LOCUS       NM_001109385            2011 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus solute carrier family 9 member B2 (Slc9b2), mRNA.
ACCESSION   NM_001109385 XM_001054115
VERSION     NM_001109385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Uzdavinys,P., Coincon,M., Nji,E., Ndi,M., Winkelmann,I., von
            Ballmoos,C. and Drew,D.
  TITLE     Dissecting the proton transport pathway in electrogenic Na+/H+
            antiporters
  JOURNAL   Proc Natl Acad Sci U S A 114 (7), E1101-E1110 (2017)
   PUBMED   28154142
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Landreh,M., Marklund,E.G., Uzdavinys,P., Degiacomi,M.T.,
            Coincon,M., Gault,J., Gupta,K., Liko,I., Benesch,J.L., Drew,D. and
            Robinson,C.V.
  TITLE     Integrating mass spectrometry with MD simulations reveals the role
            of lipids in Na+/H+ antiporters
  JOURNAL   Nat Commun 8, 13993 (2017)
   PUBMED   28071645
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Chen,S.R., Chen,M., Deng,S.L., Hao,X.X., Wang,X.X. and Liu,Y.X.
  TITLE     Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and
            male fertility
  JOURNAL   Cell Death Dis 7 (3), e2152 (2016)
   PUBMED   27010853
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Deisl,C., Simonin,A., Anderegg,M., Albano,G., Kovacs,G.,
            Ackermann,D., Moch,H., Dolci,W., Thorens,B., A Hediger,M. and
            Fuster,D.G.
  TITLE     Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in
            beta-cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 10004-10009 (2013)
   PUBMED   23720317
REFERENCE   6  (bases 1 to 2011)
  AUTHORS   Hofstetter,W., Siegrist,M., Simonin,A., Bonny,O. and Fuster,D.G.
  TITLE     Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular
            localization and role in vitro and in vivo
  JOURNAL   Bone 47 (2), 331-340 (2010)
   PUBMED   20441802
REFERENCE   7  (bases 1 to 2011)
  AUTHORS   Fuster,D.G., Zhang,J., Shi,M., Bobulescu,I.A., Andersson,S. and
            Moe,O.W.
  TITLE     Characterization of the sodium/hydrogen exchanger NHA2
  JOURNAL   J Am Soc Nephrol 19 (8), 1547-1556 (2008)
   PUBMED   18508966
REFERENCE   8  (bases 1 to 2011)
  AUTHORS   Lee,S.H., Kim,T., Park,E.S., Yang,S., Jeong,D., Choi,Y. and Rho,J.
  TITLE     NHE10, an osteoclast-specific member of the Na+/H+ exchanger
            family, regulates osteoclast differentiation and survival
            [corrected]
  JOURNAL   Biochem Biophys Res Commun 369 (2), 320-326 (2008)
   PUBMED   18269914
  REMARK    Erratum:[Biochem Biophys Res Commun. 2008 Aug 15;373(1):174]
REFERENCE   9  (bases 1 to 2011)
  AUTHORS   Xiang,M., Feng,M., Muend,S. and Rao,R.
  TITLE     A human Na+/H+ antiporter sharing evolutionary origins with
            bacterial NhaA may be a candidate gene for essential hypertension
  JOURNAL   Proc Natl Acad Sci U S A 104 (47), 18677-18681 (2007)
   PUBMED   18000046
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166815.1.
