LOCUS       NM_001414040            6399 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Rattus norvegicus solute carrier family 9 member A3 (Slc9a3),
            transcript variant 2, mRNA.
ACCESSION   NM_001414040 XM_008758677
VERSION     NM_001414040.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6399)
  AUTHORS   Sarker,R., Tse,C.M., Lin,R., McNamara,G., Singh,V. and Donowitz,M.
  TITLE     mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein,
            is an Alternative to BCECF-AM to Measure Intracellular pH to
            Determine NHE3 and DRA Activity
  JOURNAL   Cell Physiol Biochem 56 (1), 39-49 (2022)
   PUBMED   35076190
  REMARK    GeneRIF: mOrange2, a Genetically Encoded, pH Sensitive Fluorescent
            Protein, is an Alternative to BCECF-AM to Measure Intracellular pH
            to Determine NHE3 and DRA Activity.
REFERENCE   2  (bases 1 to 6399)
  AUTHORS   Wei,N., Gumz,M.L. and Layton,A.T.
  TITLE     Predicted effect of circadian clock modulation of NHE3 of a
            proximal tubule cell on sodium transport
  JOURNAL   Am J Physiol Renal Physiol 315 (3), F665-F676 (2018)
   PUBMED   29537313
  REMARK    GeneRIF: Computational model of the renal circadian clock
            predicting effect of circadian clock modulation of NHE3 on proximal
            tubule cell on sodium transport.
REFERENCE   3  (bases 1 to 6399)
  AUTHORS   Castelo-Branco,R.C., Leite-Dellova,D.C.A., Fernandes,F.B.,
            Malnic,G. and de Mello-Aires,M.
  TITLE     The effects of angiotensin-(1-7) on the exchanger NHE3 and on
            [Ca2+]i in the proximal tubules of spontaneously hypertensive rats
  JOURNAL   Am J Physiol Renal Physiol 313 (2), F450-F460 (2017)
   PUBMED   28490531
  REMARK    GeneRIF: In spontaneously hypertensive rats, a high plasma level of
            ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated
            the hypertension caused by the high plasma level of ANG II.
REFERENCE   4  (bases 1 to 6399)
  AUTHORS   Nishi,E.E., Martins,B.S., Milanez,M.I., Lopes,N.R., de Melo,J.F.
            Jr., Pontes,R.B., Girardi,A.C., Campos,R.R. and Bergamaschi,C.T.
  TITLE     Stimulation of renal afferent fibers leads to activation of
            catecholaminergic and non-catecholaminergic neurons in the medulla
            oblongata
  JOURNAL   Auton Neurosci 204, 48-56 (2017)
   PUBMED   28126464
  REMARK    GeneRIF: Results show that renal afferents leads to activation of
            catecholaminergic and non-catecholaminergic neurons in the medulla
            oblongata. When renorenal reflex is induced, NHE3 exchanger
            activity appears to be decreased, resulting in decreased sodium and
            water reabsorption in the contralateral kidney.
REFERENCE   5  (bases 1 to 6399)
  AUTHORS   Linz,B., Hohl,M., Reil,J.C., Bohm,M. and Linz,D.
  TITLE     Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced
            Cardiac End-organ Damage Without Deteriorating Renal Function in
            Obese Spontaneously Hypertensive Rats
  JOURNAL   J Cardiovasc Pharmacol 67 (3), 225-231 (2016)
   PUBMED   26727380
  REMARK    GeneRIF: Reduction of intestinal sodium absorption by selective
            NHE3 inhibition in the gut lowered high blood pressure and reduced
            LV remodeling without deteriorating renal functional and structural
            parameters in obese spontaneously hypertensive rats.
REFERENCE   6  (bases 1 to 6399)
  AUTHORS   Praetorius,J., Andreasen,D., Jensen,B.L., Ainsworth,M.A.,
            Friis,U.G. and Johansen,T.
  TITLE     NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH
            in murine duodenal epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (2), G197-G206 (2000)
   PUBMED   10666043
REFERENCE   7  (bases 1 to 6399)
  AUTHORS   Zhao,H., Wiederkehr,M.R., Fan,L., Collazo,R.L., Crowder,L.A. and
            Moe,O.W.
