LOCUS       NM_001107673            8896 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 11 (Slc7a11),
            mRNA.
ACCESSION   NM_001107673 XM_001053328 XM_227120
VERSION     NM_001107673.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8896)
  AUTHORS   Chen,B., Fan,P., Song,X. and Duan,M.
  TITLE     The role and possible mechanism of the ferroptosis-related
            SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury
  JOURNAL   BMC Cardiovasc Disord 24 (1), 531 (2024)
   PUBMED   39354361
  REMARK    GeneRIF: The role and possible mechanism of the ferroptosis-related
            SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8896)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8896)
  AUTHORS   Geng,W., Yan,S., Li,X., Liu,Q., Zhang,X., Gu,X., Tian,X. and
            Jiang,Y.
  TITLE     miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by
            Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading
            Keap1
  JOURNAL   Anal Cell Pathol (Amst) 2023, 1293200 (2023)
   PUBMED   37822721
  REMARK    GeneRIF: miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes
            Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis
            by Degrading Keap1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8896)
  AUTHORS   Hong,T., Zhao,T., He,W., Xia,J., Huang,Q., Yang,J., Gu,W., Chen,C.,
            Zhang,N., Liu,Y. and Feng,J.
  TITLE     Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to
            activate SLC7A11 signaling in ischemic stroke
  JOURNAL   FASEB J 37 (9), e23152 (2023)
   PUBMED   37603538
  REMARK    GeneRIF: Exosomal circBBS2 inhibits ferroptosis by targeting
            miR-494 to activate SLC7A11 signaling in ischemic stroke.
REFERENCE   5  (bases 1 to 8896)
  AUTHORS   Kong,R., Ji,L., Pang,Y., Zhao,D. and Gao,J.
  TITLE     Exosomes from osteoarthritic fibroblast-like synoviocytes promote
            cartilage ferroptosis and damage via delivering microRNA-19b-3p to
            target SLC7A11 in osteoarthritis
  JOURNAL   Front Immunol 14, 1181156 (2023)
   PUBMED   37691947
  REMARK    GeneRIF: Exosomes from osteoarthritic fibroblast-like synoviocytes
            promote cartilage ferroptosis and damage via delivering
            microRNA-19b-3p to target SLC7A11 in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8896)
  AUTHORS   Burdo,J., Dargusch,R. and Schubert,D.
  TITLE     Distribution of the cystine/glutamate antiporter system xc- in the
            brain, kidney, and duodenum
  JOURNAL   J Histochem Cytochem 54 (5), 549-557 (2006)
   PUBMED   16399997
REFERENCE   7  (bases 1 to 8896)
  AUTHORS   Sato,H., Shiiya,A., Kimata,M., Maebara,K., Tamba,M., Sakakura,Y.,
            Makino,N., Sugiyama,F., Yagami,K., Moriguchi,T., Takahashi,S. and
            Bannai,S.
  TITLE     Redox imbalance in cystine/glutamate transporter-deficient mice
  JOURNAL   J Biol Chem 280 (45), 37423-37429 (2005)
   PUBMED   16144837
REFERENCE   8  (bases 1 to 8896)
  AUTHORS   Chintala,S., Li,W., Lamoreux,M.L., Ito,S., Wakamatsu,K.,
            Sviderskaya,E.V., Bennett,D.C., Park,Y.M., Gahl,W.A., Huizing,M.,
            Spritz,R.A., Ben,S., Novak,E.K., Tan,J. and Swank,R.T.
  TITLE     Slc7a11 gene controls production of pheomelanin pigment and
            proliferation of cultured cells
  JOURNAL   Proc Natl Acad Sci U S A 102 (31), 10964-10969 (2005)
   PUBMED   16037214
REFERENCE   9  (bases 1 to 8896)
  AUTHORS   Lim,J., Lam,Y.C., Kistler,J. and Donaldson,P.J.
