LOCUS       NM_078620               4749 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 8 member A3 (Slc8a3), mRNA.
ACCESSION   NM_078620 XM_346774
VERSION     NM_078620.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4749)
  AUTHORS   Chen,M., Wang,X., Hu,B., Zhou,J., Wang,X., Wei,W. and Zhou,H.
  TITLE     Protective effects of echinacoside against anoxia/reperfusion
            injury in H9c2 cells via up-regulating p-AKT and SLC8A3
  JOURNAL   Biomed Pharmacother 104, 52-59 (2018)
   PUBMED   29763795
  REMARK    GeneRIF: This cardioprotective effect was potentially achieved via
            up-regulating p-AKT and SLC8A3.
REFERENCE   2  (bases 1 to 4749)
  AUTHORS   Moriguchi,S., Kita,S., Fukaya,M., Osanai,M., Inagaki,R., Sasaki,Y.,
            Izumi,H., Horie,K., Takeda,J., Saito,T., Sakagami,H., Saido,T.C.,
            Iwamoto,T. and Fukunaga,K.
  TITLE     Reduced expression of Na+/Ca2+ exchangers is associated with
            cognitive deficits seen in Alzheimer's disease model mice
  JOURNAL   Neuropharmacology 131, 291-303 (2018)
   PUBMED   29274751
REFERENCE   3  (bases 1 to 4749)
  AUTHORS   Giladi,M., Lee,S.Y., Ariely,Y., Teldan,Y., Granit,R.,
            Strulovich,R., Haitin,Y., Chung,K.Y. and Khananshvili,D.
  TITLE     Structure-based dynamic arrays in regulatory domains of
            sodium-calcium exchanger (NCX) isoforms
  JOURNAL   Sci Rep 7 (1), 993 (2017)
   PUBMED   28428550
  REMARK    GeneRIF: Data show a general mechanism for regulatory coupling
            associated with Ca2+ interactions with regulatory CBD domains of
            NCX1, NCX2, and NCX3 isoforms and their splice variants, where the
            dynamic effects of alternative splicing on conformational dynamics
            of the two-domain regulatory tandem (CBD12) control the
            contribution of a given isoform/splice variant to dynamic handling
            of cytosolic Ca2+ oscillations in many cell type.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4749)
  AUTHORS   Tal,I., Kozlovsky,T., Brisker,D., Giladi,M. and Khananshvili,D.
  TITLE     Kinetic and equilibrium properties of regulatory Ca(2+)-binding
            domains in sodium-calcium exchangers 2 and 3
  JOURNAL   Cell Calcium 59 (4), 181-188 (2016)
   PUBMED   26924806
  REMARK    GeneRIF: analyze the equilibrium and kinetic properties of Ca(2+)
            binding to purified preparations of CBD1, CBD2, and CBD12 from NCX2
            and from NCX3 splice variants
REFERENCE   5  (bases 1 to 4749)
  AUTHORS   Sun,D., Xiao,J.H., Bai,Y., Chen,M.S., Hu,J.S., Wu,G.F., Mao,B.,
            Wu,S.H. and Hu,Y.
  TITLE     Na (+) /Ca (2+) Exchanger 3 is Downregulated in the Hippocampus and
            Cerebrocortex of Rats with Hyperthermia-induced Convulsion
  JOURNAL   Chin Med J (Engl) 128 (22), 3083-3087 (2015)
   PUBMED   26608990
  REMARK    GeneRIF: There is a significant reduction in NCX3 expression in
            rats with febrile convulsions.
REFERENCE   6  (bases 1 to 4749)
  AUTHORS   Lu,J., Tong,X.Y. and Wang,X.L.
  TITLE     Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2
            and NCX3 in chronic ischemic rat brain
  JOURNAL   Neurosci Lett 332 (1), 21-24 (2002)
   PUBMED   12377375
  REMARK    GeneRIF: Brain ischemia regulates gene expression levels of
            Na+/Ca2+ exchanger isoform NCX3, especially in cerebral cortex.
REFERENCE   7  (bases 1 to 4749)
  AUTHORS   Fraysse,B., Rouaud,T., Millour,M., Fontaine-Perus,J.,
            Gardahaut,M.F. and Levitsky,D.O.