  TITLE     Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein
            kinase a and NHE-3 phosphoserines 552 and 605
  JOURNAL   J Biol Chem 274 (7), 3978-3987 (1999)
   PUBMED   9933588
REFERENCE   8  (bases 1 to 6399)
  AUTHORS   D'Souza,S., Garcia-Cabado,A., Yu,F., Teter,K., Lukacs,G.,
            Skorecki,K., Moore,H.P., Orlowski,J. and Grinstein,S.
  TITLE     The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3
            accumulates and is functional in recycling endosomes
  JOURNAL   J Biol Chem 273 (4), 2035-2043 (1998)
   PUBMED   9442041
REFERENCE   9  (bases 1 to 6399)
  AUTHORS   Kandasamy,R.A. and Orlowski,J.
  TITLE     Genomic organization and glucocorticoid transcriptional activation
            of the rat Na+/H+ exchanger Nhe3 gene
  JOURNAL   J Biol Chem 271 (18), 10551-10559 (1996)
   PUBMED   8631855
REFERENCE   10 (bases 1 to 6399)
  AUTHORS   Orlowski,J., Kandasamy,R.A. and Shull,G.E.
  TITLE     Molecular cloning of putative members of the Na/H exchanger gene
            family. cDNA cloning, deduced amino acid sequence, and mRNA tissue
            expression of the rat Na/H exchanger NHE-1 and two structurally
            related proteins
  JOURNAL   J Biol Chem 267 (13), 9331-9339 (1992)
   PUBMED   1577762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 15, 2022 this sequence version replaced XM_008758677.3.
            
            Transcript Variant: Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000001.1  30995703-30996002   c
            301-603             JAXUCZ010000001.1  30969082-30969384   c
            604-764             JAXUCZ010000001.1  30967744-30967904   c
            765-843             JAXUCZ010000001.1  30965361-30965439   c
            844-1021            JAXUCZ010000001.1  30964621-30964798   c
            1022-1242           JAXUCZ010000001.1  30963571-30963791   c
            1243-1445           JAXUCZ010000001.1  30963004-30963206   c
            1446-1535           JAXUCZ010000001.1  30962421-30962510   c
            1536-1606           JAXUCZ010000001.1  30962239-30962309   c
            1607-1736           JAXUCZ010000001.1  30961020-30961149   c
            1737-1852           JAXUCZ010000001.1  30959781-30959896   c
            1853-1982           JAXUCZ010000001.1  30959136-30959265   c
            1983-2159           JAXUCZ010000001.1  30958747-30958923   c
            2160-2232           JAXUCZ010000001.1  30958501-30958573   c
            2233-2340           JAXUCZ010000001.1  30957661-30957768   c
            2341-6399           JAXUCZ010000001.1  30953216-30957274   c
FEATURES             Location/Qualifiers
     source          1..6399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..6399
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /note="solute carrier family 9 member A3"
                     /db_xref="GeneID:24784"
                     /db_xref="RGD:3720"
     exon            1..300
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2594
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /note="sodium/hydrogen exchanger 3; plasma membrane ion
                     transport protein; NHE-3; Na(+)/H(+) exchanger 3; solute
                     carrier family 9, subfamily A (NHE3, cation proton
                     antiporter 3), member 3; Solute carrier family 9
                     (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+
                     (amiloride insensitive); solute carrier family 9
