LOCUS       NM_017163               2337 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 18 (Slc6a18),
            mRNA.
ACCESSION   NM_017163
VERSION     NM_017163.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Fairweather,S.J., Broer,A., Subramanian,N., Tumer,E., Cheng,Q.,
            Schmoll,D., O'Mara,M.L. and Broer,S.
  TITLE     Molecular basis for the interaction of the mammalian amino acid
            transporters B0AT1 and B0AT3 with their ancillary protein
            collectrin
  JOURNAL   J Biol Chem 290 (40), 24308-24325 (2015)
   PUBMED   26240152
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Singer,D., Camargo,S.M., Huggel,K., Romeo,E., Danilczyk,U.,
            Kuba,K., Chesnov,S., Caron,M.G., Penninger,J.M. and Verrey,F.
  TITLE     Orphan transporter SLC6A18 is renal neutral amino acid transporter
            B0AT3
  JOURNAL   J Biol Chem 284 (30), 19953-19960 (2009)
   PUBMED   19478081
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Danilczyk,U., Sarao,R., Remy,C., Benabbas,C., Stange,G.,
            Richter,A., Arya,S., Pospisilik,J.A., Singer,D., Camargo,S.M.,
            Makrides,V., Ramadan,T., Verrey,F., Wagner,C.A. and Penninger,J.M.
  TITLE     Essential role for collectrin in renal amino acid transport
  JOURNAL   Nature 444 (7122), 1088-1091 (2006)
   PUBMED   17167413
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Baba,T., Nonoguchi,H., Itoh,K., Nakayama,Y., Kohda,Y., Inoue,T. and
            Tomita,K.
  TITLE     Gene regulation of renal-osmotic stress-induced Na-CL organic
            solute cotransporter
  JOURNAL   Nephron Exp Nephrol 96 (3), e89-e96 (2004)
   PUBMED   15056985
  REMARK    GeneRIF: Regulation of ROSIT mRNA levels in nephrons.
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Nash,S.R., Giros,B., Kingsmore,S.F., Kim,K.M., el-Mestikawy,S.,
            Dong,Q., Fumagalli,F., Seldin,M.F. and Caron,M.G.
  TITLE     Cloning, gene structure and genomic localization of an orphan
            transporter from mouse kidney with six alternatively-spliced
            isoforms
  JOURNAL   Recept Channels 6 (2), 113-128 (1998)
   PUBMED   9932288
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Wasserman,J.C., Delpire,E., Tonidandel,W., Kojima,R. and
            Gullans,S.R.
  TITLE     Molecular characterization of ROSIT, a renal osmotic stress-induced
            Na(+)-Cl(-)-organic solute cotransporter
  JOURNAL   Am J Physiol 267 (4 Pt 2), F688-F694 (1994)
   PUBMED   7943364
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017163.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12973.1, SRR26643287.271.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000001.1  31436653-31436839
            188-328             JAXUCZ010000001.1  31438635-31438775
            329-466             JAXUCZ010000001.1  31438985-31439122
            467-648             JAXUCZ010000001.1  31439876-31440057
            649-759             JAXUCZ010000001.1  31441719-31441829
            760-872             JAXUCZ010000001.1  31442922-31443034
            873-1001            JAXUCZ010000001.1  31444561-31444689
            1002-1158           JAXUCZ010000001.1  31446490-31446646
            1159-1363           JAXUCZ010000001.1  31447507-31447711
            1364-1523           JAXUCZ010000001.1  31448112-31448271
            1524-1686           JAXUCZ010000001.1  31448481-31448643
            1687-2337           JAXUCZ010000001.1  31449828-31450478
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2337
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /note="solute carrier family 6 member 18"
                     /db_xref="GeneID:29323"
                     /db_xref="RGD:69352"
     exon            1..187
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1878
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /note="b(0)AT3; system B(0) neutral amino acid transporter
                     AT3; solute carrier family 6 (neutral amino acid
                     transporter), member 18; sodium- and chloride-dependent
                     transporter XTRP2; renal osmotic stress-induced Na-Cl
                     organic solute cotransporter; X transporter protein 2;
                     solute carrier family 6 (neurotransmitter transporter),
                     member 18"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT3"
                     /protein_id="NP_058859.2"
                     /db_xref="GeneID:29323"
                     /db_xref="RGD:69352"
