LOCUS       NM_138858               4174 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 9 member A5 (Slc9a5), mRNA.
ACCESSION   NM_138858
VERSION     NM_138858.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4174)
  AUTHORS   Fan,S.H., Numata,Y. and Numata,M.
  TITLE     Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell
            migration
  JOURNAL   Mol Biol Cell 27 (4), 702-715 (2016)
   PUBMED   26700318
  REMARK    GeneRIF: NHE5 facilitates MET recycling to the plasma membrane,
            protects MET from degradation, and modulates HGF-induced
            phosphatidylinositol-3-kinase and mitogen-activated protein kinase
            signaling.
REFERENCE   2  (bases 1 to 4174)
  AUTHORS   Diering,G.H., Numata,Y., Fan,S., Church,J. and Numata,M.
  TITLE     Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA
            cell-surface targeting and NGF-induced PI3K signaling
  JOURNAL   Mol Biol Cell 24 (21), 3435-3448 (2013)
   PUBMED   24006492
  REMARK    GeneRIF: Data indicate that NHE5 depletion reduces cell surface
            abundance of TrkA and nerve growth factor (NGF)-induced PI3K
            signaling.
REFERENCE   3  (bases 1 to 4174)
  AUTHORS   Rocha-Gonzalez,H.I., Castaneda-Corral,G., Araiza-Saldana,C.I.,
            Ambriz-Tututi,M., Caram-Salas,N.L., Torres-Lopez,J.E.,
            Murbartian,J. and Granados-Soto,V.
  TITLE     Identification of the Na+/H+ exchanger 1 in dorsal root ganglion
            and spinal cord: its possible role in inflammatory nociception
  JOURNAL   Neuroscience 160 (1), 156-164 (2009)
   PUBMED   19248819
  REMARK    GeneRIF: these data suggest that NHE1, but not NHE5, plays an
            important role reducing inflammatory pain in rats.
REFERENCE   4  (bases 1 to 4174)
  AUTHORS   Yu,H., Freedman,B.I., Rich,S.S. and Bowden,D.W.
  TITLE     Human Na+/H+ exchanger genes : identification of polymorphisms by
            radiation hybrid mapping and analysis of linkage in end-stage renal
            disease
  JOURNAL   Hypertension 35 (1 Pt 1), 135-143 (2000)
   PUBMED   10642288
REFERENCE   5  (bases 1 to 4174)
  AUTHORS   Attaphitaya,S., Park,K. and Melvin,J.E.
  TITLE     Molecular cloning and functional expression of a rat Na+/H+
            exchanger (NHE5) highly expressed in brain
  JOURNAL   J Biol Chem 274 (7), 4383-4388 (1999)
   PUBMED   9933642
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF100172.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF100172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4174
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /note="solute carrier family 9 member A5"
                     /db_xref="GeneID:192215"
                     /db_xref="RGD:620473"
     exon            1..227
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2731
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /note="sodium/hydrogen exchanger 5; NHE-5; Na(+)/H(+)
                     exchanger 5; solute carrier family 9 (sodium/hydrogen
                     exchanger), member 5; solute carrier family 9, subfamily A
                     (NHE5, cation proton antiporter 5), member 5; solute
                     carrier family 9 member 5"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 5 precursor"
                     /protein_id="NP_620213.1"
                     /db_xref="GeneID:192215"
                     /db_xref="RGD:620473"
                     /translation="MLRVALLLLPGLPLAGVGATEEPTQEPGPLGEPPGLALFRWQWH
                     EVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLALGGIVLAVAKKAEY
                     QLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQ
