LOCUS       NM_053441               2736 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 1c1 (Slco1c1), mRNA.
ACCESSION   NM_053441
VERSION     NM_053441.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2736)
  AUTHORS   Bae,H.S., Jin,Y.K., Ham,S., Kim,H.K., Shin,H., Cho,G.B., Lee,K.J.,
            Lee,H., Kim,K.M., Koo,O.J., Jang,G., Lee,J.M. and Lee,J.Y.
  TITLE     CRISRP/Cas9-mediated knockout of Mct8 reveals a functional
            involvement of Mct8 in testis and sperm development in a rat
  JOURNAL   Sci Rep 10 (1), 11148 (2020)
   PUBMED   32636400
  REMARK    GeneRIF: CRISRP/Cas9-mediated knockout of Mct8 reveals a functional
            involvement of Mct8 in testis and sperm development in a rat.
            Erratum:[Sci Rep. 2020 Nov 11;10(1):19967. doi:
            10.1038/s41598-020-76579-0.. PMID: 33177632]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2736)
  AUTHORS   Luis,E., Fernandez,Y., Alvarado,M., Juarez-Santacruz,L.,
            Garcia-Nieto,E. and Anaya-Hernandez,A.
  TITLE     Differential expression and immunoreactivity of thyroid hormone
            transporters MCT8 and OATP1C1 in rat ovary
  JOURNAL   Acta Histochem 121 (8), 151440 (2019)
   PUBMED   31561916
  REMARK    GeneRIF: Differential expression and immunoreactivity of thyroid
            hormone transporters MCT8 and OATP1C1 in rat ovary.
REFERENCE   3  (bases 1 to 2736)
  AUTHORS   Zubkov,E.A., Zorkina,Y.A., Gurina,O.I., Melnikov,P.A.,
            Morozova,A.Y. and Chekhonin,V.P.
  TITLE     Prenatal exposure to brain-specific anion transporter-1-specific
            monoclonal antibodies impairs cognitive function in post-natal life
  JOURNAL   Neuropeptides 65, 100-105 (2017)
   PUBMED   28688524
  REMARK    GeneRIF: Prenatal exposure to monoclonal antibody brain-specific
            anion transporter-1 blocks brain-specific anion transporter-1 and
            limits T4 influx to the brain. This impairs the cognitive function
            in exposed progeny in the post-natal life.
REFERENCE   4  (bases 1 to 2736)
  AUTHORS   da Conceicao,R.R., Laureano-Melo,R., Oliveira,K.C., de Carvalho
            Melo,M.C., Kasamatsu,T.S., de Barros Maciel,R.M., de Souza,J.S. and
            Giannocco,G.
  TITLE     Antidepressant behavior in thyroidectomized Wistar rats is induced
            by hippocampal hypothyroidism
  JOURNAL   Physiol Behav 157, 158-164 (2016)
   PUBMED   26861177
  REMARK    GeneRIF: This study demonstrated that reduction of the Mct8 mRNA
            expression in hippocampus of thyroidectomized Wistar rats.
REFERENCE   5  (bases 1 to 2736)
  AUTHORS   Wittmann,G., Szabon,J., Mohacsik,P., Nouriel,S.S., Gereben,B.,
            Fekete,C. and Lechan,R.M.
  TITLE     Parallel regulation of thyroid hormone transporters OATP1c1 and
            MCT8 during and after endotoxemia at the blood-brain barrier of
            male rodents
  JOURNAL   Endocrinology 156 (4), 1552-1564 (2015)
   PUBMED   25594699
  REMARK    GeneRIF: The data demonstrate that OATP1c1 and MCT8 expression are
            regulated in a parallel manner during inflammation at the
            blood-brain barrier of rodents.
REFERENCE   6  (bases 1 to 2736)
  AUTHORS   Kato,Y., Kuge,K., Kusuhara,H., Meier,P.J. and Sugiyama,Y.
  TITLE     Gender difference in the urinary excretion of organic anions in
            rats
  JOURNAL   J Pharmacol Exp Ther 302 (2), 483-489 (2002)
   PUBMED   12130705
REFERENCE   7  (bases 1 to 2736)
  AUTHORS   Meng,L.J., Wang,P., Wolkoff,A.W., Kim,R.B., Tirona,R.G.,
            Hofmann,A.F. and Pang,K.S.
