21 (organic anion
                     transporter), member 9; organic anion transporting
                     polypeptide 2B1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2B1"
                     /protein_id="NP_542964.1"
                     /db_xref="GeneID:140860"
                     /db_xref="RGD:621391"
                     /translation="MPDRSTKATMGAEDIHERKVSMEPRDSHQDAQPRGMFQNIKFFV
                     LCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFGS
                     RVHRPRMIGCGAILVAVAGLLMALPHFISEPYRYDHSSPDRSQDFEASLCLPTTMAPA
                     SALSNDSCSSRTETKHLTMVGIMFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYL
                     GILFAITMMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAG
                     LVVLAASPYFFFPREMPKEKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQ
                     IAPDLTVVQFIKVFPRVLLRTLRHPIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSI
                     TASFANLLLGCLTIPLAIVGIVVGGVLVKRLHLSPMQCSALCLLGSLLCLLLSLPLFF
                     IGCSTHHIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGC
                     TGRVVQEALDKSQVFYTNCSCVAGNGTISAGSCESACSRLVLPFILLISLGAAVASIT
                     HTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRR
                     AVCRYYDHDLLRNRFIGLQFFFKSGSLVCFALVLAILRQQSREASTKATVKSSDLQEL
                     "
     exon            460..597
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            598..760
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            761..991
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1090
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1281
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1375
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1733
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1899
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2063
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2128
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2249
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..4046
                     /gene="Slco2b1"
                     /gene_synonym="moat1; OATP2B1; Slc21a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgagcg ccagctctta ctcgtgaggg gcagccttgt accacaggct ctcactgacc
       61 agctcctaag gagccatttt ggatggcaga tgttcagatg ttctcaaagc ccagagcata
      121 ttgctgggtt tcttccccca cccaaagagt agagctttgg actttgtgca ccagaaacag
      181 acatttcact aacggacaga atgagccagg aagactttga gccttggaag aggaggctga
      241 ggtgaaaaca tcgggaagga ccaagagtga agccgcaagt aagctcacct gaggcaagtg
      301 tgtgaccctt tgggaagagc aggtgagggg ccccagatgc cagacaggag caccaaggcc
      361 acaatgggtg cagaagacat acatgaaagg aaagtcagca tggagcctcg ggactcacac
      421 caggatgcac aaccccgagg gatgttccag aacatcaagt tctttgtcct gtgtcacagt
      481 atactgcagc tggcacagct catgatctct ggctacctca agagctccat ctccacagtg
      541 gaaaagcgct ttgggctgtc cagccagacc tcagggctgc tagctgcttt caatgaggta
      601 gggaacatat ccttgatttt atttgtgagc tacttcggca gccgagtgca cagaccccgg
      661 atgatcggct gtggggctat cctggtggca gtggcgggcc tgctcatggc actccctcac
      721 ttcatctcag aaccataccg ctacgaccac agcagccccg ataggtcaca ggactttgaa
      781 gcatccctgt gcctgcccac gactatggct ccagcctctg ccctgtccaa tgacagctgt
      841 tccagtcgca cagaaaccaa gcatctgact atggtgggga tcatgttcac agcacagacc
      901 ctgcttggca ttggcggtgt gcccatacag ccctttggga tctcctacat cgacgacttt
      961 gcccaccata gcaactcacc cctctacctg ggaatcctgt ttgcaataac catgatgggg
     1021 cccggcctgg cctatgggct gggtagcctc atgctacgcc tttacgtgga cattgaccgg
     1081 atgcccgaag gaggcatcaa cctcactaca aaagaccccc gatgggtggg tgcctggtgg
