LOCUS       NM_001033079            6385 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 17 (Slc6a17),
            mRNA.
ACCESSION   NM_001033079
VERSION     NM_001033079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6385)
  AUTHORS   Iqbal,Z., Willemsen,M.H., Papon,M.A., Musante,L., Benevento,M.,
            Hu,H., Venselaar,H., Wissink-Lindhout,W.M., Vulto-van
            Silfhout,A.T., Vissers,L.E., de Brouwer,A.P., Marouillat,S.,
            Wienker,T.F., Ropers,H.H., Kahrizi,K., Nadif Kasri,N.,
            Najmabadi,H., Laumonnier,F., Kleefstra,T. and van Bokhoven,H.
  TITLE     Homozygous SLC6A17 mutations cause autosomal-recessive intellectual
            disability with progressive tremor, speech impairment, and
            behavioral problems
  JOURNAL   Am J Hum Genet 96 (3), 386-396 (2015)
   PUBMED   25704603
REFERENCE   2  (bases 1 to 6385)
  AUTHORS   Hagglund,M.G., Hellsten,S.V., Bagchi,S., Ljungdahl,A.,
            Nilsson,V.C., Winnergren,S., Stephansson,O., Rumaks,J.,
            Svirskis,S., Klusa,V., Schioth,H.B. and Fredriksson,R.
  TITLE     Characterization of the transporterB0AT3 (Slc6a17) in the rodent
            central nervous system
  JOURNAL   BMC Neurosci 14, 54 (2013)
   PUBMED   23672601
  REMARK    GeneRIF: The data of this results suggested that the B0AT3
            transporter have a role in regulation of monoaminergic as well as
            glutamatergic synapses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6385)
  AUTHORS   Zaia,K.A. and Reimer,R.J.
  TITLE     Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled
            Neutral Amino Acid Transport
  JOURNAL   J Biol Chem 284 (13), 8439-8448 (2009)
   PUBMED   19147495
  REMARK    GeneRIF: The substrate profile of the NTT4/XT1-dependent activity
            is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15),
            including a submillimolar apparent affinity for proline and leucine
            and a low millimolar apparent affinity for glutamine.
REFERENCE   4  (bases 1 to 6385)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Expression of Slc6a17 increases ~9-fold at night in the
            rat pineal gland.  Expression appears to be regulated by neural
            mechanisms involving norepinephrine and cyclic AMP signaling.
REFERENCE   5  (bases 1 to 6385)
  AUTHORS   Parra,L.A., Baust,T., El Mestikawy,S., Quiroz,M., Hoffman,B.,
            Haflett,J.M., Yao,J.K. and Torres,G.E.
  TITLE     The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic
            vesicle amino acid transporter selective for proline, glycine,
            leucine, and alanine
  JOURNAL   Mol Pharmacol 74 (6), 1521-1532 (2008)
   PUBMED   18768736
REFERENCE   6  (bases 1 to 6385)
  AUTHORS   Masson,J., Riad,M., Chaudhry,F., Darmon,M., Aidouni,Z., Conrath,M.,
            Giros,B., Hamon,M., Storm-Mathisen,J., Descarries,L. and El
            Mestikawy,S.
  TITLE     Unexpected localization of the Na+/Cl--dependent-like orphan
            transporter, Rxt1, on synaptic vesicles in the rat central nervous
            system
  JOURNAL   Eur J Neurosci 11 (4), 1349-1361 (1999)
   PUBMED   10103130
REFERENCE   7  (bases 1 to 6385)
  AUTHORS   el Mestikawy,S., Giros,B., Pohl,M., Hamon,M., Kingsmore,S.F.,
            Seldin,M.F. and Caron,M.G.
  TITLE     Characterization of an atypical member of the Na+/Cl(-)-dependent
            transporter family: chromosomal localization and distribution in
            GABAergic and glutamatergic neurons in the rat brain
  JOURNAL   J Neurochem 62 (2), 445-455 (1994)
   PUBMED   8294906
REFERENCE   8  (bases 1 to 6385)
  AUTHORS   Liu,Q.R., Mandiyan,S., Lopez-Corcuera,B., Nelson,H. and Nelson,N.