                     /translation="MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFP
                     YLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLG
                     CFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYF
                     WYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLV
                     LTIFLIRGLTLPGATEGLTYLFTPNMKILQNPRVWLDAATQIFFSLSLAFGGHIAFAS
                     YNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFD
                     FPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAV
                     LHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFI
                     CFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTG
                     RRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGW
                     VQVTCVLLSFLPSLWVPGIALAQLLFQYRQRWKNTHLESALKPQESRGC"
     exon            188..328
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..466
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..648
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..759
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..872
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1001
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1158
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1363
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1523
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1686
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..2337
                     /gene="Slc6a18"
                     /gene_synonym="Rosit; Xtrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccagccat tcccagggtg acgactcagc atggctcagg cctcagggat ggacccactt
       61 gtggacatcg aggacgagag acccaaatgg gacaacaaac ttcagtacct cctgagctgc
      121 atcggctttg ctgtggggct ggggaacata tggcggttcc cctacctgtg ccatacccac
      181 gggggagggg ccttcctcat cccctacttc atcgccctgg tctttgaggg gatcccgctt
      241 ttctacattg agcttgccat tggccagcgc ctacggaggg gaagcattgg cgtatggaag
      301 accatctccc cctaccttgg tggagtaggc ctgggctgct tctcagtgtc cttcctggtc
      361 agcctgtact acaacaccat tctcctgtgg gtcctgtggt tcttcctcaa ctccttccaa
      421 cacccactgc cctggagcac atgcccattg gatctcaaca gaacaggatt tgtgcaggaa
      481 tgccagagca gtggcaccgt gagctacttc tggtaccggc agactttgaa tattacgtct
      541 gacatcagca acacaggcac tatccagtgg aagctgtttc tctgcctggt ggcctgctgg
      601 acaactgtgt acctgtgtgt catcagaggc attgagagca cggggaaggt gatctacttt
      661 acagccctat ttccttacct ggtgctaacc atcttcctca tcagaggtct gactctgccc
      721 ggagcaacag agggcctaac ttacctgttt actcccaata tgaagattct tcagaatcca
      781 cgggtgtggt tggacgcagc cacccagatt ttcttctccc tgtccctggc cttcggaggg
      841 catattgctt tcgcaagtta caatcaaccc aggaacaatt gtgagaagga cgccgtgact
      901 attgccctgg tcaacagcat gacctccctg tatgcatcca tcaccatctt ttccatcatg
      961 gggttcaagg catccaatga ctatgggagg tgcctggaca gaaatatttt gagcctcatc
     1021 aatgagttcg actttccaga gcttagcatc tccagggatg agtacccatc tgtcctcatg
     1081 tacctgaatg ccactcagcc tgagagggtg gcccgacttc ccctgaagac ctgccatctg
     1141 gaagatttcc tggataagag tgcctcgggc ccgggcctgg ccttcatcgt tttcacagaa
     1201 gctgtcttgc acatgcccgg agcttctgtg tggtctgtgc tcttctttgg gatgctgttc
     1261 acactgggcc tgtcctccat gtttgggaac atggagggtg tcatcacacc actatttgac
     1321 atggggatct tacccaaagg tgtacccaag gagaccatga ccggggtggt ctgctttatc
     1381 tgtttcctct cagccatttg cttcacactg cagtctggaa gctactggct ggagatcttt
     1441 gacagttttg cagcttctct gaatctgatc atcttcgcct tcatggaggt ggtgggcgtc
     1501 attcacgttt atgggatcaa gcggttctgt gatgacattg agtggatgac tgggcggcgg
     1561 cccagcctgt actggcaggt gacatggagg gtggtgagcc ctatgctgct gtttggcatc
     1621 ttcctgtcct acattgtcct tctggctcag tcatcaccca gctacaaggc ctggaacccc
     1681 caatatgaac attttccctc aagagaggag aagctctatc caggctgggt acaggttacc
     1741 tgtgtgctcc tgtccttcct gccctcactg tgggtccctg gaattgctct ggctcagcta
     1801 ctgttccagt acagacagag gtggaagaac acacatctgg aaagtgctct gaagccacag
     1861 gagagcagag gctgctgaga cagagccagg gtagatcagg gttgggagga agacctgtgc
     1921 cactccgatg cagcctcatt acactctgtc tacgactgag accacgtgat tattgctttc
     1981 ctagctttcc gtatagtgga agactcatag attcagggca attgtgtatt gcccagtgga
     2041 tgtctgtgtg atgccattcc tctgaagcta ggtcccacag ggtgccgtct gcatggacat
     2101 ggcttttccc tagaatccat gcagatttgg gttgtcccga gtgtacttca ttggcacagt
     2161 ggcaagactg tggaaacctt ttctctgaat ggccttggca ttactaattt tagaaatcca
     2221 gccctatgct ggtcttcaaa gaaaagctgg aacctgacag gtgggaaact tcttcctcct
     2281 cccatattat cctggtgtta ccatgtctat aaagagaccc tcgggtgcag ataccag
//