  TITLE     Transport of the sulfated, amidated bile acid,
            sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1
            and Oatp2
  JOURNAL   Hepatology 35 (5), 1031-1040 (2002)
   PUBMED   11981753
REFERENCE   8  (bases 1 to 2736)
  AUTHORS   Ito,A., Yamaguchi,K., Onogawa,T., Unno,M., Suzuki,T., Nishio,T.,
            Suzuki,T., Sasano,H., Abe,T. and Tamai,M.
  TITLE     Distribution of organic anion-transporting polypeptide 2 (oatp2)
            and oatp3 in the rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 43 (3), 858-863 (2002)
   PUBMED   11867608
REFERENCE   9  (bases 1 to 2736)
  AUTHORS   Tygstrup,N., Bangert,K., Ott,P. and Bisgaard,H.C.
  TITLE     Messenger RNA profiles in liver injury and stress: a comparison of
            lethal and nonlethal rat models
  JOURNAL   Biochem Biophys Res Commun 290 (1), 518-525 (2002)
   PUBMED   11779202
REFERENCE   10 (bases 1 to 2736)
  AUTHORS   Li,J.Y., Boado,R.J. and Pardridge,W.M.
  TITLE     Blood-brain barrier genomics
  JOURNAL   J Cereb Blood Flow Metab 21 (1), 61-68 (2001)
   PUBMED   11149669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF306546.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF306546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2736
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /note="solute carrier organic anion transporter family,
                     member 1c1"
                     /db_xref="GeneID:84511"
                     /db_xref="RGD:628660"
     exon            1..350
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            351..503
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..2525
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /note="solute carrier family 21 member 14; BBB-specific
                     anion transporter type 1; blood-brain barrier-specific
                     anion transporter 1; thyroxine transporter; blood-brain
                     barrier specific anion transporter; solute carrier family
                     21 (organic anion transporter), member 14; organic anion
                     transporter 1C1; organic anion-transporting polypeptide
                     14"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1C1"
                     /protein_id="NP_445893.1"
                     /db_xref="GeneID:84511"
                     /db_xref="RGD:628660"
                     /translation="MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKV
                     FLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYF
                     GAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLE
                     SSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDF
                     ASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGA
                     WWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPRE
                     ESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSS
                     SKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALG
                     CENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLA
                     GCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITS
                     YTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWG
                     FKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITA
                     REKIVMSSSVKKETCAARDHGLQPKYWPGKETRL"
     exon            504..645
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            646..778
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            779..912
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1059
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1158
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1407
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1572
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1768
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1934
