LOCUS       NM_030837               2775 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 1a8 (Slco1a8), mRNA.
ACCESSION   NM_030837 XM_346723
VERSION     NM_030837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Wolff,M.W. and Su,T.Z.
  TITLE     Cloning and tissue-specific expression of spliced variants of the
            rat organic anion transporter (rOAT-K)
  JOURNAL   DNA Seq 13 (1), 15-25 (2002)
   PUBMED   12180133
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Masuda,S., Ibaramoto,K., Takeuchi,A., Saito,H., Hashimoto,Y. and
            Inui,K.I.
  TITLE     Cloning and functional characterization of a new multispecific
            organic anion transporter, OAT-K2, in rat kidney
  JOURNAL   Mol Pharmacol 55 (4), 743-752 (1999)
   PUBMED   10101033
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Saito,H., Masuda,S. and Inui,Ki.
  TITLE     Cloning and functional characterization of a novel rat organic
            anion transporter mediating basolateral uptake of methotrexate in
            the kidney
  JOURNAL   J Biol Chem 271 (34), 20719-20725 (1996)
   PUBMED   8702823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 1, 2020 this sequence version replaced NM_030837.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D79981.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000004.1  176749687-176749723 c
            38-88               JAXUCZ010000004.1  176748826-176748876 c
            89-200              JAXUCZ010000004.1  176745542-176745653 c
            201-342             JAXUCZ010000004.1  176742562-176742703 c
            343-475             JAXUCZ010000004.1  176737886-176738018 c
            476-582             JAXUCZ010000004.1  176732627-176732733 c
            583-729             JAXUCZ010000004.1  176732065-176732211 c
            730-828             JAXUCZ010000004.1  176731529-176731627 c
            829-1050            JAXUCZ010000004.1  176730224-176730445 c
            1051-1215           JAXUCZ010000004.1  176721682-176721846 c
            1216-1411           JAXUCZ010000004.1  176720719-176720914 c
            1412-1577           JAXUCZ010000004.1  176719196-176719361 c
            1578-1750           JAXUCZ010000004.1  176716923-176717095 c
            1751-1815           JAXUCZ010000004.1  176713525-176713589 c
            1816-1933           JAXUCZ010000004.1  176712324-176712441 c
            1934-2775           JAXUCZ010000004.1  176706208-176707049 c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2775
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /note="solute carrier organic anion transporter family,
                     member 1a8"
                     /db_xref="GeneID:80899"
                     /db_xref="RGD:621387"
     exon            1..37
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            38..88
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            89..200
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2153
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /note="solute carrier family 21 member 4; rOAT-K;
                     sodium-independent organic anion transporter K1; kidney
                     specific organic anion transporter"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A3"
                     /protein_id="NP_110464.2"
                     /db_xref="GeneID:80899"
                     /db_xref="RGD:621387"
                     /translation="MGDLEKGAATHGAGCFAKIKVFLMALTCAYVSKSLSGTFMSSML
                     TQIERQFGIPTAIVGFINGSFEIGNLLLIIFVSYFGMKLHRPIVIGVGCAVMGLGCFI
                     ISLPHFLMGRYEYETTILPTSNLSSNSFLCMENQTQTLNPAQDPAECVKEVKSLMWIY
                     VLVGNIIRGIGETPIMPLGVSYIENFAKSENSPLYIGILETGKMIGPIFGLLLGSFCA
                     SIYVDTGSVNTDDLTITPTDIRWVGAWWIGFLVCAGVNILISIPFFFFPKTLPKEGLQ
                     ENVDGTENAKEEKHREKAKEEKRGITKDFFPFLKSLSCNPIYMLFTLISVLQVNAFNI
                     YFSFLPKYLENQYGKSTAEVIFLMGVYNLPAICIGYLIAGFMMKKFKITVKTAAFLAF
                     CLSLSEYSFGFCNFLITCDNVPVAGLTNSYERDQKPLYLENNVLADCNTRCSCLTKTW
                     DPVCGDNGLAYMSACLAGCEKSVGTGTNMVFHNCSCIQSPGNSSAVLGLCNKGPECTN
                     KLQYLLILSGFLSILYSFAAIPGYMVFLRCIKSEEKSLGIGIHAFCIRVFAGIPAPIY
                     FGALIDRTCLHWGTQKCGAPGACRMYDINSFRRIYLGMSAALRGSSYLPAFVIVILTR
                     KFSLPGKINSSEMEIAEMKLTEKESQCTDVHRNPKFKNDGELKTKL"
     exon            201..342
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            343..475
