LOCUS       NM_017111               2759 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier organic anion transporter family,
            member 1a1 (Slco1a1), mRNA.
ACCESSION   NM_017111 XM_346725
VERSION     NM_017111.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Wang,P., Wang,W.J., Choi-Nurvitadhi,J., Lescaille,Y., Murray,J.W.
            and Wolkoff,A.W.
  TITLE     Rat Organic Anion Transport Protein 1A1 Interacts Directly With
            Organic Anion Transport Protein 1A4 Facilitating Its Maturation and
            Trafficking to the Hepatocyte Plasma Membrane
  JOURNAL   Hepatology 70 (6), 2156-2170 (2019)
   PUBMED   31102415
  REMARK    GeneRIF: optimal rOATP1A4 trafficking to the cell surface is
            dependent upon coexpression and interaction with rOATP1A1.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Kim,J., Kim,T., Hong,K.S., Moon,H., Oh,I.K., Lee,S.M.,
            Hohenwalter,M.D., Zimmerman,M.A., Cronin,D.C. and Hong,J.C.
  TITLE     Pre-Hepatectomy Assessment of Bile Transporter Expression by
            Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis
  JOURNAL   J Invest Surg 30 (4), 265-271 (2017)
   PUBMED   27780379
  REMARK    GeneRIF: Bile transporters OATP1/MRP2 mRNA expression ratio in
            liver tissue decreased with dimethylnitrosamine-induced liver
            injury, model of liver cirrhosis.
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Hotta,K., Ueyama,J., Tatsumi,Y., Tsukiyama,I., Sugiura,Y.,
            Saito,H., Matsuura,K. and Hasegawa,T.
  TITLE     Lack of Contribution of Multidrug Resistance-associated Protein and
            Organic Anion-transporting Polypeptide to Pharmacokinetics of
            Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats
  JOURNAL   Anticancer Res 35 (9), 4681-4689 (2015)
   PUBMED   26254357
  REMARK    GeneRIF: These findings suggest the possibility that ABCC2-mediated
            hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do
            not play important roles in the disposition of regorafenib.
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Shimizu,A., Kobayashi,A., Motoyama,H., Sakai,H., Yamada,A.,
            Yoshizawa,A., Momose,M., Kadoya,M. and Miyagawa,S.
  TITLE     Features of acute liver congestion on gadoxetate disodium-enhanced
            MRI in a rat model: Role of organic anion-transporting polypeptide
            1A1
  JOURNAL   J Magn Reson Imaging 42 (3), 828-836 (2015)
   PUBMED   25581836
  REMARK    GeneRIF: Oatp1a1 has a role in acute liver congestion as seen in
            gadoxetate disodium-enhanced MRI
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Maruyama,H., Ogura,J., Fujikawa,A., Terada,Y., Tsujimoto,T.,
            Koizumi,T., Kuwayama,K., Kobayashi,M., Yamaguchi,H. and Iseki,K.
  TITLE     Intestinal ischemia-reperfusion suppresses biliary excretion of
            hepatic organic anion transporting polypeptides substrate
  JOURNAL   J Pharm Pharm Sci 16 (5), 722-731 (2013)
   PUBMED   24393554
  REMARK    GeneRIF: Oatp1a1 and Oatp2b1 expression levels are decreased by
            intestinal ischemia reperfusion.
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Gotoh,Y., Kato,Y., Stieger,B., Meier,P.J. and Sugiyama,Y.
  TITLE     Gender difference in the Oatp1-mediated tubular reabsorption of
            estradiol 17beta-D-glucuronide in rats
  JOURNAL   Am J Physiol Endocrinol Metab 282 (6), E1245-E1254 (2002)
   PUBMED   12006354
  REMARK    GeneRIF: results suggest that urinary E(2)-17betaG excretion is
            subject to hormonal regulation and that the large gender difference
            can be explained by regulation in Oatp1-mediated reabsorption
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Meng,L.J., Wang,P., Wolkoff,A.W., Kim,R.B., Tirona,R.G.,
            Hofmann,A.F. and Pang,K.S.
  TITLE     Transport of the sulfated, amidated bile acid,
            sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1
            and Oatp2
  JOURNAL   Hepatology 35 (5), 1031-1040 (2002)
   PUBMED   11981753
  REMARK    GeneRIF: Transport of the sulfated, amidated bile acid,
            sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1
            and Oatp2.
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Ito,A., Yamaguchi,K., Onogawa,T., Unno,M., Suzuki,T., Nishio,T.,
            Suzuki,T., Sasano,H., Abe,T. and Tamai,M.
