LOCUS       NM_030838               2765 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 1A5 (Slco1a5), mRNA.
ACCESSION   NM_030838
VERSION     NM_030838.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Akanuma,S.I., Hashimoto,K., Yoshida,Y., Kubo,Y. and Hosoya,K.I.
  TITLE     Inflammation-Induced Attenuation of Prostaglandin D2 Elimination
            across Rat Blood-Brain Barrier: Involvement of the Downregulation
            of Organic Anion Transporter 3 and Multidrug Resistance-Associated
            Protein 4
  JOURNAL   Biol Pharm Bull 43 (11), 1669-1677 (2020)
   PUBMED   33132311
  REMARK    GeneRIF: Inflammation-Induced Attenuation of Prostaglandin D2
            Elimination across Rat Blood-Brain Barrier: Involvement of the
            Downregulation of Organic Anion Transporter 3 and Multidrug
            Resistance-Associated Protein 4.
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Arakawa,H., Shirasaka,Y., Haga,M., Nakanishi,T. and Tamai,I.
  TITLE     Active intestinal absorption of fluoroquinolone antibacterial agent
            ciprofloxacin by organic anion transporting polypeptide, Oatp1a5
  JOURNAL   Biopharm Drug Dispos 33 (6), 332-341 (2012)
   PUBMED   22899169
  REMARK    GeneRIF: The intestinal absorption of ciprofloxacin could be
            affected by influx transporters such as Oatp1a5.
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Leuthold,S., Hagenbuch,B., Mohebbi,N., Wagner,C.A., Meier,P.J. and
            Stieger,B.
  TITLE     Mechanisms of pH-gradient driven transport mediated by organic
            anion polypeptide transporters
  JOURNAL   Am J Physiol Cell Physiol 296 (3), C570-C582 (2009)
   PUBMED   19129463
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Tani,T., Gram,L.K., Arakawa,H., Kikuchi,A., Chiba,M., Ishii,Y.,
            Steffansen,B. and Tamai,I.
  TITLE     Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5)
            in the intestinal absorption of endothelin receptor antagonist in
            rats
  JOURNAL   Pharm Res 25 (5), 1085-1091 (2008)
   PUBMED   17957449
  REMARK    GeneRIF: consistently suggested that Oatp1a5 is contributing to the
            intestinal absorption
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Kikuchi,A., Nozawa,T., Wakasawa,T., Maeda,T. and Tamai,I.
  TITLE     Transporter-mediated intestinal absorption of fexofenadine in rats
  JOURNAL   Drug Metab Pharmacokinet 21 (4), 308-314 (2006)
   PUBMED   16946558
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Ohtsuki,S., Takizawa,T., Takanaga,H., Terasaki,N., Kitazawa,T.,
            Sasaki,M., Abe,T., Hosoya,K. and Terasaki,T.
  TITLE     In vitro study of the functional expression of organic anion
            transporting polypeptide 3 at rat choroid plexus epithelial cells
            and its involvement in the cerebrospinal fluid-to-blood transport
            of estrone-3-sulfate
  JOURNAL   Mol Pharmacol 63 (3), 532-537 (2003)
   PUBMED   12606759
  REMARK    GeneRIF: the functional expression of organic anion transporting
            polypeptide 3 at rat choroid plexus epithelial cells and its
            involvement in the cerebrospinal fluid-to-blood transport of
            estrone-3-sulfate.
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Deguchi,T., Ohtsuki,S., Otagiri,M., Takanaga,H., Asaba,H., Mori,S.
            and Terasaki,T.
  TITLE     Major role of organic anion transporter 3 in the transport of
            indoxyl sulfate in the kidney
  JOURNAL   Kidney Int 61 (5), 1760-1768 (2002)
   PUBMED   11967025
  REMARK    GeneRIF: Major role of organic anion transporter 3 in the transport
            of indoxyl sulfate in the kidney.
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Ito,A., Yamaguchi,K., Onogawa,T., Unno,M., Suzuki,T., Nishio,T.,
            Suzuki,T., Sasano,H., Abe,T. and Tamai,M.
