LOCUS       NM_019268               6238 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus solute carrier family 8 member A1 (Slc8a1),
            transcript variant 1, mRNA.
ACCESSION   NM_019268
VERSION     NM_019268.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6238)
  AUTHORS   Yijian,L., Weihan,S., Lin,Y., Heng,Z., Yu,W., Lin,S., Shuo,M.,
            Mengyang,L. and Jianxun,W.
  TITLE     CircNCX1 modulates cardiomyocyte proliferation through promoting
            ubiquitination of BRG1
  JOURNAL   Cell Signal 120, 111193 (2024)
   PUBMED   38679350
  REMARK    GeneRIF: CircNCX1 modulates cardiomyocyte proliferation through
            promoting ubiquitination of BRG1.
REFERENCE   2  (bases 1 to 6238)
  AUTHORS   Kang,Q., Zhang,J., Xie,C., Fang,S. and Chai,W.
  TITLE     Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by
            regulating FUS-mediated ATF3 mRNA stability in epilepsy
  JOURNAL   Exp Cell Res 434 (1), 113848 (2024)
   PUBMED   37918704
  REMARK    GeneRIF: Circular RNA SLC8A1 triggers hippocampal neuronal
            ferroptosis by regulating FUS-mediated ATF3 mRNA stability in
            epilepsy.
REFERENCE   3  (bases 1 to 6238)
  AUTHORS   Yang,L., Zhang,L., Zhu,J., Wang,Y., Zou,N., Liu,Z. and Wang,Y.
  TITLE     Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal
            Hypoxic-Ischaemic encephalopathy
  JOURNAL   Int J Exp Pathol 104 (4), 199-208 (2023)
   PUBMED   37032493
  REMARK    GeneRIF: Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in
            neonatal Hypoxic-Ischaemic encephalopathy.
REFERENCE   4  (bases 1 to 6238)
  AUTHORS   Petrozziello,T., Boscia,F., Tedeschi,V., Pannaccione,A., de
            Rosa,V., Corvino,A., Severino,B., Annunziato,L. and Secondo,A.
  TITLE     Na+/Ca2+ exchanger isoform 1 takes part to the Ca2+-related
            prosurvival pathway of SOD1 in primary motor neurons exposed to
            beta-methylamino-L-alanine
  JOURNAL   Cell Commun Signal 20 (1), 8 (2022)
   PUBMED   35022040
  REMARK    GeneRIF: Na(+)/Ca(2+) exchanger isoform 1 takes part to the
            Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons
            exposed to beta-methylamino-L-alanine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6238)
  AUTHORS   Tedeschi,V., Sisalli,M.J., Pannaccione,A., Piccialli,I.,
            Molinaro,P., Annunziato,L. and Secondo,A.
  TITLE     Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient
            receptor potential channel 6 (TRPC6) are recruited by STIM1 to
            mediate Store-Operated Calcium Entry in primary cortical neurons
  JOURNAL   Cell Calcium 101, 102525 (2022)
   PUBMED   34995919
  REMARK    GeneRIF: Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical
            transient receptor potential channel 6 (TRPC6) are recruited by
            STIM1 to mediate Store-Operated Calcium Entry in primary cortical
            neurons.
REFERENCE   6  (bases 1 to 6238)
  AUTHORS   Furman,I., Cook,O., Kasir,J., Low,W. and Rahamimoff,H.
  TITLE     The putative amino-terminal signal peptide of the cloned rat brain
            Na(+)-Ca2+ exchanger gene (RBE-1) is not mandatory for functional
            expression
  JOURNAL   J Biol Chem 270 (32), 19120-19127 (1995)
   PUBMED   7642578
REFERENCE   7  (bases 1 to 6238)
  AUTHORS   Lee,S.L., Yu,A.S. and Lytton,J.
  TITLE     Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms
  JOURNAL   J Biol Chem 269 (21), 14849-14852 (1994)
   PUBMED   8195112
REFERENCE   8  (bases 1 to 6238)
  AUTHORS   Kieval,R.S., Bloch,R.J., Lindenmayer,G.E., Ambesi,A. and
            Lederer,W.J.
  TITLE     Immunofluorescence localization of the Na-Ca exchanger in heart
            cells
  JOURNAL   Am J Physiol 263 (2 Pt 1), C545-C550 (1992)
   PUBMED   1514597
REFERENCE   9  (bases 1 to 6238)
  AUTHORS   Komuro,I., Wenninger,K.E., Philipson,K.D. and Izumo,S.
  TITLE     Molecular cloning and characterization of the human cardiac
            Na+/Ca2+ exchanger cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4769-4773 (1992)
   PUBMED   1374913
REFERENCE   10 (bases 1 to 6238)
  AUTHORS   Nicoll,D.A., Longoni,S. and Philipson,K.D.
