LOCUS       NM_012694               1985 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 3 (Slc6a3), mRNA.
ACCESSION   NM_012694
VERSION     NM_012694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Hynes,T., Fouyssac,M., Puaud,M., Joshi,D., Chernoff,C.,
            Stiebahl,S., Michaud,L. and Belin,D.
  TITLE     Pan-striatal reduction in the expression of the astrocytic dopamine
            transporter precedes the development of dorsolateral striatum
            dopamine-dependent incentive heroin seeking habits
  JOURNAL   Eur J Neurosci 59 (10), 2502-2521 (2024)
   PUBMED   38650303
  REMARK    GeneRIF: Pan-striatal reduction in the expression of the astrocytic
            dopamine transporter precedes the development of dorsolateral
            striatum dopamine-dependent incentive heroin seeking habits.
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Puzzo,C., D'Angio,R., Albanese,S., Orlando,D., Mangili,I.,
            Capobianco,M., Liberati,A.S. and Adriani,W.
  TITLE     Inheritance of wild and truncated DAT alleles from grand-parents:
            Opposite transgenerational consequences on the behavioral phenotype
            in adolescent DAT heterozygous rats
  JOURNAL   Neurosci Lett 810, 137352 (2023)
   PUBMED   37321389
  REMARK    GeneRIF: Inheritance of wild and truncated DAT alleles from
            grand-parents: Opposite transgenerational consequences on the
            behavioral phenotype in adolescent DAT heterozygous rats.
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Vilca,S., Wahlestedt,C., Izenwasser,S., Gainetdinov,R.R. and
            Pardo,M.
  TITLE     Dopamine Transporter Knockout Rats Display Epigenetic Alterations
            in Response to Cocaine Exposure
  JOURNAL   Biomolecules 13 (7), 1107 (2023)
   PUBMED   37509143
  REMARK    GeneRIF: Dopamine Transporter Knockout Rats Display Epigenetic
            Alterations in Response to Cocaine Exposure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Hamamah,S., Hajnal,A. and Covasa,M.
  TITLE     Reduced Striatal Dopamine Transporter Availability and Heightened
            Response to Natural and Pharmacological Stimulation in
            CCK-1R-Deficient Obese Rats
  JOURNAL   Int J Mol Sci 24 (11), 9773 (2023)
   PUBMED   37298724
  REMARK    GeneRIF: Reduced Striatal Dopamine Transporter Availability and
            Heightened Response to Natural and Pharmacological Stimulation in
            CCK-1R-Deficient Obese Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Shao,D., Jiang,D., Huang,Q., Ren,S., Li,J., Xiao,J., Guan,Y.,
            Lai,B., Zhao,J., Xie,F. and Hua,F.
  TITLE     Brain glucose metabolism and dopamine transporter changes in rats
            with morphine-induced conditioned place preference
  JOURNAL   Addict Biol 28 (5), e13277 (2023)
   PUBMED   37186440
  REMARK    GeneRIF: Brain glucose metabolism and dopamine transporter changes
            in rats with morphine-induced conditioned place preference.
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Gu,H., Wall,S.C. and Rudnick,G.
  TITLE     Stable expression of biogenic amine transporters reveals
            differences in inhibitor sensitivity, kinetics, and ion dependence
  JOURNAL   J Biol Chem 269 (10), 7124-7130 (1994)
   PUBMED   8125921
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Kitayama,S., Shimada,S., Xu,H., Markham,L., Donovan,D.M. and
            Uhl,G.R.
  TITLE     Dopamine transporter site-directed mutations differentially alter
            substrate transport and cocaine binding
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7782-7785 (1992)
   PUBMED   1502198
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Giros,B., el Mestikawy,S., Bertrand,L. and Caron,M.G.
  TITLE     Cloning and functional characterization of a cocaine-sensitive
            dopamine transporter
  JOURNAL   FEBS Lett 295 (1-3), 149-154 (1991)
   PUBMED   1765147
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Kilty,J.E., Lorang,D. and Amara,S.G.
  TITLE     Cloning and expression of a cocaine-sensitive rat dopamine
            transporter
  JOURNAL   Science 254 (5031), 578-579 (1991)
   PUBMED   1948035
REFERENCE   10 (bases 1 to 1985)
  AUTHORS   Shimada,S., Kitayama,S., Lin,C.L., Patel,A., Nanthakumar,E.,
            Gregor,P., Kuhar,M. and Uhl,G.
