LOCUS       NM_001399982            6542 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 7 member 1 (Slc7a1), mRNA.
ACCESSION   NM_001399982
VERSION     NM_001399982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6542)
  AUTHORS   Tachikawa,M., Hirose,S., Akanuma,S.I., Matsuyama,R. and Hosoya,K.I.
  TITLE     Developmental changes of l-arginine transport at the blood-brain
            barrier in rats
  JOURNAL   Microvasc Res 117, 16-21 (2018)
   PUBMED   29247719
REFERENCE   2  (bases 1 to 6542)
  AUTHORS   Tun,T. and Kang,Y.S.
  TITLE     Effects of simvastatin on CAT-1-mediated arginine transport and NO
            level under high glucose conditions in conditionally immortalized
            rat inner blood-retinal barrier cell lines (TR-iBRB)
  JOURNAL   Microvasc Res 111, 60-66 (2017)
   PUBMED   28089735
  REMARK    GeneRIF: In the presence of high-glucose levels, increased
            l-arginine uptake due to simvastatin treatment was associated with
            increased CAT-1 and eNOS mRNA levels, leading to higher NO
            production in immortalized rat inner blood-retinal barrier cell
            lines.
REFERENCE   3  (bases 1 to 6542)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   4  (bases 1 to 6542)
  AUTHORS   Zakoji,N., Akanuma,S., Tachikawa,M. and Hosoya,K.
  TITLE     Involvement of cationic amino acid transporter 1 in L-arginine
            transport in rat retinal pericytes
  JOURNAL   Biol Pharm Bull 38 (2), 257-262 (2015)
   PUBMED   25747984
  REMARK    GeneRIF: CAT1 is involved in L-Arg uptake by retinal pericytes and
            this is expected to play an important role in the relaxation of
            retinal pericytes, thereby modulating the microcirculatory
            hemodynamics in the retina
REFERENCE   5  (bases 1 to 6542)
  AUTHORS   Yaman,I., Fernandez,J., Liu,H., Caprara,M., Komar,A.A.,
            Koromilas,A.E., Zhou,L., Snider,M.D., Scheuner,D., Kaufman,R.J. and
            Hatzoglou,M.
  TITLE     The zipper model of translational control: a small upstream ORF is
            the switch that controls structural remodeling of an mRNA leader
  JOURNAL   Cell 113 (4), 519-531 (2003)
   PUBMED   12757712
REFERENCE   6  (bases 1 to 6542)
  AUTHORS   Fernandez,J., Yaman,I., Sarnow,P., Snider,M.D. and Hatzoglou,M.
  TITLE     Regulation of internal ribosomal entry site-mediated translation by
            phosphorylation of the translation initiation factor eIF2alpha
  JOURNAL   J Biol Chem 277 (21), 19198-19205 (2002)
   PUBMED   11877448
REFERENCE   7  (bases 1 to 6542)
  AUTHORS   Aulak,K.S., Liu,J., Wu,J., Hyatt,S.L., Puppi,M., Henning,S.J. and
            Hatzoglou,M.
  TITLE     Molecular sites of regulation of expression of the rat cationic
            amino acid transporter gene
  JOURNAL   J Biol Chem 271 (47), 29799-29806 (1996)
   PUBMED   8939918
REFERENCE   8  (bases 1 to 6542)
  AUTHORS   Kavanaugh,M.P., Wang,H., Zhang,Z., Zhang,W., Wu,Y.N., Dechant,E.,
            North,R.A. and Kabat,D.
  TITLE     Control of cationic amino acid transport and retroviral receptor
            functions in a membrane protein family
  JOURNAL   J Biol Chem 269 (22), 15445-15450 (1994)
   PUBMED   8195186
REFERENCE   9  (bases 1 to 6542)
  AUTHORS   Stoll,J., Wadhwani,K.C. and Smith,Q.R.