  TITLE     Molecular cloning and functional expression of the cardiac
            sarcolemmal Na(+)-Ca2+ exchanger
  JOURNAL   Science 250 (4980), 562-565 (1990)
   PUBMED   1700476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 10, 2021 this sequence version replaced NM_019268.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1833              JAXUCZ010000006.1  19023559-19025391
            1834-1940           JAXUCZ010000006.1  19228013-19228119
            1941-1961           JAXUCZ010000006.1  19231371-19231391
            1962-1979           JAXUCZ010000006.1  19231806-19231823
            1980-1994           JAXUCZ010000006.1  19231930-19231944
            1995-2063           JAXUCZ010000006.1  19235852-19235920
            2064-2194           JAXUCZ010000006.1  19240587-19240717
            2195-2294           JAXUCZ010000006.1  19244991-19245090
            2295-2570           JAXUCZ010000006.1  19265085-19265360
            2571-6238           JAXUCZ010000006.1  19284297-19287964
FEATURES             Location/Qualifiers
     source          1..6238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..6238
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /note="solute carrier family 8 member A1"
                     /db_xref="GeneID:29715"
                     /db_xref="RGD:3717"
     exon            1..1833
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2947
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sodium/calcium exchanger 1; Na-Ca exchanger;
                     Na(+)/Ca(2+)-exchange protein 1; solute carrier family 8
                     (sodium/calcium exchanger), member 1; solute carrier
                     family 8 member 1"
                     /codon_start=1
                     /product="sodium/calcium exchanger 1 isoform 1 precursor"
                     /protein_id="NP_062141.3"
                     /db_xref="GeneID:29715"
                     /db_xref="RGD:3717"
                     /translation="MLRLSLPPNVSMGFRLVTLVALLFTHVDHITADTEAETGGNETT
                     ECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV
                     ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA
                     GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYII
                     LSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHE
                     GDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKH
                     PDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHE
                     VNMDVVENDPVSKVFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANA
                     GSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSEVSEDGILD
                     SNHVSAIACLGSPNTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGN
                     VIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIG
                     EPRLVEMSEKKALLLNELGGFTLTGKKMYGQPVFRKVHARDHPIPSTVISISEEYDDK
                     QPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNS
                     WREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGW
                     ACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQ
                     DQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIF
                     AFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF"
     exon            1834..1940
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..1961
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..1979
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..1994
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2063
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2194
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2294
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2570
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..6238
                     /gene="Slc8a1"
                     /gene_synonym="Ncx; Ncx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggttggaa caattggaag tctcattgta caacatgctt cgactaagtc tcccacccaa
