LOCUS       NM_013034               2665 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 4 (Slc6a4), mRNA.
ACCESSION   NM_013034 XM_001080660 XM_001080667
VERSION     NM_013034.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Boillot,M., Ter Horst,J., Lopez,J.R., Di Fazio,I., Steens,I.L.M.,
            Cohen,M.X. and Homberg,J.R.
  TITLE     Serotonin transporter knockout in rats reduces beta- and gamma-band
            functional connectivity between the orbitofrontal cortex and
            amygdala during auditory discrimination
  JOURNAL   Cereb Cortex 34 (8) (2024)
   PUBMED   39128940
  REMARK    GeneRIF: Serotonin transporter knockout in rats reduces beta- and
            gamma-band functional connectivity between the orbitofrontal cortex
            and amygdala during auditory discrimination.
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Sun,M., Brivio,P., Shan,L., Docq,S., Heltzel,L.C.M.W.,
            Smits,C.A.J., Middelman,A., Vrooman,R., Spoelder,M.,
            Verheij,M.M.M., Buitelaar,J.K., Boillot,M., Calabrese,F.,
            Homberg,J.R. and Hanswijk,S.I.
  TITLE     Offspring's own serotonin transporter genotype, independently from
            the maternal one, increases anxiety- and depression-like behavior
            and alters neuroplasticity markers in rats
  JOURNAL   J Affect Disord 350, 89-101 (2024)
   PUBMED   38220097
  REMARK    GeneRIF: Offspring's own serotonin transporter genotype,
            independently from the maternal one, increases anxiety- and
            depression-like behavior and alters neuroplasticity markers in
            rats.
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Ngoupaye,G.T., Mokgokong,M., Madlala,T. and Mabandla,M.V.
  TITLE     Alteration of the alpha5 GABA receptor and 5HTT lead to cognitive
            deficits associated with major depressive-like behaviors in a
            14-day combined stress rat model
  JOURNAL   Int J Neurosci 133 (9), 959-976 (2023)
   PUBMED   34937496
  REMARK    GeneRIF: Alteration of the alpha5 GABA receptor and 5HTT lead to
            cognitive deficits associated with major depressive-like behaviors
            in a 14-day combined stress rat model.
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Yildirim,H., Efe Daskan,B., Aksoz,E., Sen,F. and Celebi,M.
  TITLE     Regional expression differences of SERT and TSPAN8 in hippocampus,
            cerebellum and cortex of wild-type young, adult and middle-aged
            rats
  JOURNAL   Gene 885, 147706 (2023)
   PUBMED   37572802
  REMARK    GeneRIF: Regional expression differences of SERT and TSPAN8 in
            hippocampus, cerebellum and cortex of wild-type young, adult and
            middle-aged rats.
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Thorne,B.N., Ellenbroek,B.A. and Day,D.J.
  TITLE     The serotonin reuptake transporter modulates mitochondrial copy
            number and mitochondrial respiratory complex gene expression in the
            frontal cortex and cerebellum in a sexually dimorphic manner
  JOURNAL   J Neurosci Res 100 (3), 869-879 (2022)
   PUBMED   35043462
  REMARK    GeneRIF: The serotonin reuptake transporter modulates mitochondrial
            copy number and mitochondrial respiratory complex gene expression
            in the frontal cortex and cerebellum in a sexually dimorphic
            manner.
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Ramamoorthy,J.D., Ramamoorthy,S., Papapetropoulos,A.,
            Catravas,J.D., Leibach,F.H. and Ganapathy,V.
  TITLE     Cyclic AMP-independent up-regulation of the human serotonin
            transporter by staurosporine in choriocarcinoma cells
  JOURNAL   J Biol Chem 270 (29), 17189-17195 (1995)
   PUBMED   7615516
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Ramamoorthy,S., Bauman,A.L., Moore,K.R., Han,H., Yang-Feng,T.,
            Chang,A.S., Ganapathy,V. and Blakely,R.D.