  TITLE     Molecular characterization of the cystine/glutamate exchanger and
            the excitatory amino acid transporters in the rat lens
  JOURNAL   Invest Ophthalmol Vis Sci 46 (8), 2869-2877 (2005)
   PUBMED   16043861
REFERENCE   10 (bases 1 to 8896)
  AUTHORS   Swank,R.T., Reddington,M. and Novak,E.K.
  TITLE     Inherited prolonged bleeding time and platelet storage pool
            deficiency in the subtle gray (sut) mouse
  JOURNAL   Lab Anim Sci 46 (1), 56-60 (1996)
   PUBMED   8699821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001107673.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2025282.1,
                                           SRR26360194.43805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               JAXUCZ010000002.1  136667858-136668264 c
            408-534             JAXUCZ010000002.1  136663725-136663851 c
            535-650             JAXUCZ010000002.1  136660437-136660552 c
            651-776             JAXUCZ010000002.1  136652425-136652550 c
            777-876             JAXUCZ010000002.1  136648675-136648774 c
            877-921             JAXUCZ010000002.1  136642726-136642770 c
            922-1045            JAXUCZ010000002.1  136613145-136613268 c
            1046-1149           JAXUCZ010000002.1  136611270-136611373 c
            1150-1246           JAXUCZ010000002.1  136610378-136610474 c
            1247-1396           JAXUCZ010000002.1  136608433-136608582 c
            1397-1574           JAXUCZ010000002.1  136606955-136607132 c
            1575-8896           JAXUCZ010000002.1  136593952-136601273 c
FEATURES             Location/Qualifiers
     source          1..8896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..8896
                     /gene="Slc7a11"
                     /note="solute carrier family 7 member 11"
                     /db_xref="GeneID:310392"
                     /db_xref="RGD:1309275"
     exon            1..407
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1639
                     /gene="Slc7a11"
                     /note="solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 11; solute carrier family
                     7 (anionic amino acid transporter light chain, xc-
                     system), member 11"
                     /codon_start=1
                     /product="cystine/glutamate transporter"
                     /protein_id="NP_001101143.2"
                     /db_xref="GeneID:310392"
                     /db_xref="RGD:1309275"
                     /translation="MVRKPVVATISKGGYLQGNVSGRLPSVGDQEPPGHEKVVLKKKI
                     TLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGT
                     SIKKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRYILEPFFIQCEI
                     PELAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQLIKGQT
                     HHFKDAFSGRDTNLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAI
                     ITVGYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGG
                     VFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMIMLFSGDLYSLLNFL
                     SFARWLFMGLAVAGLIYLRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFST
                     GVGFLITLTGVPAYYLFIVWDKKPKWFRRLSDRITRTLQIILEVVPEDSKEL"
     exon            408..534
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            535..650
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            651..776
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            777..876
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            877..921
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1045
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1149
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1246
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1396
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1574
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..8896
                     /gene="Slc7a11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaccagtg atctgtcacc tctagagaaa caagttcaag ttgaaagttt tttttgtttt
       61 gttttgtttc tcttcctctg ttttcttttt catcccccac caccctcccc tcctctggtg
      121 tgacactgcc atggtcagaa agccagttgt ggccaccatc tccaaaggag gttacctgca
      181 gggcaatgtg agcgggaggc tcccctccgt gggggaccaa gagccacctg ggcatgagaa
      241 ggtggttctg aaaaagaaga tcactttgct gaggggggtc tccatcatca tcggcaccgt
      301 catcggatcg ggcatcttca tctcccccaa gggcatactc cagaacacgg gcagcgtggg
      361 catgtcactg gtgttctggt ctgcctgtgg agtactgtca ctttttggag ccctgtctta
      421 tgctgaattg ggtacgagca taaagaaatc tggtggtcat tacacataca ttctggaggt
      481 ctttggtccc ttgctagctt ttgttcgagt ctgggtggaa ctgctggtaa tacgccccgg
      541 agctacggct gtgatatccc tggcttttgg acgctacatt ctagaaccgt tttttattca
      601 atgtgaaatt cctgaacttg caatcaagct tgtaacagct gtgggcatca ctgtggtgat
      661 ggttctaaat agcacgagtg tcagctggag tgcccggatc cagattttcc taaccttttg
      721 caagctcaca gcaattctga taattatagt ccctggagtt atacagctaa ttaaagggca
      781 aacacatcac tttaaagatg cattttcagg aagagataca aatctaatgg ggttgccctt
      841 ggctttttat tacgggatgt atgcatatgc tggctggttt tacctcaact ttattactga
      901 agaagtagac aaccctgaaa aaaccatccc ccttgcaatc tgcatctcta tggccatcat
      961 cacagttggc tatgtcctga caaatgtggc ctattttaca accattagcg ccgaggagct
     1021 gttgcagtcc agcgctgtgg cggtgacctt ctctgagcgg ctgctgggaa aattctcatt
     1081 agcagtcccg atctttgttg ccctctcctg cttcggctcc atgaacggtg gtgtgtttgc
     1141 tgtctccagg ttattctatg ttgcatctcg agaagggcac cttccggaaa tcctctccat
     1201 gattcacgtc cacaagcaca ctcctctgcc agctgttatt gttttgcatc ctctgacaat
     1261 gataatgctc ttctccggag acctctacag tcttctgaat ttcctcagtt ttgccaggtg
     1321 gctttttatg ggcctggcag tcgccgggct gatttatctt cgatacaaac gcccagatat
     1381 gcatcgtcct ttcaaggtgc ctctgttcat cccagcatta ttctccttca cctgcctctt
     1441 catggttgtc ctctcccttt actcggatcc gtttagcacc ggggttggct tccttatcac
     1501 cttgactggg gtcccggcgt attacctctt cattgtatgg gacaagaaac ccaagtggtt
     1561 cagacgattg tcagacagaa taaccagaac attacagatt atactagaag ttgtaccaga
     1621 agactctaaa gaattatgaa cttaatgtat caaatccttg gccatctgcc caggactgag
