LOCUS       NM_001039722            2437 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 19 (Slc6a19),
            mRNA.
ACCESSION   NM_001039722
VERSION     NM_001039722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Jando,J., Camargo,S.M.R., Herzog,B. and Verrey,F.
  TITLE     Expression and regulation of the neutral amino acid transporter
            B0AT1 in rat small intestine
  JOURNAL   PLoS One 12 (9), e0184845 (2017)
   PUBMED   28915252
  REMARK    GeneRIF: Investigation of the chronic dietary regulation of B0AT1,
            ACE2 and CD13 by different diets revealed an increased B0AT1
            protein expression under amino acid-supplemented diet in the
            proximal section but not in the distal one and for ACE2 protein
            expression a reverse localization of the effect.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2437)
  AUTHORS   Ducroc,R., Sakar,Y., Fanjul,C., Barber,A., Bado,A. and Lostao,M.P.
  TITLE     Luminal leptin inhibits L-glutamine transport in rat small
            intestine: involvement of ASCT2 and B0AT1
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 299 (1), G179-G185 (2010)
   PUBMED   20448142
  REMARK    GeneRIF: Leptin controls active glutamine entry through reduction
            of both B(0)AT1 and ASCT2 protein trafficking to the apical plasma
            membrane and modulation of their gene expression.
REFERENCE   3  (bases 1 to 2437)
  AUTHORS   Wolff,B.S., Meirelles,K., Meng,Q., Pan,M. and Cooney,R.N.
  TITLE     Roux-en-Y gastric bypass alters small intestine glutamine transport
            in the obese Zucker rat
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 297 (3), G594-G601 (2009)
   PUBMED   19556357
  REMARK    GeneRIF: Roux-en-Y gastric bypass selectively increased glutamine
            absorption in biliopancreatic and Roux limbs by a mechanism
            involving increased B(0)AT1 expression.
REFERENCE   4  (bases 1 to 2437)
  AUTHORS   Camargo,S.M., Singer,D., Makrides,V., Huggel,K., Pos,K.M.,
            Wagner,C.A., Kuba,K., Danilczyk,U., Skovby,F., Kleta,R.,
            Penninger,J.M. and Verrey,F.
  TITLE     Tissue-specific amino acid transporter partners ACE2 and collectrin
            differentially interact with hartnup mutations
  JOURNAL   Gastroenterology 136 (3), 872-882 (2009)
   PUBMED   19185582
REFERENCE   5  (bases 1 to 2437)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2437)
  AUTHORS   Pinho,M.J., Serrao,M.P., Jose,P.A. and Soares-da-Silva,P.
  TITLE     Organ specific underexpression renal of Na+-dependent B0AT1 in the
            SHR correlates positively with overexpression of NHE3 and salt
            intake
  JOURNAL   Mol Cell Biochem 306 (1-2), 9-18 (2007)
   PUBMED   17646927
REFERENCE   7  (bases 1 to 2437)
  AUTHORS   Pinho,M.J., Serrao,M.P. and Soares-da-Silva,P.
  TITLE     High-salt intake and the renal expression of amino acid
            transporters in spontaneously hypertensive rats
  JOURNAL   Am J Physiol Renal Physiol 292 (5), F1452-F1463 (2007)
   PUBMED   17264310
REFERENCE   8  (bases 1 to 2437)
  AUTHORS   Danilczyk,U., Sarao,R., Remy,C., Benabbas,C., Stange,G.,
            Richter,A., Arya,S., Pospisilik,J.A., Singer,D., Camargo,S.M.,
            Makrides,V., Ramadan,T., Verrey,F., Wagner,C.A. and Penninger,J.M.