  TITLE     Antidepressant- and cocaine-sensitive human serotonin transporter:
            molecular cloning, expression, and chromosomal localization
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2542-2546 (1993)
   PUBMED   7681602
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Mayser,W., Betz,H. and Schloss,P.
  TITLE     Isolation of cDNAs encoding a novel member of the neurotransmitter
            transporter gene family
  JOURNAL   FEBS Lett 295 (1-3), 203-206 (1991)
   PUBMED   1765155
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Blakely,R.D., Berson,H.E., Fremeau,R.T. Jr., Caron,M.G., Peek,M.M.,
            Prince,H.K. and Bradley,C.C.
  TITLE     Cloning and expression of a functional serotonin transporter from
            rat brain
  JOURNAL   Nature 354 (6348), 66-70 (1991)
   PUBMED   1944572
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Hoffman,B.J., Mezey,E. and Brownstein,M.J.
  TITLE     Cloning of a serotonin transporter affected by antidepressants
  JOURNAL   Science 254 (5031), 579-580 (1991)
   PUBMED   1948036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M79450.1, CB736426.1, JAXUCZ010000010.1, BF548147.1 and AI547408.1.
            
            On Jul 7, 2012 this sequence version replaced NM_013034.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11024.1, X63995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                M79450.1           126-161
            37-448              CB736426.1         18-429
            449-700             M79450.1           573-824
            701-913             JAXUCZ010000010.1  62356525-62356737
            914-1562            M79450.1           826-1474
            1563-1775           JAXUCZ010000010.1  62356525-62356737
            1776-2127           M79450.1           1476-1827
            2128-2538           BF548147.1         31-441
            2539-2751           JAXUCZ010000010.1  62356525-62356737
            2752-3089           AI547408.1         1-338               c
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2665
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /note="solute carrier family 6 member 4"
                     /db_xref="GeneID:25553"
                     /db_xref="RGD:3714"
     exon            1..450
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2000
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /note="Solute carrier family 6 (neurotransmitter
                     transporter serotonin) member 4 (5-hydroxytryptamine
                     (serotonin) transporter); serotonin transporter; 5HTT; 5HT
                     transporter; solute carrier family 6 (neurotransmitter
                     transporter), member 4; solute carrier family 6
                     (neurotransmitter transporter, serotonin), member 4"
                     /codon_start=1
                     /product="sodium-dependent serotonin transporter"
                     /protein_id="NP_037166.2"
                     /db_xref="GeneID:25553"
                     /db_xref="RGD:3714"
                     /translation="METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQIS
                     NGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNI
                     WRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKG
                     IGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNI
                     TWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKT
                     SGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIF
                     FSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNE
                     DVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAV
                     LDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIE
                     AVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLF
                     QYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGD
                     IRMNAV"
     exon            451..585
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            586..805