       61 tgtttcaatg ggatttcgtc tggtaactct ggtggctctc ttgtttaccc atgttgacca
      121 tataactgca gatacagagg cagaaacagg aggaaatgaa accactgaat gtactggctc
      181 atattactgt aagaaagggg tgattctgcc catttgggaa ccccaagacc catcttttgg
      241 ggataaaatt gctagagcaa ctgtgtattt tgtggccatg gtctacatgt tcctcggagt
      301 ttctattatt gccgaccggt ttatgtcctc tatagaagtc atcacctctc aagaaaagga
      361 gattaccata aagaaaccaa atggagagac caccaagact acagtgcgta tctggaatga
      421 gactgtgtcc aacctgacct tgatggccct gggatcttcc gctcctgaga ttctcctgtc
      481 tgtcattgaa gtgtgtggcc ataacttcac cgcaggggac cttggtccca gcaccattgt
      541 gggaagcgcc gccttcaaca tgttcatcat catcgcgctt tgtgtttatg tggtcccaga
      601 tggagagacg aggaagatta aacatctgcg tgtgttcttt gtgacagcag cctggagcat
      661 ctttgcctat acctggcttt acataatttt gtctgtcagc tctcctggtg tcgtggaggt
      721 ctgggaagga ttactcactt tcttcttctt tcccatctgt gttgtgttcg cttgggttgc
      781 agacaggcgg cttctctttt acaagtatgt ctacaagcgg tacagggctg gcaagcagag
      841 ggggatgatc attgaacatg aaggagacag accagcttcc aaaactgaaa ttgaaatgga
      901 tgggaaagta gtcaactccc acgttgacaa tttcttagat ggcgctctgg ttttggaagt
      961 cgatgagagg gaccaagatg acgaggaagc caggcgtgag atggcaagga ttctgaagga
     1021 acttaagcag aagcatcccg acaaagagat cgaacaatta atagaattag ccaactatca
     1081 agtcctaagt cagcagcaaa agagccgagc attttaccga attcaagcta ctcgcctgat
     1141 gactggagct ggtaacattt tgaagaggca tgcagctgac caagcgagga aggctgtcag
     1201 catgcatgaa gtcaacatgg atgtggttga aaatgaccca gtcagtaagg tcttctttga
     1261 gcaagggaca taccagtgtc tagaaaactg tggtactgtg gccctcacca ttattcgaag
     1321 agggggtgac ttgaccaaca ctgtgtttgt tgacttcagg acggaagatg gcacagccaa
     1381 tgctgggtct gattatgagt tcacggaagg gactgtgatc ttcaaacctg gggagaccca
     1441 gaaggaaatc agagttggca tcattgatga tgatatcttt gaagaagatg aaaactttct
     1501 tgtgcatctt agcaacgtca gggtctcttc agaagtctcg gaagatggca tactagactc
     1561 caatcacgtg tctgcgattg cttgtctcgg gtcacccaac actgccacca taaccatttt
     1621 tgatgatgac cacgcgggca tctttacttt cgaggaaccc gtgactcacg tgagcgagag
     1681 cattggcatc atggaggtga aggtgctgag aacctctgga gcgcgaggaa atgttatcat
     1741 tccctataaa accattgaag gcacagcccg aggtggaggg gaggactttg aggacacctg
     1801 tggagagctg gaattccaga atgatgaaat agtcaaaaca atatcagtca aggtaatcga
     1861 tgacgaggag tatgagaaaa acaagacctt cttcattgag attggagaac cccgtctggt
     1921 ggagatgagt gagaagaaag ccctgttgtt aaatgagctt ggtggcttca cattaacagg
     1981 aaaaaagatg tatggccaac ctgtcttcag gaaggtccat gctagagatc atccgattcc
     2041 ctctaccgta atcagcattt cagaggagta cgatgacaag cagccactga ccagcaaaga
     2101 ggaggaggag aggcgcattg cagaaatggg gcgccccatt ctaggcgaac acaccaagct
     2161 ggaagtgatc attgaagagt cttacgaatt caagagcact gtggacaaac tcattaagaa
     2221 gacgaacctg gccctcgtgg tggggaccaa cagctggaga gagcagttca ttgaagcgat
     2281 caccgtcagc gctggggaag atgacgatga tgatgaatgt ggggaggaga agctgccctc
     2341 ctgttttgat tacgtgatgc actttctcac agtgttctgg aaggttctgt ttgccttcgt
     2401 cccacctaca gaatattgga atggctgggc ctgcttcatt gtctccatcc tcatgatcgg
     2461 cctactgaca gccttcattg gagatctggc ttcccacttt ggctgcacca ttggtctgaa
     2521 agattccgtg actgcagttg tgtttgtcgc tcttggaacc tcagtgccag acacatttgc
     2581 cagcaaagta gcagctaccc aggaccagta tgcagatgcg tccataggca atgtcaccgg
     2641 aagcaacgct gtgaatgtct tcctgggaat cggcgtggcc tggtccattg ctgccatcta
     2701 ccatgcggcc aacggggaac agttcaaagt gtcccctggc acgctagctt tctctgtcac
     2761 tctcttcacc atttttgctt tcatcaacgt gggggtgctg ctgtatcggc ggaggccaga
     2821 aataggaggt gagctgggtg ggccccggac tgccaagctc ctcacatctt ccctgtttgt
     2881 gctcctgtgg ctcttgtaca ttttcttctc ctccctggag gcctactgcc acataaaagg
     2941 cttctaaagg aacaatcaag atataataaa tttatatata tatgtataca tatatatata
     3001 cataaaaatt atgtataatg aacagaggaa actgacattt gtcatgttca cttaacctgc
     3061 tgatggaatc cagcttcaag aacgtactct gtactaggcc ggaagtcaga aaccatcatc
