LOCUS       NM_001017488            2693 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 8 member B1 (Slc8b1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001017488 XM_573402
VERSION     NM_001017488.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2693)
  AUTHORS   Purroy,R., Britti,E., Delaspre,F., Tamarit,J. and Ros,J.
  TITLE     Mitochondrial pore opening and loss of Ca2+ exchanger NCLX levels
            occur after frataxin depletion
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (2), 618-631 (2018)
   PUBMED   29223733
  REMARK    GeneRIF: neurons display reduced levels of the mitochondrial
            calcium transporter NCLX that can be restored by calcium-chelating
            agents and by external addition of frataxin fused to TAT peptide
REFERENCE   2  (bases 1 to 2693)
  AUTHORS   Luongo,T.S., Lambert,J.P., Gross,P., Nwokedi,M., Lombardi,A.A.,
            Shanmughapriya,S., Carpenter,A.C., Kolmetzky,D., Gao,E., van
            Berlo,J.H., Tsai,E.J., Molkentin,J.D., Chen,X., Madesh,M.,
            Houser,S.R. and Elrod,J.W.
  TITLE     The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+
            homeostasis and viability
  JOURNAL   Nature 545 (7652), 93-97 (2017)
   PUBMED   28445457
REFERENCE   3  (bases 1 to 2693)
  AUTHORS   Ben-Kasus Nissim,T., Zhang,X., Elazar,A., Roy,S., Stolwijk,J.A.,
            Zhou,Y., Motiani,R.K., Gueguinou,M., Hempel,N., Hershfinkel,M.,
            Gill,D.L., Trebak,M. and Sekler,I.
  TITLE     Mitochondria control store-operated Ca2+ entry through Na+ and
            redox signals
  JOURNAL   EMBO J 36 (6), 797-815 (2017)
   PUBMED   28219928
REFERENCE   4  (bases 1 to 2693)
  AUTHORS   Kim,B., Takeuchi,A., Hikida,M. and Matsuoka,S.
  TITLE     Roles of the mitochondrial Na(+)-Ca(2+) exchanger, NCLX, in B
            lymphocyte chemotaxis
  JOURNAL   Sci Rep 6, 28378 (2016)
   PUBMED   27328625
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2693)
  AUTHORS   De Marchi,U., Santo-Domingo,J., Castelbou,C., Sekler,I.,
            Wiederkehr,A. and Demaurex,N.
  TITLE     NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion,
            thereby limiting Ca2+-induced NAD(P)H production and modulating
            matrix redox state
  JOURNAL   J Biol Chem 289 (29), 20377-20385 (2014)
   PUBMED   24898248
REFERENCE   6  (bases 1 to 2693)
  AUTHORS   Rizzuto,R., De Stefani,D., Raffaello,A. and Mammucari,C.
  TITLE     Mitochondria as sensors and regulators of calcium signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (9), 566-578 (2012)
   PUBMED   22850819
  REMARK    Review article
REFERENCE   7  (bases 1 to 2693)
  AUTHORS   Nita,I.I., Hershfinkel,M., Fishman,D., Ozeri,E., Rutter,G.A.,
            Sensi,S.L., Khananshvili,D., Lewis,E.C. and Sekler,I.
  TITLE     The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent
            Ca2+ signalling linked to insulin secretion
  JOURNAL   PLoS One 7 (10), e46649 (2012)
   PUBMED   23056385
REFERENCE   8  (bases 1 to 2693)
  AUTHORS   Palty,R., Silverman,W.F., Hershfinkel,M., Caporale,T., Sensi,S.L.,
            Parnis,J., Nolte,C., Fishman,D., Shoshan-Barmatz,V., Herrmann,S.,
            Khananshvili,D. and Sekler,I.
  TITLE     NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 436-441 (2010)
   PUBMED   20018762
REFERENCE   9  (bases 1 to 2693)
  AUTHORS   Palty,R., Ohana,E., Hershfinkel,M., Volokita,M., Elgazar,V.,
            Beharier,O., Silverman,W.F., Argaman,M. and Sekler,I.
