LOCUS       NM_053818               3253 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 9 (Slc6a9), mRNA.
ACCESSION   NM_053818
VERSION     NM_053818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3253)
  AUTHORS   Jimenez,E., Piniella,D., Gimenez,C. and Zafra,F.
  TITLE     Regulation of the Glycine Transporter GLYT1 by microRNAs
  JOURNAL   Neurochem Res 47 (1), 138-147 (2022)
   PUBMED   33484385
  REMARK    GeneRIF: Regulation of the Glycine Transporter GLYT1 by microRNAs.
REFERENCE   2  (bases 1 to 3253)
  AUTHORS   Shen,H.Y., van Vliet,E.A., Bright,K.A., Hanthorn,M., Lytle,N.K.,
            Gorter,J., Aronica,E. and Boison,D.
  TITLE     Glycine transporter 1 is a target for the treatment of epilepsy
  JOURNAL   Neuropharmacology 99, 554-565 (2015)
   PUBMED   26302655
  REMARK    GeneRIF: Study demonstrated a biphasic response of GlyT1 expression
            during epileptogenesis with initial downregulation of GlyT1 after
            epileptogenesis-precipitating seizures followed by sustained
            pathological overexpression of GlyT1 in chronic epilepsy
REFERENCE   3  (bases 1 to 3253)
  AUTHORS   Aroeira,R.I., Sebastiao,A.M. and Valente,C.A.
  TITLE     BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in
            astrocytes
  JOURNAL   Glia 63 (12), 2181-2197 (2015)
   PUBMED   26200505
  REMARK    GeneRIF: Study showed that glycine uptake mediated by GlyT1 and
            GlyT2 in astrocytes is modulated by BDNF
REFERENCE   4  (bases 1 to 3253)
  AUTHORS   Sipila,S.T., Spoljaric,A., Virtanen,M.A., Hiironniemi,I. and
            Kaila,K.
  TITLE     Glycine transporter-1 controls nonsynaptic inhibitory actions of
            glycine receptors in the neonatal rat hippocampus
  JOURNAL   J Neurosci 34 (30), 10003-10009 (2014)
   PUBMED   25057202
  REMARK    GeneRIF: Inhibition of GlyT1 reduces the frequency of spontaneous
            network events in the hippocampus.
REFERENCE   5  (bases 1 to 3253)
  AUTHORS   Cubelos,B., Leite,C., Gimenez,C. and Zafra,F.
  TITLE     Localization of the glycine transporter GLYT1 in glutamatergic
            synaptic vesicles
  JOURNAL   Neurochem Int 73, 204-210 (2014)
   PUBMED   24036061
  REMARK    GeneRIF: Double labeling for GLYT1 and synaptophysin of this
            vesicular fraction revealed that more of ninety percent of them
            were synaptic vesicles
REFERENCE   6  (bases 1 to 3253)
  AUTHORS   Borowsky,B. and Hoffman,B.J.
  TITLE     Analysis of a gene encoding two glycine transporter variants
            reveals alternative promoter usage and a novel gene structure
  JOURNAL   J Biol Chem 273 (44), 29077-29085 (1998)
   PUBMED   9786914
REFERENCE   7  (bases 1 to 3253)
  AUTHORS   Borowsky,B., Mezey,E. and Hoffman,B.J.
  TITLE     Two glycine transporter variants with distinct localization in the
            CNS and peripheral tissues are encoded by a common gene
  JOURNAL   Neuron 10 (5), 851-863 (1993)
   PUBMED   8494645
REFERENCE   8  (bases 1 to 3253)
  AUTHORS   Guastella,J., Brecha,N., Weigmann,C., Lester,H.A. and Davidson,N.
  TITLE     Cloning, expression, and localization of a rat brain high-affinity
            glycine transporter
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7189-7193 (1992)
   PUBMED   1353889
REFERENCE   9  (bases 1 to 3253)
  AUTHORS   Liu,Q.R., Nelson,H., Mandiyan,S., Lopez-Corcuera,B. and Nelson,N.
  TITLE     Cloning and expression of a glycine transporter from mouse brain
  JOURNAL   FEBS Lett 305 (2), 110-114 (1992)
   PUBMED   1618338
REFERENCE   10 (bases 1 to 3253)
  AUTHORS   Smith,K.E., Borden,L.A., Hartig,P.R., Branchek,T. and
            Weinshank,R.L.
