LOCUS       NM_031341               2068 bp    mRNA    linear   ROD 25-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 7 (Slc7a7), mRNA.
ACCESSION   NM_031341
VERSION     NM_031341.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Toyooka,T., Nawashiro,H., Shinomiya,N., Yano,A., Ooigawa,H.,
            Ohsumi,A., Uozumi,Y., Yanagawa,Y., Matsuo,H. and Shima,K.
  TITLE     Up-regulation of L type amino acid transporter 1 after spinal cord
            injury in rats
  JOURNAL   Acta Neurochir Suppl 102, 385-388 (2008)
   PUBMED   19388351
  REMARK    GeneRIF: LAT1 may be transiently upregulated as part of the
            tissue-repair process after traumatic contusion injury in the
            spinal cord
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Sperandeo,M.P., Annunziata,P., Bozzato,A., Piccolo,P., Maiuri,L.,
            D'Armiento,M., Ballabio,A., Corso,G., Andria,G., Borsani,G. and
            Sebastio,G.
  TITLE     Slc7a7 disruption causes fetal growth retardation by downregulating
            Igf1 in the mouse model of lysinuric protein intolerance
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C191-C198 (2007)
   PUBMED   17376816
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Shoji,Y., Noguchi,A., Shoji,Y., Matsumori,M., Takasago,Y.,
            Takayanagi,M., Yoshida,Y., Ihara,K., Hara,T., Yamaguchi,S.,
            Yoshino,M., Kaji,M., Yamamoto,S., Nakai,A., Koizumi,A., Hokezu,Y.,
            Nagamatsu,K., Mikami,H., Kitajima,I. and Takada,G.
  TITLE     Five novel SLC7A7 variants and y+L gene-expression pattern in
            cultured lymphoblasts from Japanese patients with lysinuric protein
            intolerance
  JOURNAL   Hum Mutat 20 (5), 375-381 (2002)
   PUBMED   12402335
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Torrents,D., Mykkanen,J., Pineda,M., Feliubadalo,L., Estevez,R., de
            Cid,R., Sanjurjo,P., Zorzano,A., Nunes,V., Huoponen,K.,
            Reinikainen,A., Simell,O., Savontaus,M.L., Aula,P. and Palacin,M.
  TITLE     Identification of SLC7A7, encoding y+LAT-1, as the lysinuric
            protein intolerance gene
  JOURNAL   Nat Genet 21 (3), 293-296 (1999)
   PUBMED   10080182
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Bohme,E., Graf,H. and Schultz,G.
  TITLE     Effects of sodium nitroprusside and other smooth muscle relaxants
            on cyclic GMP formation in smooth muscle and platelets
  JOURNAL   Adv Cyclic Nucleotide Res 9, 131-143 (1978)
   PUBMED   27075
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031341.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020520.1, SRR26643285.40195.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000015.1  31835545-31835683   c
            140-691             JAXUCZ010000015.1  31833966-31834517   c
            692-817             JAXUCZ010000015.1  31800470-31800595   c
            818-962             JAXUCZ010000015.1  31799264-31799408   c
            963-1086            JAXUCZ010000015.1  31796167-31796290   c
            1087-1190           JAXUCZ010000015.1  31795834-31795937   c
            1191-1287           JAXUCZ010000015.1  31795465-31795561   c
            1288-1437           JAXUCZ010000015.1  31794387-31794536   c
            1438-1621           JAXUCZ010000015.1  31792773-31792956   c
            1622-2068           JAXUCZ010000015.1  31792125-31792571   c
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2068
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /note="solute carrier family 7 member 7"
                     /db_xref="GeneID:83509"
                     /db_xref="RGD:619902"
     exon            1..139
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..691
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1722
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /note="y+LAT-1; y(+)L-type amino acid transporter 1;
                     solute carrier family 7 (cationic amino acid transporter,
                     y+ system), member 7; solute carrier family 7 (amino acid
                     transporter light chain, y+L system), member 7"
                     /codon_start=1
