LOCUS       NM_031650               3218 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family
            member 1B2 (Slco1b2), transcript variant 1, mRNA.
ACCESSION   NM_031650
VERSION     NM_031650.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Chen,S., Li,K., Jiang,J., Wang,X., Chai,Y., Zhang,C., Deng,Q.,
            Shuai,L., Feng,K., Ma,K. and Zhang,L.
  TITLE     Low expression of organic anion-transporting polypeptide 1B3
            predicts a poor prognosis in hepatocellular carcinoma
  JOURNAL   World J Surg Oncol 18 (1), 127 (2020)
   PUBMED   32534581
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Ma,X., Shang,X., Qin,X., Lu,J., Liu,M. and Wang,X.
  TITLE     Characterization of organic anion transporting polypeptide 1b2
            knockout rats generated by CRISPR/Cas9: a novel model for drug
            transport and hyperbilirubinemia disease
  JOURNAL   Acta Pharm Sin B 10 (5), 850-860 (2020)
   PUBMED   32528832
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Alam,K., Farasyn,T., Ding,K. and Yue,W.
  TITLE     Characterization of Liver- and Cancer-type-Organic Anion
            Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in
            Normal and Cancerous Human Tissues
  JOURNAL   Drug Metab Lett 12 (1), 24-32 (2018)
   PUBMED   29577869
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Verboom,M.C., Kloth,J.S.L., Swen,J.J., van der Straaten,T.,
            Bovee,J.V.M.G., Sleijfer,S., Reyners,A.K.L., Mathijssen,R.H.J.,
            Guchelaar,H.J., Steeghs,N. and Gelderblom,H.
  TITLE     Genetic polymorphisms in angiogenesis-related genes are associated
            with worse progression-free survival of patients with advanced
            gastrointestinal stromal tumours treated with imatinib
  JOURNAL   Eur J Cancer 86, 226-232 (2017)
   PUBMED   29054076
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Sun,B., Chen,Y., Xiang,T., Zhang,L., Chen,Z., Zhang,S., Zhou,H. and
            Chen,S.
  TITLE     The Chinese Herb Jianpijiedu Contributes to the Regulation of
            OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation
            Liver Cancer Pretreated with Food Restriction and Diarrhea
  JOURNAL   Biomed Res Int 2015, 752850 (2015)
   PUBMED   26665149
REFERENCE   6  (bases 1 to 3218)
  AUTHORS   Cattori,V., van Montfoort,J.E., Stieger,B., Landmann,L.,
            Meijer,D.K., Winterhalter,K.H., Meier,P.J. and Hagenbuch,B.
  TITLE     Localization of organic anion transporting polypeptide 4 (Oatp4) in
            rat liver and comparison of its substrate specificity with Oatp1,
            Oatp2 and Oatp3
  JOURNAL   Pflugers Arch 443 (2), 188-195 (2001)
   PUBMED   11713643
REFERENCE   7  (bases 1 to 3218)
  AUTHORS   Ismair,M.G., Stieger,B., Cattori,V., Hagenbuch,B., Fried,M.,
            Meier,P.J. and Kullak-Ublick,G.A.
  TITLE     Hepatic uptake of cholecystokinin octapeptide by organic
            anion-transporting polypeptides OATP4 and OATP8 of rat and human
            liver
  JOURNAL   Gastroenterology 121 (5), 1185-1190 (2001)
   PUBMED   11677211
REFERENCE   8  (bases 1 to 3218)
  AUTHORS   Choudhuri,S., Ogura,K. and Klaassen,C.D.
  TITLE     Cloning of the full-length coding sequence of rat liver-specific
            organic anion transporter-1 (rlst-1) and a splice variant and
            partial characterization of the rat lst-1 gene
  JOURNAL   Biochem Biophys Res Commun 274 (1), 79-86 (2000)
   PUBMED   10903899
REFERENCE   9  (bases 1 to 3218)
  AUTHORS   Cattori,V., Hagenbuch,B., Hagenbuch,N., Stieger,B., Ha,R.,
            Winterhalter,K.E. and Meier,P.J.
