LOCUS       NM_078619               3002 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 8 member A2 (Slc8a2), mRNA.
ACCESSION   NM_078619
VERSION     NM_078619.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Ballarini,E., Malacrida,A., Rodriguez-Menendez,V., Pozzi,E.,
            Canta,A., Chiorazzi,A., Monza,L., Semperboni,S., Meregalli,C.,
            Carozzi,V.A., Hashemi,M., Nicolini,G., Scuteri,A., Housley,S.N.,
            Cavaletti,G. and Alberti,P.
  TITLE     Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced
            Peripheral Neurotoxicity and Axonal Damage?
  JOURNAL   Int J Mol Sci 23 (17), 10063 (2022)
   PUBMED   36077454
  REMARK    GeneRIF: Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin
            Induced Peripheral Neurotoxicity and Axonal Damage?
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Calabrese,L., Serani,A., Natale,S., Tedeschi,V., Guida,N.,
            Valsecchi,V., Secondo,A., Formisano,L., Annunziato,L. and
            Molinaro,P.
  TITLE     Identification and characterization of the promoter and
            transcription factors regulating the expression of cerebral
            sodium/calcium exchanger 2 (NCX2) gene
  JOURNAL   Cell Calcium 102, 102542 (2022)
   PUBMED   35114589
  REMARK    GeneRIF: Identification and characterization of the promoter and
            transcription factors regulating the expression of cerebral
            sodium/calcium exchanger 2 (NCX2) gene.
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Moriguchi,S., Kita,S., Fukaya,M., Osanai,M., Inagaki,R., Sasaki,Y.,
            Izumi,H., Horie,K., Takeda,J., Saito,T., Sakagami,H., Saido,T.C.,
            Iwamoto,T. and Fukunaga,K.
  TITLE     Reduced expression of Na+/Ca2+ exchangers is associated with
            cognitive deficits seen in Alzheimer's disease model mice
  JOURNAL   Neuropharmacology 131, 291-303 (2018)
   PUBMED   29274751
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Giladi,M., Lee,S.Y., Ariely,Y., Teldan,Y., Granit,R.,
            Strulovich,R., Haitin,Y., Chung,K.Y. and Khananshvili,D.
  TITLE     Structure-based dynamic arrays in regulatory domains of
            sodium-calcium exchanger (NCX) isoforms
  JOURNAL   Sci Rep 7 (1), 993 (2017)
   PUBMED   28428550
  REMARK    GeneRIF: Data show a general mechanism for regulatory coupling
            associated with Ca2+ interactions with regulatory CBD domains of
            NCX1, NCX2, and NCX3 isoforms and their splice variants, where the
            dynamic effects of alternative splicing on conformational dynamics
            of the two-domain regulatory tandem (CBD12) control the
            contribution of a given isoform/splice variant to dynamic handling
            of cytosolic Ca2+ oscillations in many cell type.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Poletaeva,I.I., Perepelkina,O.V., Boyarshinova,O.S.,
            Golibrodo,V.A., Lilp,I.G., Lipp,H.P. and Shin,H.S.
  TITLE     The ability to solve elementary logic tasks in mice with the
            knockout of sodium-calcium exchanger gene 2 (NCX2)
  JOURNAL   Dokl Biol Sci 469 (1), 159-162 (2016)
   PUBMED   27595821
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Polumuri,S.K., Ruknudin,A., McCarthy,M.M., Perrot-Sinal,T.S. and
            Schulze,D.H.
  TITLE     Sodium-calcium exchanger NCX1, NCX2, and NCX3 transcripts in
            developing rat brain
  JOURNAL   Ann N Y Acad Sci 976, 60-63 (2002)
   PUBMED   12502534
  REMARK    GeneRIF: gene expression regulation in developing rat brain
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Lu,J., Tong,X.Y. and Wang,X.L.
  TITLE     Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2
            and NCX3 in chronic ischemic rat brain
  JOURNAL   Neurosci Lett 332 (1), 21-24 (2002)
   PUBMED   12377375
  REMARK    GeneRIF: Brain ischemia regulates gene expression levels of
            Na+/Ca2+ exchanger isoform NCX2, especially in cerebral cortex.