  TITLE     Distribution of organic anion-transporting polypeptide 2 (oatp2)
            and oatp3 in the rat retina
  JOURNAL   Invest Ophthalmol Vis Sci 43 (3), 858-863 (2002)
   PUBMED   11867608
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Tygstrup,N., Bangert,K., Ott,P. and Bisgaard,H.C.
  TITLE     Messenger RNA profiles in liver injury and stress: a comparison of
            lethal and nonlethal rat models
  JOURNAL   Biochem Biophys Res Commun 290 (1), 518-525 (2002)
   PUBMED   11779202
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Jacquemin,E., Hagenbuch,B., Stieger,B., Wolkoff,A.W. and Meier,P.J.
  TITLE     Expression cloning of a rat liver Na(+)-independent organic anion
            transporter
  JOURNAL   Proc Natl Acad Sci U S A 91 (1), 133-137 (1994)
   PUBMED   8278353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On May 11, 2021 this sequence version replaced NM_017111.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209854.1, SRR26643287.12278.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000004.1  176681923-176681992 c
            71-189              JAXUCZ010000004.1  176663830-176663948 c
            190-331             JAXUCZ010000004.1  176658802-176658943 c
            332-464             JAXUCZ010000004.1  176655484-176655616 c
            465-571             JAXUCZ010000004.1  176651859-176651965 c
            572-718             JAXUCZ010000004.1  176651148-176651294 c
            719-817             JAXUCZ010000004.1  176648202-176648300 c
            818-1039            JAXUCZ010000004.1  176633376-176633597 c
            1040-1204           JAXUCZ010000004.1  176629077-176629241 c
            1205-1400           JAXUCZ010000004.1  176627772-176627967 c
            1401-1566           JAXUCZ010000004.1  176625766-176625931 c
            1567-1739           JAXUCZ010000004.1  176622790-176622962 c
            1740-1804           JAXUCZ010000004.1  176613204-176613268 c
            1805-1922           JAXUCZ010000004.1  176611648-176611765 c
            1923-2759           JAXUCZ010000004.1  176608139-176608975 c
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..2759
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /note="solute carrier organic anion transporter family,
                     member 1a1"
                     /db_xref="GeneID:50572"
                     /db_xref="RGD:3700"
     exon            1..70
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            71..189
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2142
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /function="mediates transport of organic anion"
                     /note="solute carrier family 21 member 1; organic
                     anion-transporting polypeptide 1; sodium-independent
                     organic anion transporter 1; solute carrier family
                     (organic anion transporter) member 1; solute carrier
                     family (organic anion transporter) member 3; solute
                     carrier organic anion transporter family member 1A1-like"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1A1"
                     /protein_id="NP_058807.1"
                     /db_xref="GeneID:50572"
                     /db_xref="RGD:3700"
                     /translation="MEETEKKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSML
                     TQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLL
                     MSLPHFFMGRYEYETTISPTGNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIC
                     VMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIGILEMGKVAGPIFGLLLGSYCA
                     QIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIPFFFLPKALPKKGQQ
                     ENVAVTKDGKVEKYGGQAREENLGITKDFLTFMKRLFCNPIYMLFILTSVLQVNGFIN
                     KFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAAYLAF
                     CLSVFEYLLFLCHFMLTCDNAAVAGLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTW
                     DPVCGDNGVAYMSACLAGCKKFVGTGTNMVFQDCSCIQSLGNSSAVLGLCKKGPECAN
                     RLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPAPVY
                     FGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMR
                     KFQFPGDIDSSATDHTEMMLGEKESEHTDVHGSPQVENDGELKTKL"
     exon            190..331