  TITLE     Essential role for collectrin in renal amino acid transport
  JOURNAL   Nature 444 (7122), 1088-1091 (2006)
   PUBMED   17167413
REFERENCE   9  (bases 1 to 2437)
  AUTHORS   Kleta,R., Romeo,E., Ristic,Z., Ohura,T., Stuart,C.,
            Arcos-Burgos,M., Dave,M.H., Wagner,C.A., Camargo,S.R., Inoue,S.,
            Matsuura,N., Helip-Wooley,A., Bockenhauer,D., Warth,R.,
            Bernardini,I., Visser,G., Eggermann,T., Lee,P., Chairoungdua,A.,
            Jutabha,P., Babu,E., Nilwarangkoon,S., Anzai,N., Kanai,Y.,
            Verrey,F., Gahl,W.A. and Koizumi,A.
  TITLE     Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
  JOURNAL   Nat Genet 36 (9), 999-1002 (2004)
   PUBMED   15286787
REFERENCE   10 (bases 1 to 2437)
  AUTHORS   Broer,A., Klingel,K., Kowalczuk,S., Rasko,J.E., Cavanaugh,J. and
            Broer,S.
  TITLE     Molecular cloning of mouse amino acid transport system B0, a
            neutral amino acid transporter related to Hartnup disorder
  JOURNAL   J Biol Chem 279 (23), 24467-24476 (2004)
   PUBMED   15044460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001039722.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF474455.2, AJ890206.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000001.1  31414744-31415002
            260-400             JAXUCZ010000001.1  31421377-31421517
            401-538             JAXUCZ010000001.1  31422677-31422814
            539-720             JAXUCZ010000001.1  31424661-31424842
            721-831             JAXUCZ010000001.1  31424947-31425057
            832-944             JAXUCZ010000001.1  31425390-31425502
            945-1073            JAXUCZ010000001.1  31428304-31428432
            1074-1230           JAXUCZ010000001.1  31428574-31428730
            1231-1435           JAXUCZ010000001.1  31430069-31430273
            1436-1595           JAXUCZ010000001.1  31430391-31430550
            1596-1758           JAXUCZ010000001.1  31432510-31432672
            1759-2437           JAXUCZ010000001.1  31432839-31433517
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2437
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /note="solute carrier family 6 member 19"
                     /db_xref="GeneID:664630"
                     /db_xref="RGD:1594328"
     exon            1..259
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1962
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /note="neutral amino acid transporter; b(0)AT1; system
                     B(0) neutral amino acid transporter AT1; solute carrier
                     family 6 (neurotransmitter transporter), member 19; solute
                     carrier family 6 (neutral amino acid transporter), member
                     19"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT1"
                     /protein_id="NP_001034811.2"
                     /db_xref="GeneID:664630"
                     /db_xref="RGD:1594328"
                     /translation="MVRLVLPNPGLEDRIPSLDELEVIEKEEASSRPKWDNKAQYMLT
                     CVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLHLEFAIGQRLRKGSVG
                     VWSSIHPALKGVGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSECPLNQNQT
                     GYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCTIRGIET
                     TGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVF
                     YSFSLAFGGLISFSSYNSVHNNCEMDSVIVSIINGFTSVYAATVVYSIIGFRATERFD
                     DCVNTNILTLINGFDLPEGNVTAENFEAYQHWCNATNPEAYAQLTFQTCDINTFLSEG
                     VEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITP
                     KKWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFAVVYV
                     YGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKQLMYSVWDPD
                     YEEFPKSQKVPYPDWVYAVVVIVAGVPCLTIPCFAIYKLIRNYCQKSGDQHGLVNALS