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Linck,B., Qiu,Z., He,Z., Tong,Q., Hilgemann,D.W. and Philipson,K.D.
  TITLE     Functional comparison of the three isoforms of the Na+/Ca2+
            exchanger (NCX1, NCX2, NCX3)
  JOURNAL   Am J Physiol 274 (2), C415-C423 (1998)
   PUBMED   9486131
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Li,Z., Matsuoka,S., Hryshko,L.V., Nicoll,D.A., Bersohn,M.M.,
            Burke,E.P., Lifton,R.P. and Philipson,K.D.
  TITLE     Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+
            exchanger
  JOURNAL   J Biol Chem 269 (26), 17434-17439 (1994)
   PUBMED   8021246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_078619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08141.1, SRR26643298.1543.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               JAXUCZ010000001.1  85950762-85951436
            676-1340            JAXUCZ010000001.1  85956393-85957057
            1341-1763           JAXUCZ010000001.1  85961016-85961438
            1764-1867           JAXUCZ010000001.1  85966108-85966211
            1868-1885           JAXUCZ010000001.1  85966341-85966358
            1886-2010           JAXUCZ010000001.1  85968180-85968304
            2011-2110           JAXUCZ010000001.1  85968591-85968690
            2111-2389           JAXUCZ010000001.1  85973040-85973318
            2390-3002           JAXUCZ010000001.1  85974638-85975250
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3002
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="solute carrier family 8 member A2"
                     /db_xref="GeneID:140447"
                     /db_xref="RGD:620194"
     CDS             1..2766
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /note="sodium/calcium exchanger 2; Na(+)/Ca(2+)-exchange
                     protein 2; solute carrier family 8 (sodium/calcium
                     exchanger), member 2; solute carrier family 8 member 2"
                     /codon_start=1
                     /product="sodium/calcium exchanger 2 precursor"
                     /protein_id="NP_511174.2"
                     /db_xref="GeneID:140447"
                     /db_xref="RGD:620194"
                     /translation="MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQ
                     GSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMASIEVITS
                     KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGEL
                     GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAV
                     FSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDP
                     PKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQL
                     VGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGANDGAPDDEDDG
                     ASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGT
                     LVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVA
                     PLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTA
                     RGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISAL
                     LLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNL
                     ALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDYVMHFLTVFWKVLFACV
                     PPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDT
                     FASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLA
                     FSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEA
                     YCHIRGF"
     exon            1..675
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1340
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1763
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1867
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1885
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2010
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2110
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2389
