LOCUS       NM_001134686            2500 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 2 (Slc7a2),
            transcript variant 2, mRNA.
ACCESSION   NM_001134686
VERSION     NM_001134686.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Hultstrom,M., Helle,F. and Iversen,B.M.
  TITLE     AT(1) receptor activation regulates the mRNA expression of CAT1,
            CAT2, arginase-1, and DDAH2 in preglomerular vessels from
            angiotensin II hypertensive rats
  JOURNAL   Am J Physiol Renal Physiol 297 (1), F163-F168 (2009)
   PUBMED   19386725
  REMARK    GeneRIF: CAT1, CAT2, DDAH2, and arginase-1 expression in renal
            resistance vessels is regulated through the AT(1) receptor.
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Huang,T.Y., Tsai,P.S. and Huang,C.J.
  TITLE     HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes
            expression
  JOURNAL   J Surg Res 148 (2), 172-180 (2008)
   PUBMED   18028947
  REMARK    GeneRIF: HO-1 overexpression significantly attenuates
            endotoxin-induced increases in nitric oxide and l-arginine
            transport, as well as the expression of iNOS and CAT-2 isozymes in
            septic rats.
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Schwartz,I.F., Chernichovsky,T., Hagin,D., Ingbir,M., Reshef,R.,
            Chernin,G., Levo,Y. and Schwartz,D.
  TITLE     Differential regulation of L-arginine transporters (cationic amino
            acid transporter-1 and -2) by peroxynitrite in rat mesangial cells
  JOURNAL   Nephrol Dial Transplant 21 (12), 3409-3414 (2006)
   PUBMED   16998217
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Rothenberg,M.E., Doepker,M.P., Lewkowich,I.P., Chiaramonte,M.G.,
            Stringer,K.F., Finkelman,F.D., MacLeod,C.L., Ellies,L.G. and
            Zimmermann,N.
  TITLE     Cationic amino acid transporter 2 regulates inflammatory
            homeostasis in the lung
  JOURNAL   Proc Natl Acad Sci U S A 103 (40), 14895-14900 (2006)
   PUBMED   17003120
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Yeramian,A., Martin,L., Arpa,L., Bertran,J., Soler,C., McLeod,C.,
            Modolell,M., Palacin,M., Lloberas,J. and Celada,A.
  TITLE     Macrophages require distinct arginine catabolism and transport
            systems for proliferation and for activation
  JOURNAL   Eur J Immunol 36 (6), 1516-1526 (2006)
   PUBMED   16703566
REFERENCE   6  (bases 1 to 2500)
  AUTHORS   Stevens,B.R., Kakuda,D.K., Yu,K., Waters,M., Vo,C.B. and
            Raizada,M.K.
  TITLE     Induced nitric oxide synthesis is dependent on induced
            alternatively spliced CAT-2 encoding L-arginine transport in brain
            astrocytes
  JOURNAL   J Biol Chem 271 (39), 24017-24022 (1996)
   PUBMED   8798637
REFERENCE   7  (bases 1 to 2500)
  AUTHORS   Gill,D.J., Low,B.C. and Grigor,M.R.
  TITLE     Interleukin-1 beta and tumor necrosis factor-alpha stimulate the
            cat-2 gene of the L-arginine transporter in cultured vascular
            smooth muscle cells
  JOURNAL   J Biol Chem 271 (19), 11280-11283 (1996)
   PUBMED   8626679
REFERENCE   8  (bases 1 to 2500)
  AUTHORS   Kavanaugh,M.P., Wang,H., Zhang,Z., Zhang,W., Wu,Y.N., Dechant,E.,
            North,R.A. and Kabat,D.
  TITLE     Control of cationic amino acid transport and retroviral receptor
            functions in a membrane protein family
  JOURNAL   J Biol Chem 269 (22), 15445-15450 (1994)
   PUBMED   8195186
REFERENCE   9  (bases 1 to 2500)
  AUTHORS   Kudo,H., Hirayoshi,K., Kitagawa,Y., Imamura,S. and Nagata,K.
  TITLE     Two collagen-binding proteins, osteonectin and HSP47, are
            coordinately induced in transformed keratinocytes by heat and other
            stresses
  JOURNAL   Exp Cell Res 212 (2), 219-224 (1994)
   PUBMED   8187816
REFERENCE   10 (bases 1 to 2500)
  AUTHORS   Closs,E.I., Albritton,L.M., Kim,J.W. and Cunningham,J.M.