                     (sodium/hydrogen exchanger), member 3; solute carrier
                     family 9 member 3"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 3 precursor"
                     /protein_id="NP_001400969.1"
                     /db_xref="GeneID:24784"
                     /db_xref="RGD:3720"
                     /translation="MWHPALGPGWKPLLALALALTSLRGVRGIEEEPNSGGSFQIVTF
                     KWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHI
                     ASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLY
                     GVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLND
                     AVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFT
                     KHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRY
                     TMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNR
                     YRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQG
                     LTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFD
                     RKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVN
                     VDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYK
                     PRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRE
                     RAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKD
                     VASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRL
                     TPFRLSNKSVDSFLQADGPEEQLQPASPESTHM"
     exon            301..603
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            604..764
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..843
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1021
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1242
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1445
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1535
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1606
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1736
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1852
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1982
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2159
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2232
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2340
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..6399
                     /gene="Slc9a3"
                     /gene_synonym="Nhe3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgactgctg ccagctccgg gatagcgcag agggctgtga cgaagagcgc agcaggtacc
       61 acggtatgcg tgtcggctcc tggagctgag cagcagcgat gtggcacccg gctctgggac
      121 cagggtggaa gccgctgctg gcgctggcgc tggcgctgac cagcctgcga ggcgtgaggg
      181 gcattgagga ggaaccgaac agtggtggga gcttccagat agtcaccttc aaatggcacc
      241 acgtccagga tccatacatc atcgcactct ggatcctcgt ggccagcttg gccaaaatcg
      301 tcttccatct gtcccacaag gtcaccagtg ttgtcccgga gagtgctctg ctcatcgttc
      361 tgggcctggt gctgggcggc atcgtctggg cagctgacca catcgcctcc ttcacactca
      421 cacccacact cttcttcttc tacctgctgc cccctattgt gttggatgct gggtacttca
      481 tgcccaatcg actcttcttt ggcaacctgg gcaccatcct gctatatgct gtcattggca
      541 ctatatggaa cgcagctacc acaggattgt ccctctatgg tgtcttcctc agtggcctga
      601 tgggcgaact gaagatcggc ctcctggatt tcctgctatt tggcagcctc attgcagctg
      661 tggacccggt ggctgtgctg gctgtgtttg aggaagtcca tgtcaatgaa gtcctgttca
      721 tcattgtttt tggggagtca ctgcttaatg acgcggtgac tgtggtcttg tacaatgtgt
      781 ttgagtcttt cgtgacgctg ggtggtgatg cagtgactgg cgtggactgt gtgaaaggca