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..3002
                     /gene="Slc8a2"
                     /gene_synonym="Ncx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctccct tggctttggt gggggttgcc ctccttctgg gggcacccca ctgcttgggg
       61 gaagctactc cgaccccatc cctgccacct cccccagcta atgacagcga tgccagccca
      121 ggcggctgcc aaggttccta ccgctgccaa ccaggggtgc tgctgcctgt gtgggaaccc
      181 gacgacccat cactggggga caaggctgca cgggccgtgg tgtactttgt ggccatggtc
      241 tacatgttct tgggtgtgtc tatcattgct gatcgtttta tggcatccat tgaggtcatc
      301 acatccaagg agaaagagat caccatcacc aaggcaaatg gggagaccag cgtgggcact
      361 gtacgcatct ggaatgaaac ggtgtccaac cttacactca tggccctggg ctcctcagca
      421 cctgagattc tgctgtctgt catcgaggtc tgtggccaca acttccaggc gggtgagcta
      481 ggcccaggca ccatcgtggg cagtgccgcc ttcaacatgt ttgtggtcat tgctgtgtgt
      541 gtgtatgtca tcccggctgg tgagagccgt aagatcaagc acttaagggt cttcttcgtc
      601 acagcctctt ggagcatctt tgcctatgtc tggctttatc tcattctagc agttttctct
      661 ccaggcgtgg tccaggtgtg ggaggcactg ctcacgctgg tcttcttccc ggtgtgtgtg
      721 gtgttcgcct ggatggcgga caagcgactg ctcttctaca agtacgtgta caagcgctat
      781 cgcaccgacc ctcgcagcgg aatcatcatc ggggcagagg gagacccgcc caagagcatc
      841 gagctggatg gcacattcgt gggcactgag gtcccaggcg agctgggtgc attgggcaca
      901 ggtcccgctg aggcgcgtga gctggacgcc agccggcgcg aggtcatcca gattcttaag
      961 gacttaaagc agaagcaccc ggataaggac ctggagcagc tggtgggcat cgccaagtac
     1021 tatgcactgc tgcaccagca gaagagccgt gccttctacc gcatccaggc cacgcggctg
     1081 atgacaggtg cgggcaacgt gctgcgccga cacgctgcgg atgctgcccg caggcctggg
     1141 gccaacgatg gtgcccccga tgatgaggac gatggtgcca gccgcatctt ctttgagccc
     1201 agcctctacc actgcctgga gaactgcggg tcagtgctgc tgtcggtggc ttgccagggt
     1261 ggtgagggca acagcacctt ctacgtggat taccgcacgg aggatggctc tgcaaaggca
     1321 ggctccgatt atgagtacag cgagggcacg ctggtgttca agcccgggga gacgcagaag
     1381 gagctgcgca tcggcatcat cgacgacgac atcttcgagg aggacgagca cttcttcgtg
     1441 aggctgctga acctgcgtgt gggcgatgct cagggcatgt tcgagcccga cggcggtggg
     1501 cggcccaagg ggcggctggt ggcgccactg ctggccaccg tcaccattct ggacgacgac
     1561 cacgcgggca tcttctcctt ccaggaccgc ctgctgcatg tgagcgagtg catgggcacc
     1621 gtggatgtgc gtgtggtgcg cagctctggc gcacgtggca ccgtacgcct tccctaccgc
     1681 acagtggacg gcacggctcg tggtggtggt gtgcactacg aggatgcttg tggagagctg
     1741 gagttcggcg atgacgagac catgaagact cttcaggtca agatagtgga cgacgaagag
     1801 tatgagaaga aggacaactt cttcatcgag ctgggccagc cccagtggct taagcggggc
     1861 atctcagctc tgctactcaa ccaaggggat ggagacagga agctgactgc agaggaggag
     1921 gaggcccaga ggatagcaga gatgggcaag ccagttcttg gggagaactg tcgcctcgag
     1981 gtcatcatcg aggagtctta tgactttaag aatacggtgg ataaactcat aaagaaaaca
     2041 aacctggcct tggtgattgg gacccactca tggagggagc agtttttaga ggcagttaca
     2101 gtgagcgcag gggacgagga ggaggatgag gatgggtctc gtgaggagcg gctgccatcc
     2161 tgctttgact acgtgatgca cttcctgacg gtgttctgga aagttctgtt cgcctgcgtt
     2221 ccacccacgg agtactgcca tggctgggcc tgctttggtg tctgcatcct ggtcattggt
     2281 ctgctcactg ccctcatcgg agacctggcc tcacactttg ggtgcaccgt gggcctcaag
     2341 gactcagtca acgccgtggt cttcgtggct ctgggcacct ccatccctga cacgtttgcc
     2401 agcaaggtgg ccgcgctgca ggaccagtgc gccgacgcgt ccatcggtaa cgtgaccggc
     2461 tccaatgcgg tgaacgtgtt cctgggcctg ggtgtggcct ggtcggtggc cgcagtgtac
     2521 tgggcggtgc agggtcgccc cttcgaggtg cgtacaggca cgctggcctt ctcggtcaca
     2581 ctgttcaccg tcttcgcctt cgtgggcatc gcagtgctct tgtaccggcg ccggccacac
     2641 atcggcggcg agctgggcgg cccgcgggga cccaagctag ccaccaccgc tctcttcctg
     2701 ggcctctggt tcctctacat tctcttcgcc agcctggagg cttattgcca cattcggggc
     2761 ttctagggcc ccagccgcta ccctgagggt ggggacttgt tggcacttgc tcttggaccc
     2821 acccctgtct ccctacccag actcaacctg ggtacttcct aggctcctcc tcatcagcct
     2881 tcttcctggg atcagcctcc ctttccccct ggaatcccat cccttgccct cccttctcag
     2941 aggcaccccc ttcagcccat ctttgtgagt tacacctgag ccctctggcc agacacccag
     3001 cc
//