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2119
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2184
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2302
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2720
                     /gene="Slco1c1"
                     /gene_synonym="BAST1; Bsat1; OATP-14; Oatp14; OATP1C1;
                     Slc21a14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaattgca aagaaatggc tcaaaggctc cagctctttc cgtgccctgg gagctgagat
       61 gcagggcagt gcccttgcca gggtgcccaa ttccctgcag actgccagaa aaaaaagagg
      121 ccaactggaa aggcgaaaga gaaagattgc ctaggggaga gatcagaccc ttgggctctt
      181 ctttgctcta atctgtcctg tctgtgccca ccacctctcc tgacttgcca gaacgattca
      241 gagctgctgt gggggtactg cctcagtttc ctcattcagg ctgggctctg tgatccagcg
      301 tctcgctgaa cgttctgaaa gaactggaga gctttgactt ctacctccag gccgggataa
      361 gaaatatttt cataatggac acttcatcca aagaaaatgc ccatttgttc cacaaaaatt
      421 cagcgcaacc tgccggaggg ccatctttta aagcgggata tccgtccaca gaggaagcgc
      481 ggccatgctg tggaaaactc aaggtgttct taggtgccct gtcttttgtt tactttgcca
      541 aagcattgac agaaggctac ctgaagagca ctattactca gatagagaga aggtttgata
      601 tcccttcctc tctggtggga ataattgatg gtagtttcga aattgggaat ctcctggtca
      661 taacattcgt tagctacttt ggtgccaaac ttcacaggcc aaaaataatt ggagcaggat
      721 gcctggtcat gggctttgga actatgctca tcgcagttcc ccagttcttc atggagaagt
      781 acagctatga gaaatatgag aggtattctc cctcctccaa cctcactccc aacatctctc
      841 cgtgctacct agagtccagc agtccatcac cacgctcaat cgtggggaaa tcacaaaaca
      901 agataaacga tgagtgtgaa gtggatacca gttcctccat gtgggtttat gtcttcctgg
      961 gaaaccttct ccgaggatta ggggaaactc ctatccaacc cctgggcatc gcctacctgg
     1021 atgatttcgc cagtgaagac aatgctgcct tctacatcgg gtgtgtgcag acagtggcaa
     1081 ttatagggcc cattttcggc ttcctcttgg gttcattatg tgccaaactc tatgttgata
     1141 ttggctttgt gaatctagac cacataacta tcaccccaaa ggatccccag tgggtcgggg
     1201 cctggtggct tggttaccta atagcagggt tcctaagtct tcttgcagcc gtgcctttct
     1261 ggtgcttacc caagactcta ccaagatccc aaagtagaga ggactccggc tcctcctctg
     1321 agaaatccaa gttcattaca gatgaccctg ttaactacca aatggccccc agagaagaaa
     1381 gcatgaaaat catggaaatg gcgagggatt ttcttccatc actgaagagt ctttttagaa
     1441 atccagtata catcttatac ttgtgtgcaa gcactgttca gttcaattct ctattcggca
     1501 tggtcacata taaaccaaag tacattgagc agcagtatgg gcagtcttcc tccaaagcca
     1561 actttgtcat tggtctcatc aatattcctg cagtggccct tggaatattc tctgggggaa
     1621 tagttatgaa aaaattcagg ctgggtattt gtgaagctac aaaactctac ttgggatcat
     1681 ctgtctttgg ctacctcctc ttcctctctc tgtttgcact gggatgtgaa aattccagtg
     1741 tggccggact aactgtctcc taccaaggaa ccaaacctgt ctcttatcat gaacgagctc
     1801 tcttttcaga ttgcaactca agatgcaaat gttcagactc aaaatgggag cccatgtgtg
     1861 gggacaatgg gattacctat gcgtcggctt gtcttgctgg ctgtcaatcc tccagccgga
     1921 gtggaaagaa cattatattt tctaactgca cttgtgtggg atttgctgcc cctaaatcag
     1981 gaaactggtc aggcatgatg ggcaggtgtc agaaagataa tggatgttcc caaatgtttc
     2041 tgtatttcct tgtgatttca gtcatcacat catatacatt atctctaggt ggcatacctg
     2101 gatatatatt actcttgagg tgcattcaac cacaacttaa gtcttttgct ctgggcatct
     2161 acaccttagc agtaagagtt cttgcaggaa tcccagcccc cgtgtacttt ggtgttttaa
     2221 tcgacacttc gtgcctcaag tggggattta agaaatgtgg aagcagaggc tcctgcagac
     2281 tgtacgactc tcatgctttc agacatatat acctgggact aaccacgctc ttgggcacgg
     2341 tgtctgtctt cctaagcacg gctgtgcttt tggttttaaa gaaaaaatac gtctcaaaac
     2401 gcagcagctt cataaccgca agagaaaaaa tagtgatgtc ctcaagcgtc aaaaaggaga
     2461 cgtgtgccgc aagggatcat gggttgcagc ccaagtactg gccaggcaag gagacccgac
     2521 tttaagaaca agaaatcacg gaaacgaaca aacatgaagg tcatttttat ccaatatatg
     2581 taaatgaata aaatcataat caaaagggcc tcaacgtgta atttcgtcct gctttcaaag
     2641 gtatgcctgc tttgtttttg accctaagca ttagatgatg aacctctaaa aatgtcatta
     2701 aatttatttt aaaactttta aaaaaaaaaa aaaaaa
//