     1141 ctgggcttcc tcatctctgc aggcctggtg gttctggctg ccagccccta cttcttcttc
     1201 cccagagaga tgcccaaaga gaaatatgag cttcacttca ggcagaaggt cttggcagga
     1261 ggggcctcga ttggcagcaa gggtgaggag ctctcctccc agcatgagcc tttaaagaaa
     1321 caggctggat tgccccagat tgccccagac ttgactgtgg tccagtttat taaagtcttc
     1381 cccagggtgc tgctgcggac gctgcgccac cccatcttct tgctggtagt cctgtcccag
     1441 gtgtgcacct catccatggt ggcgggcacg gccaccttcc tgcctaagtt cctggaacgc
     1501 cagttttcca tcacagcctc ctttgccaac ctgctcctcg gctgcctcac tatccccctg
     1561 gccattgtgg gcatcgtggt gggaggtgtc ttagtcaagc gactccacct gagtcccatg
     1621 cagtgcagtg ccctctgcct gctcgggtcg ctgttgtgtc tgctactcag cttgccgctc
     1681 ttcttcattg gctgctctac ccatcatatt gcaggcatca cgcaggacct gggtgcccag
     1741 ccagggccaa gcctgtttcc tggctgctca gagccctgct cctgccaatc agatgacttt
     1801 aaccctgttt gtgataccag tgcctatgtg gagtacacca caccctgcca tgcaggctgc
     1861 acaggtcgtg tggtccagga agctctggac aaaagccagg tcttctacac caactgcagc
     1921 tgtgtggcag ggaatggcac catatctgca ggttcctgtg agtcagcctg cagccgcctg
     1981 gtgctgccct tcattctcct catcagcctg ggagcagcag tggccagcat cacccacaca
     2041 ccttccttca tgctcatcct gagaggtgtg aagaaagaag ataagaccct ggcagtggga
     2101 atgcaattca tgctcctgcg agtgttggcc tggatgccca gtcctgtgat ccatggcagt
     2161 gccatcgata ctacctgtgt gcactgggcc ctgacctgtg gacggcgagc tgtctgccgc
     2221 tactatgacc atgatctgct ccgaaaccga ttcataggcc tccagttctt cttcaaaagc
     2281 ggatccctgg tgtgctttgc cttagttttg gccatcttga ggcagcagag cagagaggcc
     2341 agcaccaagg ccactgtaaa gagctcagac ctacaagaac tgtaagcgtc aggaccagag
     2401 aaggattcca ggaggtcgac agtcccagcc ccaccaggaa ggcagccaca gccatgcatc
     2461 ttctgagcct ttgccaatga tgggtaaagc agcagccaca gataacagaa gtaccacagt
     2521 ccaatgccgg gtcatctgct aaatcgtgaa gtgactctga aggaacttct ggctttgctt
     2581 gctctttgga accaaggagt cactgtgttg gccatttctc aagcaagagg gtcatcctcc
     2641 ttcctcccct agccagatgg ccaacccaga accacgctta agtggcgggg tggagctgta
     2701 cagcatctct ctcccctgat tctagaagag ggagttaggc tgactagata atgctgcacc
     2761 ccacacagag cctcagccta gctctgccac ttgtggagac cctctccatg cttaagcaga
     2821 agggggttcc agctctctgg ctccagctgt gcacatcagt gcagtcaagg taggtatagg
     2881 cctcctcccc aggcccaggt ggcctttgag tagtgtctat ttggcgcccc ctggaggcag
     2941 aatccagaga cgagattaag gagatctcca aatgcaggag ggagcaggac accacagttg
     3001 atgaagggtg tgggagaggg gctctttgat tcagaatgtt gcagttttta tggttgggga
     3061 gccacggctg ggaaaggaag gtttatcctt tccttcaaag gccttgtaac ttcagagacc
     3121 acattatatt cagacccatt cctacttaat gtgtattgtc aagatctcgt acatttgacc
     3181 agggaccacc aaagccactc tagcttttga gaatagaatc ctagtccata ttcccggggc
     3241 tttgtagcta agacctgata ctgtcatagc caagtcatgg gtgacctctg tttctctgag
     3301 gtctttggac caatgtgagg tctctgggcg gagaagagca aagccaaccc aattcctcac
     3361 agtgagctgt ggtgtagtat tctagggtca gattccctgg aaccccagtc ttttccaaga
     3421 cagacctggt cctgctttct agacaattct gtctggccta gttgcttccg ggcagcagaa
     3481 gagaaacccc tgatctgctc ccaggctggc ctgttaacgc tactcctccc tgtgtagcca
     3541 tgaagggagg tgaggaacta ccagcagcct tccaacctgt gtgccagctc ttagctaagg
     3601 gaccaggtat ttgtcctcgg tgcagaagaa gggactacag aagctctcat tcctgtcagg
     3661 catggtggct tggcacacat ctgtcaccta gcatttagag gctagatcag aagttcaatc
     3721 agtgagtctc agctccatag tgagtttgag tctaacctgg actacatgag aatgtcttga
     3781 aaaatctaaa aagaataaag agaaggaaag aggagaaggg gaggaggatg aggagaagat
     3841 cctggtcgac gatgtcagtc ctacagttga gtagtttaac cagtgcctga tcctacacta
     3901 atcagtgcca agacttttga aaatcacttt catcaagatg agtctgttag cgggtttcca
     3961 ttctgtctgt tctcctgctc cccgggctgt acaggaatag cctggccgta tacatacagc
     4021 ttattattaa atttgtctct gcataa
//