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            332..464
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..571
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..718
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..817
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1039
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1204
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1400
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1566
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1739
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1804
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1922
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2759
                     /gene="Slco1a1"
                     /gene_synonym="OATP-1; Oatp1; Slc21a1; Slc21a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttaccac caccagcaag aggaccattt cctatggttt cttcatgagt gtacttctct
       61 cttggctaag aaagacagca aagcaaagac ttttaaagcg aagaagctgg aaacaatcag
      121 aagaacacca tggaagaaac agagaaaaag attgcaacac aagagggtag attgttttcc
      181 aagatgaagg tgtttctgct gtcattaaca tgtgcatgtt taaccaaatc actatcagga
      241 gtatatatga attccatgct cacacaaata gagagacaat ttgatatctc cacatctgta
      301 gctggattaa tcaatgggag ctttgagatt ggaaaccttt ttttcattgt atttgtgagt
      361 tattttggaa caaaactgca cagacctgtg gtgattggta ttggatgtgt gattatgggc
      421 ctggggtgtc tcttaatgtc attacctcat ttcttcatgg gcagatacga atatgaaaca
      481 acgatctcac ctacaggcaa cttgtcctca aacagcttct tgtgtatgga gaaccgaaca
      541 cagaccttaa agccaacgca agacccagca gaatgtgtga aagaaatgaa atcattaatg
      601 tggatatgtg taatggtagg aaatattata cgtggaattg gtgaaactcc tattgtgccc
      661 ttgggtatct cttacatcga agactttgcc aaatcagaaa actctccttt atacattggg
      721 attttagaaa tggggaaggt tgctggccca atttttggac ttttgttggg atcttactgt
      781 gcacaaattt atgtagacat tgggtctgtg aatacagatg acctgaccat aacacccagt
      841 gatacacgct gggttggtgc ttggtggatt ggctttttgg tctgtgcagg agtgaatatc
      901 ctgaccagca tccccttttt ctttttgccg aaagcacttc caaagaaagg acaacaggag
      961 aatgttgctg tgactaaaga tggcaaagtt gagaaatatg gaggacaagc cagagaggaa
     1021 aatcttggaa tcactaaaga tttcttgacg ttcatgaaga ggctcttctg caatccgatt
     1081 tacatgcttt tcatccttac aagtgtgctc caggtgaatg gctttattaa taaatttacg
     1141 ttcttgccca aatacctgga acagcagtat ggaaaatcta ctgcagaggc aatattcctc
     1201 ataggtgttt atagcttacc tcccatatgc ctcgggtatc taattggtgg ctttattatg
     1261 aagaagttta agattactgt caagaaagct gcatacctag cattttgcct atcggtgttt
     1321 gaatatcttc tttttctttg tcactttatg ttgacctgtg acaatgcagc agttgctgga
     1381 ttaaccacct cttacaaagg agttcagcac caactacatg tggagagcaa ggtccttgct
     1441 gactgcaaca caaggtgtag ctgctcaacg aacacatggg atccagtgtg tggagacaat
     1501 ggtgtagcat acatgtcagc ttgccttgcg ggctgtaaga agtttgttgg aactggaacc
     1561 aacatggtgt ttcaggattg cagctgcatt cagtcattag gaaactcgtc tgcagtcctg
     1621 ggtctgtgta aaaaaggtcc tgagtgtgcc aacaggctgc agtacttttt aatcttaaca
     1681 ataattatca gtttcatcta ctcacttaca gccatacctg ggtacatggt ttttttgagg
     1741 tgtgtcaagt ctgaagagaa gtcacttgga gttggattac atacattttg cataagagta
     1801 tttgctggta ttcccgcacc tgtttacttt ggcgctttga tagacagaac ctgtttacat
     1861 tggggaaccc tgaaatgtgg tcagcgaggg gcatgcagga tgtatgacat aaacagtttc
     1921 aggcacattt acctggggtt gcctatagca ctaagaggat caagctatct gcctgccttc
     1981 ttcattctga tacttatgag gaaattccag ttccccgggg acattgactc ttcagcaact
     2041 gatcatacag agatgatgct cggagagaag gaaagcgagc acacagatgt gcatggaagt
     2101 cctcaggtcg agaatgacgg agaactgaaa acgaagctgt aatgagtttt ctactgccct
     2161 gttcaaggcc atgaacagaa tgcacacttc ccttcctcgg aatcctgaga gatacaatag
     2221 gaaccttctc tttaaggacc tcaacaattg tttttctcac tataaaaata attgctgata
     2281 tcattttcag aatttcaggt gatatttaag atttccctgg ggaagacttt tatggtgacc
     2341 cccacactac actttaaagc ttccttcatt ttcacataac attttctctt aactcaatca
     2401 agggaaatat gtgtttccca cacatcttca aatgagtata aaactttcct attcctgaaa
     2461 cagtatttaa tttcattgaa tttatggttc acagttggaa gtatttagag ctgaaaagat
     2521 acattctcat taagccacat tgaaaagtta acttttctat gttcaggatg tctccatatg
     2581 tctatatgta ggagttctca aatattatta ttattgtaga catgatgctc ctagattaga
     2641 cttctcactc ctgtgtcatt tcctgtttct agtcccttct ttcattactc ctgtcacaca
     2701 gttgaatgtt ttgtttagag cactgacaaa cttaatcagg ttattaaaaa tcacattag
//