  TITLE     Distribution of organic anion-transporting polypeptide 2 (oatp2)
            and oatp3 in the rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 43 (3), 858-863 (2002)
   PUBMED   11867608
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Walters,H.C., Craddock,A.L., Fusegawa,H., Willingham,M.C. and
            Dawson,P.A.
  TITLE     Expression, transport properties, and chromosomal location of
            organic anion transporter subtype 3
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (6), G1188-G1200 (2000)
   PUBMED   11093941
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Abe,T., Kakyo,M., Sakagami,H., Tokui,T., Nishio,T., Tanemoto,M.,
            Nomura,H., Hebert,S.C., Matsuno,S., Kondo,H. and Yawo,H.
  TITLE     Molecular characterization and tissue distribution of a new organic
            anion transporter subtype (oatp3) that transports thyroid hormones
            and taurocholate and comparison with oatp2
  JOURNAL   J Biol Chem 273 (35), 22395-22401 (1998)
   PUBMED   9712861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF083469.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2765
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /note="solute carrier organic anion transporter family,
                     member 1A5"
                     /db_xref="GeneID:80900"
                     /db_xref="RGD:70985"
     exon            1..187
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..297
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2250
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /note="solute carrier family 21 member 7; organic
                     anion-transporting polypeptide 3; sodium-independent
                     organic anion transporter 3; solute carrier family 21
                     (fatty acid transporter) member 7; solute carrier organic
                     anion transporter family, member 1A2"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A5"
                     /protein_id="NP_110465.1"
                     /db_xref="GeneID:80900"
                     /db_xref="RGD:70985"
                     /translation="MGETEKRVATHEVRCFSKIKMFLLALTWAYVSKSLSGIYMNTML
                     TQIERQFDIPTSIVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCVIMGLGCFL
                     MSLPHFLMGRYEYETTISPTSNLSSNSFLCMENRSQTLKPTQDPAECIKEMKSLMWIY
                     VLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGKVFGPIVGLLLGSFCA
                     SIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLICAGVNILSSIPFFFFPKTLPKEGLQ
                     DDVDGTNNDKEEKHREKAKEENRGITKDFLPFMKSLSCNPIYMLLILTSVLQINAFIN
                     MFTFLPKYLEQQYGKSTAEVVLLIGVYNLPPICIGYLLIGFIMKKFKITVKKAAYMAF
                     CLSLFEYLLYFLHFMITCDNFPVAGLTASYEGVHHPLYVENKVLADCNRGCSCSTNSW
                     DPVCGDNGLAYMSACLAGCKKSVGTGTNMVFQNCSCIRSSGNSSAVLGLCKKGPECAN
                     KLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKPEEKSLGIGLHAFCTRVFAGIPAPIY
                     FGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYLPALFILILMR
                     KFQFPGEIDSSETELAEMKITVKKSECTDVHGSPQVENDGELKTRL"
     exon            298..439
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..572
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..679
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..826
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..925
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1147
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1312
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1508
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1674
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1847
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1912