  TITLE     Cloning and expression of a cocaine-sensitive dopamine transporter
            complementary DNA
  JOURNAL   Science 254 (5031), 576-578 (1991)
   PUBMED   1948034
  REMARK    Erratum:[Science 1992 Mar 6;255(5049):1195]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M80233.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012694.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80233.1, M80570.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760396 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1985
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /note="solute carrier family 6 member 3"
                     /db_xref="GeneID:24898"
                     /db_xref="RGD:3715"
     exon            1..45
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..374
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1948
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /note="DAT; DA transporter; solute carrier family 6
                     (neurotransmitter transporter, dopamine), member 3; solute
                     carrier family 6 (neurotransmitter transporter), member 3"
                     /codon_start=1
                     /product="sodium-dependent dopamine transporter"
                     /protein_id="NP_036826.1"
                     /db_xref="GeneID:24898"
                     /db_xref="RGD:3715"
                     /translation="MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTN
                     STLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY
                     LLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVII
                     AWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFER
                     GVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVL
                     TALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSY
                     NKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFII
                     YPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLG
                     IVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIK
                     QMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATS
                     SMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL"
     exon            375..506
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..738
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..877
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1012
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1116
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1241
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1354
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1483
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1583
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1684
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1852
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1924
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1985
                     /gene="Slc6a3"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcttac aggacctcag agctgaagcc tgacgcagga gtcagtcgaa gaagaaagaa
       61 gcagagttcc ttgggctccg gtctacccat gagtaagagc aaatgctccg tgggaccaat
      121 gtcttcagtg gtggccccgg ctaaagagtc caatgctgtg ggccccagag aggtggagct
      181 catcctggtc aaggagcaga acggagtgca gctgaccaac tccaccctca tcaacccgcc
      241 acagacacca gtggaggctc aagagcggga gacctggagc aagaaaattg atttcctgct
      301 atcagtcatc ggctttgctg tggacctggc caatgtctgg aggtttccct acctgtgcta
      361 caaaaatggt ggaggtgcct tcctggtgcc ctacctgctc ttcatggtta ttgctgggat
      421 gcccctcttc tacatggagc tggctctcgg acagttcaac agagaaggag ctgctggtgt
      481 ctggaagatc tgtcctgtcc tgaaaggtgt gggcttcact gttatcctca tctctttcta
      541 cgtgggcttc ttctacaatg tcatcatcgc atgggcactg cactacttct tctcctcctt
      601 caccatggac ctcccatgga tccactgcaa caacacctgg aatagcccca actgctccga
      661 tgcccatgcc agcaactcta gcgacggcct gggcctcaat gacacctttg ggaccacacc
      721 cgctgctgag tactttgagc gtggcgtgct gcaccttcac cagagccgtg gcattgatga
      781 cctgggccct ccacggtggc agctcacagc ctgcctggtg ctggtcattg ttctgctcta
      841 cttcagccta tggaagggag taaagacctc agggaaggtg gtgtggatca cagctaccat
      901 gccctatgtg gtcctcacgg ccctgctcct gcgtggagtt acccttcctg gagccatgga
      961 tggcatcaga gcatacctca gtgtggactt ctaccgactc tgtgaggcat ctgtgtggat
     1021 cgatgctgcc acccaggtgt gcttctccct cggcgttggg tttggagtgc tgattgcctt
     1081 ctccagttac aataagttca ccaataactg ctatagagac gcaatcatca ccacctccat
     1141 taactccctg acaagcttct cctctggctt cgtcgtcttc tccttcctgg ggtacatggc
     1201 acagaagcac aatgtgccca tcagagatgt ggccacagat ggacctgggc tcatcttcat
     1261 catctatcct gaggcgatcg ccacactccc gctgtcttct gcctgggctg ctgtcttctt
     1321 cctcatgctg ctcactctgg gtatcgacag tgcaatgggg ggcatggagt cagtgatcac
     1381 tgggctcgtc gatgagttcc agctgctaca tcggcatcga gagctcttca ctcttggcat
     1441 tgtcctggct actttcctgc tgtctctctt ctgcgtcacc aacggtggca tctacgtctt
     1501 cacactgctg gaccactttg cagctggcac atctatcctc tttggcgtgc tcattgaagc
     1561 cattggggtg gcctggttct acggcgtcca gcaattcagt gatgacatca agcaaatgac
     1621 agggcagcga cccaacctgt actggcggct atgctggaag ctggtcagcc cctgcttcct
     1681 cctgtatgtg gtcgtggtca gcattgtgac cttcagaccc ccacactatg gggcctacat
     1741 cttcccagac tgggccaatg ccctgggctg gatcatcgcc acatcctcca tggccatggt
     1801 gcccatttat gcgacctaca agttctgcag cctgccgggg tccttccggg agaaactggc
     1861 ctatgccatc acacctgaga aagaccatca gctagtggac agaggggagg tgcgccaatt
     1921 cacgctgcgt cactggctgt tgctgtaaag tggaaggaga cagctgccag ctgggccacc
     1981 tcaca
//