     1681 atacaaaatg gctctttatt tcaagaaaac acaattttga tgatgggcta aaggaattgg
     1741 ttatctctaa tcatagcctc tagtgtattt gaattaattt ctgagcaact taccggtaac
     1801 tccatatatt tgtagcaagc taatatgcaa gtcatacagt ggggcaagct cacagttctt
     1861 gagtctagtg cctatctgct gagggaaagg aaaaggagaa acctaagggc attggcacct
     1921 gggtatcatt ctctacaaca tttcttatcg tgactgagaa ccttgaatag aagaccaaaa
     1981 tggtttctgt acatatgagg cctgtaaaca tagctttacc tactggggac atctatactg
     2041 tgaaaaggat tttgttttta tttttctgaa aaaaaaagag tcattattgt agcaaaggaa
     2101 gcagaatgac ttttacattg atcttggatt gttttccctt agtgaccaac atggctgtca
     2161 cttatctttc agtggcttat actcagagca tcagaacaaa tgaagatgag agaggagaga
     2221 gacagagaca gagacagaga cagagacaga gacagagaga gagagagaga gagagagaga
     2281 gagagaaaga gagaaagaga gaaagagaga aagagagaaa gagagaaaga gagagtagct
     2341 ggaggtcaaa ttcagggctt tccaaaagcc aggcaagaac tctaccgttg ggatacgtct
     2401 atactctaat tttcttaaat gaacaaaaga agcattccca ggggctaaca tttatgacgc
     2461 aatcctaaac tgtgtttgaa ctaaagtcat tgagaacttg ttaggttaac tacgtcattg
     2521 tttattgtca ggaaactcgg tgtttgtaac gtcactgtgg tttgtaacgt ttcagtgtgg
     2581 tttgtttgtt ttattcctga aaacctgtat ggtttggtat gacatccttg gtgagacacc
     2641 tctttggtaa tttacgtctt agtggataaa accgtttcgc tcattgcagt ccaacacccg
     2701 catgggagaa attgcccaca agactccaaa catcaggcct catctctata aaccgcatta
     2761 tacgcagggt tagcagttca ttctcctttt ctttaacttt gtggctgttt ttacctgggg
     2821 atgattttcg acagtgtgtg catccccttt accgttctgt tcaaatatct ctggataaaa
     2881 ctatctggat ccatcataaa ggcacagctt tacataagaa ctgtgcaaga aatgcatgcc
     2941 accacttagg aagactttca actgactttt gaaaaatcta ggcggtttca ttcatctcta
     3001 cactttactt ataattcaat ttgccaaaga gggatctgtg accaaaccta tcgaaggaga
     3061 gtcttcagta atgtcgttca gctccctgac gtcgagtctg agttagaaaa acactagcag
     3121 tgttcaaatg ggattaatgt gatggtggga tttttaaaac attttcctaa catctgaaaa
     3181 ttaaatgcat agcatggtca cagtgaatta aatttgatct cttatatttt gaccacttaa
     3241 aaacaaaatg ttttaaaaaa ttatcctgaa ctggttgtgg tggcacatac ctttaatctc
     3301 agcacttggg aggcagaggc agggaatctc tgagttccag aagagctagg gctacccaga
     3361 gaaaccttgt cttggaaaaa accaaaccaa accaaacaaa caaaaagtat tttcccaaat
     3421 aaaagctatt gagttcatag ataattgccc aaagtacaaa tgatgacctt aatttggaac
     3481 aattcaccaa ttcagcattt ttagtatcaa taatgtttaa tacataccca aagttgactt
     3541 tgtttctgaa ggccaaacca agtgtttatt tccctaagtg aactgctaac aggttttttg
     3601 tttttattaa catgggcttt tccaaaccat aagtctagtc tctagggcta acatagtgtt
     3661 catttgttga cgtctatctc tgtcagatgt ggctagaggt gcacattatt atgttgttat
     3721 ctttatacca gacccatgag atgtatcaag gcagggtctt ctgattacct atgaaacaga
     3781 gtaaagccat ggagaaggtc ctgtggtcca cgattcttcc tgaggttcat gtgcccctcg
     3841 ctgattgtcc tcattgtgtc atttgcttgc cagtctgtgt gcaagctggt caggttatac
     3901 tttatcattc ctcctctcgt ttctaagaca tttttgtatt gttaaattta taacgcagtt
     3961 ttaaccaagc ataaagaaac tcagtatttc tataaagtac tgtccatggg gctgtgtttt
     4021 tgcctatgct gaagaagaga acacacagtt cctttattca tgggattcat gttcataatt