  TITLE     Expression of the Na(+)/Ca(2+) exchanger in skeletal muscle
  JOURNAL   Am J Physiol Cell Physiol 280 (1), C146-C154 (2001)
   PUBMED   11121386
REFERENCE   8  (bases 1 to 4749)
  AUTHORS   Sakaue,M., Nakamura,H., Kaneko,I., Kawasaki,Y., Arakawa,N.,
            Hashimoto,H., Koyama,Y., Baba,A. and Matsuda,T.
  TITLE     Na(+)-Ca(2+) exchanger isoforms in rat neuronal preparations:
            different changes in their expression during postnatal development
  JOURNAL   Brain Res 881 (2), 212-216 (2000)
   PUBMED   11036162
REFERENCE   9  (bases 1 to 4749)
  AUTHORS   Linck,B., Qiu,Z., He,Z., Tong,Q., Hilgemann,D.W. and Philipson,K.D.
  TITLE     Functional comparison of the three isoforms of the Na+/Ca2+
            exchanger (NCX1, NCX2, NCX3)
  JOURNAL   Am J Physiol 274 (2), C415-C423 (1998)
   PUBMED   9486131
REFERENCE   10 (bases 1 to 4749)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 11, 2015 this sequence version replaced NM_078620.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000006.1  106738189-106738505 c
            318-2162            JAXUCZ010000006.1  106719568-106721412 c
            2163-2266           JAXUCZ010000006.1  106621630-106621733 c
            2267-2284           JAXUCZ010000006.1  106617222-106617239 c
            2285-2409           JAXUCZ010000006.1  106612592-106612716 c
            2410-2509           JAXUCZ010000006.1  106611827-106611926 c
            2510-2785           JAXUCZ010000006.1  106609979-106610254 c
            2786-4749           JAXUCZ010000006.1  106605621-106607584 c
FEATURES             Location/Qualifiers
     source          1..4749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4749
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="solute carrier family 8 member A3"
                     /db_xref="GeneID:140448"
                     /db_xref="RGD:620197"
     exon            1..317
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..2162
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..3162
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /note="sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange
                     protein 3; solute carrier family 8 (sodium/calcium
                     exchanger), member 3"
                     /codon_start=1
                     /product="sodium/calcium exchanger 3 precursor"
                     /protein_id="NP_511175.1"
                     /db_xref="GeneID:140448"
                     /db_xref="RGD:620197"
                     /translation="MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGDLRDVPSAGQN
                     NESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASI
                     EVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
                     IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSVFAYIWLY
                     MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKRYRTDKHRGIIIE
                     TEGEHPKGIEMDGKMMNSHFLDGNLIPLEGKEVDESRREMIRILKDLKQKHPEKDLDQ
                     LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTASMSEVHTDEPE
                     DFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTE
                     GTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLEEGMTPAILNSLPL
                     PRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF
                     RTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWM
                     ERGISALLLSPEVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDK
                     LIKKTNLALVVGTHSWRDQFMEAITVSAAGDEEEDESGEERLPSCFDYVMHFLTVFWK
                     VLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFG
                     TSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHV
                     SAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYVL
                     FATLEAYCYIKGF"
     exon            2163..2266
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2284
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2409
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2509
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2785
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..4749
                     /gene="Slc8a3"
                     /gene_synonym="Ncx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggccttg cctgggccac tcaggcagtc cctgcttctt ggctgggtgc cgagggtccg
       61 tacaacccgc cctgctccct ggccccagcg atcgagctcc agatgcgctg cctggtagcc
      121 ccctgacagc tgctagccca cgagctccgg ccggcagccg cggcggactg tcatgccctg
      181 gacgccgctg cagccggccc gcagcccgcg ggggcgatga gccgctgcgg ccggtgagga
      241 gccgggcggc gcgggcatcg tgcaccttcc tagcccgcct tacttgccca ttgagctctg
      301 gaagctaagg ggaatcggtc tcaggcctgt cgggaagacc attggtgctg tggtggggcc
      361 agagcctaag tcttgtgtat ggcgtggtta cggctgcagc ctctcacctc tgccttcctc
      421 catttcgggc tggttacttt tgtgctcttc ctgaatggtc ttcgagcaga ggctggtgac
      481 ttgagggatg tgcccagtgc aggacagaac aatgagtcct gttcagggtc atcagactgc
      541 aaggagggtg tcatcttgcc aatctggtat ccagagaacc cttcccttgg ggacaagatt
      601 gcaagggtca ttgtctattt tgtggccctg atatacatgt ttcttggagt gtctatcatt
      661 gctgaccgat tcatggcatc tattgaagtt attacctccc aagagaggga ggtgacaatc
      721 aagaagccca atggagagac cagcacaact acaattcggg tatggaatga aactgtctcc
      781 aacctgaccc tgatggccct aggctcttct gctccggaga ttctcctgtc tttaattgag
      841 gtgtgtggtc acgggttcat tgctggtgat ttgggaccgt ctaccattgt cggcagtgca
      901 gccttcaaca tgttcatcat cattggcatc tgtgtctatg tgatcccaga tggggagact
      961 cgcaagatca agcaccttcg agtcttcttt gtcacggctg cttggagcgt ctttgcctat
     1021 atttggctct acatgatcct ggcagtcttc tctcctggtg tggtccaggt ttgggaaggc
     1081 ctccttactc tcttcttctt tccagtgtgt gtcctgctgg cttgggtggc agataagcga
     1141 ctgctcttct acaaatacat gcacaaaaga taccgcacag ataaacaccg aggaattatc
     1201 attgagacag agggtgaaca ccctaagggc attgagatgg atgggaaaat gatgaattct
     1261 cacttcctgg atgggaacct tatacccttg gaaggaaagg aggtagatga atctcgcagg
     1321 gaaatgatcc gaattcttaa ggatctgaag caaaaacacc cagaaaaaga cttagatcag
     1381 ctggtggaga tggccaatta ctatgctctt tcccaccaac agaagagccg tgctttctac
     1441 cgcatccaag ccacccggat gatgactggt gcaggcaata tacttaagaa acatgcagca
     1501 gagcaagcca agaagaccgc cagcatgagt gaggtgcata ctgatgagcc tgaggacttt
     1561 gcctcgaagg tcttttttga cccatgctct taccagtgcc tggagaactg tggagctgtc
     1621 ctcctgactg tggtgaggaa agggggagat atatccaaga ctatgtacgt ggactacaaa
     1681 acagaggacg gctctgccaa tgcaggggct gactatgagt tcacagaagg cactgtggtt
     1741 ctgaagccag gagagaccca gaaggagttc tccgtgggca tcatcgatga tgacattttt
     1801 gaagaggatg aacacttctt cgtgagactg agcaatgtcc gtgtagaaga ggagcagctg
     1861 gaagagggga tgacccccgc catcctcaat agtcttcctt tgccacgggc tgtcctggct
     1921 tccccttgtg tggccacagt aaccatcttg gatgatgacc atgcaggaat tttcactttt
     1981 gaatgtgata ccattcatgt cagtgaaagt attggtgtta tggaagtcaa ggttttgagg
