LOCUS       NM_133296               1950 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 20a (Slc6a20a),
            mRNA.
ACCESSION   NM_133296
VERSION     NM_133296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Cano,M., Calonge,M.L. and Ilundain,A.A.
  TITLE     Na+-dependent and Na+-independent betaine transport across the
            apical membrane of rat renal epithelium
  JOURNAL   Biochim Biophys Acta 1848 (10 Pt A), 2172-2179 (2015)
   PUBMED   26028423
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Broer,S., Bailey,C.G., Kowalczuk,S., Ng,C., Vanslambrouck,J.M.,
            Rodgers,H., Auray-Blais,C., Cavanaugh,J.A., Broer,A. and Rasko,J.E.
  TITLE     Iminoglycinuria and hyperglycinuria are discrete human phenotypes
            resulting from complex mutations in proline and glycine
            transporters
  JOURNAL   J Clin Invest 118 (12), 3881-3892 (2008)
   PUBMED   19033659
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Anas,M.K., Lee,M.B., Zhou,C., Hammer,M.A., Slow,S., Karmouch,J.,
            Liu,X.J., Broer,S., Lever,M. and Baltz,J.M.
  TITLE     SIT1 is a betaine/proline transporter that is activated in mouse
            eggs after fertilization and functions until the 2-cell stage
  JOURNAL   Development 135 (24), 4123-4130 (2008)
   PUBMED   19029042
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Romeo,E., Dave,M.H., Bacic,D., Ristic,Z., Camargo,S.M., Loffing,J.,
            Wagner,C.A. and Verrey,F.
  TITLE     Luminal kidney and intestine SLC6 amino acid transporters of
            B0AT-cluster and their tissue distribution in Mus musculus
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F376-F383 (2006)
   PUBMED   16174864
REFERENCE   5  (bases 1 to 1950)
  AUTHORS   Kowalczuk,S., Broer,A., Munzinger,M., Tietze,N., Klingel,K. and
            Broer,S.
  TITLE     Molecular cloning of the mouse IMINO system: an Na+- and
            Cl--dependent proline transporter
  JOURNAL   Biochem J 386 (Pt 3), 417-422 (2005)
   PUBMED   15689184
REFERENCE   6  (bases 1 to 1950)
  AUTHORS   Takanaga,H., Mackenzie,B., Suzuki,Y. and Hediger,M.A.
  TITLE     Identification of mammalian proline transporter SIT1 (SLC6A20) with
            characteristics of classical system imino
  JOURNAL   J Biol Chem 280 (10), 8974-8984 (2005)
   PUBMED   15632147
REFERENCE   7  (bases 1 to 1950)
  AUTHORS   Smith,K.E., Fried,S.G., Durkin,M.M., Gustafson,E.L., Borden,L.A.,
            Branchek,T.A. and Weinshank,R.L.
  TITLE     Molecular cloning of an orphan transporter. A new member of the
            neurotransmitter transporter family
  JOURNAL   FEBS Lett 357 (1), 86-92 (1995)
   PUBMED   8001687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 3, 2022 this sequence version replaced NM_133296.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211786.1, SRR26643295.34212.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000008.1  132199651-132199900 c
            251-391             JAXUCZ010000008.1  132184274-132184414 c
            392-483             JAXUCZ010000008.1  132182778-132182869 c
            484-711             JAXUCZ010000008.1  132180510-132180737 c
            712-822             JAXUCZ010000008.1  132177536-132177646 c
            823-1064            JAXUCZ010000008.1  132176420-132176661 c
            1065-1227           JAXUCZ010000008.1  132175229-132175391 c
            1228-1432           JAXUCZ010000008.1  132164460-132164664 c
            1433-1592           JAXUCZ010000008.1  132163307-132163466 c
            1593-1758           JAXUCZ010000008.1  132160544-132160709 c
            1759-1950           JAXUCZ010000008.1  132159768-132159959 c
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1950
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /note="solute carrier family 6 member 20a"
                     /db_xref="GeneID:113918"
                     /db_xref="RGD:621651"
     exon            1..250
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1908
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /note="transporter rB21A; sodium/imino-acid transporter 1;
                     solute carrier family 6 (proline IMINO transporter),
                     member 20; X transporter protein 3; solute carrier family
                     6 (neurotransmitter transporter), member 20; solute
                     carrier family 6 member 20"