     4081 gttagtgaga taatgtaaaa cagattttta tttgggaaat actcctgcac acttataatg
     4141 tgtgttttta tacaaagtaa attttctcat attttagatt tatgcatgta tgtacacatg
     4201 tgattacatg tgttaatgtt cgtgctgatg tacatatttg aatgtttata taaaaacacg
     4261 aattgattgc tacaatacag agttaaatgc agcctacaca gtttaaaata tacaatactc
     4321 tattttcaaa tattctttgt tttgtataca aagtgtcaaa catgtaactt tttaaggcat
     4381 ctggtaaaga tttccaaagc ttaggtgtga ttttattcta cacggttata aatatttcca
     4441 ttgattgata ttcttatagt gctactttat atctagaaga tataaagcac tagattctcc
     4501 cctttgattt caagtggctc ttgtaaatgg tggctctgct tagctgacaa caggtcctgc
     4561 tcttgtcttt cagtgggaga ttggacattt ctcttagcaa acatgactgg gtctgggtct
     4621 gcttgtgggt tcatgagtgt acacccacag tgtgtgcaca tttgctcccc agccctgcag
     4681 gtacagggtc aggacaactg atgggattag ttctccatgc tctgcagttt ctataacact
     4741 aaaatatgca tatagaaaca ttccagtttt cagattgcct tctgtgtctg cctaaattgt
     4801 tttcttaatt gtcatttgaa cagcaacagg tgactaccat gaggaccatt ccttgctaga
     4861 agtcttagcc agttgagatc agcccttggc aaagtcccta tttcatctca gtttacaggt
     4921 gagcgggatg ctgagaaagc ctgcttctct cccttttgtt gatagcctct tactgaggtg
     4981 tgaaaagaca acttaaggtt actaccagtt taccttcatg tagcaaagaa gggaaatatc
     5041 agtgttgaat gtatgtgagc atcctgagac gctaattaag catgagttta ggtgtctcta
     5101 atgcacttaa actccttcca ggatcccata cctagccctc ctttggaaag attatatatt
     5161 tttaaaagaa gatcagggat tggggctgaa gagttggctt ggcttctaag aacacttact
     5221 accgttgcag agaacttgag ttcaatttcc agcacccaca tgggtaactt tagttccagg
     5281 ggacccagtg ccctcttatg tatacaggca tgcacacagt gcacatatat ccatgcagac
     5341 aaaacactca tctacattaa atgtatgtga aaaaatttta aagacaagga aaagtacata
     5401 tactttggat actataatat ctatattttc tttgtgaata gttttcataa tttttccatt
     5461 aaaagtaacc atagaatatt ggtaaaacac attttaaata tataaataca atgttaattg
     5521 aaatattcac ataaaaacca tttagggctg tcttgtaagg tctatgtgat acagaagtca
     5581 gtgatgtcta ctgtgttagg ctgtgaataa caatggaaaa acaatgaatg aggttttatt
     5641 tgtagctctt tttttcttat ttttggagag aaatatattt gagatttcaa aggaaatgac
     5701 tcaagaaact tcatttgaat atcattggct tcatgataca ctgtgtgtca gggctgagag
     5761 aatgcagggt gatattttat gcccctaatc atacaagctg gaaattaagt catggcattg
     5821 tgtaatggca aagagcttat agagaagata atgagtcatt tgcataactt ctgtttatat
     5881 tatatagata aaagaacgat tgcctgcata tatagtttag ctaaatttcc cccacaaaca
     5941 atatttcaaa agtctattct caatatattt gacaactaaa agtgtgacct ctaggtagac
     6001 ctctgatggc taagattata gtttaaaata tgtgatttaa taaccaattt tacaagcaat
     6061 cctttatttt attgaatttt cctattattt ggtatctcaa aatgaatgcc ttgtctgctt
     6121 tgtgtcataa gtggtgcaaa aacatacgtc acgggcacat aggaggtcac ctattcattt
     6181 tatcagacct tgtctttctt catcaacttg tgacaacact gttactcttt cttctttatc
     6241 atttctgttc tatttacata aaaccacagt tccctgcaat tcagtttttg atgttatgcc
     6301 ttcaaggtgg taactgtaga aagacttcac ttcctaagat ttttcttaat gaaaaaaatc
     6361 tgctcctccc ttctcttcct tatttacagt tggcttgaaa tacagagggt ggtttcagcc
     6421 tcagacggct ccctgctgcg tggtatattt cagcctgtag agaacaaagg tacttttgta
