LOCUS       NM_017206               2479 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 6 (Slc6a6), mRNA.
ACCESSION   NM_017206
VERSION     NM_017206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Ansar,M., Ranza,E., Shetty,M., Paracha,S.A., Azam,M., Kern,I.,
            Iwaszkiewicz,J., Farooq,O., Pournaras,C.J., Malcles,A., Kecik,M.,
            Rivolta,C., Muzaffar,W., Qurban,A., Ali,L., Aggoun,Y.,
            Santoni,F.A., Makrythanasis,P., Ahmed,J., Qamar,R., Sarwar,M.T.,
            Henry,L.K. and Antonarakis,S.E.
  TITLE     Taurine treatment of retinal degeneration and cardiomyopathy in a
            consanguineous family with SLC6A6 taurine transporter deficiency
  JOURNAL   Hum Mol Genet 29 (4), 618-623 (2020)
   PUBMED   31903486
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Tachikawa,M., Yokoyama,R., Akanuma,S.I. and Hosoya,K.I.
  TITLE     Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger
            Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by
            Increasing the Maximum Transport Velocity
  JOURNAL   Biol Pharm Bull 41 (3), 338-341 (2018)
   PUBMED   29491210
  REMARK    GeneRIF: The purpose of this study was to clarify the assembly of
            taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ)
            domain of Na(+)-H(+) exchanger regulatory factor 1 as a regulatory
            mechanism of Slc6a6-mediated GABA transport activity
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Oenarto,J., Gorg,B., Moos,M., Bidmon,H.J. and Haussinger,D.
  TITLE     Expression of organic osmolyte transporters in cultured rat
            astrocytes and rat and human cerebral cortex
  JOURNAL   Arch Biochem Biophys 560, 59-72 (2014)
   PUBMED   25004465
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Ubhi,K., Rockenstein,E., Kragh,C., Inglis,C., Spencer,B.,
            Michael,S., Mante,M., Adame,A., Galasko,D. and Masliah,E.
  TITLE     Widespread microRNA dysregulation in multiple system atrophy -
            disease-related alteration in miR-96
  JOURNAL   Eur J Neurosci 39 (6), 1026-1041 (2014)
   PUBMED   24304186
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Zhou,Y., Holmseth,S., Guo,C., Hassel,B., Hofner,G., Huitfeldt,H.S.,
            Wanner,K.T. and Danbolt,N.C.
  TITLE     Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and
            SLC6A13) gene in mice leads to changes in liver and brain taurine
            contents
  JOURNAL   J Biol Chem 287 (42), 35733-35746 (2012)
   PUBMED   22896705
REFERENCE   6  (bases 1 to 2479)
  AUTHORS   Heller-Stilb,B., van Roeyen,C., Rascher,K., Hartwig,H.G., Huth,A.,
            Seeliger,M.W., Warskulat,U. and Haussinger,D.
  TITLE     Disruption of the taurine transporter gene (taut) leads to retinal
            degeneration in mice
  JOURNAL   FASEB J 16 (2), 231-233 (2002)
   PUBMED   11772953
REFERENCE   7  (bases 1 to 2479)
  AUTHORS   Remmers,E.F., Griffiths,M.M., Longman,R.E., Gulko,P.S.,
            Kawahito,Y., Chen,S., Chang,L., Shepard,J., Ge,L., Dracheva,S.,
            Wang,J.P., Joe,B., Cannon,G.W. and Wilder,R.L.
  TITLE     An integrated rat genetic map: analysis of linkage conservation
            with the mouse and human maps
  JOURNAL   Transplant Proc 31 (3), 1549-1554 (1999)
   PUBMED   10330996
REFERENCE   8  (bases 1 to 2479)
  AUTHORS   Vinnakota,S., Qian,X., Egal,H., Sarthy,V. and Sarkar,H.K.
