LOCUS       NM_053726               1938 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 10 (Slc7a10),
            mRNA.
ACCESSION   NM_053726 XM_346540
VERSION     NM_053726.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Billard,J.M. and Freret,T.
  TITLE     Asc-1 transporter activation: an alternative to rescue age-related
            alterations in functional plasticity at rat hippocampal CA3/CA1
            synapses
  JOURNAL   J Neurochem 147 (4), 514-525 (2018)
   PUBMED   30187927
  REMARK    GeneRIF: Asc-1 activation significantly increased NMDA-R-dependent
            long-term potentiation (LTP) in both groups of animals and fully
            rescued the age-related LTP deficits
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Maucler,C., Pernot,P., Vasylieva,N., Pollegioni,L. and Marinesco,S.
  TITLE     In vivo D-serine hetero-exchange through alanine-serine-cysteine
            (ASC) transporters detected by microelectrode biosensors
  JOURNAL   ACS Chem Neurosci 4 (5), 772-781 (2013)
   PUBMED   23581544
  REMARK    GeneRIF: D-serine heteroexchange through ASC transporters, in
            particular high affinity ASC1, is present in vivo and may
            constitute a key component in the regulation of D-serine
            extracellular concentration.
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Rutter,A.R., Fradley,R.L., Garrett,E.M., Chapman,K.L.,
            Lawrence,J.M., Rosahl,T.W. and Patel,S.
  TITLE     Evidence from gene knockout studies implicates Asc-1 as the primary
            transporter mediating d-serine reuptake in the mouse CNS
  JOURNAL   Eur J Neurosci 25 (6), 1757-1766 (2007)
   PUBMED   17432963
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Matsuo,H., Kanai,Y., Tokunaga,M., Nakata,T., Chairoungdua,A.,
            Ishimine,H., Tsukada,S., Ooigawa,H., Nawashiro,H., Kobayashi,Y.,
            Fukuda,J. and Endou,H.
  TITLE     High affinity D- and L-serine transporter Asc-1: cloning and
            dendritic localization in the rat cerebral and cerebellar cortices
  JOURNAL   Neurosci Lett 358 (2), 123-126 (2004)
   PUBMED   15026164
  REMARK    GeneRIF: Localization of Asc-1 in brain suggests the significant
            contribution of Asc-1 to amino acid mobilization in brains,
            including synaptic clearance of D-serine and neuronal uptake of
            L-serine essential for survival and dendrite growth of Purkinje
            neurons.
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Nakauchi,J., Matsuo,H., Kim,D.K., Goto,A., Chairoungdua,A.,
            Cha,S.H., Inatomi,J., Shiokawa,Y., Yamaguchi,K., Saito,I., Endou,H.
            and Kanai,Y.
  TITLE     Cloning and characterization of a human brain Na(+)-independent
            transporter for small neutral amino acids that transports D-serine
            with high affinity
  JOURNAL   Neurosci Lett 287 (3), 231-235 (2000)
   PUBMED   10863037
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Fukasawa,Y., Segawa,H., Kim,J.Y., Chairoungdua,A., Kim,D.K.,
            Matsuo,H., Cha,S.H., Endou,H. and Kanai,Y.
