LOCUS       NM_131906               3622 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 1a4 (Slco1a4), mRNA.
ACCESSION   NM_131906
VERSION     NM_131906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3622)
  AUTHORS   Guo,Y., Li,J., Kang,Y. and Jiang,L.
  TITLE     miR-23a-3p is involved in drug resistance by directly targeting the
            influx drug transporter organic anion-transporting polypeptide 2
  JOURNAL   Childs Nerv Syst 37 (8), 2545-2555 (2021)
   PUBMED   33779805
  REMARK    GeneRIF: miR-23a-3p is involved in drug resistance by directly
            targeting the influx drug transporter organic anion-transporting
            polypeptide 2.
REFERENCE   2  (bases 1 to 3622)
  AUTHORS   Huo,X.C., Yang,H.W., Huang,L.H., Zhang,F., Pan,Z.Y. and Liao,Q.
  TITLE     Organic anion transporting polypeptide 1A2 mediates fentanyl uptake
            in cultured cells
  JOURNAL   Mol Med Rep 21 (1), 485-492 (2020)
   PUBMED   31746415
  REMARK    GeneRIF: Organic anion transporting polypeptide 1A2 mediates
            fentanyl uptake in cultured cells.
REFERENCE   3  (bases 1 to 3622)
  AUTHORS   Wang,P., Wang,W.J., Choi-Nurvitadhi,J., Lescaille,Y., Murray,J.W.
            and Wolkoff,A.W.
  TITLE     Rat Organic Anion Transport Protein 1A1 Interacts Directly With
            Organic Anion Transport Protein 1A4 Facilitating Its Maturation and
            Trafficking to the Hepatocyte Plasma Membrane
  JOURNAL   Hepatology 70 (6), 2156-2170 (2019)
   PUBMED   31102415
  REMARK    GeneRIF: optimal rOATP1A4 trafficking to the cell surface is
            dependent upon coexpression and interaction with rOATP1A1.
REFERENCE   4  (bases 1 to 3622)
  AUTHORS   Akanuma,S.I., Kida,R., Tsuchiyama,A., Tachikawa,M., Kubo,Y. and
            Hosoya,K.I.
  TITLE     Organic anion-transporting polypeptide 1a4-mediated heterogeneous
            distribution of sulforhodamine-101 in rat hepatic lobules
  JOURNAL   Drug Metab Pharmacokinet 34 (4), 239-246 (2019)
   PUBMED   31174976
  REMARK    GeneRIF: The Oatp1a4 function is dominant in the region around the
            hepatic CV in rat hepatic lobules.
REFERENCE   5  (bases 1 to 3622)
  AUTHORS   Yaguchi,Y., Tachikawa,M., Zhang,Z. and Terasaki,T.
  TITLE     Organic Anion-Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the
            Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101
            Clearance from Cerebrospinal Fluid of Rats
  JOURNAL   Mol Pharm 16 (5), 2021-2027 (2019)
   PUBMED   30977661
  REMARK    GeneRIF: Oatp1a4 appears to play a major role in Cerebrospinal
            Fluid detoxification by limiting the distribution of organic anions
            to the brain and spinal cord.
REFERENCE   6  (bases 1 to 3622)
  AUTHORS   van Montfoort,J.E., Schmid,T.E., Adler,I.D., Meier,P.J. and
            Hagenbuch,B.
  TITLE     Functional characterization of the mouse organic-anion-transporting
            polypeptide 2
  JOURNAL   Biochim Biophys Acta 1564 (1), 183-188 (2002)
   PUBMED   12101011
REFERENCE   7  (bases 1 to 3622)
  AUTHORS   Meng,L.J., Wang,P., Wolkoff,A.W., Kim,R.B., Tirona,R.G.,
            Hofmann,A.F. and Pang,K.S.
  TITLE     Transport of the sulfated, amidated bile acid,
            sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1
            and Oatp2
  JOURNAL   Hepatology 35 (5), 1031-1040 (2002)
   PUBMED   11981753
REFERENCE   8  (bases 1 to 3622)
  AUTHORS   Shih,D.Q., Bussen,M., Sehayek,E., Ananthanarayanan,M.,
            Shneider,B.L., Suchy,F.J., Shefer,S., Bollileni,J.S.,
            Gonzalez,F.J., Breslow,J.L. and Stoffel,M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   9  (bases 1 to 3622)
  AUTHORS   Abe,T., Kakyo,M., Sakagami,H., Tokui,T., Nishio,T., Tanemoto,M.,
            Nomura,H., Hebert,S.C., Matsuno,S., Kondo,H. and Yawo,H.