      841 tagtgtcctt cttcgtggtg agcctggggg gcactctggt gggtgtcatc ttcgccttcc
      901 tgctgtcctt ggtgactcgt ttcaccaagc atgtgcgtat catcgagcct ggcttcgtct
      961 ttgtcatttc ctacctgtcc tatctgacct ccgagatgct gtccttgtca gccatcctgg
     1021 ccatcacctt ttgtggcatc tgctgtcaga agtacgtgaa ggccaacatc tcagagcagt
     1081 cggccaccac cgtgcgctac actatgaaga tgctggcaag tggagcagag accattatct
     1141 tcatgttcct gggcatctcg gctgtggacc ccgtcatctg gacatggaac acagcttttg
     1201 tgttgctgac actggtcttc atttctgtat accgagccat tggtgttgtt ctgcagacct
     1261 ggatcctgaa tcgctaccgc atggtgcagc tagagaccat tgaccaggtg gtcatgtcct
     1321 acggtggcct gcgtggggca gtggcctatg ccttggtggt acttctggat gagaaaaaag
     1381 tcaaggagaa aaacctgttt gtcagcacca ctctcattgt ggtcttcttc acagtcatct
     1441 ttcagggcct gaccattaag cccctggtgc agtggctgaa ggtgaagagg agcgagcagc
     1501 gtgagccgaa gctcaacgag aagctgcatg gccgggcttt cgaccacatc ctctcagcca
     1561 ttgaggacat ctcaggacaa attggacaca attacctcag agataagtgg tccaattttg
     1621 ataggaagtt cctcagcaaa gtcctcatga gaagatctgc tcaaaaatct cgagatcgga
     1681 tcctgaatgt tttccatgag ctgaatttga aggatgccat tagctatgtg gccgagggag
     1741 agcgccgtgg gtccctggcc ttcattcgct ccccaagtac ggacaatatg gtcaatgtgg
     1801 acttcagcac accccgccca tctacagtgg aggcatccgt ctcctatttc ttgagggaaa
     1861 atgtcagtgc tgtatgcctg gacatgcagt ccttggaaca gaggcggagg agcatccgtg
     1921 acaccgagga catggtcacc caccacacgt tgcagcagta cctctacaag cctcggcagg
     1981 agtacaagca tctctacagt cggcacgagc tcacacccaa tgaggatgag aagcaggaca
     2041 aggagatctt ccacaggacc atgcggaagc gcctggagtc ctttaagtcg gctaagctgg
     2101 gcatcaacca gaacaagaag gcagccaagc tatataagag ggagcgcgca cagaagcgga
     2161 ggaatagcag cattcctaat gggaagctgc ctatggagaa tctggcacac aacttcacca
     2221 tcaaggagaa agatttggaa ctttcagagc ctgaggaggc caccaactat gaagagatca
     2281 gtggaggcat tgaatttctg gccagcgtca ccaaagatgt agcctctgac tctggggcag
     2341 gaattgataa tcctgtgttc tcccctgacg aggatctgga cccaagcatc ctatccaggg
     2401 tgccaccctg gctgtcccct ggggagactg tggtgccctc ccagagggcc cgtgtccaga
     2461 ttcccaactc tcccagcaac ttccgccgcc tgactccatt ccgcctcagc aacaaatcag
     2521 tggattcctt cctgcaggct gatggccccg aggaacagct ccaacccgct tcccctgagt
     2581 ccacacacat gtaactggtt ccttcctcca atgccttctt tcttcccagc tgttgccttc
     2641 aggcctctct acagtacctg caccttttca gactttgcag cagctgtctt cattctgtaa
     2701 accctgcctt ggccatctgt ccagctgtat atttcttggg aggacttcca tttgagtctg
     2761 cttctctagc taatgtgtag tatccagatg gatttaaggg cctggcatga cggtgtatgc
     2821 ctataaccgc agtatttaca gaagatagga agactaaggg tttgaggcta gcctgagcaa
     2881 cgtagaagta taccgtggtc aggtctcagg cccatttcag atgaaaatga aagtggtttt
     2941 ctatttagtg gacatttaca gagtccttta atcagtccag tgtgaaatga aatgaagcac
     3001 gctcctttat aattggagat tctcgctagc cctggtcatg cacgcacgca cgcacgcacg
     3061 cacgcaacac acacacgcaa tgcacgcacg cacgcacgca cgcacgcacg cacgcacgcg
     3121 ccactgattc tctcctagga gtccagttct gaaatgctgt agtaataaca ggaaacctgt
     3181 ttgttccagc gctcttccac ctgctctttg cttctgcctc tgggctcgcc tccacttcct
     3241 ctctttcgac agggtctcgc tgtgcagccc tggctgttct ggaactagct ctgaaaacta
     3301 ggctgtcttg gaactcagaa aaatgcctac ctttgcctcc tgagtactgg gattaaaggc
     3361 ctggcccttt gaaagagcct tgtgtacctt gaggcttgtg ataggttgca agggtagcgc
     3421 agtagtaccc aggagtgggt gtgcacccct tgtagaggga actgctatca atgacagggt
     3481 ttgaaagtgt cagaatagcg ggagtgatcc agatctgctg gctgctcagt gcacagctgc
     3541 caaggaaggt tcagagacac tggctggaac gccttgtaac tgcagtggtg catagcggaa
     3601 aattccccat tgtgtatgaa aggctagggg tccttctgag gtaccttttc tatggtcagg