  TITLE     Identification of the cationic amino acid transporter (System y+)
            of the rat blood-brain barrier
  JOURNAL   J Neurochem 60 (5), 1956-1959 (1993)
   PUBMED   8473910
REFERENCE   10 (bases 1 to 6542)
  AUTHORS   Closs,E.I., Albritton,L.M., Kim,J.W. and Cunningham,J.M.
  TITLE     Identification of a low affinity, high capacity transporter of
            cationic amino acids in mouse liver
  JOURNAL   J Biol Chem 268 (10), 7538-7544 (1993)
   PUBMED   8385111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000224.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399982.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: D67087.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132262, SAMD00132275 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JACYVU010000224.1  2594859-2594938
            81-468              JACYVU010000224.1  2646998-2647385
            469-627             JACYVU010000224.1  2651176-2651334
            628-790             JACYVU010000224.1  2653292-2653454
            791-909             JACYVU010000224.1  2656156-2656274
            910-1132            JACYVU010000224.1  2656842-2657064
            1133-1272           JACYVU010000224.1  2658064-2658203
            1273-1375           JACYVU010000224.1  2661419-2661521
            1376-1593           JACYVU010000224.1  2663078-2663295
            1594-1760           JACYVU010000224.1  2663613-2663779
            1761-1869           JACYVU010000224.1  2664293-2664401
            1870-6542           JACYVU010000224.1  2665748-2670420
FEATURES             Location/Qualifiers
     source          1..6542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..6542
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /note="solute carrier family 7 member 1"
                     /db_xref="GeneID:25648"
                     /db_xref="RGD:3716"
     exon            1..80
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            81..468
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1973
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /note="cationic amino acid transporter, y+ system;
                     cationinc amino acid transporter 1; ERR; ecotropic
                     retrovirus receptor; ecotropic retroviral leukemia
                     receptor; system Y+ basic amino acid transporter; Solute
                     carrier family 7 member A1 (amino acid transporter
                     cationic 1); solute carrier family 7 (cationic amino acid
                     transporter, y+ system), member 1"
                     /codon_start=1
                     /product="high affinity cationic amino acid transporter 1"
                     /protein_id="NP_001386911.1"
                     /db_xref="GeneID:25648"
                     /db_xref="RGD:3716"
                     /translation="MGCKNLLSLGQQMLRRKVVDCSREESRLSRCLNTYDLVALGVGS
                     TLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSY
                     VTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGKPIGEFSRQHMALNAPGVL
                     AQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLVLCFIMVSGFVKGSIENWQ
                     LTENKSSPLCGNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKN
                     PQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDTDSPLPGAFKYRGWEEAKYAV
                     AVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINDRTKTPIIATVTSGAIAA
                     VMAFLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMARTTDELDQVDQ
                     NEMVSASESQTGFLPAAEKFSLKTILSPKNMEPSKFSGLIVNISAGLLAVLIITVCIV
                     AVLGREALAEGTLWAVFVMTGSVLLCMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSI
                     FVNIYLMMQLDQGTWVRFAVWMLIGFAIYFGYGVWHSEEASLAAGQAKTPDSNLDQCK
                     "
     exon            469..627
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            628..790
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            791..909
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1132
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1272
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1375
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1593
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1760
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1869
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..6542
                     /gene="Slc7a1"
                     /gene_synonym="Atrc1; Cat-1; CAT1; EcoR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccatccc ctcagctagc aggtgtgagc ggctttctgc ccgcagtctc tacacagctc
       61 agcatcctga cgcctcctcc acagatttgc tcagcgcgat gggctgcaaa aacctgttga
      121 gcctgggtca gcagatgctg cgccggaaag tggtggactg cagccgggag gagagccggc
      181 tgtcccgctg cctcaacacc tatgatctgg tagctcttgg ggtgggcagc accttgggtg
      241 ctggtgtcta cgtcctagcc ggtgcagtgg cccgtgagaa tgctggtcct gccatcgtca
      301 tctccttcct gatcgctgct cttgcctcag tgctggccgg cctgtgctat ggcgagtttg
      361 gtgcccgtgt ccccaagacg ggctcagcct acctctacag ctatgtgaca gtgggggagc
      421 tctgggcctt catcactggc tggaacctga ttctctccta catcatcggt acatccagcg
      481 tggcaagagc ctggagtgca acttttgacg agctgatagg caaacccatc ggagagttct
      541 cgcgtcaaca catggccctg aacgcccctg gggtgctggc ccaaaccccg gatatatttg
      601 ctgtgattat aattatcatc ctgacaggac tgttaactct cggtgtgaaa gaatcagcca
      661 tggtcaacaa aatcttcacc tgtatcaatg tcctggtctt gtgcttcatc atggtgtcgg
      721 gatttgtgaa aggctccatt gagaactggc agctcacgga gaataaatcc agtcctctct
      781 gtgggaacaa tgacacaaac gtgaaatacg gtgagggagg gttcatgccc tttggattct
      841 ctggtgtcct gtcaggggca gcgacctgct tttatgcctt cgtgggcttt gactgcatcg
      901 ccaccacagg ggaagaagtc aagaaccccc agaaggccat tcctgtgggc atcgtggcgt
      961 ccctcctcat ttgcttcata gcttactttg gggtgtccgc tgctctcacc ctcatgatgc
     1021 cctacttctg cctggacact gacagcccac tgcctggcgc cttcaagtac aggggctggg
     1081 aagaagctaa gtatgcagtg gccgtgggct ccctctgcgc actctccacc agtctcctag
     1141 gttccatgtt ccccatgccc cgagttatct atgccatggc tgaagatgga ctactgttta
     1201 aatttttggc caaaatcaac gataggacca aaacaccaat aatcgctact gtgacctcag
     1261 gcgccatcgc tgctgtgatg gccttcctct ttgaactgaa ggatctggtg gacctcatgt
     1321 ccattggtac tctcctggct tactctttgg tggctgcctg tgttttggtc ttacggtacc
     1381 agccagaaca acctaatctg gtataccaga tggccagaac caccgatgag ctagaccagg
     1441 tagaccagaa tgagatggtc agtgccagtg agtcccagac aggcttttta ccagcagccg
