LOCUS       NM_012652               4578 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 9 member A1 (Slc9a1), mRNA.
ACCESSION   NM_012652
VERSION     NM_012652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4578)
  AUTHORS   Lombari,P., Mallardo,M., Petrazzuolo,O., Amruthraj Nagoth,J.,
            Fiume,G., Scanni,R., Iervolino,A., Damiano,S., Coppola,A.,
            Borriello,M., Ingrosso,D., Perna,A.F., Zacchia,M., Trepiccione,F.
            and Capasso,G.
  TITLE     miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies
            in medullary thick ascending limb of salt-induced hypertensive rats
  JOURNAL   Nephrol Dial Transplant 38 (3), 586-598 (2023)
   PUBMED   35921220
  REMARK    GeneRIF: miRNA-23a modulates sodium-hydrogen exchanger 1
            expression: studies in medullary thick ascending limb of
            salt-induced hypertensive rats.
REFERENCE   2  (bases 1 to 4578)
  AUTHORS   Liu,X., Qiu,Y., Huang,N., Liu,Y.H., Wang,H.H., Yu,Y.N., Song,Y.T.,
            Wan,G.R., Wang,S.X., Li,P. and Yin,Y.L.
  TITLE     Citronellal alleviates doxorubicin-induced cardiotoxicity by
            suppressing oxidative stress and apoptosis via Na+ /H+ exchanger-1
            inhibition
  JOURNAL   J Biochem Mol Toxicol 36 (3), e22971 (2022)
   PUBMED   34813134
  REMARK    GeneRIF: Citronellal alleviates doxorubicin-induced cardiotoxicity
            by suppressing oxidative stress and apoptosis via Na(+) /H(+)
            exchanger-1 inhibition.
REFERENCE   3  (bases 1 to 4578)
  AUTHORS   Martinez-Rojas,V.A., Salinas-Abarca,A.B., Gomez-Viquez,N.L.,
            Granados-Soto,V., Mercado,F. and Murbartian,J.
  TITLE     Interaction of NHE1 and TRPA1 Activity in DRG Neurons Isolated from
            Adult Rats and its Role in Inflammatory Nociception
  JOURNAL   Neuroscience 465, 154-165 (2021)
   PUBMED   33957206
  REMARK    GeneRIF: Interaction of NHE1 and TRPA1 Activity in DRG Neurons
            Isolated from Adult Rats and its Role in Inflammatory Nociception.
REFERENCE   4  (bases 1 to 4578)
  AUTHORS   Goerg,J., Sommerfeld,M., Greiner,B., Lauer,D., Seckin,Y.,
            Kulikov,A., Ivkin,D., Kintscher,U., Okovityi,S. and Kaschina,E.
  TITLE     Low-Dose Empagliflozin Improves Systolic Heart Function after
            Myocardial Infarction in Rats: Regulation of MMP9, NHE1, and
            SERCA2a
  JOURNAL   Int J Mol Sci 22 (11), 5437 (2021)
   PUBMED   34063987
  REMARK    GeneRIF: Low-Dose Empagliflozin Improves Systolic Heart Function
            after Myocardial Infarction in Rats: Regulation of MMP9, NHE1, and
            SERCA2a.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4578)
  AUTHORS   Fang,Z., Zhang,D., Yao,L., Wu,G., Zhang,Z., Deng,X., Han,J. and
            Yang,X.
  TITLE     Burn-Induced Apoptosis of Pulmonary Microvascular Endothelial Cell
            is NHE1 Dependent and Regulated by PI3K-Akt and p38 MAPK Pathways
  JOURNAL   Shock 54 (6), 819-827 (2020)
   PUBMED   32496418
  REMARK    GeneRIF: Burn-Induced Apoptosis of Pulmonary Microvascular
            Endothelial Cell is NHE1 Dependent and Regulated by PI3K-Akt and
            p38 MAPK Pathways.
REFERENCE   6  (bases 1 to 4578)
  AUTHORS   Praetorius,J., Andreasen,D., Jensen,B.L., Ainsworth,M.A.,
            Friis,U.G. and Johansen,T.