     3661 cacctagttt ggggcaagcc acagaggaac agcaaactca gggggaaggg aatcttgggc
     3721 cgagtacaag tttctgtatg tcagtgttga tctggactgg gagtcattca cactctttct
     3781 tcccacaggt gatacaggct ctggcacacc acttactgga cgcttgtctc gtcagtcatc
     3841 tgctgctgcc cagcagccat tgctccctgc agggcttgcc cacccacgtg ccccaagccc
     3901 cgccccacct gagcgcactt cgactgtcac ttttgcctct ggtgttcctg ggacagagcc
     3961 agagcaccgg gccccaccca gtgcccacgc tcggtcggcg gctgcgcgcc gggtacacag
     4021 taggcgctca ttccaaaagc ctcgcccacg ccgacgccca gctctgctaa aactcgcttc
     4081 tcttccgggc tctacagaac tgccactgca cgctctggag caagaagaga cgccgctgtg
     4141 atcgctgcct ggccgatggc ccagctccga gggtctccct cagtggcccc tccccaacca
     4201 gctagtgttc ttagggtcca acgcacccta ggagttttaa tgcatagcct agccctagga
     4261 agaatctttt aatccatatg gtgtcctcag gataccacat tgccacctgc cgtcttcttg
     4321 ccctggttca gttcctaggg ctctgtggtg ctgcctcccc acccctaccc agaggcgagc
     4381 ccttgttagt gtttgccacc cttattctga gaggagaaag atccatgaga ggcctgtagc
     4441 ggacttaatc actgctggta caaacaaagg tctcaaaaat tgagatttgt agaagtggca
     4501 ccacccaaat caacctcatt ctaaataggc agcagttttt tgtgcgtccc cagaatatac
     4561 acccctgtgg ccctatctga ccccttccaa gttagttctc cagactgccc tatcacctta
     4621 tgatcaactg cagaaatatt tggctcttct agctcagact ttcctgtcca gccccttcca
     4681 gcctgggcct tgccgtcaaa aacaaggtgt ccggcctgaa ctatccctaa gttgggaaca
     4741 ctgcagatgg ccaggcaagc tgggctaggg gctagaagtg gcccactgga agccttcctt
     4801 ggtcaaaatt atagccagct ctggcatcta tcaaaggagg gctctacatc acccaggagt
     4861 agaggaatgc aggaatccag tctctgaaca ttttgtcctg tccctaggtc ttcagggcct
     4921 ccgccttaga acattggccc tctggagggg taagaggctg ggccctcagc ccttatcaac
     4981 ttcctcagaa gtccagtgtt caagagtcac ctgagttttg cttccaactc actagaaact
     5041 ttgcctgcac cacagggaga tcgagatggg gctaaaggtg gacttaatga cttcctggag
     5101 acttctgaaa caaagcactc aggtctctgc tcaggaaact aaatactgtg tctcaggaac
     5161 aaggttgaca gttaccttca gaggagtcac aggaaagtct gtcaatctgt attaatgctg
     5221 cagttgattt gtagacagga agagagctgg gaggagtgaa agcaaagcaa gttcgcccaa
     5281 catactgcat tctgcttcag agtgtcgccc ccccccccaa ctgagcctgc cagtatgctg
     5341 ttgactgtct agttcacact cagccatcag atgctcagca tctggtttcc acagcccttg
     5401 aagcatttgt ccctttccga attgaagtcc agccactgga caatgccagg gtcagtaatt
     5461 tcaccagact atttggagct gccatttggg gtacttccaa ggcaggctgt gcttggctac
     5521 tgtacccggg gtgttctgag aggcatctat cagcctctgc tctgcagaca agtttctcag
     5581 acctttctgt gccaggacac tgccttaaca cctcatccaa tctgctggac atggggtcca
     5641 attcccactg cagaattaga agccaagtgt gacgagacag tgcctcagca actgtcacct
     5701 tgcaccagat acccagagat accaaagcta gcagccgggg gtgatcaatc tgtggaaccc
     5761 tttgacactc tgtccatgtt ttagctgtgc acaggccatg tcctttgagt gtgtgaacta
     5821 caccactggg catagccata tggaatcagt cttgacaaga aagcctcatt cacaaaaccc
     5881 cacttcctgt acctaaatga tacatacagt ggctacattt catagttgag gaccctcttg
     5941 ttcttgtcat tgttgtacaa tagaatgtaa aatcctatga atgtatttcc ttaggaaaac
     6001 tattgtaaaa gttttttttt tattaggaga gaatttctat ttatttaata ctgaactttg
     6061 acctactttg tggtactaca aagtatacaa atttaggaaa tttgtatttc cgcttctgta
     6121 ttttcttgaa aataatttta ttacagtgtt caatatacta tgtattaata atctttttat
     6181 gaaaggaaat ttaaagaact tcatcaaaac cagaaatata ttttgagtgg ttaaaattgt
     6241 gtattaatgt tgtgaacata atcatagttg aactttaatt ctgatctcag aataatgtgc
     6301 cttaaaatgc ccccatgtgt tgggcagcat ctgtacaagg agtccattag caaagctgca
     6361 gtgactactt gtttatgcct attaaagaca cttcaaggc
//