  TITLE     Identification of a low affinity, high capacity transporter of
            cationic amino acids in mouse liver
  JOURNAL   J Biol Chem 268 (10), 7538-7544 (1993)
   PUBMED   8385111
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF245002.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001134686.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            exon in the coding region compared to variant 1. The resulting
            protein (isoform b) is longer but has the same N- and C-termini
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF245002.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2500              AF245002.1         2-2501
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..2500
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /note="solute carrier family 7 member 2"
                     /db_xref="GeneID:64554"
                     /db_xref="RGD:68387"
     exon            1..164
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            165..555
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2156
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /note="isoform b is encoded by transcript variant 2; low
                     affinity cationic amino acid transporter 2; CAT-2;
                     cationic amino acid transporter-2A; solute carrier family
                     7 (cationic amino acid transporter, y+ system), member 2"
                     /codon_start=1
                     /product="cationic amino acid transporter 2 isoform b"
                     /protein_id="NP_001128158.1"
                     /db_xref="GeneID:64554"
                     /db_xref="RGD:68387"
                     /translation="MIPCRAVLTFTRCLIRRKIVTLDSLEDSKLCRCLTTMDLIALGV
                     GSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLY
                     TYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTG
                     LAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANW
                     KISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIAT
                     TGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGW
                     GPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATL
                     SSGAVAAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYTPEKD
                     ILESCTNATSKSESQVTMLQGQGFSLRTLFNPSALPTRQSASLVSFLVGFLAFLIAGL
                     SILTTYGVQAIARLEAWSLALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPA
                     FSILVNIYLMVQLSADTWVRFSIWMVLGFLIYFAYGIRHSLEGNPRDEEEDEDVCPDN
                     VNAAAEEKSAMQANDHHQRNLSLPFILHEKTSEC"
     exon            556..711
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            712..877
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1011
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1234
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1374
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1477
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1683
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1850
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1959
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2500
                     /gene="Slc7a2"
                     /gene_synonym="Cat2; Cat2a; Cat2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcccagcc cgccttctgc agctcggcgg cgggagcttc tgtctgcgcg gacctggaag
       61 acggcggcag ctcgtctagc cttcgagagc ttgggaaccg cagagcgctg cagccggtcg
      121 tccgctggtg cccgtctccg tcgcgcagcc agggcactgc cccagttgct cccttcacca
      181 tgattccctg cagagcagtg ctgactttca cacgatgtct gatccggaga aaaattgtca
      241 cactggacag tctggaagat tccaaactct gccgctgctt aaccaccatg gacctcatcg
      301 ccctgggagt tggaagcact ctcggcgctg gggtttacgt cctggctgga gaagtcgcca
      361 aagctgactc cggccctagt attgtggtgt ctttcctcat cgctgccctg gcttcggtga
      421 tggccggcct ttgctacgct gaatttgggg cccgagtacc aaagactgga tctgcgtatc
      481 tatacacata cgtcacggtt ggagagctgt gggccttcat cactggttgg aatctcattc
      541 tgtcatatgt cataggtacg tccagtgtcg caagagcttg gagtggcacc ttcgatgagc
      601 ttcttaacaa acagattggc cagtttttca agacctactt caaaatgaat tacaccggtc
      661 tggcggagta tccggacttc tttgccgtgt gccttgtatt acttctggca ggtcttttat
      721 cttttggagt aaaggagtct gcttgggtga ataaattttt tacagctatt aatatcctgg
      781 tccttctctt tgtcatggtg gctgggtttg tgaaaggaaa tgtggctaac tggaagatca
      841 gtgaagaatt tctcaagaat atatcagcaa gtgccagaga accaccttct gaaaatggaa
      901 caagcatcta cggggctggc ggcttcatgc cttatggctt tacagggacg ctggctggtg
      961 ctgcaacgtg cttttatgcc tttgtgggct ttgactgcat tgcaacaacc ggcgaagagg
     1021 tccggaatcc ccaaaaggct attcccattg gaatagtaac ttccttactt gtttgcttta
     1081 tggcctattt tggggtttct gcagctttaa cacttatgat gccttactac ctcctggatg
     1141 agaaaagccc actccctgtt gcatttgaat atgtcggatg gggtcctgct aaatacgttg
     1201 tcgccgcagg ctccctctgc gccttatcaa caagtcttct tggatccatt ttcccaatgc
     1261 ctcgtgtaat ctatgctatg gcggaggatg ggttgctttt caaatgtcta gctcaaatca
     1321 attccaaaac gaagacacca ataattgcta ctttgtcatc gggtgcagtg gcagctgtga
     1381 tggcctttct ttttgacctg aaggctctcg tggacatgat gtctattggc accctcatgg
     1441 cctactctct ggtcgcagcc tgtgtgctca ttctcaggta ccaacctggc ttgtgttatg
     1501 agcagcccaa atacacccct gagaaagaca ttctggagtc atgtaccaat gcgacctcga
     1561 agagcgagtc ccaggtcacc atgctgcaag gacagggttt cagcctacga accctcttca
     1621 acccctctgc tctgcccaca cgacagtcag cctccctcgt gagcttcctg gtgggattcc
     1681 tggctttcct catcgccggc ttgagtattc tgaccacgta cggagtccag gccatcgcca
     1741 gactggaagc ctggagcctg gctcttctcg ccctgttcct tgtcctctgc gctgccgtca
     1801 tcctgaccat ttggaggcag ccacagaatc agcaaaaagt agccttcatg gtcccgttct
     1861 taccgtttct gccggccttc agcatcctgg tcaacattta cttgatggtc cagttaagcg
     1921 cggacacttg ggtcagattc agcatctgga tggtgcttgg ctttctgatt tacttcgcct
     1981 atggcattag acacagcttg gagggtaacc ccagggatga agaagaagat gaagatgtct
     2041 gtccagacaa cgtcaatgca gcagcagaag aaaagtctgc catgcaggca aatgaccatc
     2101 accaaagaaa cctcagcttg cctttcatac ttcatgaaaa gacaagtgaa tgttgatgcc
     2161 ggtccgcagc cctaccacac atgccttaac aatgagtact ttacggcagg aagccaccat
     2221 cgtgctgggt tgtcatgggt ttgctgcagc cacggtttgc ctaacttata cttcctcctc
     2281 cggacagctt cttttcaaat ggtggattat gtgtttgggg agactgcctg agagcactcc
     2341 tcagtgatac gtatccccaa aacagtatgt ctgtgtgggt acatgtgtgc ttgggaatgt
     2401 gagtgttcaa tgttgttggt tcttactctg tgacatgatt ccagtgcagt aactggtggc
     2461 atgtactgca catgctagta aacagtatat tgctgaatag
//