  TITLE     NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH
            in murine duodenal epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 278 (2), G197-G206 (2000)
   PUBMED   10666043
REFERENCE   7  (bases 1 to 4578)
  AUTHORS   Shrode,L.D., Gan,B.S., D'Souza,S.J., Orlowski,J. and Grinstein,S.
  TITLE     Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using
            chymotryptic cleavage
  JOURNAL   Am J Physiol 275 (2), C431-C439 (1998)
   PUBMED   9688597
REFERENCE   8  (bases 1 to 4578)
  AUTHORS   Rutherford,P.A., Pizzonia,J.H., Biemesderfer,D., Abu-Alfa,A.,
            Reilly,R. and Aronson,P.S.
  TITLE     Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney
            and blood cells of rabbit and rat
  JOURNAL   Exp Nephrol 5 (6), 490-497 (1997)
   PUBMED   9438178
REFERENCE   9  (bases 1 to 4578)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12631-12636 (1996)
   PUBMED   8901634
REFERENCE   10 (bases 1 to 4578)
  AUTHORS   Orlowski,J., Kandasamy,R.A. and Shull,G.E.
  TITLE     Molecular cloning of putative members of the Na/H exchanger gene
            family. cDNA cloning, deduced amino acid sequence, and mRNA tissue
            expression of the rat Na/H exchanger NHE-1 and two structurally
            related proteins
  JOURNAL   J Biol Chem 267 (13), 9331-9339 (1992)
   PUBMED   1577762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012652.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M85299.1, SRR26643299.24710.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1125              JAXUCZ010000005.1  150860285-150861409
            1126-1586           JAXUCZ010000005.1  150900986-150901446
            1587-1837           JAXUCZ010000005.1  150904775-150905025
            1838-2055           JAXUCZ010000005.1  150905813-150906030
            2056-2258           JAXUCZ010000005.1  150907738-150907940
            2259-2348           JAXUCZ010000005.1  150909242-150909331
            2349-2419           JAXUCZ010000005.1  150909729-150909799
            2420-2593           JAXUCZ010000005.1  150909884-150910057
            2594-2708           JAXUCZ010000005.1  150910284-150910398
            2709-2810           JAXUCZ010000005.1  150910569-150910670
            2811-2883           JAXUCZ010000005.1  150911291-150911363
            2884-4578           JAXUCZ010000005.1  150911829-150913523
FEATURES             Location/Qualifiers
     source          1..4578
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4578
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /note="solute carrier family 9 member A1"
                     /db_xref="GeneID:24782"
                     /db_xref="RGD:3718"
     exon            1..1125
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             762..3224
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /note="NHE-1; solute carrier family 9 member 1; Na(+)/H(+)
                     exchanger 1; solute carrier family 9 (sodium/hydrogen
                     exchanger), member 1; Solute carrier family 9
                     (sodium/hydrogen exchanger 1), antiporter, Na+/H+,
                     (amiloride sensitive); solute carrier family 9, subfamily
                     A (NHE1, cation proton antiporter 1), member 1"
                     /codon_start=1
                     /product="sodium/hydrogen exchanger 1"
                     /protein_id="NP_036784.1"
                     /db_xref="GeneID:24782"
                     /db_xref="RGD:3718"
                     /translation="MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTA
                     STIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLH
                     VRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFL
                     QSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLV
                     GGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVV
                     LYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIE
                     PLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSS
                     VSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTP
                     KDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVD
                     LLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCL
                     IAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERIL
                     PALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQ
                     KITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEE
                     LKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQR
                     CLSDPGPHPEPGEGEPFIPKGQ"
     exon            1126..1586
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1837
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2055
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2258
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2348
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2419
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2593
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2708
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2810
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2883
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..4578
                     /gene="Slc9a1"
                     /gene_synonym="Nhe1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgggactc ggggctctgt cagggctgga agtggagctg gagctgaccg aaggagctgc
       61 cgctgggccg gggtggaaca cagctctgca ccggggtctc aaggagggct gtgttgctgc
      121 tggctcactg cgagccgtct tcagcctgcg ccgaggcgcc ttcccgccag gccgtctgcc
      181 tctgtcttcc gcctccctcc atttccccgg aatctcagcc cggcgcggct ggaccctggc
      241 tctcctgtgg gtggggaagc cccagccttt tttctgcttt actcctttcc cccaggctgc
      301 ccttccagcc ttctctcgcc tttttctgcg gagtggggct cacccttttc ggtctttagc
      361 acaggctcct cacccctccc ctttagccga gttccagcac cctggtgatt ttccttagcc
      421 aaaggtcctc tccttccttc ctcctttccc ttgcctgtgg tccagcctat tctggccctt
      481 cctctttcct caggacgtag tttccccgat ttccttctct cagcctgaag ttgtagatct
      541 tttggttttc ctccttagtc cctccaaagg tacttatccc ctttttgcag tttggacttt
      601 cagattgtga atctctagaa aatgaaaata actctctaaa acatgaactt ttcctagaga
      661 ctgccccagt ctcatcccat ctgcagactc cttgctacct atgtcccagg tcttacacgc
      721 acttcactaa gggctgaggc ctcctaggct gggggatcag tatgatgcta aggtggtctg
      781 gcatctgggg actttatcca cctcggatct tcccctcctt gctggtggtg gttgccttgg
      841 tggggctgct acctgttctc aggagccacg gcctccagct caaccctact gccagcacca
      901 tcagaggttc tgaaccaccc cgggaacgct caattgggga tgtcaccaca gctccatcag
      961 agcctctcca ccacccagat gaccgcaatt tgaccaactt atacattgaa cacggcgcta
     1021 agccagttcg aaaggccttt ccagtcctgg acattgacta cttacatgta cgcacaccct
     1081 tcgagatctc cctctggatt ctcctggcct gcctcatgaa gataggtttc catgtgatcc
     1141 ccaccatctc gagcatcgtc ccggagagct gcctgctgat cgtagtgggg ctgctggtgg
     1201 ggggcctgat caagggcgtt ggagagacgc cccccttcct gcagtcggac gtcttcttcc
     1261 tcttcctgct gccacccatc atcctggacg caggctactt cctgcctctg aggcagttca
     1321 cggagaacct gggcaccatc ctgatctttg ctgtggtggg cacgctgtgg aatgctttct
     1381 tcctgggtgg cctcctgtac gccgtgtgcc tggtgggcgg cgagcagatc aataacatcg
     1441 gcctgctgga caccctgctg ttcggtagca tcatctccgc ggtggacccg gtggccgtgc
     1501 tggccgtctt cgaggagatc cacatcaatg agctgctgca catcctggtc tttggggagt
     1561 ccctgctcaa cgatgccgtc actgtggtcc tctaccacct ctttgaggag tttgccagct