                     /product="Y+L amino acid transporter 1"
                     /protein_id="NP_112631.1"
                     /db_xref="GeneID:83509"
                     /db_xref="RGD:619902"
                     /translation="MVASTKYEVAAQNEADEADGSAQGDGAGPAAEQVKLKKEISLLN
                     GVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKK
                     SGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAA
                     GRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATTNFE
                     DSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTII
                     YLLTNVAYYSVLDIKDILASDAVAVTFADQIFGIFNWTIPLAVALSCFGGLNASIVAA
                     SRLLFVGSREGHLPDAICMIHVERFTPVPSLLFNGILALVYLCVEDIFQLINYYSFSY
                     WFFVGLSIVGQLYLRWKEPDRPRPLKLSLFFPIVFCLCTIFLVAVPLYSDTINSLIGI
                     GIALSGLPFYFLIIRVPEHKRPLCLRRIVASTTRYLQIICMSVAAEMDLEDGELPKQG
                     PKSK"
     exon            692..817
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..962
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1086
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1190
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1287
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1437
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1621
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..2068
                     /gene="Slc7a7"
                     /gene_synonym="y+LAT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgtctggg tttccctttt actgctggag gaaggaggag ctgtcagacc actgttcttg
       61 gagggtgtgt gtgcctcttt gtctcagaga ctgcgcctgg ccattgctgt gggaacctcc
      121 ttatatccag aggcagggaa gggcgatgca agggagctgg tgaagacttg ccttctctcc
      181 gccatggtcg ccagcaccaa gtatgaagtg gccgctcaga acgaggcaga cgaggcagat
      241 ggctctgctc agggggatgg ggcaggccct gcggctgagc aggtaaaact gaagaaggag
      301 atctcgctgc ttaatggcgt gtgcctgata gtggggaaca tgatcggctc cgggatcttt
      361 gtctccccca agggcgtact catgtacagt gcctcttttg gcctctcgct ggtcatctgg
      421 gctgttgggg gcattttctc cgtctttggg gccctgtgtt atgccgaact gggtaccacc
      481 attaagaaat cgggggccag ctatgcgtac atcctggagg ccttcggggg atttctcgcc
      541 ttcatccgcc tctggacttc tctgctcatc attgaaccca ccagccaggc cgtcattgcc
      601 atcacctttg ccaactacat ggtgcagccc ctcttcccga gctgtggcgc tccctatgct
      661 gctggccgcc tgctggccgc tgcctgcatc tgtctcttaa ccttcattaa ctgtgcctat
      721 gtcaagtggg gaaccctggt ccaagatatt ttcacctacg ctaaagtgtt ggcgctgatt
      781 gcggtcatca ttgcgggaat tgttagactt ggccagggag ccacaactaa ctttgaggac
      841 tcctttgagg gctcatcgtt tgcaatgggt gacattgccc tggcactata ctcagctttg
      901 ttctcctact ctggctggga cacccttaac tatgtcactg aagagatcag aaatcccgag
      961 aggaacttgc ccctctccat tggcatttcc atgcccatcg tcaccatcat ctacctcttg
     1021 accaatgtgg cctattacag tgtgctagac ataaaggaca tcttggccag cgacgcggtt
     1081 gctgtgacct ttgcagatca gatttttgga atattcaact ggacaattcc attagcagtt
     1141 gcattatcct gctttggtgg cctcaatgct tccattgtgg ctgcttctag gcttttattt
     1201 gtgggctcga gagaaggcca cctcccggat gccatctgta tgattcatgt tgaacggttc
     1261 acaccagtgc cttctctact cttcaatggt atcttggcac tggtctactt gtgtgtggag
     1321 gacatcttcc agctcattaa ctactacagc ttcagctact ggttctttgt gggactttct
     1381 attgtgggtc agctttacct acgctggaag gaacctgacc ggccccgccc tctcaagctc
     1441 agcctgttct tccccatcgt cttctgcctc tgtaccatct tcctggtggc tgtcccgctt
     1501 tatagcgata ccatcaactc cctcatcggc atcggcatcg cgctctcggg cctgcccttc
     1561 tatttcctca tcatcagagt gcccgagcac aaacgacctc tgtgccttcg caggatcgta
     1621 gcgtctacca cacggtacct ccagatcatc tgtatgtcag ttgctgcaga aatggacttg
     1681 gaagatggag agttgcccaa acaaggtccc aagtctaaat agagcgtgga attctgagat
     1741 gcgggcaaac tcggcgtttc tcatctccca ttggccagaa cctctggagg ccccacccag
     1801 agcccaggct tggcagcttc aactcggaac ttgcttttga gggatgaaga gtaatttatt
     1861 tgttttgcta cgtgttgttt cggactttat aagtggataa tgcagactgt ggcggaagca
     1921 ggccatttct gaggcttggt tctggcagca cccggggtgc ctacccactc ctctcttcct
     1981 ttaccagggc caacaatgct ccaaatttgt ctcctttaga gggacacaaa actgtcacag
     2041 atgcaaaaca ataaaaagat tatgttcc
//