                     QAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAV
                     TAVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKR
                     VRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTAVKYTM
                     KTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQTWVLNQFR
                     LAPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLT
                     IKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKK
                     YLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSAGLTLPSMPSRNSVA
                     ETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRH
                     FISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGHKKKDGVANPEA
                     TNGKPPRDLGFQDTAAVILTVESEEEEESESSETEKEDDEGIIFVARATSEVLQEGKV
                     SGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSIS
                     SLESLASPPCTQPPTLTRLPPHPLVPEEPQVPLDLSSDPRSSFAFPPSLAKAGRSRSE
                     SSADIPQQQELQPLMGHKDHTHLSPGPANSHWCIQFNRGGRL"
     exon            228..530
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..694
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..773
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..951
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1172
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1375
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1465
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1536
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1666
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1755
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1882
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2053
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2123
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2258
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..4149
                     /gene="Slc9a5"
                     /gene_synonym="Nhe5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcggcc gtgcagtgcc cggaggacag caagatgctg cgcgtcgcac tgcttcttct
       61 gcccgggttg cccctagctg gagtgggggc cacagaagaa cccacccagg agccggggcc
      121 gttaggtgag cctccaggct tggcgctctt ccgctggcag tggcacgagg tggaggcgcc
      181 ctacctggtg gccctgtgga tcctggtggc cagcttggcc aaaatcgtgt tccacctgtc
      241 tcggaaggtg acgtctctgg tccctgagag ctgcctgctg attttgctgg gcctggcgtt
      301 agggggcatt gtcttagctg tggccaagaa ggctgagtac cagctggagc cggggacctt
      361 cttccttttc ctgctccctc ccatcgtgct agactctggc tatttcatgc cgagccggct
      421 gttttttgac aacttgggtg ccattctcac ctatgccgtg gtgggcacgc tgtggaacgc
      481 cttcacaaca ggtgttgccc tttggggcct gcagcaggct ggacttgtgg ctcctagggt
      541 acaggctggc ctgctggact tcttgctctt tggaagcctc atctcagcgg tggaccctgt
      601 ggctgtgttg gctgtctttg aggaggtgca cgtcaatgag accctcttta tcatcgtctt
      661 cggcgagtcc ctgcttaatg atgcagtaac tgcggtgctg tacaaggtct gcaactcctt
      721 tgtggagatg ggctctgcca acgtgcaggc cactgactac ctaaagggag tcgcctccct
      781 gtttgtggtc agtctgggcg gggcagccgt gggcttagtc tttgccttcc tcctggccct
      841 gaccacacgc ttcaccaagc gggtccgcat catcgagccg ttgctggtct tcctcctcgc
      901 ctatgcagcc tacctcactg ccgaaatggc ctcattgtct gccattcttg cggtgaccat
      961 gtgtggcctg ggatgtaaga agtatgtgga ggccaacatc tcccataagt cacgcacagc
     1021 tgtgaaatac acaatgaaaa cgcttgccag ctccgcagaa acggtcatct tcatgctcct
     1081 tggcatctca gccgtggact cttccaaatg ggcctgggac tctgggctgg tgctgggcac
     1141 cctcttcttc atcctgttct tccgagccct cggcgtagtc ctgcagacgt gggtgctgaa
     1201 tcagttccgg ctggcccctc tggacaagat tgaccaggtg gtgatgtcct atgggggcct
     1261 tcggggggct gtggcctttg ctctcgtcat cctactggac aggaccaagg tccctgccaa