     2041 acatcgggtg cccggggcac agtcatcgtc ccttttagga cagtagaagg aacagccaag
     2101 ggtggtggtg aggactttga agatacttat ggggagctgg agtttaagaa tgatgaaacg
     2161 gtgaaaacca taagggttaa aatagtagat gaggaggagt acgaaaggca agagaatttc
     2221 ttcattgccc ttggtgaacc gaaatggatg gaacgtggaa tatcagcgct cctgttatct
     2281 ccagaggtga cagacaggaa gctgactatg gaggaagagg aggccaagag aatagcagag
     2341 atgggaaagc cagtattggg tgaacaccct aaactagagg tcatcattga agagtcctat
     2401 gagttcaaga gtacagtgga taaactgatc aagaagacaa acctggcatt ggttgtgggg
     2461 acccattcct ggagggacca attcatggaa gccatcactg ttagtgcagc aggagatgag
     2521 gaggaagatg aatctggaga ggagaggctg ccatcatgct ttgactatgt catgcacttc
     2581 ctgacggtct tttggaaggt gctctttgcc tgtgtgcccc ccacagagta ctgccatggc
     2641 tgggcctgct tcgtggtctc catcctcatc atcggcatgc tcaccgccat catcggggac
     2701 ctggcctctc acttcggctg caccatcggg ctcaaggatt cggtcacagc tgttgttttt
     2761 gtggcattcg gcacctctgt gccagataca tttgccagca aagctgctgc cctgcaggat
     2821 gtgtatgcag atgcttctat tggcaatgtc accggcagta atgctgtcaa tgtcttcctg
     2881 ggtattggtt tggcctggtc cgtcgccgcc atctactggg ccatgcaggg acaggagttc
     2941 catgtgtccg ctggtactct ggccttctcg gtcactcttt tcaccatctt tgcatttgtc
     3001 tgcctcagtg tgctcttgta ccgtcggcgg ccccacctgg gcggggagct tggaggtcct
     3061 cgtggctgca agcttgccac aacgtggctc tttgtgagcc tgtggctcct ctacgtactc
     3121 tttgccacgc tggaggccta ctgctacatc aaggggttct gaaccaccag aacaagacct
     3181 ccacagggca ggcctaggac ttctcttgag agaaaggcgc tttctcacca accttcccag
     3241 gttgagcatc cctggagaag aagcatcgag acctgagccc caggaacttc acctgaccta
     3301 ggccctggca ctgcacagaa aggggcaaaa cttaaccaat ccaatggaat ggagacgata
     3361 cccactgtcc aaagtatcta attacaaaca aaccaacaac agcaacaaat ccacctctcc
     3421 ccatcctgcc actcacaccc ctgagcctcc ccttctattc taccactcga ctattccttt
     3481 gactctagtt cctcaagggg caagatctcc cctgcctcca gcaaaatgca tcaagacttc
     3541 ctcattcagc tgtcacggtg tgagaatgag ccgtctcggc aatggctgct ttggggtgct
     3601 ctttggggtg ctcttttcat ctggtcatca ttgtggtcat tttcattctc ctaccaggtt
     3661 ccacttattg tcttgtcttc ttttcctgaa gttagtgaca aaggaccctg aaggaatccc
     3721 aagtctgagt gacagatacc ctcctgctct catcaggctg ctgctgtccc ttggatccaa
     3781 ctcagggcat aggaggacct tcattctgcg tgcattgaca tcaaatccaa accacagagg
     3841 agtcaccctc ttcttggtgg aagccattct acgtctctgt tgtgtgtcag cacctgtgtg
     3901 tgcaccctcc acagaaagac ttcagagcag aaataacagc attctgggct gaccaagggc
     3961 agcaggggaa acacagggaa cacctctcca atgtttgtgt ctgaggtggg ggagaagaag
     4021 gtattctact gaggatgtct ctaagggagt gggccatatt taaagagtca gtgtttgggg
     4081 gaatggcagt gtcaccaccc ctcccaggct gatgtgccat actcagaggg ccaaggaggt
     4141 ggctttaaat gatgttagaa tttggaggct tgtaagataa caggggcttt cttccccctc
     4201 tcctgacctt caggctgctt ttgaaagcat gttcataaga taggaactgg aatccttcat
     4261 cttccccaac accccccttg ttcctgcctg tttttaaact tcataaagct ctctgttccc
     4321 agactgtggg gtatttctta taccctgccc ccaagggatc caagtcacca cattgccaag
     4381 gggccaagcc ttctagacag taaggactga cacgctgaca ccccacctcc cagacccttt
     4441 cccaatgtgt tttgaaacct ggctttaaaa catacacaga cacacacaca cacacacaca
     4501 cacacacaca cacacacaca cacacacaca ctacagaact gcccacgggt cttgaggctt
     4561 tctgcattga cataaataca ttttctaaga gaggaaaaca aaataaaaac acctgtttaa
     4621 ttttaaacag ttttttttaa agaaaataaa aaataaaaca gtgctcgtgt cctaagctat
     4681 gttgacagtt gccggtggaa atgttgggtt ggttcaaaaa ataaaaataa aaggtctacc
     4741 tatatgtct
//