                     TASVNGDLKN"
     exon            260..400
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..538
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..720
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..831
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..944
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1073
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1230
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1435
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1595
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1758
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..2437
                     /gene="Slc6a19"
                     /gene_synonym="B0at1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttgccctt tgactgccga actgcctgag tgtgccaagc ccagcccagc gaccaccatg
       61 gtgaggcttg tgctacccaa ccctggccta gaggaccgga ttccgtctct ggatgaatta
      121 gaggtcattg aaaaggaaga ggccagctcc aggcccaaat gggacaacaa ggcccagtac
      181 atgctcacct gtgtgggctt ctgtgtgggg ctgggcaatg tctggcgctt cccttacctg
      241 tgccagagcc atggaggagg ggccttcatg atccccttcc tcatccttct ggtcctggag
      301 ggcattccct tgctgcacct ggagtttgcc atcggacaga ggctacgcaa gggcagtgtg
      361 ggcgtctgga gctccatcca ccctgctctg aagggtgtag gcatcgcctc catgttcgtg
      421 tccttcatgg tgggcctgta ctacaacacc atcatcgcct gggtcatgtg gtatttcttc
      481 aactcctttc aggaacctct gccatggagc gaatgcccac tcaaccagaa tcagacaggc
      541 tatgtggaag agtgtgccaa gagctcttct gtggactact tctggtaccg agagactctc
      601 aacatctcca cttctatcag tgactcaggc tccatccagt ggtggatcct gctctgcctg
      661 acatgtgcct ggagtgttct gtatgtgtgt actatccgtg gcatcgagac cactgggaag
      721 gctgtttaca tcacctccac cctgccctat gtcgtactga ccatctttct catccgtggc
      781 ttgactctga agggtgccac caacggcatt gtcttccttt tcacacccaa tatcacagag
      841 ctgagcaacc ccaacacgtg gctggatgca ggtgctcagg tcttctactc cttctcactg
      901 gccttcgggg gcctcatctc cttctccagc tacaactctg tacacaataa ttgtgagatg
      961 gattccgtga tcgtgtccat catcaatggc ttcacatctg tgtatgcggc caccgtggtc
     1021 tactctatca ttggcttcag ggccaccgag cgctttgatg actgtgtgaa cacgaacatc
     1081 ctgaccctca tcaatgggtt cgacctgccc gagggcaatg tgactgcgga gaacttcgag
     1141 gcctatcaac attggtgcaa tgccactaat cccgaggcct atgcccagct gacgtttcag
     1201 acctgtgaca ttaacacctt cctctctgag ggtgtagagg gcacaggcct ggccttcatt
     1261 gtcttcactg aagccatcac gaagatgcca gtgtccccac tgtggtcggt gctcttcttt
     1321 atcatgctct tctgcctggg cctctcctct atgtttggga acatggaggg tgtggtcgta
     1381 ccccttcagg atctcaatat cacccctaag aagtggccca aagaactgct cacaggtctc
     1441 atctgcttgg ggacatatct catcgccttc attttcacac tgaattcggg ccagtactgg
     1501 ctctccctgc tggacagcta tgctggctcc atccctctgc taatcatcgc cttttgtgag
     1561 atgtttgctg tcgtctacgt gtatggagtt gacaggttca acaaggacat cgagttcatg
     1621 atcggccata agcccaacat cttctggcaa gtcacgtgga gagtggtcag tccgctgatc
     1681 atgctggtca tcttcctctt ctttttcgtg attgaagtca acaaacagct catgtatagc
     1741 gtatgggacc ctgactatga ggagttcccg aaatctcaga aggttccata ccccgactgg
     1801 gtgtacgcag ttgtggtcat tgtggctgga gtaccctgcc ttaccatccc ctgctttgcc
     1861 atctacaaac tcatcagaaa ctattgccag aagtctgggg accaacatgg gctggtcaat
     1921 gcgctgtcca cagcctctgt gaatggggac cttaagaact gattgggctt agtttgcata
     1981 aggcagaaga cagtgtgtgg aggaaacaag gtggaagacc catgggggaa gtaggctgta
     2041 atatgtgtga atgtgtgaat acatatacat gtattcatgt cacacagatg tgtacatatg
     2101 tgttacacaa atatgtgggg catatggaca tgtttatgtg tatataccag ttttacacat
     2161 gtgtatatat agatgcacat gaactacatg tgtacataaa tgtatatgca tgtgtgagtt
     2221 tatgtataca agatgtttgt gtatatattt tgaggagggt atatttatat atacatgtat
     2281 atatgcacac atgtgttatc tacatgtata tatatgctca tgtgttaact catatatgtg
     2341 cacacatgtg tatacatata ttcacaaatg gagtctattg atatgtgtat atgaatgtat
     2401 gaacatgcac tcataaactt atatatgtat gtctgaa
//