     1321 ggactacttt gtggccacca ctattgtggt ggtcttcttc acagtcatcg tgcagggttt
     1381 gaccatcaag ccactggtca agtggctgag ggtgaagagg agtgattacc acaaacccac
     1441 cttgaaccag gagctacacg agcacacttt tgaccacatt ctggctgcag tggaggacgt
     1501 tgtggggcac catggctacc actactggag ggacaggtgg gagcagtttg acaagaagta
     1561 cctgagccag ctcttgatgc ggcggtcagc ctatcgtatc cgagaccaga tctgggatgt
     1621 gtactacagg ctcaacatcc gagacgccat cagctttgtg gaccagggag gccacgtctt
     1681 gtcctccgcg ggactcactc taccctctat gcctagcaga aactctgtgg cagagacttc
     1741 tgtcaccaac ctgttgaggg agagcggcag tggagcgtgt ctggatctgc aggtgattga
     1801 cacagtacgc agtggccgag accgagagga tgctgtgatg catcatctgc tctgcggagg
     1861 cctctacaag ccacggcgca ggtacaaagc tagctgcagc cgccacttca tctcagagga
     1921 cgcccaggag cgacaggaca aggaggtctt ccagcagaac atgaagagac ggctcgagtc
     1981 ttttaagtcc accaaacata acatctgttt caccaagagc aaacctcgac cccgcaagac
     2041 cggccataag aagaaggatg gtgtggctaa tcccgaagct acaaatggga agcctcctcg
     2101 agacctgggc tttcaggaca cagctgctgt gatcctaact gtggagtctg aggaggagga
     2161 agaaagtgag agttcagaga cagagaaaga agatgatgaa gggatcatct tcgtggctcg
     2221 agccaccagt gaggttctcc aagaaggcaa agtctcagga agcctcgagg tgtgtccgag
     2281 cccacgcatc atccccccat ccccgacctg cgcggagaaa gagctaccct ggaagagtgg
     2341 gcagggagac ctggctgtgt atgtgtcttc agaaacaacc aagatcgtgc ctgtggacat
     2401 gcagacaggc tggaaccaga gcatctcatc cctggagagc ctggcatccc ctccctgtac
     2461 ccagcccccg actttaaccc gcttacctcc ccacccactc gtccctgaag agccccaggt
     2521 tcctcttgac ctgtcttctg accctcgctc tagctttgct ttccccccaa gcctggccaa
     2581 agctggccgt tctcgcagtg agagcagcgc cgacatcccg cagcagcagg agctgcaacc
     2641 cctcatgggc cacaaggacc acactcatct tagtccaggc cctgccaact cccactggtg
     2701 catccagttc aacagaggag gcaggctgta gcccagggcc tcggggagga gcaggatgtg
     2761 gagtccctat ggggagtgtt cctcaacatg ggcagaggtg cctacccagc ctggtatggg
     2821 actagggggg gctggactga agtggcagtg gcctccttgg gactggtcag aagggtttcc
     2881 tgggctggtc ctcatgggga cccttcttct ctccctaccc ttaaccactc ccacttttca
     2941 tttcaaaaaa cagctcagga tccagtccag agttctaggg gataggccca caacccaatg
     3001 tcccttccct agggcatctt cctggactta ctgttggcag ctgttcctcc ccacaaagca
     3061 tcattcttca gtggacactg gtcttccctg acctccaccc ccttgccagc ccaggtcagg
     3121 atcagtgcac aggcaatgaa gctttatgag gggtctggtc ctcagaggga ctgggctagg
     3181 atagagggca ggcctcaatc ttcggtcccc taacttgttg agtcagctac atgagagtgg
     3241 gagtgtcccc acatcttgct ttaacctttt ccctttgctt ccagttactg atgtaatggt
     3301 gactcttttt tttttcctag gacctaggca agctttagtt cagagcttct tcatagccag
     3361 tctaccgtac taggtctaag tctggaactt tctgaggctt ggatctgaga tttttagagt
     3421 aggaattttc ctcagaattt tcccaaaggg agaaggaacc aagtatccca gagtcactgc
     3481 accattacca tgggggctgg gatgtccggc tgcagtgttt ggggacagct gactagtagg
     3541 tggttttcct gaggttagcc cctgccttgt gctttgtacc ttaaacccag gatacattaa
     3601 acatctctca gatgggtgag tgttctctgt ccacttgtct caaggtttca gggttgggac
     3661 aggaagggat ctgcctattt catttcaaga tctttcaggg gttgagaata gtaagggata
     3721 tcttagacag aactgttagt tcctctggtc cctgtacttt tccagtattg tcccactagc
     3781 aggaggcatg gattggctgt ttaggggatt actggatggg ttggagaaga aggcatctca
     3841 gaactgggaa tccacaaatg ggaaaggtca gagtctaagc tatccaagga cgaagcttcc
     3901 acatgtagca ccacagagac atttctaggg aaatgtaagg acagctgcca gccaaatgaa
     3961 caagtgtcac tctgcgtatg acaggtagga attcaagctc cagggagcta gctaccctgg
     4021 gaacttataa gatgaaggag tatgggccct gaaatcctta gatggcagca ttctcccagt
     4081 ccaggtccta ctgtctgaag aattttttaa aagcgtcttt gagaataaaa tggcataaaa
     4141 tttacttgta aaaaaaaaaa aaaaaaaaaa aaaa
//