  TITLE     Cloning and expression of a glycine transporter reveal
            colocalization with NMDA receptors
  JOURNAL   Neuron 8 (5), 927-935 (1992)
   PUBMED   1534013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 26, 2021 this sequence version replaced NM_053818.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128732.1, M95413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000005.1  136660076-136660244
            170-286             JAXUCZ010000005.1  136667843-136667959
            287-443             JAXUCZ010000005.1  136680519-136680675
            444-575             JAXUCZ010000005.1  136681351-136681482
            576-846             JAXUCZ010000005.1  136681846-136682116
            847-979             JAXUCZ010000005.1  136688251-136688383
            980-1114            JAXUCZ010000005.1  136688512-136688646
            1115-1218           JAXUCZ010000005.1  136688736-136688839
            1219-1456           JAXUCZ010000005.1  136689215-136689452
            1457-1591           JAXUCZ010000005.1  136689561-136689695
            1592-1691           JAXUCZ010000005.1  136689774-136689873
            1692-1792           JAXUCZ010000005.1  136689969-136690069
            1793-1963           JAXUCZ010000005.1  136692622-136692792
            1964-3253           JAXUCZ010000005.1  136692884-136694173
FEATURES             Location/Qualifiers
     source          1..3253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3253
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /note="solute carrier family 6 member 9"
                     /db_xref="GeneID:116509"
                     /db_xref="RGD:621243"
     exon            1..169
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..286
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2158
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /note="glycine transporter 1; solute carrier family 6
                     (neurotransmitter transporter, glycine), member 9"
                     /codon_start=1
                     /product="sodium- and chloride-dependent glycine
                     transporter 1"
                     /protein_id="NP_446270.1"
                     /db_xref="GeneID:116509"
                     /db_xref="RGD:621243"
                     /translation="MVGKGAKGMLNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYA
                     VGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRIS
                     PMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVL
                     DASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLL
                     GCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLT
                     PKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATS
                     VYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFML
                     ILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYW
                     LLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSP
                     TIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDT
                     LLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNG
                     SSRLQDSRI"
     exon            287..443
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..575
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..846
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..979
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1114
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1218
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1456
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1591
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1691
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1792
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1963
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..3253
                     /gene="Slc6a9"
                     /gene_synonym="GLYT-1; GLYT-1b; Glyt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaaaccaaa acacaacaag ctctggagga gcggcgagca acgcggcggg gcgggaggac