  TITLE     Identification of organic anion transporting polypeptide 4 (Oatp4)
            as a major full-length isoform of the liver-specific transporter-1
            (rlst-1) in rat liver
  JOURNAL   FEBS Lett 474 (2-3), 242-245 (2000)
   PUBMED   10838093
REFERENCE   10 (bases 1 to 3218)
  AUTHORS   Kakyo,M., Unno,M., Tokui,T., Nakagomi,R., Nishio,T., Iwasashi,H.,
            Nakai,D., Seki,M., Suzuki,M., Naitoh,T., Matsuno,S., Yawo,H. and
            Abe,T.
  TITLE     Molecular characterization and functional regulation of a novel rat
            liver-specific organic anion transporter rlst-1
  JOURNAL   Gastroenterology 117 (4), 770-775 (1999)
   PUBMED   10500057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF208545.2 and JAXUCZ010000004.1.
            
            On Jul 19, 2012 this sequence version replaced NM_031650.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271682.1, AF208545.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2497              AF208545.2         1-2497
            2498-3218           JAXUCZ010000004.1  176350370-176351090
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3218
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="solute carrier organic anion transporter family
                     member 1B2"
                     /db_xref="GeneID:58978"
                     /db_xref="RGD:69300"
     exon            1..40
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            41..198
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2178
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 member 10; sodium-independent
                     organic anion-transporting polypeptide 4; solute carrier
                     organic anion transporter family, member 1b3; solute
                     carrier family 21 (organic anion transporter) member 10;
                     solute carrier family (organic anion transporter) member
                     10; organic anion transporting polypeptide 4;
                     liver-specific transporter-1; liver-specific organic anion
                     transporter 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1B2 isoform 1"
                     /protein_id="NP_113838.1"
                     /db_xref="GeneID:58978"
                     /db_xref="RGD:69300"
                     /translation="MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALG
                     GVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCF
                     IMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCE
                     KGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPI
                     LGFIMSSVFAKIYVDVGYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFL
                     PKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEI
                     YVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGY
                     IVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLTLTYDGMNPVDSHID
                     VPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISN
                     SGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAM
                     GFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNL
                     ALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQS
                     NETPL"
     exon            199..340
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..473
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..586
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..733
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..832
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1075
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1240
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1436
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1608
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1778
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1843
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1961
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..3218
                     /gene="Slco1b2"