  TITLE     Molecular characterization and tissue distribution of a new organic
            anion transporter subtype (oatp3) that transports thyroid hormones
            and taurocholate and comparison with oatp2
  JOURNAL   J Biol Chem 273 (35), 22395-22401 (1998)
   PUBMED   9712861
REFERENCE   10 (bases 1 to 3622)
  AUTHORS   Noe,B., Hagenbuch,B., Stieger,B. and Meier,P.J.
  TITLE     Isolation of a multispecific organic anion and cardiac glycoside
            transporter from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10346-10350 (1997)
   PUBMED   9294213
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U88036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..3622
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /note="solute carrier organic anion transporter family,
                     member 1a4"
                     /db_xref="GeneID:170698"
                     /db_xref="RGD:621389"
     exon            1..60
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            61..178
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2104
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /note="OATP-B1; brain digoxin carrier protein; solute
                     carrier family 21 member 5; brain-specific organic anion
                     transporter; sodium-independent organic anion-transporting
                     polypeptide 2; solute carrier family 21 (organic anion
                     transporter), member 5; organic anion transporter 2;
                     solute carrier organic anion transporter family, member
                     1A2"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A4"
                     /protein_id="NP_571981.1"
                     /db_xref="GeneID:170698"
                     /db_xref="RGD:621389"
                     /translation="MGKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSML
                     TQIERQFGIPTSIVGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFL
                     ISLPHFLMGQYEYETILPTSNVSSNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYV
                     LVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCAN
                     IYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQE
                     NVDGTENAKEKKHRKKAKEEKRGITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINS
                     FTFMPKYLEQQYGKSTAEVVFLMGLYMLPPICLGYLIGGLIMKKFKVTVKKAAHLAFW
                     LCLSEYLLSFLSYVMTCDNFPVAGLTTSYEGVQHQLYVENKVLADCNTRCNCSTNTWD
                     PVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNSSAVLGLCNKGPDCANK
                     LQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPAPIYF
                     GALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAALRGASFVPAFFILRLTRT
                     FQFPGDIESSKTDHAEMKLTLKESECTEVLRSKVTED"
     exon            179..320
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..453
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..557
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..704
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..803
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1025
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1190
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1386
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1552
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1725
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1790
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1908
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..3622
                     /gene="Slco1a4"
                     /gene_synonym="Oatp2; Slc21a5; Slco1a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctctga ctttctttta gtctcagcat ggagaggacc gtcttctaaa gcttcttcat
       61 aaaaacagca gtaagattat ttaaagaata gatatctgga aacaatcaga agaacaacat
      121 gggaaaatct gagaaaaggg ttgcaaccca tggggtcaga tgttttgcca agatcaagat
      181 gtttctgttg gcattaacat gtgcatatgt atccaaatca ttatcaggaa cttatatgaa
      241 ttccatgctc acacaaatag agagacaatt cggtatcccc acatctatag ttgggcttat
      301 caatgggagc tttgaaatag gaaacctttt gttgattata tttgtgagtt attttggaac