     6481 ctctcagtcc ccacctgccc aggtttatag acaatgcttt caaagaccca gttactcatt
     6541 atgcatctga gagccctgtg gctgtcagag gcaattcaaa aggaagcaca cctaccacac
     6601 acacttcggc atacacacta cgaatgttta agagtgaatg aattattgtt tagaggacct
     6661 acttgctatg tccttactac ctcctgatga agccactaaa ggcagtgttg aaggccaggt
     6721 tgagaaagag aagactcgtg ctcagttaac tcttgctgca ggaactgtat tctgagcact
     6781 ccgtgtgatg gtattttcac agcatcttgt gggaaaatgt gttaggtctt tggatggata
     6841 agtgggtcct gtgtggtcag acctccctta ttcttactaa tgaccctttt actaaccata
     6901 gactcagaat tccattcaga tcctaccagg agacaagaca ttgtgggttc ctactcttaa
     6961 aattgaaaga tcttgtttca aagaatttag gaaggagtct atgcctgtaa tttctccatc
     7021 actctactta ttaaataata tgataagatt ttgtcttaga gtagaagagt actttgggga
     7081 aatagaagaa aaaacattat tcgtgatgaa tgagagttta tagcaggaaa agttacttac
     7141 attaaataac agcattctaa ttatttcaga tactagtcaa tagcactttt ataactctaa
     7201 atcaaaagca ttttgtatta tcataccaat atttttctat gtccatgtat atatgtcata
     7261 gtgtttattt cacaagtcac cagcattatt ttataattct gagcaaccta actatcttct
     7321 tggagagaaa cttgctagcc aacagtttta tctgacaatt tcattaatgc tgctgtaaaa
     7381 aaaatgcaac taacatttta atgaggttct tcttgatatt atctatgttc agagagtttt
     7441 gcccttagga agctcctaga attagtagca atagcagaat attctccatt tcaaaacttg
     7501 catattttga acacagacac tgaccttgaa tttctgtttc tgttgatgag tttcagtaca
     7561 atggtattga gggtcagtag ttttcaacat gttgaaattt tgcaagcata agcatcaggt
     7621 atgttttcta tttgtgctgc acaagataaa aaaaacctag gtagttatgt ttcactaatg
     7681 cagtgctgga tgcctggaga acttaatttg tcttccttct ctggtaagac ttgaaccctg
     7741 aatttcatag catgtagttc ttattgtgta gtgagactta catggtagtc gtgcactggg
     7801 aaaggaggat tttagttatt agttcagaat tcagttgata ccatcatcct ctttatttta
     7861 atatgtctgg atttactttg ctaaaatgtg tttgtaagtt ttatctaaat atttagccta
     7921 ctaacttttt ctttttatgt ctaggagtag aaatattcat atgtgtgctg gtatgtttgt
     7981 agtaatgtat taggtactgt atataaatgt gtttagcttt actttcattc ttctgtaaac
     8041 atccttaact ggtcctggtg aaatcacttt agcccagtgg tagccagttt acccttaggg
     8101 ttatgttgac aactgtcctt tggtctatgc ttcagttata acttataaac ttgctatgct
     8161 ctgtgttggt tctagaccat gttttcccat gaccttggag cattctccat attgcaggag
     8221 catggtacct atgttctggc ggtctcagta tgaaaacatt gctgcctaca caaagacgtt
     8281 ttctggctcc tcacctctgg ctgagttctt taccctggca ttgtgatgtt gaaccttgag
     8341 gaaggtgatg ggtatatttt gtacaaatat gacacgatat cttatattga gtggtgaata
     8401 cttaaagggc aaggcggcct ggctatacag atgctgaatg atgagttgtg agcacggcag
     8461 agatgtatct tcagattcct tggcactggt atacaaacac gggatgtgtg agggtgaagt
     8521 aggttctgta gttaatgact tccctctctg gagagtgctg ctgtaacaaa ctcattgcta
     8581 gatggtgttt gcgggctatt tgtatgactg ggaaaccaca gcgaaacaag tgtacttcct
     8641 gacgagaatt cttgtttatc ttttcatatg gatgcatttt ggtgcagtat gatgtcactc
     8701 caatttgcat tgttgaatta tatttcagtt gtatttgtgg agctggccac ttgtgcttcc
     8761 agctgcttct ctgtatgtct gtcttctcta tatttttact tgaaaaccct tcaaatggac
     8821 atttgaataa atatttgata gtttacatat taaacaccat gtttcttttc gataataaat
     8881 accactttaa actgaa
//