     1621 atgagtatgt gggcatctcg gacatcttcc tcggcttcct gagcttcttt gtcgtgtccc
     1681 tcggcggggt gtttgtgggc gtggtctacg gggtcatcgc agccttcacc tcacgattta
     1741 cctcccacat ccgggtcatc gagccgctct tcgtcttcct ttacagctat atggcttacc
     1801 tgtcagccga gctcttccac ctgtctggaa tcatggccct catcgcctca ggagtggtga
     1861 tgcgccccta cgtggaggcc aacatctccc acaaatccca caccaccatc aagtacttcc
     1921 tgaagatgtg gagcagcgtc agcgagaccc tcatcttcat cttccttggc gtctccaccg
     1981 tggccggctc ccaccagtgg aactggacct ttgtcatcag caccctgctc ttctgcctca
     2041 tcgcccgggt gctgggggtc ctggtcctga cctggttcat caacaagttc cgaattgtca
     2101 agctgacccc caaggaccag ttcatcattg cctatggggg cctgcgaggg gccatcgcct
     2161 tctcactggg ctacctcctg gacaagaagc acttccccat gtgtgatctg ttcctcaccg
     2221 ccatcatcac cgtcatcttc ttcacagtct ttgtgcaggg catgaccatt cggcccctgg
     2281 tagacctgtt ggctgtgaag aaaaagcaag aaacaaagcg ctccatcaac gaggagatcc
     2341 acacacagtt cctggaccac cttctgacag gcatcgagga catctgtggt cattatggcc
     2401 accatcactg gaaggacaag ctcaaccgct ttaataagaa gtatgtgaag aagtgtctaa
     2461 tagctggaga gcgctccaag gagccccagc tcattgcctt ctaccacaag atggagatga
     2521 agcaggccat cgagctggtg gagagtgggg gcatgggcaa gatcccatct gccgtctcaa
     2581 ctgtctctat gcagaacatc caccccaagt ctgcagcttc agagcgcatc ttgccagcgc
     2641 tgtctaagga caaggaggag gagatccgca aaatcctgag gagtaacctg cagaaaaccc
     2701 ggcaacggct gcggtcctat aacagacaca cgctggtggc cgacccctac gaggaagcct
     2761 ggaaccagat gctgctccgg aggcagaagg cccggcaact ggagcagaag atcaccaact
     2821 acctgacggt accggcccac aagctggact cacccaccat gtctcgggcc cgcataggct
     2881 cagacccact ggcctatgaa cccaaggccg acctccctgt catcaccatc gacccagcct
     2941 ccccgcagtc ccccgagtct gtggacctgg tgaatgagga gttgaagggc aaagtccttg
     3001 ggctaaagcg gggtcctagg acgactccgg aagaggaaga ggaagatgag gatggcgtca
     3061 tcatgattcg gagcaaggag ccctcatccc caggcaccga tgatgtcttc acccccggac
     3121 caagtgacag ccccggctcc cagagaatac aacgctgcct cagtgacccg ggcccccacc
     3181 ctgagcctgg ggagggagag cctttcatcc ccaaagggca gtagagccag gctagtgggt
     3241 gtcccataga ctctcccacg agagtggggg ctgggcgctc cccttgtctc ctgacctggt
     3301 ttggctctgc cccctccctc cgcatggcag ctgggtccac acccccactg cagcacggct
     3361 tgctcctgcc tcctgggaag cctcctctcc taccagatct gccttcccaa tccatccatt
     3421 ggcagaacag ctggtgagac aggccctgcc ccatctctag atccaggctc tcccatagtg
     3481 gaaccagggc tcctcaggcc ctccctcccc tccagccccc tcctcatcca gaccaacttt
     3541 ccatctttga tcatcatttc taaccaaaga gccagtggct ccactgtggt cctaccggga
     3601 aaggagggag ctgaaccttc cttggcctta actgggccct cctgtatcag aggacaggac
     3661 agcaggcatg tggctgggaa acaagacggg tgacctatgg cagacccacg gttctcccac
     3721 tagcctcggt gctctggcca gccacctgag ctgtccttac tcggagctgc aggctgaggg
     3781 catctctgag cttctctgtt gggaactggg gcacattcaa cagtggagtg acttgggtga
     3841 tgaggaccac tgggcctttc tggggtttac acgggaggga ctgtccgagg ctccggaaag
     3901 tgtcgtcttc ttccatttgg tttatttgca cctccacgta agtatgattc tgtttgcaca
     3961 gaggtactcc agtctttaga ccctttgaat cttccctgcc agtcagagct ccaccctttc
     4021 cccctcgtcc tccctcctgc cgtctaacac cttcccttaa atggaacctc tgctgcccgg
     4081 gctctggcct gcagcactga ttcagacgtg gcccagcttg tcatgattca agctcagcag
     4141 caagggtcct ggtacctccc ttgctcttgg gcctgctttt acctctgttg tcctggtcca
     4201 gcaccacccc tcgtctagac cactctctta cctgcatcct gtagagtaga cagcagtgga
     4261 cccctagcgg cctttgctca caggcatgta ctcctaccgc catggctggg ccagcccgtg
     4321 ggtgtctgtc caacccctga gcactccctc cccaggatcg tgcaatagtc agaggggtcc
     4381 ctcccagggg atggggctat gggtgcttgg cccagctgtc tcctctccat gcaagtgctg
     4441 ttttaggcag gagttgccat gcaaggtgac atcgacaacc atgtacaaag ccaccgcagc
     4501 cgctgcctct ctgccgcctg tacagaggaa actgaacctt ttttcatatt ctaataaatc
     4561 aatgtgagtt tttgataa
//