  TITLE     Lithium-calcium exchange is mediated by a distinct
            potassium-independent sodium-calcium exchanger
  JOURNAL   J Biol Chem 279 (24), 25234-25240 (2004)
   PUBMED   15060069
REFERENCE   10 (bases 1 to 2693)
  AUTHORS   Cai,X. and Lytton,J.
  TITLE     Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+
            exchanger gene family, NCKX6
  JOURNAL   J Biol Chem 279 (7), 5867-5876 (2004)
   PUBMED   14625281
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079350.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573402.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2693
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /note="solute carrier family 8 member B1"
                     /db_xref="GeneID:498185"
                     /db_xref="RGD:1565818"
     exon            1..65
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            66..288
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1890
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /note="solute carrier family 24 member 6;
                     Na(+)/K(+)/Ca(2+)-exchange protein 6; mitochondrial
                     sodium/calcium exchanger protein; solute carrier family 24
                     (sodium/potassium/calcium exchanger), member 6;
                     sodium/calcium exchanger protein, mitochondrial;
                     sodium/potassium/calcium exchanger 6, mitochondrial;
                     solute carrier family 24 (sodium/lithium/calcium
                     exchanger), member 6; solute carrier family 8
                     (sodium/lithium/calcium exchanger), member B1"
                     /codon_start=1
                     /product="mitochondrial sodium/calcium exchanger protein
                     precursor"
                     /protein_id="NP_001017488.1"
                     /db_xref="GeneID:498185"
                     /db_xref="RGD:1565818"
                     /translation="MAGRWLDPLWAPGFLCVALILETASGAGDLSTKAHGHIQFSARG
                     VNQTAMADCRAVCSLNTSDRCDFVKRNPDCHSEGGYLDYLKGIFCYFPPNLLPLAITL
                     YVFWLLYLFLILGVTAAKFFCPNLSAISTSLKLSHNVAGVTFLAFGNGAPDIFSALVA
                     FSDPRTAGLAIGALFGAGVLVTTVVAGGITILRPFMAASRPFLRDITFYMVAVFLTFT
                     ALYLGRITLVWALGYLGLYVFYVVTVIICTWVYQRQRSRSLVHSISETPELLTDSEED
                     QMSSNTNSYDYGEEYRPLLLGEETTGQILLQALNPLDYRKWRTQSISCKLLKVAKLPV
                     EFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEIGGLLPVWA
                     VVVIVGTALASVTFFATSNSEPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVV
                     FRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCL
                     LQIVRSHASEVKLEPDGLLVWVLASALGLSLVFSLVSVPLQCFQLSKAYGLCLLLFYI
                     CFIVVVLLTEFGVIHLKAD"
     exon            289..441
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            442..494
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            495..552
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            553..658
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            659..826
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            827..934
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            935..994
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1125
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1267
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1389
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1543
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1624
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1692