            
            On May 11, 2008 this sequence version replaced NM_001109385.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2011
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /note="solute carrier family 9 member B2"
                     /db_xref="GeneID:679958"
                     /db_xref="RGD:1598112"
     exon            1..8
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            9..149
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1703
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /note="Na+/H+ exchanger domain containing 2; mitochondrial
                     sodium/hydrogen exchanger NHA2; solute carrier family 9,
                     subfamily B (cation proton antiporter 2), member 2;
                     mitochondrial sodium/hydrogen exchanger 9B2; solute
                     carrier family 9, subfamily B (NHA2, cation proton
                     antiporter 2), member 2"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 9B2"
                     /protein_id="NP_001102855.1"
                     /db_xref="GeneID:679958"
                     /db_xref="RGD:1598112"
                     /translation="MEDEDQTVECQYSKPPLGTTHAASRHHELQEERVTNLKSPDGNE
                     PTEDSNLLTGGEKKPQDSLAEPRSLQSPRRFLACPPHGRLAGVITNGTMVVLLWAVVW
                     SITGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNVP
                     VISDNVRIQHKWSSSLRSIALSVILVRAGLGLDSKALKKLKGVCVRLAMGPCIVEACA
                     SALLSHFLMGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVEKGIPTLLMAAGS
                     FDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIGVATGSLLGFFIQYFPSRDQDN
                     LVWKRAFLVLGFAVLAVFSSVIFSFPGSGGLCTLVMAFLAGMRWTDKKSEVEKIIALT
                     WDVFQPLLFGLIGAEVSIASLRAETVGLCVATLGIAVLIRILTTFLMVCFAGFNIKEK
                     IFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLAILITAPIGSLL
                     IGLLGPRVLQKSEHRNEEEVQGETSAHVQRKSGDSVTEA"
     exon            150..330
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..501
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..644
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..772
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..948
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1055
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1205
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1314
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1451
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1672
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1988
                     /gene="Slc9b2"
                     /gene_synonym="Nhedc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagatac cagacctggc tcctcctctc tggacttcga atcttcgaag ttgtaagata
       61 tggaggatga agatcagaca gttgaatgtc agtattcaaa gccacccctg ggaaccactc
      121 acgcggcttc tcgacatcac gaactgcagg aggagagagt cacgaacctc aaaagtccag
      181 atggaaatga accgacggaa gacagtaacc tgctgaccgg cggggagaaa aagccccagg
      241 actcactagc ggaacccaga agcctgcaga gtccaaggcg attcctggcc tgccctccac
      301 acggccggct ggccggagtg ataactaatg gtaccatggt tgttctccta tgggccgtgg
      361 tttggtcaat tacgggccct gaatgtcttc ctggaggaaa tctgtttgga attataatcc
      421 tcttctattg ctccatcacc ggaggtaaac tttttggact cattaagttt ccaacgttgc
      481 ctcctctgcc tcctcttctt ggcatgctgc tagctgggtt tctcttgagg aacgtcccag
      541 tcatcagtga taatgtccgc atccagcaca agtggtcgtc atctttgaga agcatagccc
      601 tttctgtcat tctggttcgt gctggcctcg gtctggattc aaaggccctg aagaagctga
      661 agggtgtgtg tgtgcgactg gccatgggtc cctgcatcgt ggaggcctgt gcgtctgccc
      721 ttctctcaca cttcctgatg gggttgccat ggcaatgggg gttcatcctg ggttttgtcg
      781 taggtgctgt gtctcctgct gttgtggtgc cttcaatgct ccttttgcag gaaggaggct
      841 atggtgtcga aaagggaatc ccaactttac tcatggctgc tggcagcttc gatgacatcc
      901 tggccatcac cggcttcaac acgtgcttgg gtgtggcctt ttccacaggg tctacagttt
      961 ttaacatctt cagaggcatc ttggaggtgg taattggtgt ggcgactgga tctcttcttg
     1021 ggttttttat ccagtacttt cccagcaggg accaggacaa cctcgtgtgg aagcgagcct
     1081 tcctggttct gggctttgct gtgctagctg tgttcagcag tgtaattttt agcttcccgg
     1141 ggtcaggagg actgtgcacg ttggtcatgg ctttcctagc aggcatgagg tggactgaca
     1201 agaagtcaga ggtggaaaag atcattgcac ttacctggga cgttttccaa cctcttcttt
     1261 tcggcctgat tggagcagag gtatccattg cgtctctcag agcagaaacg gttggccttt
     1321 gtgttgcaac ccttggcatt gcagtgttga tacggattct gactacattc ctgatggtgt
     1381 gttttgctgg ttttaacata aaggaaaaga tatttatttc ttttgcctgg cttccaaagg
     1441 ccacggtcca ggctgccatt ggctctgtgg ctctggacac agcgagatcc catggagaga
     1501 agcagctaga agactatggg atggatgtgc tgacggtagc atttttggcc atcctcatta
     1561 cagcaccaat tggaagccta ctgattggtt tgctgggtcc cagggtactt cagaaatctg
     1621 aacatcgaaa cgaagaagag gttcaaggag agacttctgc acacgttcag aggaagtctg
     1681 gggattccgt gacagaagcc tgatgggccg tgtttaccac cccaacccaa aggctttggc
     1741 ccaccgtcaa ccaggacaac tttatttccc cttgatccag atgaaaaatt tcataaacaa
     1801 caaaaaaaaa atgagaaagg tttatactgc taacagtacc tcaggggttt ccttcggaga
     1861 aagactggag gacaggttac ttcagaaagt gagagaaagt aatttggaca aagaaagcat
     1921 tcacaatttt gttaaaatct tgatgcattt cttattatgg tattaaaaat tctcatatca
     1981 aaaagcaaaa aaaaaaaaaa aaaaaaaaaa a
//
