LOCUS       NP_073158                644 aa            linear   ROD 03-APR-2024
DEFINITION  solute carrier organic anion transporter family member 2A1 [Rattus
            norvegicus].
ACCESSION   NP_073158
VERSION     NP_073158.2
DBSOURCE    REFSEQ: accession NM_022667.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 644)
  AUTHORS   Nakanishi,T., Takashima,H., Uetoko,Y., Komori,H. and Tamai,I.
  TITLE     Experimental Evidence for Resecretion of PGE2 across Rat Alveolar
            Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport
  JOURNAL   J Pharmacol Exp Ther 368 (2), 317-325 (2019)
   PUBMED   30420359
  REMARK    GeneRIF: OATP2A1 mediates transcellular transport of PGE2 in the
            apical membrane-to-basolateral direction in alveolar epithelium.
REFERENCE   2  (residues 1 to 644)
  AUTHORS   Bihoreau,M.T., Megel,N., Brown,J.H., Kranzlin,B., Crombez,L.,
            Tychinskaya,Y., Broxholme,J., Kratz,S., Bergmann,V., Hoffman,S.,
            Gauguier,D. and Gretz,N.
  TITLE     Characterization of a major modifier locus for polycystic kidney
            disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved
            with a mouse modifier locus for Alport syndrome
  JOURNAL   Hum Mol Genet 11 (18), 2165-2173 (2002)
   PUBMED   12189169
REFERENCE   3  (residues 1 to 644)
  AUTHORS   Endo,S., Nomura,T., Chan,B.S., Lu,R., Pucci,M.L., Bao,Y. and
            Schuster,V.L.
  TITLE     Expression of PGT in MDCK cell monolayers: polarized apical
            localization and induction of active PG transport
  JOURNAL   Am J Physiol Renal Physiol 282 (4), F618-F622 (2002)
   PUBMED   11880322
  REMARK    GeneRIF: endogenous PGT is exocytically inserted into the
            collecting duct apical membrane, where it could control the
            concentration of luminal PGs
REFERENCE   4  (residues 1 to 644)
  AUTHORS   Pucci,M.L., Bao,Y., Chan,B., Itoh,S., Lu,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Schuster,V.L.
  TITLE     Cloning of mouse prostaglandin transporter PGT cDNA:
            species-specific substrate affinities
  JOURNAL   Am J Physiol 277 (3), R734-R741 (1999)
   PUBMED   10484490
REFERENCE   5  (residues 1 to 644)
  AUTHORS   Kanai,N., Lu,R., Satriano,J.A., Bao,Y., Wolkoff,A.W. and
            Schuster,V.L.
  TITLE     Identification and characterization of a prostaglandin transporter
  JOURNAL   Science 268 (5212), 866-869 (1995)
   PUBMED   7754369
REFERENCE   6  (residues 1 to 644)
  AUTHORS   Hakes,D.J. and Berezney,R.
  TITLE     Molecular cloning of matrin F/G: A DNA binding protein of the
            nuclear matrix that contains putative zinc finger motifs
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6186-6190 (1991)
   PUBMED   2068100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 27, 2011 this sequence version replaced NP_073158.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64862.1, SRR26643285.32454.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..644
                     /product="solute carrier organic anion transporter family
                     member 2A1"
                     /note="solute carrier family 21 (prostaglandin
                     transporter), member 2; PGT; solute carrier family 21
                     member 2; matrin F/G 1"
                     /calculated_mol_wt=70262
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            27..47
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Region          30..542
                     /region_name="MFS_SLCO2A_OATP2A"
                     /note="Solute carrier organic anion transporter 2A
                     subfamily of the Major Facilitator Superfamily of
                     transporters; cd17461"
                     /db_xref="CDD:341019"
     Site            order(45..46,49..50,53,85,184..185,187..189,192,212,
                     215..216,219,334,337..338,341..343,346,375,379,420..421,
                     425,429,489,492..493,496,498)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341019"
     Site            71..91
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            101..121
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00910.3)"
     Site            172..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            210..230
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            258..278
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            321..341
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            365..385
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            399..419
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            478
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00910.3)"
     Site            491
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00910.3)"
     Site            511..531
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            551..571
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            606..626
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00910.3)"
     Site            639
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00910.3)"
     CDS             1..644
                     /gene="Slco2a1"
                     /gene_synonym="Matr1; OATP2A1; PHOAR2; Slc21a2"
                     /coded_by="NM_022667.4:87..2021"
                     /db_xref="GeneID:24546"
                     /db_xref="RGD:3051"
ORIGIN      
        1 mglllkpgar qgsgtssvpd rrcprsvfsn ikvfvlchgl lqlcqllysa yfksslttie
       61 krfglsssss glisslneis natliifisy fgsrvnrprm igigglllaa gafvltlphf
      121 lsepyqytst tdgnrssfqt dlcqkhlpal ppskchstvp dthketsslw glmvvaqlla
      181 gigtvpiqpf gisyvddfae ptnsplyisi lfaiavfgpa fgyllgsvml rifvdygrvd
      241 tatvnlspgd prwigawwlg llissgfliv tslpffffpr amsrgaersv taeetmktee
      301 dksrgslmdf ikrfpriflr llmnplfmlv vlsqctfssv iaglstflnk flekqygata
      361 ayanfligav nlpaaalgml fggilmkrfv fplqtiprva atiitismil cvplffmgcs
      421 tsavaevypp stsssihpqq ppacrrdcsc pdsffhpvcg dngveyvspc hagcsstnts
      481 seaskepiyl ncscvsggsa saktgscpts caqlllpsif lisfaaliac ishnplymmv
      541 lrvvnqdeks faigvqfllm rllawlpaps lygllidssc vrwnylcsgr rgacayydnd
      601 alrnrylglq mvykalgtll lffiswrmkk nreyslqent sgli
//