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            476..582
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..729
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..828
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1050
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1215
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1411
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1577
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1750
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1815
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1933
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2775
                     /gene="Slco1a8"
                     /gene_synonym="OAT-K1; OAT-K2; rOAT-K1; rOAT-K11;
                     rOAT-K13; rOAT-K14; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6;
                     rOAT-K7; rOAT-K8; rOAT-K9; Slc21a4; Slco1a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggccgtc cggtcgctga gttgtcctga agctcgggtt aagagggcct gtaagagctg
       61 ttggtagtca tcccaagtag gctggtggtt agcagtggaa ttttaaagta gagacatcat
      121 taaggagtca gaagatcaac atgggagacc ttgaaaaggg ggctgcaacc catggggccg
      181 gatgctttgc caagatcaag gtgtttctga tggcattaac atgtgcatat gtatccaaat
      241 cgctatcagg aactttcatg agttccatgc tcacacaaat agagagacaa ttcggtatcc
      301 ccacagctat agttggattc atcaatggga gctttgagat aggaaatctt ttgttgatta
      361 tatttgtgag ttattttgga atgaaactgc acagacctat cgtgattggt gttggatgtg
      421 cagttatggg cctgggttgc ttcataatat cactacctca tttcctcatg ggccgatatg
      481 aatatgaaac aacgatttta cctacaagca acttgtcctc aaacagcttc ttgtgtatgg
      541 agaaccaaac ccagacctta aatccagcgc aagacccagc agagtgtgtg aaagaagtga
      601 aatcactaat gtggatatat gtactggtag gaaatattat acgtggaatt ggtgaaactc
      661 ccatcatgcc cttgggtgtt tcctacatag aaaactttgc caaatctgaa aactctcctt
      721 tatacattgg aattctagaa acaggaaaga tgattggccc aatatttggg cttttgttgg
      781 gatccttctg tgcaagcatt tatgtagaca cagggtctgt gaatacagat gacctgacca
      841 taactcccac agatatacgc tgggttggtg cttggtggat cggctttttg gtctgtgcag
      901 gagtgaatat cctgattagc attccctttt tcttttttcc caaaacactc ccaaaggaag
      961 gattacagga aaatgtggat ggaactgaaa atgccaaaga ggagaagcac agagaaaagg
     1021 ccaaggaaga aaaacgagga atcactaaag atttctttcc gttcctgaag agcctgtcct
     1081 gcaacccgat ttacatgctg ttcaccctta taagtgtgct ccaggtcaat gcatttaaca
     1141 tttactttag cttcctgcct aagtaccttg aaaaccaata tggaaaatcc actgcagagg
     1201 tcatcttcct catgggtgtt tataacttac ctgcaatatg cattggatat ttaattgctg
     1261 gcttcatgat gaagaaattc aagatcactg tcaagacagc tgcattcctc gcattctgcc
     1321 tatccttgtc tgaatatagt tttggtttct gtaacttcct aattacctgt gataatgtcc
     1381 cagttgctgg tttgactaac tcttatgaaa gagatcagaa acctctatac ttggaaaata
     1441 atgttcttgc tgactgcaac acaaggtgca gctgcttgac gaaaacatgg gatccagtgt
     1501 gtggagacaa tggcctagca tacatgtcag cctgcctcgc aggctgcgag aagtctgttg
     1561 gaactggaac caacatggtg tttcacaatt gcagctgcat tcagtcacca ggaaactcgt
     1621 ccgcagtcct ggggctgtgt aataaaggcc ccgagtgcac caacaagctg cagtaccttt
     1681 taatactatc aggatttctc agtatcctct actcattcgc agccatacct ggatacatgg
     1741 tttttctgag gtgtatcaag tctgaagaga agtcacttgg gattggaata catgcatttt
     1801 gcataagagt atttgctggc attccagcac ctatttactt tggagctttg atagacagaa
     1861 cctgtttaca ctggggaact cagaaatgtg gtgcgccagg ggcgtgcagg atgtatgata
     1921 taaatagctt caggcgcatt taccttggga tgtctgcagc tctaagagga tcaagctatc
     1981 tccctgcatt tgttattgta atacttacaa ggaagttctc tcttcctggg aaaatcaact
     2041 cttcagaaat ggaaattgca gagatgaagc tcacagagaa ggaaagccag tgcacagatg
     2101 tgcacagaaa tcctaagttc aagaatgatg gagaactgaa aacgaagctg taatgacttt
     2161 tctactgcct tgtgtaaggc catgaacaga atgctagaat tcaaaacact tcacttttga
     2221 atcatgagat aaacaacagg aatgcttaac tttaagaacc tcaacaatta gttttacact
     2281 catgataaaa gtagcatttt catgaggctg gtgtaggact taagtttttc ccaggataga
     2341 tttctataga gacccccaca ttgaacatta aagcttcctt catttgcaaa cagcattttc
     2401 tattgtatca aggaaagtat gtatttctaa gatatcttca agtagcttta aagcctagtc
     2461 cttaaacact atttcattct gttgaactta tgtttcgatg tggggggtat ttagagagac
     2521 aaatatgcat tgtggctgtg ccacatcaga aaaaaaaacc tattctttct atgcacaagc
     2581 tgtctgcata cgtttatatc tagaagttat taacccttat tttttatttt agtcatgatg
     2641 cttccgagat tagacttctc tctcatgtgc catctcctgg ttttagttcc atttttcttt
     2701 acttatgtca cacatttgat catttatctt acagtactga caaacctgat cacattatta
     2761 aaaaattcac attgc
//