  TITLE     Identification and characterization of a Na(+)-independent neutral
            amino acid transporter that associates with the 4F2 heavy chain and
            exhibits substrate selectivity for small neutral D- and L-amino
            acids
  JOURNAL   J Biol Chem 275 (13), 9690-9698 (2000)
   PUBMED   10734121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB126813.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_346540.1, NM_053726.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB126813.1, BC127467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1938
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /note="solute carrier family 7 member 10"
                     /db_xref="GeneID:114518"
                     /db_xref="RGD:621672"
     exon            1..222
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1646
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /note="D- and L-serine transporter Asc-1; D-serine
                     transporter; solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 10; solute carrier family
                     7, (neutral amino acid transporter, y+ system) member 10;
                     solute carrier family 7 (neutral amino acid transporter
                     light chain, asc system), member 10"
                     /codon_start=1
                     /product="asc-type amino acid transporter 1"
                     /protein_id="NP_446178.2"
                     /db_xref="GeneID:114518"
                     /db_xref="RGD:621672"
                     /translation="MRRDSDMTGHIQQPGGRGNPSPAPSPSPGPGPGPGASERVALKK
                     EIGLVSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAEL
                     GVTIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNC
                     IPPATASRVLSMACLMLLTWVNSSSVRWATRIQVIFTGGKLLALSLIITVGFVQIFQG
                     HFEELRPTNAFTFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEELVDPRKNLPRAIF
                     ISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFG
                     GINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYT
                     LINYVSFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLIPVVYLVFWAFLLVFSFIS
                     EPMVCGVGIIIILTGVPIFFLGVFWRSKPKCVHRFTESMTRWGQELCFVVYPQGSLEE
                     EENGPMGQPSPLPITDKPLKTQ"
     exon            223..427
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..579
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..705
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..859
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..983
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1087
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1184
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1334
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1512
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1879
                     /gene="Slc7a10"
                     /gene_synonym="Asc-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgacggagg actggcggcg ggccggatag acggggtagc gcagagagct gggatgaggc
       61 gggacagcga catgacaggc catatacagc agccaggcgg gcgcgggaac cccagccctg
      121 cgccctcgcc ctccccgggc cctggtcctg gcccgggcgc ctcggagcgg gtggcactca
      181 agaaagagat cgggctggtg agcgcctgca ccatcatcat cgggaacatc attggctcgg
      241 gtatcttcat ctcaccgaag ggcgtcctgg aacactcggg ctccgtgggt ttggccctct
      301 tcgtctgggt cctgggtggg ggcgtgacag ctctaggctc tctctgctat gcagagctgg
      361 gcgtcaccat ccccaagtct ggtggggact acgcctatgt cactgagatc ttcgggggcc
      421 tggctggatt cctgctgctc tggagtgctg tcctcatcat gtaccccacc agcctggctg
      481 tcatctccat gacattctcc aactatgtgc ttcagcctgt ctttcccaac tgtatccccc
      541 cagccacagc ctctcgagta ctctccatgg cctgcctgat gctcctgaca tgggtgaaca
      601 gctccagcgt acgctgggcc acgcgcatcc aggttatctt cactggcggg aagctgttgg
      661 cgttgtctct catcatcacc gtgggctttg tccagatctt ccaaggacac tttgaagagc
      721 tgagacccac caatgccttc accttctgga tgacaccgtc tgtgggtcac ctagccctgg
      781 ctttcctcca aggttctttt gccttcagtg gttggaactt cctcaactat gtcaccgagg
      841 agctggttga ccctcgaaag aacctacctc gtgccatctt catttccatc ccactggtca
      901 cctttgtgta cacattcacc aatgttgcct acttcactgc catgtccccc caggagctgc
      961 tgtcctccaa cgcagtggct gtgaccttcg gcgagaagct gctgggctac ttttcgtggg
     1021 tcatgcctgt gtctgtggcg ctgtctactt ttggagggat caatggctac ctgttcacct
     1081 catccaggct atgtttctct ggagcccgag agggacactt acccagcttt ctggccatga
     1141 ttcatgtcag acgctgtacc ccaatccctg ccctccttgt ctgttgcggg gccacagcgg
     1201 tcatcatgct cgtgggtgac acatacacac tcatcaacta tgtgtccttc atcaactacc
     1261 tctgctacgg agtcactatc ctgggcctgc ttgtgctgcg ctggagacgg ccggcacttc
     1321 acaggcccat taaggtgaac ctcctcattc ctgttgtgta cttggtgttc tgggcattcc
     1381 tcctggtctt cagcttcatc tcggagccca tggtctgtgg ggtcggcatc atcattatcc
     1441 tcactggggt ccccatcttc ttcctgggag tgttctggag aagcaaacca aagtgtgtac
     1501 acagattcac agagtccatg acacgctggg gccaggagct gtgtttcgtg gtttaccccc
     1561 agggctccct ggaggaggag gaaaatggcc ccatgggcca gccctcccca ttgcccatca
     1621 cggacaagcc cttgaagaca caatgagacc tagtagagac tggaacagct gattctgttt
     1681 acatgttgtt tattgagaag gggtttgtgt tctgttttgt tttcaaaaat ttttttttct
     1741 gcacaaaaaa agagacccga cccttagagg cctattgtaa gggactggcc actggggtcg
     1801 ggcttcctgc cttagcaatg ccctgctagc ttctccagaa aagtctgtaa ataaacaggg
     1861 ctggttgttc tgtgtgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaa
//