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            806..944
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1079
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1183
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1311
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1424
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1556
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1656
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1757
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1925
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2650
                     /gene="Slc6a4"
                     /gene_synonym="SERT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctttccgt cttgtcccca taacccgaga ggagattcaa accaagaacc aagagctagc
       61 ctgggtcctc ggcagatggg aatccgcatc acttactgac cagcagcatg gagaccacac
      121 ccttgaattc tcagaaagtg ctgtcagagt gtaaggacag agaggactgt caagaaaatg
      181 gtgttctaca gaagggtgtc cccaccacag cggacagggc agagcctagc caaatatcca
      241 atgggtactc tgcagtcccc agcacaagtg caggggacga agcttcacac tcgatcccag
      301 ctgccaccac caccctggtg gctgagattc gccaagggga gcgggagacc tggggcaaga
      361 agatggattt cctcctgtcc gtcattggct atgccgtgga cctgggcaac atctggcggt
      421 ttccttacat atgctaccag aatggcggag gggccttcct cctcccttat accatcatgg
      481 ccattttcgg ggggatcccg ctcttttaca tggagctcgc actgggccag taccaccgaa
      541 acgggtgcat ttccatatgg aggaagatct gcccgatttt caaaggcatt ggttacgcca
      601 tctgcatcat cgccttttac atcgcctcct actacaacac catcatagcc tgggcgctct
      661 actacctcat ctcctccctc acggaccggc tgccctggac tagctgcacg aactcctgga
      721 acactggcaa ctgcaccaac tacttcgccc aggacaacat cacctggacg ctgcattcca
      781 cgtcccccgc tgaggagttc tacttgcgcc atgtcctgca gatccaccag tctaagggac
      841 tccaggacct gggcaccatc agctggcagc tgactctctg catcgtgctc atcttcaccg
      901 taatctactt tagcatctgg aaaggcgtca aaacatctgg caaggtggtg tgggtgacag
      961 ccaccttccc atacattgtc ctctctgtcc tgctggtgag gggggccacc cttcctggag
     1021 cctggagagg ggtcgtcttc tacttgaaac ccaactggca gaaactcttg gagacagggg
     1081 tgtgggtaga tgccgccgct cagatcttct tctctcttgg cccgggcttt ggggttctcc
     1141 tggcttttgc tagctacaac aagttcaaca acaactgtta ccaagatgcc ctggtgacca
     1201 gtgtggtgaa ctgcatgaca agcttcgtct ctggcttcgt catcttcacg gtgcttggct
     1261 acatggcgga gatgaggaat gaagatgtgt cagaggtggc caaagacgca ggccccagcc
     1321 tcctcttcat cacgtatgca gaggcaatag ccaacatgcc agcatccacg ttctttgcca
     1381 tcatcttctt cctcatgtta atcacgctgg gattggacag cacgttcgca ggcctggaag
     1441 gtgtgatcac agctgtgctg gatgagttcc ctcacatctg ggccaagcgc agggaatggt
     1501 tcgtgctcat cgtggtcatc acgtgcgtct tgggatccct gctcacactg acgtcaggag
     1561 gggcatacgt ggtgactctg ctggaggagt atgccacggg gccagcagtg ctcaccgtgg
     1621 ccctcatcga ggccgtcgcc gtgtcttggt tctatggaat cactcagttc tgcagcgatg
     1681 tgaaggagat gctgggcttc agcccgggat ggttttggag gatctgctgg gtggccatca
     1741 gccctctgtt tctcctgttc atcatttgca gttttctgat gagcccaccc cagctacggc
     1801 ttttccaata caactatccc cactggagta tcgtcttggg ctactgcata gggatgtcgt
     1861 ccgtcatctg catccctacc tatatcattt atcggctgat cagcactccg gggacactta
     1921 aggagcgcat tattaaaagt atcactcctg aaacacccac agaaatcccg tgtggggaca
     1981 tccgcatgaa tgctgtgtaa cacaccctgg gagaggacac ctcttcccag ccacctctct
     2041 cagctctgaa aagccccact ggactcctcc cctctaagcc aagcctgatg aagacacggt
     2101 cctaaccact atggtgccca gactcttgtg gattccgacc acttctttcc gtggactctc
     2161 agacatgcta ccacattcga tggtgacacc actgagctgg cctcttggac acgtcaggga
     2221 gtggaaggag ggatgaacgc cacccagtca tcagctagct tcaggtttag aattaggtct
     2281 gtgagagtct gtatcatgtt tttggtaaga tcatactacc ccgcatctgt tagcttctaa
     2341 agccttcaat gttcatgaat acataaacca cctaagagaa aacagagatg tcttgctagc
     2401 catatatatt ttctcggtag catagaattc tatagctgga atctcctaga accctgtaac
     2461 ccacgtgctg ctgtgaggtt aaggagggaa ggtgtaagga ttgctacact gaaaaaatgg
     2521 tgtatatgtg tgagctattg tgtctgtcca ttatcgtctg tgagccctcg atcccaatac
     2581 tccaggtcca tttcaaactg tataaatggc ctctaatttt tcttacatta aacagattct
     2641 acctactcaa aaaaaaaaaa aaaaa
//
