LOCUS       NM_053929               1746 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 9 (Slc7a9), mRNA.
ACCESSION   NM_053929
VERSION     NM_053929.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Shigeta,Y., Kanai,Y., Chairoungdua,A., Ahmed,N., Sakamoto,S.,
            Matsuo,H., Kim,D.K., Fujimura,M., Anzai,N., Mizoguchi,K., Ueda,T.,
            Akakura,K., Ichikawa,T., Ito,H. and Endou,H.
  TITLE     A novel missense mutation of SLC7A9 frequent in Japanese cystinuria
            cases affecting the C-terminus of the transporter
  JOURNAL   Kidney Int 69 (7), 1198-1206 (2006)
   PUBMED   16609684
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Kwak,J.O., Kim,H.W., Jung,S.M., Song,J.H., Hong,S.B., Oh,K.J.,
            Ko,C.B. and Cha,S.H.
  TITLE     Co-localization and interaction of b0,+-type amino acid transporter
            1 (BAT1) with caveolin-1 in rat kidney
  JOURNAL   J Nephrol 18 (6), 681-689 (2005)
   PUBMED   16358225
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Fernandez,E., Carrascal,M., Rousaud,F., Abian,J., Zorzano,A.,
            Palacin,M. and Chillaron,J.
  TITLE     rBAT-b(0,+)AT heterodimer is the main apical reabsorption system
            for cystine in the kidney
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F540-F548 (2002)
   PUBMED   12167606
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Chairoungdua,A., Segawa,H., Kim,J.Y., Miyamoto,K., Haga,H.,
            Fukui,Y., Mizoguchi,K., Ito,H., Takeda,E., Endou,H. and Kanai,Y.
  TITLE     Identification of an amino acid transporter associated with the
            cystinuria-related type II membrane glycoprotein
  JOURNAL   J Biol Chem 274 (41), 28845-28848 (1999)
   PUBMED   10506124
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Feliubadalo,L., Font,M., Purroy,J., Rousaud,F., Estivill,X.,
            Nunes,V., Golomb,E., Centola,M., Aksentijevich,I., Kreiss,Y.,
            Goldman,B., Pras,M., Kastner,D.L., Pras,E., Gasparini,P.,
            Bisceglia,L., Beccia,E., Gallucci,M., de Sanctis,L., Ponzone,A.,
            Rizzoni,G.F., Zelante,L., Bassi,M.T., George,A.L. Jr., Manzoni,M.,
            De Grandi,A., Riboni,M., Endsley,J.K., Ballabio,A., Borsani,G.,
            Reig,N., Fernandez,E., Estevez,R., Pineda,M., Torrents,D.,
            Camps,M., Lloberas,J., Zorzano,A. and Palacin,M.
  CONSRTM   International Cystinuria Consortium
  TITLE     Non-type I cystinuria caused by mutations in SLC7A9, encoding a
            subunit (bo,+AT) of rBAT
  JOURNAL   Nat Genet 23 (1), 52-57 (1999)
   PUBMED   10471498
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB029559.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029559.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1746
                     /gene="Slc7a9"
                     /note="solute carrier family 7 member 9"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
     exon            1..36
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            37..144
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            145..256
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1633
                     /gene="Slc7a9"
                     /note="b(0,+)AT; solute carrier family 7 (amino acid
                     transporter light chain, bo,+ system), member 9;
                     glycoprotein-associated amino acid transporter b0,+AT1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 9; solute carrier family 7
                     (glycoprotein-associated amino acid transporter light
                     chain, bo,+ system), member 9"
                     /codon_start=1
                     /product="B(0,+)-type amino acid transporter 1"
                     /protein_id="NP_446381.1"
                     /db_xref="GeneID:116726"
                     /db_xref="RGD:619905"
                     /translation="MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTII
                     GSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLME
                     AFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAIL
                     LITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSV
                     GSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFT
                     VMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGRE
                     GHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILG
                     LVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIF
                     YFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE"
     exon            257..404
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            405..647
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            648..773
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            774..873
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            874..918
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1042
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1146
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1243
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1393
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1568
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1739
                     /gene="Slc7a9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggatctag acacagggta ccaccatcac ctctctacaa gagtctttct acgtatccca
       61 ggttggcttg acttgctgaa tagcccaggc tggccctgaa tttatcattt ttctacctca
      121 actacctcag tgctgggagt tcagcccctg gaactcacag tgagcaagga tggaggagac
      181 aagcccgagg agacggagag aggatgagaa gtccgtccac agtacagagc ccaagaccac
      241 aagtctccag aaagaggtgg gtcttctcag tggtatctgt atcattgtgg gcaccatcat
      301 cggctccggg atcttcatct cccccaagtc tgtgctggcc aacacagaat ccgtggggcc
      361 ctgtctcatc atatgggcag cctgtggagt cctggctaca ctgggcgccc tgtgctttgc
      421 agagcttggc acaatgatca ccaagtcagg gggtgagtac ccctatctga tggaggcctt
      481 cggccccatc cctgcctacc tcttctcctg gaccagcctg attgtcatga agccctcatc
      541 cttcgccatc atctgcctca gcttttcaga gtatgtgtgt gcggcctttt acttaggctg
      601 caggcctcct gctgtggtag tgaaactcct ggctgctgct gccatcttgc ttatcactac
      661 agtgaatgcg ctgagcgtgc ggcttggcag ctatgtgcag aatgtcttca cggcagccaa
      721 gctggtgatc gtcgccatca tcatcatcag cggactggtc ctcctggcgc aaggaaatgt
      781 taagaacttt cagaattctt ttgagggttc acagacctct gtgggctcca tcagcctggc
      841 attttacaac ggactctggg cctacgatgg gtggaaccaa cttaactaca tcactgaaga
      901 gcttagaaac ccttacagaa acctgcccat ggccattgtc attgggatcc ctctggtgac
      961 agtatgctac atcctcatga atattgctta cttcacagtg atgaccccaa cggagctctt
     1021 gcagtcccag gctgtggctg tgaccttcgg agaccgtgtt ctctatccgg catcttgggt
     1081 agtcccactt tttgtggcat tttcaaccat tggtgctgcg aatgggacct gctttacggc
     1141 gggcaggctc atctatgtgg cgggccggga aggccacatg cttaaagtgc tatcctacat
     1201 cagtgtcaag cgcctcactc cggcccctgc cctcgtattc tatggcataa tagccatcat
     1261 ttacatcatc cccggggaca tcaactcctt agtcaattat ttcagttttg ctgcatggct
     1321 cttttatggc atgacaatcc taggactcgt tgtgatgaga ttcacaagga aagacctaga
     1381 gaggcccatc aaggtgccca tcttcatccc tatcattgtg attctcgtat ctgttttctt
     1441 gatcctggcc cccatcatca gttcgccagc ctgggaatat ctctactgcg tgttgttcat
     1501 actgagtgga cttatatttt acttcctttt tgtccactac aagttcagat gggcccagaa
     1561 aatctccagg ccgatcacca agcacctgca gatgctgatg gaagttgtcc caccagagaa
     1621 ggacccagag taaaaggccc atcactcgta gcccaaagct gtgatcaatt tatttttgta
     1681 agcaattatt tgtggttatt tcttcctggt gtttttctta atgaaaacat gtattcagaa
     1741 aaaaaa
//