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..2666
                     /gene="Slc8b1"
                     /gene_synonym="Slc24a6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtggcgc tggctgtcct agctagagga agactccagg ctctcgtacc caggccccac
       61 ccgaggcact ggagtggcca acccgcggaa actcaagtga gcagagggcg ctggtcaggc
      121 cccaaggggc ccatggcagg cagatggctg gatccgctct gggcgcctgg cttcctctgt
      181 gtggctctga tactggagac ggcatctggg gccggagatc tatccacaaa agcacatgga
      241 cacatccagt tttcagccag aggtgtcaac cagactgcca tggcagactg ccgagctgtg
      301 tgtagcctga acacatctga ccgctgtgac tttgtcaaga ggaatcccga ctgccacagc
      361 gaggggggct acctggacta cctcaagggc atcttctgct acttcccccc caacctcctc
      421 cctctggcca tcaccctcta tgttttctgg ctcctttacc tctttctgat cctcggagtc
      481 accgcagcca agttcttctg ccctaacttg tcagccatct ccaccagcct caagctctcc
      541 cacaacgtgg caggtgtcac cttcctggcc tttggaaatg gcgctccaga cattttcagt
      601 gctctcgtgg ctttctcaga ccctcgtact gctggcctgg ccattggggc tctgtttggt
      661 gcaggggtgc tggtcactac tgtggtggct ggtggcatca ccatcctgcg tcccttcatg
      721 gctgcctcca ggcccttcct cagggacatc actttctata tggtggccgt gttcctcacc
      781 ttcaccgcac tctatctcgg caggatcaca ctggtgtggg cactgggtta cctgggcctc
      841 tatgtcttct atgtggtcac ggtcatcatc tgcacttggg tctaccaaag gcagcggagc
      901 aggtctttgg tccactccat atcagagaca ccagagctac tgactgattc agaagaggat
      961 cagatgtctt ccaacaccaa cagctatgac tatggagagg agtaccggcc tctgctgctg
     1021 ggtgaggaga ccactgggca gatcctgctc caagccctga atcccttgga ctacaggaag
     1081 tggagaactc agtcgatatc ctgcaagctc ctgaaagtgg ccaagttgcc tgtggagttc
     1141 ttgttgctgc tcacggtacc cgttgtggac cccgacaagg atgatcggaa ctggaaacgg
     1201 ccactcaact gtctgcagct ggtcatcagc cccctggtcc tggtcctgac cctgcagtcg
     1261 ggggtctatg gcatctatga gatcggtggc ctccttcctg tgtgggctgt agtggtgatc
     1321 gtgggcacag ccctggcttc agtgaccttc tttgccacat ctaacagcga accccctaga
     1381 ctgcactggc tctttgcttt cctgggtttc ctgaccagcg ccctgtggat caatgcagct
     1441 gccacggagg tggtgaacat cttgcggtcc ctgggcgtgg tcttccgtct gagcaacacc
     1501 gtcctagggc tgaccctcct ggcctggggg aacagcattg gagatgcgtt ctcagatttc
     1561 acgctggccc gccagggata ccctcggatg gccttctctg cctgttttgg cggcatcatc
     1621 ttcaatatcc tggttggtgt gggactgggc tgcttgctac aaattgtccg gagccatgct
     1681 tccgaggtga agctggaacc agacggactg ctggtgtggg tgctggccag tgcgctgggc
     1741 ctcagcctgg tcttctccct ggtctcggtt ccgctccagt gtttccagct cagcaaggcc
     1801 tacggcctct gcctcctcct cttctatata tgtttcattg tggtggtcct cctcacggag
     1861 ttcggggtga ttcacttgaa ggctgactga agctgcttgg cctggaggtt taggggtgat
     1921 tctgctagcc tcctgaggag agaacaggag tggggtgggg gaaccccctg tagttcccat
     1981 gtagctcctg agaaggtagt ctcactgccg gagctctgca cggatgggaa ggtcctggct
     2041 gccggcaccc aacagcctta gcatggggat ctggaggctg gttttgctgg ggacaatccc
     2101 aagtgggaat gacagatctg aatgacagcg gagactctgg ggagggcagc ccgtcagccc
     2161 ccatccctgc tgggctctag gcagccctgt ggcttcctgg taggctcttc cactctctgt
     2221 ggtgtcagct gagtcccacg ccagcagtgt tggctgaaca gactccgcca gactgggtct
     2281 ctcagcctct gtgtcaggtc agccagagga aataggtcaa gttgacagca gcagcaggca
     2341 gtaagtactg agtggggtgc ctcagaagca cccaggctct gcccttccca gttggtagct
     2401 gctgcattgg actgtgggac taaatccttc tagaacattg tgttccaaac tctggctccc
     2461 cgcatctaca agacaggagc cagcttgggc cctgtgtcta cctcaagggg agctggggag
     2521 tgggatgacc ctcccagggg tgtcttgcaa ggggtgtgac cagcctttta aaaataccac
     2581 tcattccctg accgccttca gctgtaacta ggagacttga cttgttgttg ttgttcaaaa
     2641 ataaaagact cgttaattca agtgtaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