       61 tggcggctgc agagagcctc gggaggctga tgcaactttc cctttaagaa agccacctgg
      121 gcgcaccgcg gtgcggaccc agcacgcctg ggccgggggc tgcagtatgc tcttgaggcc
      181 tcttgtctga gaggcactga acgcaggagt ctgcaggtgt ggtccagatc tccagatccc
      241 ccaacccact gccaccatgg taggaaaagg tgccaaaggg atgctgaatg gtgctgtgcc
      301 cagcgaggcc accaagaagg accagaacct cacacggggc aactggggca accagatcga
      361 gtttgtactg acgagcgtgg gctatgccgt gggcctgggc aatgtgtggc gtttcccata
      421 cctctgctat cgcaacgggg gaggcgcctt catgtttccc tacttcatca tgctggtctt
      481 ctgcggcatt cctctcttct tcatggagct ctccttcggc cagtttgcaa gccagggctg
      541 cctgggggtc tggaggatca gccccatgtt caaaggcgtg ggctatggta tgatggtggt
      601 gtccacgtac atcggtatct actacaacgt ggtcatctgc atcgccttct actacttctt
      661 ctcgtccatg acgcatgtgc tgccctgggc ttactgcaat aatccctgga acacacctga
      721 ctgtgccggt gtgctggatg cttccaatct caccaatggc tcccggccca ctgccctgtc
      781 tggcaacctg tctcacctgt tcaactacac cttgcaaagg accagcccca gtgaggagta
      841 ctggaggctg tatgtgctga agctgtcgga tgacattgga gattttggag aagtgcggct
      901 tcctctccta ggctgccttg gcgtctcctg ggtggttgtc ttcctctgcc tcattcgagg
      961 agtcaagtct tcagggaaag tggtgtactt cacggccaca tttccctatg tggtgctgac
     1021 cattctgttt gttcgtggag tgaccctgga aggagccttc acgggtatca tgtactacct
     1081 gaccccaaag tgggacaaga tcctggaggc caaggtgtgg ggggatgcag cctctcagat
     1141 cttctattcc ctgggctgtg catggggtgg cctcatcacc atggcatcct acaacaaatt
     1201 ccacaacaac tgctaccggg acagcgtcat catcagcatc accaattgtg ctaccagtgt
     1261 ctatgctggc ttcgtcatct tctctatcct aggcttcatg gccaatcacc tgggtgtgga
     1321 tgtgtctcgg gtggcagacc acgggcccgg gctagctttc gtggcttacc ccgaggctct
     1381 cacactgctt cccatctccc cgctctggtc cttgctgttt ttcttcatgc tcatcctgct
     1441 gggactcggt actcagttct gcctcctgga gaccctagtc actgccattg tggatgaggt
     1501 ggggaatgag tggattctgc agaagaagac ctacgtgacc ttgggtgtgg ctgtggctgg
     1561 cttcttgctg ggtatccctc ttaccagcca ggcgggcatc tactggctgc tgttgatgga
     1621 caactacgca gccagcttct ccttggttgt catctcctgc atcatgtgcg tgtccatcat
     1681 gtatatctat gggcaccgga actacttcca ggacattcag atgatgctgg ggttcccacc
     1741 gcctctcttc ttccagatct gttggcgttt tgtctctccc actatcatct ttttcattct
     1801 catcttcacg gtgatccagt accggccaat cacttacaac cactaccagt acccaggctg
     1861 ggctgtggcc atcggcttcc tcatggcttt gtcgtctgtc atctgcatcc cattgtacgc
     1921 attgttccag ctctgccgca cagatgggga cacacttctt cagcgtttga aaaatgccac
     1981 aaagccaagc agagactggg gccctgccct cctggagcac cggactgggc gctatgcccc
     2041 cactacaacc ccctctcctg aagatgggtt tgaggttcag ccactgcacc cggacaaggc
     2101 ccagatcccc atcgtgggca gtaacggctc cagccgcctc caggactccc ggatatgagc
     2161 acagttgttg caaggggaga agccccaccc aacccttgct cctaccacag agactgagga
     2221 ggtggtggac cggtgtgact gcctgcccca tcatgccctg gccagggtgg ctgctgtcac
     2281 cttggccacc actgctcatg tccccagtgt ttacacatcc tttggatgcc aagacagcag
     2341 ctgggggtgg aaaagtgatg ggggtggggg ggaggtgcgt gggggtgggg catggggcgg
     2401 cagtgtccaa agcactttgg aggaggtctc aggccatgtc cccagaggcc ttccaggctt
     2461 cattatccct catgctctgc cctgagctgt ttcactacgg gataagaggt tttgtttcca
     2521 caccccacct gttcccctcc agcctcatga ccagtgttcc tgaccccaga acagacccta
     2581 gcctcttgcc caggcaaatc tgtatcttcc tgctccggac aaggtgaggg ccccgggggc
     2641 tgtacagtgt tacttgttgg actgcaccac tcagccctgt ttatttgtgt aattattttt
     2701 ttaaaaaatt gtattacctg tggttgccac ccccctgccc cagccttggg tccagtctgt
     2761 cttccaggcc tgcctgcacc tcacttggct gctccagggt cccttgtcct ttgttccaat
     2821 cctggttgtc aggcccagcc agcaaaggcc acgacccagc agcctgccca aagcacttgt
     2881 ttatggaggg aaagaagggg acttatctgt aggaagcttg agcccagagc cctggggaag
     2941 gggaccctgc acaacattcc cttgcccacc ctccaccagg ttgaaggccc agtcttccca
     3001 gacgtgctaa ccctattcaa tgtgccaaat ggccccagtc cacgtgcctg tccccccctc
     3061 tgcagtcaga gcaccttctc ccaagacctg cagtccgtgt gtccgtcctc tgtgccctct
     3121 gcagtgacag ccctggccaa gccccttcta atcctctgta gcaataacgg tgtgccgccc
     3181 gccgctgccc agcgtgcagc actcgggttt taaagtccgt aggttttaat gaaatttcta
     3241 ttcctgtctc tga
//