     3121 tcccatcatc gagttgaaca aggcatggag gcggggccat cttgcagctc gtcctagaaa
     3181 gagttatatt ctctccaagt gcataaatgg ttaaggcttt tatttgtttt cttgttttgt
     3241 tttgttttgt ttccagcggg tggggagggg ggagggggag gtggctgatg tttggctttt
     3301 ggttttttgg tttggttttg tttgttctgt ttggagggcc aagatcctac ttcttcttat
     3361 agaaagtggt gatccacccc aaggtgagtg gattcgggat cgatattaaa atcataacga
     3421 ttctctcctc acctcctcca aacactttaa acgttacttt ggattaagga aggatctggg
     3481 catggaagaa ggaaaacgca catctttact atattaccaa attttatgct tatctccgga
     3541 atgtgaacag tggtaaactg cctccaggaa gaagcatgag agctgagacg gagccaggaa
     3601 aagcaatggt tctagatgta gtctaaggat atggtgcctg gcactcttgt tcaacaggta
     3661 caggggataa tgtgcctaga ttcccagtac tcgcagaact cttcatccct tatctcttta
     3721 gctcgaactg tgactaacaa gacccttatt ccttccagcc cagccaattc cccaggtatt
     3781 ccatcccaga cctcctcctg ccctccaccc aacccctgca agcagcagga tgattaaccc
     3841 cacccctgat tcctgccatt ttagtcatca catgtgtcca ggtcccatgt tgctattgcc
     3901 tgggattttc catcagtttt attttcagtg gcatccatgg cttgcacaat cctgttccag
     3961 tcatgactga acatttgccc tccttcatgt gcctgtttgg gactgttgtc gtgattcccc
     4021 attacacagt gcatggatga aaatctaata aacgaagcgt atctgtatat agtagagtag
     4081 agcaaatact gtcctcccat tcagcgatgt tgattggaca ttgaagacat aagtgagttt
     4141 tcttttcacc tgagttgttc cttttgagtt gttcttgagt ttggatatta atagggataa
     4201 aagaagaaaa tggcttgttg ttcatgaatc tgcacgctca cttctaagaa gcaataactg
     4261 tcatgggaag agaggttagc attattgaga ggatgacagg caaactacaa agaagtccat
     4321 gaaataggag ccacacagag cacatcagag gcctctaaga atcacccatt gatccatgta
     4381 ggccgaggag aaaggctggg gagacaagtg gttacttcgg atgtgcctgg acttttagaa
     4441 cctcagtttc cacaccaccc ctcccccaat gtatttattg cacatctgct ctgtctggca
     4501 cagatgatag atagtgctag ttcatttttt ttttaatgga gaaggctgtt ttgagccctg
     4561 tttcattcac ctcttggtcc agactccctg aatttcttag caactcctga gtggaaagga
     4621 agtctgagtg accagtggga ctttagaggt ccactgggta tgactacgag gaaattactc
     4681 aaagagactg gggagttttt aacccttgga aaggaatggc tctttccatt caaaaatacc
     4741 aaagagcaga gataaaccca acattccaaa agctgtgatt ctactaatgg gaagagggat
     4801 ggctttgcct atctctcaga cacttctctg agcctccctg gccctctgca ttgactccag
     4861 atatttaaga aataaatgtt gctgagaact ccttttcctc cttccaatga gtggtgatca
     4921 tagccattca ttgtttaaca aacatttagt gactgggtga atagttagtg atgtgttgcc
     4981 cattcaatag gccaggtagt attctacaac ctgggagccg agcagtgacc aagacagccc
     5041 agattcctgc tcccaagggg tatgtaggga atgggatttc tactcaaaga gtaagagctg
     5101 acactgagac agtttttaat cttgcaagag aaaaaataat tatgacttta acatagtcac
     5161 attaaaattg cacaacaaag gcagttgacc aaatgctcat gtattttttt ttcctaagag
     5221 aatgtaatgt ttagctctgg aaaagtactc tttagagcct tggccaatgg gcaggtattt
     5281 tcatcttcct agtttagacc aagcagggca ctatgtcggt gaccgacatc accaagaaga
     5341 cccaactagc ctatttttaa tctctgtggc tatggtacct ttccataaca acatgccaca
     5401 ggccaccaac agtggtgacc ctggggactc ctccatggag ggagcactct aagccatcct
     5461 gttttgattg ttttaatctt aattttagat tttaaaggtg gaaagctaga ctagaaataa
     5521 ccagtaaata tagtcaaagg atatatatgg ttaaaaacct taggaagatt ttgcactggt
     5581 tttcgttctg ttctgttctg ttttgttttt aagccatttt tcgcatgtca gtaattctgt
     5641 agtgaatttt cacagagaac ttccccaaaa ctacttgcta ttggtcagtt tcaagttcaa
     5701 gctttctggt ttgtttgcct tctcagtctt catgctgtag ggaaaatctg attctggatg
     5761 ttcagggttc ttaattaatt atgtgtaaat gatttcattt tctttgtttg attattttta
     5821 ttttgtgtgt attgtgcacg gctttagggg gacaggcact cgcagtactg ttccttaaaa
     5881 ttggtacact ttattgacac aggaaaaaaa aaccaataaa gtttcttact gtttgtgatt
     5941 tcatcaccag tgtcacagca tgttctgtac tgtggaatgt cccttctcct cactgtcatt
     6001 gatttcattt tttggttgtt tgttttcatg ctctgaaaaa ataaagacca aaaaggtatc
     6061 cctgtgcaat cggtatcctc atccattggg aaagagacag ccaaaattca agctcatgcg
     6121 aatgtcagcc cttgggtcct gctatgtttg aatggcccac aagcagccca tgaagtcaga
     6181 atgtttgtcc cgtgatgctg tgataaaaat aaacattggg tgtgccttct tttcacca
//