  TITLE     Molecular characterization and in situ localization of a mouse
            retinal taurine transporter
  JOURNAL   J Neurochem 69 (6), 2238-2250 (1997)
   PUBMED   9375654
REFERENCE   9  (bases 1 to 2479)
  AUTHORS   Liu,Q.R., Lopez-Corcuera,B., Nelson,H., Mandiyan,S. and Nelson,N.
  TITLE     Cloning and expression of a cDNA encoding the transporter of
            taurine and beta-alanine in mouse brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12145-12149 (1992)
   PUBMED   1465453
REFERENCE   10 (bases 1 to 2479)
  AUTHORS   Smith,K.E., Borden,L.A., Wang,C.H., Hartig,P.R., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Cloning and expression of a high affinity taurine transporter from
            rat brain
  JOURNAL   Mol Pharmacol 42 (4), 563-569 (1992)
   PUBMED   1435737
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017206.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96601.1, SRR26643429.17298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000004.1  125752502-125752572
            72-115              JAXUCZ010000004.1  125767017-125767060
            116-355             JAXUCZ010000004.1  125790655-125790894
            356-490             JAXUCZ010000004.1  125792189-125792323
            491-725             JAXUCZ010000004.1  125793343-125793577
            726-858             JAXUCZ010000004.1  125801609-125801741
            859-993             JAXUCZ010000004.1  125806867-125807001
            994-1097            JAXUCZ010000004.1  125808012-125808115
            1098-1222           JAXUCZ010000004.1  125808236-125808360
            1223-1335           JAXUCZ010000004.1  125811920-125812032
            1336-1473           JAXUCZ010000004.1  125815411-125815548
            1474-1576           JAXUCZ010000004.1  125816847-125816949
            1577-1677           JAXUCZ010000004.1  125817395-125817495
            1678-1848           JAXUCZ010000004.1  125819142-125819312
            1849-2479           JAXUCZ010000004.1  125821838-125822468
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2479
                     /gene="Slc6a6"
                     /note="solute carrier family 6 member 6"
                     /db_xref="GeneID:29464"
                     /db_xref="RGD:61912"
     exon            1..71
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            72..115
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            116..355
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1992
                     /gene="Slc6a6"
                     /note="Solute carrier 6, member 6 (taurine transporter);
                     taurine/beta-alanine transporter; solute carrier family 6
                     (neurotransmitter transporter, taurine), member 6; solute
                     carrier family 6 (neurotransmitter transporter), member 6"
                     /codon_start=1
                     /product="sodium- and chloride-dependent taurine
                     transporter"
                     /protein_id="NP_058902.1"
                     /db_xref="GeneID:29464"
                     /db_xref="RGD:61912"
                     /translation="MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEADGKPPQREKW
                     SSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIG
                     QYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKDLPWA
                     HCNHSWNTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLSLSSGIDHPGSLKW
                     DLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKF
                     YLYPNISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNS
                     GTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFF
                     IMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSISYLLGLTMVTEG
                     GMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSW
                     AVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLVIVILLC
                     RTEGPLRVRIKYLITPREPNRWAVEREGATPFHSRATLMNGALMKPSHVIVETMM"
     exon            356..490
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            491..725
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            726..858
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            859..993
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1097
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1222
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1335
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1473
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1576
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1677
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1848
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2479
                     /gene="Slc6a6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaacgccg cgatcgccgc caatcccgcc agcctcgggc cgggccatcc gctgtgggct
       61 tagccaccca ggtgcagagc cagtgccaca gcctcttcag aggagcctct caagcaaaac
      121 gaggagatgg ccaccaagga gaagcttcaa tgtctgaaag acttccacaa agacatcctg
      181 aagccttctc cagggaagag cccaggcacg cggcctgagg atgaggctga tgggaagccc
      241 cctcagaggg agaagtggtc cagcaagatc gactttgtgc tgtctgtggc cggaggcttc
      301 gtgggtttgg gcaatgtctg gcgtttcccg tacctctgct acaaaaatgg tggaggtgca
      361 ttcctcatac cgtattttat tttcctgttt gggagcggcc tgcctgtgtt tttcctggag
      421 gtcatcatag gccagtacac ctcagaaggg ggcatcacct gctgggagaa gatctgcccc
      481 ttgttctctg gcattggcta cgcgtccatc gtcatcgtgt ccctcctgaa tgtgtactac
      541 atcgtcatcc tggcctgggc cacatactac ctattccagt ctttccagaa ggatcttccc
      601 tgggcccact gcaaccatag ctggaacacg ccacagtgca tggaggacac cctgcgtagg
      661 aacgagagtc actgggtctc ccttagcgcc gccaacttca cttcgcctgt gatcgagttc
      721 tgggagcgca acgtgctcag cctgtcctcc ggaatcgacc acccaggcag tctgaaatgg
      781 gacctcgcgc tctgcctcct cttagtctgg ctcgtctgtt ttttctgcat ctggaagggt
      841 gttcggtcca caggcaaggt tgtctacttc actgctactt tcccgtttgc catgcttctg
      901 gtgctgctgg tccgtggact gaccctgcca ggtgctggtg aaggcatcaa attctacctg
      961 taccctaaca tcagccgcct tgaggaccca caggtgtgga tcgacgctgg aactcagata
     1021 ttcttttcct acgctatctg cctgggggcc atgacctcac tgggaagcta taacaagtac
     1081 aagtataact cgtacaggga ctgtatgctg ctgggatgcc tgaacagtgg taccagtttt
     1141 gtgtctggct tcgcaatttt ttccatcctg ggcttcatgg cacaagagca aggggtggac
     1201 attgctgatg tggctgagtc aggtcctggc ttggccttca ttgcctaccc aaaagctgtg
     1261 accatgatgc cgctgcccac cttttggtcc attctgtttt ttattatgct cctcttgctt
     1321 ggactggaca gccagtttgt tgaagtcgaa ggacagatca catccttggt tgatctttac
     1381 ccgtccttcc taaggaaggg ttatcgtcgg gaaatcttca ttgccatcgt gtgcagcatc
     1441 agctacctgc tggggctgac gatggtgacg gagggtggca tgtatgtgtt tcaactcttt
     1501 gactactatg cagctagtgg tgtatgcctt ttgtgggtcg cattctttga atgttttgtt
     1561 attgcctgga tatatggcgg tgataactta tatgacggta ttgaggacat gatcggctat
     1621 cggcctggac cctggatgaa gtacagctgg gctgtcatca ctccagctct ctgtgttgga
     1681 tgtttcatct tctctctcgt caagtatgta cccctgacct acaacaaagt ctaccggtac
     1741 cctgattggg caatcgggct gggctggggc ctggcccttt cctccatggt gtgtatcccc
     1801 ttggtcattg tcatcctcct ctgccggacg gagggaccgc tccgcgtgag aatcaaatac
     1861 ctgataaccc ccagggagcc caaccgctgg gctgtggagc gtgaaggggc tacgcccttt
     1921 cactccagag caaccctcat gaacggtgca ctcatgaaac ccagtcacgt cattgtggag
     1981 accatgatgt gaggtccggg ctgtgtgacc ggcgccgctt tcctgccgtt tactaacctt
     2041 agattctcct aggaccaggt ttacagagct ttatatttgt actaggattt tttttttaat
     2101 tgtcacagaa aatgttactc tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2161 tgtttcgtgt gtgtctgtat atgtgtattt tgttttgttt gggggattat tttgtacaaa
     2221 aagaaaaccc atgggcctat gtcctggggg gagaggatgg actttcatat tgattttgat
     2281 gtattttatg ggaacttggt aaatttttct ttgtattttt ttaacatata actatatata
     2341 gagtctgtca tacactttgc cacttgaatt ggtcttgcca gcaacggatc tcgttttttg
     2401 ttttttgttt ttttttcaaa agcaattctt cggtgcttac atagctggca gagagttctg
     2461 cccaaaaaca aatgaaaaa
//