     1501 agaagttttc tctgaaaacc atactctcac ccaagaacat ggagccgtcc aaattctcag
     1561 ggctaattgt gaacatttca gccggcctcc tagccgttct tatcatcacc gtgtgcattg
     1621 tggccgtgct tggaagagag gccctggctg aagggacgct gtgggcagtc tttgtaatga
     1681 cagggtcagt cctcctctgc atgctggtga cgggcatcat ctggaggcag cctgagagca
     1741 agaccaagct ctcgtttaag gtaccctttg tccccgtact tcctgtctta agcatctttg
     1801 tgaacatcta tctcatgatg caactggacc agggcacgtg ggtccggttc gcagtgtgga
     1861 tgctgatagg ctttgccatc tactttggct atggggtctg gcacagtgag gaagcatccc
     1921 tggctgctgg ccaggcaaag actcctgaca gcaacttgga ccagtgcaaa tgacccatag
     1981 ccccacccac caaggtgaca gcggttgacg ggtgccggca gaggcctggg accctcacac
     2041 tctctcccct catgcctcgg gaccagctca cacccccaat gtcaccaaag ctggtttgta
     2101 gcctcagcca tagctgacat ggcttggtca gacagccctg cagccagctc cagagatcct
     2161 ggtcacttct ggacagttcc ttggtttttc tcatctccct ctgaacaaag aaagcagccc
     2221 ttctccctgc cagctgggcg ctttgctgct tcggccccag cagaagggag gcccccttct
     2281 cctcttattc gggaagcagg cctccctcct tccctgggac caccctgcgt acactcatac
     2341 gtacactcca gagggttagt gggcgtctat ctccctgtca acccagccag gacagccacc
     2401 tgaccccaag atgcgagact agcccagtga ggaagctgtc tcccagcagt gcaacccaac
     2461 agcccatcaa ctccagaata cctagaggac caacaggccc gcatcttact gctttcaggc
     2521 tggggtatta ggatggggcc ctgatctgca tagaggcttc tgaaccaagc ccagcacagt
     2581 gtgagccatt ctcacgcgca gaaaacggga ggtccctgga gtgatcgatt gtatcaagac
     2641 tggatggcca gctctgctca cgtggacgag ggcgacattc tctagcctta ttcttagcag
     2701 gcctggatca gtttctgctg ctcttggcat ctgtcctcac tgtcctgagt cactggaaca
     2761 cgaggctata tcagtaggat tgtcattctc tcaggtcttc caaggtggtt cggacaggtg
     2821 gcactcaata cagggtggtg acactcttct aaccgctgac gcgaaggact gctgtggggg
     2881 tcctccagtc gcttgctgtg aatcactcca ctggattaac ttggggctca ctgttgttaa
     2941 tgttccaacc ttgggagatg gtcaaataat tacccagtgc catatcagct tgtggttcgt
     3001 gatgtgtgct ctgcacaaga ggtggcttgg ggtcctaccg ctatccctcc tgtagctgtg
     3061 gtgcctttgc ctgccgtgct actggtaaga tttctaccct ggcctggacc ttctgctccc
     3121 cgagtctgcc ttcatttccc ctcccccatg ctccttatct ctctgggtga ggccctaggg
     3181 cctacacctc ttcacttact ctgtgtagat agaaaggatg gtgagtgagt gctggtggat
     3241 tcctggaacc agcagggcac ccctcctcca cacccacgcc atgacaacag ggcggggaag
     3301 gctggtgtct tagactaata ttaatgctgt ttttaaagcc tagctttctt tcctgtctgg
     3361 cctttgaccc atgtctggtg gaaaccggcc gggtaaactg atgacactgt cttcccctct
     3421 gctctggaag gttcttggga atggccggag ttggtggaac tggcctggca cggaacctag
     3481 tggtggagca cttgcctagc atatgcaggg ccccagtgct acggaaaatt agagaaaccg
     3541 cccggttgct gtgtcagcca gtggagggta gcagagcagc caagagccag gcatcgtgcc
     3601 aggccctgac ccccatccag gcactttgtc tcctaggctg tctgagaaaa cttcaaaggg
     3661 agtattataa gaccctaaat gttgagtttc taaaggtatt taaagttatg tagattggtg
     3721 ctgtaaaata ttttgataaa tattaactta tttcgttcgg gtcttaatta cctgttgtct
     3781 tcttagggcc tgttagatat gtctgggttg gttttttttc ccccccttgt tacttacata
     3841 ggcagagaag gagtgcccag tgaggtgttg ggagaattag gtttcactct gtagctgccc
     3901 tagtctagcc tctgcctcag gctcctgagt gctaaggtcg taggtgtgag cctcctctcc
     3961 tcctgctaaa ctgtctcctc gctttctgga tgaaactttc ctgtctaagg cagctgaaca