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2030
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2765
                     /gene="Slco1a5"
                     /gene_synonym="OATP-3; Oatp3; Slc21a7; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaactaga gcatggcctc atggtgttca gattataacg aatgtttgtt tacctgtaag
       61 acagtcaagt gtggctctac ctaggtgagt ttctgcagcc gacaaatgag tgaagacaca
      121 tcccgaatgt gggcagcttc attctactga ccgtaccaca gaacagaata gagcaagagc
      181 aagtcaggag taagactgtt taaagagtag acatctggaa acaatcagaa gaacaatatg
      241 ggagaaacag agaaaagggt tgcaacccat gaggtcagat gcttttccaa gatcaagatg
      301 tttctgttgg cattaacatg ggcatatgta tccaaatcac tatcaggaat ttatatgaat
      361 accatgctta cacaaataga gagacaattt gatatcccca catctatagt tggattcatt
      421 aatgggagct ttgagattgg aaatcttttg ttgattatat tcgtgagtta ttttggaaca
      481 aaactgcaca gacctatcat gattggtgtt ggatgtgtga ttatgggcct ggggtgtttc
      541 ttaatgtcat tacctcattt cctcatgggc agatacgaat atgaaacaac gatttcacct
      601 acaagcaact tgtcctcaaa cagcttcttg tgtatggaga acagatccca gaccttaaag
      661 ccaacgcaag acccagcaga gtgtataaaa gaaatgaaat cattaatgtg gatatatgta
      721 ctggtaggaa acattatacg tggaattggt gaaactccca tcatgccctt gggtatttcc
      781 tacattgaag actttgccaa atcggaaaac tctcctttat acattgggat tttagaaaca
      841 ggaaaggtct ttggcccaat agttggactt ttgttgggat ccttctgtgc aagcatttat
      901 gtagacacag ggtctgtgaa tacagatgac ctgaccataa ctcccactga tacccgctgg
      961 gttggtgctt ggtggatcgg ctttttgatc tgtgcgggag tgaatatcct gtctagcatc
     1021 ccttttttct tctttcccaa aacgctccca aaggaagggt tgcaggatga tgtggatgga
     1081 actaacaatg acaaggagga gaaacacaga gaaaaagcca aagaggaaaa ccgaggaatc
     1141 actaaagatt tcttgccatt catgaagagc ctctcctgca atccgattta catgcttctc
     1201 atccttacaa gtgtgctcca gataaatgca tttattaata tgtttacctt cttgcccaaa
     1261 tacctggaac agcaatatgg gaaatccact gcagaggtgg tccttctcat aggtgtttat
     1321 aacttacctc caatatgcat tggatattta cttattggct ttattatgaa gaagttcaag
     1381 attactgtca agaaagctgc atacatggcg ttctgcctct ccctgtttga gtaccttctg
     1441 tatttcttgc actttatgat aacctgcgat aacttcccag ttgccggctt aactgcctct
     1501 tatgaaggag ttcaccaccc tctgtatgtg gagaacaagg tccttgctga ctgcaacaga
     1561 gggtgtagct gctcaacgaa ctcctgggat ccagtgtgtg gagacaatgg cctagcatac
     1621 atgtccgcct gcctcgcagg ctgtaagaag tctgttggaa caggaaccaa catggtgttt
     1681 caaaattgca gctgcatccg gtcatcagga aattcatctg cagtcctggg gttatgtaaa
     1741 aaaggccctg agtgtgctaa taaactacag tactttttaa tcatgtcagt aattggcagt
     1801 ttcatctact cgatcacagc catacctggg tatatggttc ttctgaggtg tatcaagcct
     1861 gaagagaagt cgcttgggat tggattacat gcattttgca caagagtatt cgctggcatt
     1921 ccggcaccca tttactttgg cgctttgata gacagaacct gtttacattg gggaaccctg
     1981 aaatgtggtg agcccggggc atgcaggatg tacaatataa ataacttcag gcgcatttac
     2041 ctagtgttgc ctgcagctct tagaggatca agctatctcc ctgcactctt cattctgata
     2101 cttatgagga aattccagtt ccctggggaa atcgactctt cagaaactga acttgcagag
     2161 atgaagatca cagtgaagaa aagtgagtgc acagatgtgc atggaagtcc tcaggtcgag
     2221 aatgacggag aactgaaaac gaggctgtaa tgagttttct actgccctgt gcaagatcat
     2281 gaacagaatg catacttcat gtcctttgcg tcacgagaag cactagagca actctttgat
     2341 gctctcagat gcactctggc attcaggtgc atcaagttgt gtgtcgtttc atgctgctac
     2401 ttggggtatt ttaggagtat ttttctaaaa tatatcaggg ctggatacag tgtaagatat
     2461 tctccaaagg ccactgtctc atcctcagga ggtctctaat gttcagtgtt catattattc
     2521 atgtgtcctc agagcacatg gctactaact ttcaaaatca acttagggta aaacctttaa
     2581 ggaggggaca gttaaatatc tcagtggaga ggtgtgcttt ctaccaagcc tgacaaggtg
     2641 ggtttgatct ctgggaccaa catagtaggc cagaaccaac tttttccagt tgatcttctc
     2701 cctttactcc tgtactgtgg tgaatatgtc ctaccacaaa caaacaaata aaaaatttag
     2761 aaagt
//