                     /gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttagacat gccacgcttg ctctagaagc ctgagctcag ggtagacgac catttcaaaa
       61 gaaatattta tcaacagtga ttgcagacgt tcccatcaca accactgttc agtcatggac
      121 cacactcagc agtcaaggaa agctgcagag gcccaacctt cacgatcaaa gcaaacaagg
      181 ttctgcgatg gattcaagct atttttggca gccctctcct tcagctacat atgcaaagca
      241 ctaggtggag ttgttatgaa gagttccatc acccaaatcg aaagaagatt cgacatacca
      301 tcttccattt ctggtttgat tgatggaggc tttgaaattg ggaatttatt agttattgta
      361 tttgtgagtt actttggatc caaactacac aggccaaagc tgattggaat tggctgcttc
      421 atcatgggca ttgggagcat tttgacagcg ttgccacatt tcttcatggg atattacaag
      481 tatgcaaaag aaaacgacat tggctctcta ggcaactcta cattgacctg tttcatcaat
      541 caaatgacat cacccactgg accttcacct gagatagtgg agaaaggttg tgaaaagggg
      601 ttaaagtcac acatgtggat ttatgtcttg atggggaaca tgcttcgtgg gataggggaa
      661 acaccaatag tgcccctggg aatttcctac cttgatgact ttgcaaaaga agggcacact
      721 tccatgcacc taggtactct gcatactata gcaatgattg gaccaatcct tggctttatc
      781 atgtcatctg tgtttgctaa gatatatgta gacgttggat atgtagacct gaacagtgtc
      841 cgaataactc ctaatgatgc tcgttgggtt ggtgcctggt ggctcagctt cattgtgaat
      901 ggactattat gcattacttc ttccataccc ttcttttttc tgcccaaaat tccaaagagg
      961 tcacaggagg aaaggaaaaa ttcagtatct cttcatgcac ccaaaacaga tgaggagaag
     1021 aaacacatga ctaatttaac aaagcaagag gaacaagatc cttccaacat gactggtttt
     1081 ctaaggtctc tgagaagcat ccttaccaat gaaatatatg ttatattctt gatactgacg
     1141 ttactacaag tcagcggctt cattggctcc tttacttacc tgttcaagtt catagagcag
     1201 cagttcggcc ggacagcatc tcaggccaac ttcttgttag gaattataac catacctact
     1261 atggcaactg caatgttttt aggaggatat attgttaaaa aattcaaatt gacatcggtt
     1321 ggaatcgcca agtttgtatt tttcacctcc tcagtggcct atgcgtttca gttcttatat
     1381 tttcctctac tctgtgaaaa caagccattt gctggcctaa ccttgaccta cgatggaatg
     1441 aacccagtgg actctcacat agatgtacca ctttcttatt gtaactcgga ctgcagttgt
     1501 gataaaaatc aatgggaacc catctgtggg gaaaatggag tcacttacat ttcaccttgt
     1561 ctggcaggat gcaaatcttt tcgtggtgat aagaagccga ataacacaga gttctatgac
     1621 tgcagttgta tcagcaactc tggaaacaac tcagcacatt tgggtgaatg cccaagatac
     1681 aaatgcaaaa ccaactatta cttttatata attcttcaag tcactgtgtc ctttttcact
     1741 gcaatgggaa gcccatcttt aatcttgatt ctgatgaaga gcgtccaacc tgaattgaaa
     1801 tcacttgcaa tgggtttcca ttcactgatt attcgagcac taggagggat tctagctcca
     1861 atctattatg gggcattcat tgacagaacg tgtattaagt ggtctgtcac cagctgtgga
     1921 aaacgtggtg catgtaggct atataactcc agattatttg gattctccta cttgggtttg
     1981 aacttagctt taaaaactcc accacttttt ttatatgttg tattaattta tttcacaaag
     2041 agaaaatata aaagaaatga taacaagaca ttggaaaatg gaagacagtt cacagatgaa
     2101 ggaaacccag attctgtaaa taaaaatgga tactattgtg taccttatga tgaacaaagc
     2161 aatgaaacac ctctttaagg aaagagaaag atacatctgt tgctgtgttt tcaaataccc
     2221 ccggggttct ttcactgaaa tttttcatac tttatatgta atagagaatt tataacccta
     2281 tgcatttata attaaacaaa ttgcaaatca aaagaaataa gagaaccctt gttagggtat
     2341 agctgtgcat ttgtagctaa agatttggag atatataaac aggtattcgc ttaagcattt
     2401 ataactcaat aaaatagaga atggggcaag gatggacaaa ggggaaaggg actgtgaaaa
     2461 attgttgtct ttaaaaatca aaatttgaat cgtactattc atgccagaag cttctgtgat
     2521 aggtgacttc atgatgtggc atattctggt atccccggta agtcaaatat atatatatat
     2581 atatatatat atatatatat atatatatat atatatatat tttttttttt ttttttggag
     2641 ctggggaccg aacccagagc cttgcgcttg ctaggcaagt gctctaccac tgagttaaat
     2701 ccccaaccct aagtcatata tttttaatta ttaattttaa attgtgttta atgacatatc
     2761 catcttcttt gtacatactg tacagaatat tgagaataaa acagagacgt ttaggatgtg
     2821 agatatctct gtctatctct atctctaccc ctagcttcac ctccttctct gtctccatct
     2881 ccctatctat ctatctatct atctatctat ctatctatct atcatctatc tatccatcta
     2941 tgtatctgtc tatctattat ctatctatct atctatctat ctatctatct atctatctat
     3001 ctatctatct acaatctccc caaatatcta aaattaagat agagtgaatg agacagatat
     3061 ctgtagacac tgtattttct tgtgtgatca gatctagtgt ggtggatgat agaagttgaa
     3121 cttgctttat tgctatgtgt taaaatattt tgtttgcatt aaaatggcct attgaaatgc
     3181 ttttctgttc ctataataaa ataacctgat gaaaaagt
//