      361 aaaacttcac agacctatca tgattggtgt tggatgtgca gttatgggcc tggggtgttt
      421 cttaatctcg ctaccccatt tcctcatggg ccaatatgaa tatgaaacga ttttacctac
      481 aagcaacgtg tcctcaaaca gcttcttctg tgtggaaaac agatcccaga ccttaaatcc
      541 aacacaagac ccctcagagt gtgtgaaaga aatgaaatca ttaatgtgga tatatgtact
      601 ggtaggaaac ataatacgtg gaattggtga aactcccatc atgcccttgg gtatttccta
      661 cattgaagac tttgccaaat ctgaaaactc tcctttatac attgggattt tagaaacagg
      721 aatgaccatt ggccctttga ttggacttct gttggcttct tcctgtgcaa acatttatgt
      781 agacattgag tctgtgaata cagatgacct gaccataact cccacagata cacgctgggt
      841 cggagcttgg tggatcggct ttttggtctg tgcaggagtg aatatcctga ccagctttcc
      901 ctttttcttt tttcccaaaa cacttccaaa ggaaggatta caggagaatg tggatggaac
      961 tgaaaatgcc aaagagaaga aacacagaaa aaaggccaag gaagaaaaac gaggaatcac
     1021 taaagatttc tttgtgttca tgaagagcct ctcctgcaat ccaatttaca tgcttttcat
     1081 ccttataagt gttctccagt tcaatgcatt tatcaattca tttaccttca tgcctaagta
     1141 tctggaacag caatatggaa aatccactgc tgaggtagtc ttccttatgg gtctttatat
     1201 gttacctcca atatgcctcg gatatttaat tggtggtttg attatgaaga agttcaaggt
     1261 tactgtcaag aaagctgcac acttagcatt ctggctctgc ctgtctgagt accttctgtc
     1321 tttccttagc tatgtgatga cctgtgataa ttttccagtg gcaggcttaa caacctctta
     1381 tgaaggggtt cagcaccaac tatatgtgga gaacaaggtc cttgctgact gtaacacaag
     1441 gtgtaactgc tcaacgaaca catgggatcc agtgtgtgga gacaatggcc tggcatacat
     1501 gtcagcctgc cttgcaggct gtgagaagtc tgttggaaca ggaaccaaca tggtgtttca
     1561 gaattgcagc tgcattcagt catcgggaaa ctcatctgca gtcctgggcc tgtgtaacaa
     1621 aggccctgac tgtgccaaca agctgcagta cttcttaatc atagcaatat ttggctgttt
     1681 catatactcg ctggcaggca ttccagggta tatggttctt ctgaggtgta tcaagtctga
     1741 agagaagtca cttggagttg ggttacatgc attttgcata agaatattag ctggcattcc
     1801 tgcacccatt tactttggag ctttgataga cagaacctgt ttacattggg gaaccctgaa
     1861 atgtggtgag cccggggcat gcaggatgta tgacataaac agcttcagac gtctttacct
     1921 tggattgccg gctgcactaa gaggagcaag ctttgtcccc gccttcttca ttctaagact
     1981 tacgaggaca ttccagttcc ctggggacat tgagtcttca aaaactgatc atgcggagat
     2041 gaagctcacc ttgaaggaaa gtgagtgcac agaagtccta aggtcgaaag tgacggagga
     2101 ctgaaaacga agctgtaatg agttttctac tgccctatgc aaggccatga agagaatgta
     2161 cacttcacta gttttgaatc atgagagata caattggaac tcttaggtta tccataaggc
     2221 cgtcaaagtt acttcattca tgataaaatt atttactgat agcattttca gaaggctgac
     2281 atagtactca agattttccc agggaaaact tctatagtgg ccttcaccct taaccttaaa
     2341 gctgccttca ttttcaacca gcatgttctc ttttaactca atcaagggaa gtggatgttt
     2401 cccacacatt ctcaaatatc tttgaaactt tcctattgca gaaatatcat ttagatgttt
     2461 ttaatttata tactgatgct ggagatcaaa atatacatct tggttaagcc agattgcgtt
     2521 agtttgtttt gatttatcct ctgcatgtgc aaaacttctg catctgtctt gtgtacttag
     2581 gagtggtaac tctcttttac ttctaagatt agactcttca gagtgtgcca tctcctgttt
     2641 tcagtccctt ctatcattac ttctgtcaca cagttgatca tttcacatac atcactgaaa
     2701 actttaatca ggttgttaac cagtcatgta gcaaagatga ttgggactct ttttctctaa
     2761 caattcaaag ctggtcatga aactcttttt taaaaatcaa gagtagggga aaactagtcc
     2821 tttcaaaggc tccttgtaga gatgggctgt atctcagtgg aatagttatt acctaatgta
     2881 tgtgaggccc caggttcaac cacaacgtag ggtaaaccaa taaagtaata aaaataacgt
     2941 aagtccagat gcatcatcag atattctaaa aggctattct catattcagg gggcttcaat
     3001 ggcttagtgt tcattctatt caagggccat ggagcacata gttattaaca ttcataataa
     3061 acttagagta aaacctttaa agagggacca gatagaaagt tcgatagaaa gaactgtttg
     3121 ccaccgaacc tgaaaaggtt gttgtgatcc ttgggaccaa cgtgaaggag agaacaaact
     3181 ctcacaagtt gtgctatatc tctttttaat tgtgcatgcc ccattgcaaa tcaattaata
     3241 aaaaaagcat taaaaggttt aagaccgaca tttgctgtaa aattatagct cataaacgtg
     3301 aaagtacaca tcaaaaataa aatcaagttg tggttgtttt aatgagaaat atccctccta
     3361 ggcataggca tttggatatt tggtttctaa tgaatgactc tgcttaggga agattggatg
     3421 tgcatcccta agacaaaagg tgaatcactg agatgggttg aaagttaaaa gcctcaccta
     3481 cttccagtac actctctgct ttgtgctttg gttgatgata tgaaatcatg gtttcctgct
     3541 ccagccacca tgcctggtgc ttgccttcat gaacttccat ccctggagtc atgcgttaaa
     3601 ataaactcct ttttttaatg tg
//