     4021 atgtgtttac agttgacatt tcagccagca gcctggatcc caccaagggg aaaggtatat
     4081 atatatatat atatatatat atatatatat atatatatat atatatatat atatatgggt
     4141 ttgatccgcc gacagcaatg gtggcagatc tgctctgtgt gtttcactat gtgacacagg
     4201 agcaaacaca ggccttggct gggggtgggg gtggaggggt gacatcctat acccacttcc
     4261 tagtcaggaa aagatatgca ggggtgactt gcctagttag ttgattggcc actgagcttt
     4321 cactaagtgt ggacagttaa ccagggaagc tcttttgggg tgcacgggaa caatgaagct
     4381 tggagggagc ccctaatatg cttttttatt atgcccccag ttccttttcc tgaaaggaaa
     4441 acacaagccc caaacccaga caacacacat acacacatcc ctccggaccc acagtaggta
     4501 gggtcgagtc tcctagtctc ccgtccaaaa aagagtccca ttggatttca aagcgtggcc
     4561 agtatttcct acctggttgg gacttaaaca ttttaaagac aacttcccat gccttccctt
     4621 caactagagt gctcacattg gaaagaccca ttttctcagg agcctgtgcc cttccttctt
     4681 gtctctgggt cgaagttcat gaagaagcca atacccaggg agctgtgctt aggagtgggg
     4741 cccaagatgt ctccaccttt cagaaggtgg ccccagtggt ggcttggtgg ccagaagtga
     4801 ctgcaggacc gtggcaggac atcaggctcc tccacctgcc cctagtgggc aagggttgga
     4861 tatcccccct cccaaacccc ccctcctgag cacagccagc gtgtgcacac caaagggaat
     4921 atatgacaca ctccaccctg tccactacct gccactctca tgcacagggc tggggatacc
     4981 agtggctatg tttgtacgtt ggccctaacc ccaggcagac attctgaatt gggtagtgtt
     5041 catagtctcc tctaacaagg aacttgccca acgctggaag aagcttagaa acagcagtgt
     5101 gagggactgg gttcctggga taagcgtgga caagtcccac agaccccctc atatctaccg
     5161 gccaagccac gggcaccgct ggcctgtgta cctacctaca atgaaaacat ggctggctct
     5221 cgccggggcc catcctttct gacttgaatg tcgtatgtcc ccacagaaac ttatttcatt
     5281 ctaataaaag cttactgttt tcttggtacc caaacactaa agaatcttag tggggatctc
     5341 agtgccagga tacttgagtc caggtatggt tgaggtagcc aagtgagtgg ccaacagaga
     5401 atacatgagc catggaactg ctacagaagt caaagtcagc ggtgaatgta tgttatgtgc
     5461 ggttatttta tggagttcaa accgtcctgt ctgtttggcc tcctcgtgag aagattgtac
     5521 gtgaggctcc tggggggaga gtgaacggtc cattccttca gctcattttg gtgtgtggaa
     5581 tgcttttatt gacacagtgg tacaggtgaa atgtgcacca gtccaatgtg gttaggatga
     5641 aaattttaag gcaaaaagaa aaaaaaatca gctggttttc acctccctta ctctagccca
     5701 gtctggccgt atccgctgct ccattgaact ggaagaatat ggtgtggcca agggtcttgg
     5761 gacatggtga ccaaggagcc ttcctggacc atcctgttac atgtgctgaa tggctagcaa
     5821 aaaaagccca ggagagatga aaagaccacg tccaaaaaat gttctcaggg cgctggcgtg
     5881 tccagcaggg tcaggaagca agatttagga agagacatca tgcaaactaa tttattgaca
     5941 agtgttacct ttgcgttcct tgacaagctt ttttgcgttt gggacttatt ttcccatttg
     6001 agaagttata atatatcttt gtatttaagg tatttactgc tttgtttgtg ccttgcagct
     6061 tcgatgggtt taaggttcac agagggtcat gatactaatg agggctggtt tattagcaaa
     6121 cctgagcagt taagtggttt ctccaggaca atttttttac ttctactgaa cacagagcca
     6181 ttattaaaag agttatgtgt ggattttcat tatgtaaatt gtatatattt ttttgcttgt
     6241 tcgaggttct atttttctaa tagtcttctt acagtttctt acaatgacat tagattaagt
     6301 ccgatactaa ctgtaaatca agctggtctc tgttggattc ccgtggatta attctatttt
     6361 attttaaggc caagtgcagg tgtcgtccat caccctttta agaaatgtga aacttgtgtc
     6421 tcccctcgtg gctgaataca ttgtacactg gcaaaccccc tcccgtccct gtgtgtcaga
     6481 gctattttgt ggtacattgt gtcatgcttc tgcagatgct aataaatcct gtctggcttc
     6541 ca
//
