LOCUS       NM_022667               3394 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 2a1 (Slco2a1), mRNA.
ACCESSION   NM_022667
VERSION     NM_022667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3394)
  AUTHORS   Nakanishi,T., Takashima,H., Uetoko,Y., Komori,H. and Tamai,I.
  TITLE     Experimental Evidence for Resecretion of PGE2 across Rat Alveolar
            Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport
  JOURNAL   J Pharmacol Exp Ther 368 (2), 317-325 (2019)
   PUBMED   30420359
  REMARK    GeneRIF: OATP2A1 mediates transcellular transport of PGE2 in the
            apical membrane-to-basolateral direction in alveolar epithelium.
REFERENCE   2  (bases 1 to 3394)
  AUTHORS   Bihoreau,M.T., Megel,N., Brown,J.H., Kranzlin,B., Crombez,L.,
            Tychinskaya,Y., Broxholme,J., Kratz,S., Bergmann,V., Hoffman,S.,
            Gauguier,D. and Gretz,N.
  TITLE     Characterization of a major modifier locus for polycystic kidney
            disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved
            with a mouse modifier locus for Alport syndrome
  JOURNAL   Hum Mol Genet 11 (18), 2165-2173 (2002)
   PUBMED   12189169
REFERENCE   3  (bases 1 to 3394)
  AUTHORS   Endo,S., Nomura,T., Chan,B.S., Lu,R., Pucci,M.L., Bao,Y. and
            Schuster,V.L.
  TITLE     Expression of PGT in MDCK cell monolayers: polarized apical
            localization and induction of active PG transport
  JOURNAL   Am J Physiol Renal Physiol 282 (4), F618-F622 (2002)
   PUBMED   11880322
  REMARK    GeneRIF: endogenous PGT is exocytically inserted into the
            collecting duct apical membrane, where it could control the
            concentration of luminal PGs
REFERENCE   4  (bases 1 to 3394)
  AUTHORS   Pucci,M.L., Bao,Y., Chan,B., Itoh,S., Lu,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Schuster,V.L.
  TITLE     Cloning of mouse prostaglandin transporter PGT cDNA:
            species-specific substrate affinities
  JOURNAL   Am J Physiol 277 (3), R734-R741 (1999)
   PUBMED   10484490
REFERENCE   5  (bases 1 to 3394)
  AUTHORS   Kanai,N., Lu,R., Satriano,J.A., Bao,Y., Wolkoff,A.W. and
            Schuster,V.L.
  TITLE     Identification and characterization of a prostaglandin transporter
  JOURNAL   Science 268 (5212), 866-869 (1995)
   PUBMED   7754369
REFERENCE   6  (bases 1 to 3394)
  AUTHORS   Hakes,D.J. and Berezney,R.
  TITLE     Molecular cloning of matrin F/G: A DNA binding protein of the
            nuclear matrix that contains putative zinc finger motifs
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6186-6190 (1991)
   PUBMED   2068100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022667.4.
            
            On Feb 10, 2021 this sequence version replaced NM_022667.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JACYVU010000200.1  6547699-6547880
            183-320             JACYVU010000200.1  6592278-6592415
            321-483             JACYVU010000200.1  6595938-6596100
            484-711             JACYVU010000200.1  6613300-6613527
            712-810             JACYVU010000200.1  6614587-6614685
            811-947             JACYVU010000200.1  6615508-6615644
            948-1023            JACYVU010000200.1  6617740-6617815
            1024-1188           JACYVU010000200.1  6618335-6618499
            1189-1378           JACYVU010000200.1  6619547-6619736
            1379-1547           JACYVU010000200.1  6621247-6621415
            1548-1711           JACYVU010000200.1  6623617-6623780
            1712-1776           JACYVU010000200.1  6626404-6626468
            1777-1900           JACYVU010000200.1  6628942-6629065
            1901-3394           JACYVU010000200.1  6629836-6631329
FEATURES             Location/Qualifiers
     source          1..3394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3394
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /note="solute carrier organic anion transporter family,
                     member 2a1"
                     /db_xref="GeneID:24546"
                     /db_xref="RGD:3051"
     exon            1..182
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2021
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /note="solute carrier family 21 (prostaglandin
                     transporter), member 2; PGT; solute carrier family 21
                     member 2; matrin F/G 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2A1"
                     /protein_id="NP_073158.2"
                     /db_xref="GeneID:24546"
                     /db_xref="RGD:3051"
                     /translation="MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLC
                     QLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIG
                     IGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHLPALPPSKCHSTVP
                     DTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFG
                     PAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFF
                     FFPRAMSRGAERSVTAEETMKTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQ
                     CTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFP
                     LQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSC
                     PDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCP
                     TSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWL
                     PAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFI
                     SWRMKKNREYSLQENTSGLI"
     exon            183..320
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..483
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..711
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..810
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..947
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1023
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1188
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1378
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1547
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1711
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1776
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1900
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..3394
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagcccg aagcaccgga gtcccgcaga acctgactcc ggcctgtcac caccaccaaa
       61 ggctagggga cgtcgcctcg gtcactatgg ggctcctgct caagcctgga gcgcgccagg
      121 gcagcggcac ctcctcggtc ccagacagac gttgtccccg ctccgtcttc agcaacatta
      181 aggtatttgt tctttgccat ggcctgctac agctctgtca gctgctctac agcgcctact
      241 tcaagagcag tctcaccaca atcgagaagc gctttgggct ctccagctct tcctctggtc
      301 tcatctccag tttgaatgag atcagcaacg ctaccctcat catcttcatt agctacttcg
      361 gcagccgggt caaccgccca cggatgattg gcataggggg tctcctcctg gctgcagggg
      421 cctttgtcct caccctccca cacttcctgt cagagcccta tcaatacacc tcgaccacgg
      481 atggaaacag gagcagcttt cagactgacc tctgtcagaa gcatttgcca gccctgcccc
      541 ccagtaagtg ccatagcacc gtgccagata cccacaagga gaccagcagc ctgtggggcc
      601 tgatggtggt tgctcaacta ctggccggca ttgggacagt gcccatccag ccctttggga
      661 tctcctacgt ggatgacttt gccgagccta ccaactcacc tctgtatatc tccatcctat
      721 tcgccatcgc tgtgttcgga ccggctttcg ggtacctgct gggctcagtc atgctgagaa
      781 tcttcgtgga ctacggcaga gtggacactg ctaccgtaaa cctgagccca ggtgaccctc
      841 ggtggattgg agcctggtgg ctgggcctgc tcatctcctc aggcttcttg attgtcacct
      901 ctttgccctt ctttttcttt ccccgagcaa tgtccagagg agcagagagg tctgttaccg
      961 cagaggaaac aatgaagacg gaggaggaca agtcaagagg ctccctgatg gatttcatta
     1021 aacggttccc ccgcatcttc ctgaggctgc tgatgaaccc gctcttcatg ctggtggtcc
     1081 tgagccagtg taccttctcc tcagtcatcg ctggcctctc cacattcctc aacaagttcc
     1141 tggagaagca gtatggagcc acggcagcct atgccaactt cctcatcggt gctgtaaatc
     1201 ttccggctgc agccttgggg atgctgtttg gaggaatcct catgaagcgt tttgttttcc
     1261 ctctgcaaac tatcccccga gtggctgcca ccatcatcac catctccatg atcctctgtg
     1321 tacctctctt ctttatggga tgctccacat cagccgtggc tgaggtctac cctcccagca
     1381 catcaagttc tatacatccg cagcagcctc ctgcctgccg cagggactgc tcgtgcccag
     1441 attccttctt ccacccagtc tgtggagaca atggagtcga gtacgtttcc ccttgccacg
     1501 ccggctgcag cagcaccaac acaagctcag aagcttctaa ggaaccgatc tacttgaact
     1561 gcagctgtgt gagtggagga tcggcgtcag ccaagacagg ctcatgcccc acgtcctgcg
     1621 cgcagctact gctcccgtcc atcttcctca tttcctttgc ggcgctcatt gcctgcatct
     1681 cccacaaccc gctctacatg atggtccttc gcgtggtgaa ccaggatgaa aagtcgtttg
     1741 ccattggggt acagttcttg ttgatgcgct tgctggcctg gctgccggct ccatcccttt
     1801 atggcctcct catcgactcc tcctgtgtcc ggtggaacta cctatgctca gggagacgag
     1861 gggcctgtgc gtattatgac aacgatgctc tccgaaacag gtacctgggc ctacagatgg
     1921 tctacaaggc cttgggcaca ctgctgctct tcttcatcag ctggaggatg aagaagaaca
     1981 gggaatacag cctgcaggag aacacctcag gcctcatctg accctcagct gggactactg
     2041 ccccacccca gagactggat cctatccctt ccacacctac ctgtattaac taatgttaac
     2101 atgccttcct cctcctcttc ttcctcctcc tcctcctcct cctccttctt cttcttcctc
     2161 tctctctctc tctctctctc tctctctctc tctctctctc tctcacacac acacacacac
     2221 acacacacat gagagagagt tcactcaccc tttgagtcac ctgccttttc tcttctgcct
     2281 aaagtcttaa ggcctgaagt acactgagct gaatgagcac cgggcctgag agtttagttt
     2341 ctccaagtcc ttggaaggta tccccagtgt aggccctacg tcctccagac aagatgccca
     2401 taatgaggcg gcctctgttt tcaccagtgt ctcaggaata cttaatggag tgaaaagagg
     2461 gagtcttgcc ttctgggcca ggcagcccgg atctcctctg cctctgccca cacccaggag
     2521 agccagagga gaagcaggta gttggtttct tatcagctcc agcggggcta agggagctgg
     2581 ctgtgtccac ttttcatctg gattccgtct agcatgaaag ccgtgccctc gaggctgttt
     2641 tggaaaccac cattttggga agtatccctc tctataaact atgccccggt atctgaggag
     2701 gaatgaaggg accaacaagg ctggatcatc caaaactgtt cacaggaacc tgaggcctat
     2761 cctcccgtcg gcatacgctt ctttctgcct ttcaacccaa cagagtcaca aggaacccac
     2821 ctaagaaggg cccagtctcc caccctcaca gtggagacaa ggcctttccc ttcagagaca
     2881 caaatggtga tctctaccgt gcctcacgtg gacttcgctg tctggacttc agctcctgtg
     2941 cagaggagtg tgggggcagg ggggggggac ctgagataca gccagagtaa tggtggagca
     3001 gaatggatgc cacttgtcac tgtgctcgat gacaagttgc agcccataaa aaggttgact
     3061 tgcttgcaaa cacattgtgt tcgttggcat tttctcagct tctcctcact acctctgggt
     3121 ggagatgggc accttctgtg ggcctgggct gggggccacc cctgctatgc aatggagagg
     3181 caaaggcaga ggtccaggaa taaggaggct tctaccaatg attttgttta atggtgcttg
     3241 acagagatat tgtatggttc tctgagagct cccctgaaaa ccttacctcc aaccacacaa
     3301 gggcttcctc ccagagagcg ctcgctgggc agcaaggaca cactcccata cttgccaagc
     3361 atatcaagta cccaaagatt ggcagaaaag atcc
//