                     /codon_start=1
                     /product="sodium- and chloride-dependent transporter
                     XTRP3"
                     /protein_id="NP_579830.2"
                     /db_xref="GeneID:113918"
                     /db_xref="RGD:621651"
                     /translation="MRLAIKRRASRGQRPGPDEKRARDMEKARPQWGNPLQFVFACIS
                     YAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELAVGQRMRQGSIGAWR
                     TISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNRTGYD
                     EECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGK
                     VVYFTALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQIFFSL
                     GLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCL
                     NKVILLLTNSFDLEDGFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAV
                     QGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISS
                     YLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVY
                     GLRRFESDLRAMTGRPLNWYWKAMWAFVSPLLIIGLFIFYLSDYILTGTLQYQAWDAT
                     QGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSSPVA"
     exon            251..391
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..483
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            484..711
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..822
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1064
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1227
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1432
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1592
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1758
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1950
                     /gene="Slc6a20a"
                     /gene_synonym="rB21a; Slc6a20; Xtrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagggtgg ggctcaccgc tccccactta ccggcctcgc ccctctcgtg cgcgttaatg
       61 agattagcaa ttaaaaggcg ggcgagccgc ggccagagac caggccctga cgagaagcga
      121 gcgcgggaca tggagaaggc acggcctcaa tggggcaatc cgctgcagtt cgttttcgcc
      181 tgtatctcct acgccgtggg tttgggcaat gtgtggcgct tcccctacct gtgccagatg
      241 tacggcggag ggagtttcct ggtcccctac ctcatcatgc tcattgtgga ggggatgcca
      301 ctcttgtacc tggagctggc tgtggggcag cgcatgcggc agggcagcat tggtgcctgg
      361 aggaccatca gcccctacct tagtggtgtc ggtgttgcca gtgtggtggt ctccttcttc
      421 ctctccatgt actacaatgt catcaatgcc tggggcttct ggtacctctt ccactccttc
      481 caggatcccc tgccgtggtc tgtctgccca ctgaatagta accgcacagg ctatgatgag
      541 gagtgtgaga aggcttcgtc gacacagtac ttctggtaca ggaaaacact caacatctca
      601 ccgtccatcc aggagaatgg aggagtgcag tgggagccag ccctgtgcct caccctggcc
      661 tggctgatgg tatatctgtg catcctgaga ggcaccgaat ctactggcaa ggtggtctac
      721 ttcaccgcat tgatgcctta ctgtgttctt attatctact tggtccgtgg cctcacactc
      781 catggagcca ccaatggcct gatgtacatg ttcacaccta agatggagca gctagccaac
      841 cccaaggcct ggatcaatgc agccacgcag atcttcttct cactgggctt gggttttggc
      901 agcctgatcg cttttgccag ctacaatgaa ccctccaacg actgccagaa gcatgctgtc
      961 attgtgtctg tcatcaacag ctccacctcc atatttgcca gcattgtcac cttctccatc
     1021 tatggcttca aggccacctt caactatgaa aactgcttaa acaaggtgat tctgctgctg
     1081 accaattctt ttgaccttga agatggcttt ctgacagcca gcaacctgga ggaggtgaag
     1141 gactacctgg catctactta cccaaacaag tacagtgaag tgttcccaca cattagaaac
     1201 tgcagcttgg aatcagagct gaacacggct gtccagggca caggcctggc cttcatcgtc
     1261 tacactgagg ccattaaaaa catggaagtg tcccagctct ggtcagtgct ctacttcttc
     1321 atgctgctga tgctgggaat ggggagcatg cttggaaata cagcggccat cctcacccct
     1381 ctgactgaca gcaaggtcat ctccagctac ctgcccaagg aggccatttc aggtctggtg
     1441 tgcctcatta actgtgctgt tggcatggtg ttcaccatgg aggctgggaa ctactggttt
     1501 gacatattca atgactatgc agccacgctg tctctgctgc tcattgtgct ggtggagact
     1561 atagctgtgt gctacgtgta tgggctgagg agatttgaaa gtgatcttcg ggccatgact
     1621 ggccggcccc tcaactggta ctggaaggcc atgtgggctt ttgtgagccc actgctcatc
     1681 atcggcctct ttatcttcta cctgagtgac tacatcctca cgggaacgct gcagtaccaa
     1741 gcctgggatg ctactcaggg gcagctggtg accaaggatt accctccaca tgcactagct
     1801 gtcatcggtt tgctggtggc ttcatctact atgtgcatcc ccctggtggc cctggggact
     1861 ttcatcagga atcgcctcaa gaggggaggc tcttccccag tggcctaaga atggacctcc
     1921 caaagaccga agtcagccac tctgtttcac
//