  TITLE     A rat brain cDNA encoding the neurotransmitter transporter with an
            unusual structure
  JOURNAL   FEBS Lett 315 (2), 114-118 (1993)
   PUBMED   8093354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 4, 2021 this sequence version replaced NM_001033079.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06434.2, SRR26643298.12928.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               JAXUCZ010000002.1  197843510-197843883 c
            375-747             JAXUCZ010000002.1  197826236-197826608 c
            748-905             JAXUCZ010000002.1  197821873-197822030 c
            906-1032            JAXUCZ010000002.1  197820166-197820292 c
            1033-1214           JAXUCZ010000002.1  197819319-197819500 c
            1215-1325           JAXUCZ010000002.1  197817695-197817805 c
            1326-1567           JAXUCZ010000002.1  197805363-197805604 c
            1568-1760           JAXUCZ010000002.1  197804915-197805107 c
            1761-1953           JAXUCZ010000002.1  197802378-197802570 c
            1954-2113           JAXUCZ010000002.1  197801676-197801835 c
            2114-2276           JAXUCZ010000002.1  197800227-197800389 c
            2277-6385           JAXUCZ010000002.1  197795622-197799730 c
FEATURES             Location/Qualifiers
     source          1..6385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6385
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /note="solute carrier family 6 member 17"
                     /db_xref="GeneID:613226"
                     /db_xref="RGD:1587185"
     exon            1..374
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            375..747
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..2645
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /note="orphan sodium- and chloride-dependent
                     neurotransmitter transporter NTT4; sodium-dependent
                     neurotransmitter transporter NTT4; solute carrier family 6
                     (neurotransmitter transporter), member 17; solute carrier
                     family 6 (neutral amino acid transporter), member 17"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     SLC6A17"
                     /protein_id="NP_001028251.1"
                     /db_xref="GeneID:613226"
                     /db_xref="RGD:1587185"
                     /translation="MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGET
                     GGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPY
                     LVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVI
                     IGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSIS
                     ESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRG
                     AVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAA
                     LVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHV
                     NFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMT
                     HFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVG
                     LLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYR
                     FYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITL
                     IAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPS
                     EAPSPMPTHRSYLGPGSTSPLESSSHPNGRYGSGYLLASTPESEL"
     exon            748..905
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1032
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1214
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1325
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1567
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1760
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1953
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2113
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2276
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..6385
                     /gene="Slc6a17"
                     /gene_synonym="Ntt4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctgcgct ccgcccagct ccgttccgct ccgcagagcc gacgcggacc gggcgcgggg
       61 acagcggcac tcggctgggg ccttcgcagc cacgcgctcc ctccgggatc tgtacccggg
      121 cggctcccta gagcccagag cgggcagaag gcgggagttg ggttgggact ggcggcaaca
      181 ggggaagcga cgagccagtt gagtcgcgtg cgccggcgcg cgcagctccg ggtcccgcaa
      241 gccccggctg gggcctgttg ccgcttgact ccagttgccc tctggaagga cggtgcaccc
      301 gcgacccgtt ggggaccacg gccgctcggc gggaatccag gggccgagtc cgcgcgacgg
      361 cccacgcggg acaggctttt ggatgagaga aagctgacag gagctgagcc ccaccttctc
      421 tgtgtgctgg ggaatagggc tacgcagccc cagtggcacc catgccgaag aacagcaagg
      481 tgacccagcg tgaacacagc aatgagcatg tcactgagtc ggtggctgac ctgctggccc
      541 tcgaggagcc tgtggactat aagcagagtg tactgaacgt ggctggtgag acaggtggca
      601 agcagaaggt ggcggaggag gagctggacg cagaggaccg gccagcctgg aacagcaagc
      661 tgcagtacat cctggcccag atcggctttt ctgtgggcct tggcaacatc tggaggttcc
      721 cctacctgtg ccagaaaaat ggaggaggtg cctacctggt gccctacctg gtgctgctga
      781 tcattattgg catccccctc ttctttctgg agctggctgt gggccagagg atccgccgtg
      841 gcagcattgg ggtctggcac tatgtgtgcc cccgcctggg gggcattggc ttttccagct
      901 gtattgtctg cctcttcgtt gggctgtact acaacgtgat cattggatgg agcgtcttct
      961 acttcttcaa gtctttccag tacccactgc cctggagtga atgtcctgtc atcaggaatg
     1021 ggactgtggc agtggtggag cctgagtgcg agaagagctc agctactacc tacttctggt
     1081 atcgagaggc cttggacatc tccaactcca tctcagagag tgggggcctc aactggaaga
     1141 tgacagtctg cctccttgtg gcctggagca tcgtgggcat ggctgtagtc aagggcatcc
     1201 agtcctctgg aaaggtaatg tatttcagct ccctcttccc ctatgtggtg ttggcctgct
     1261 tcctggtccg gggactgctg cttcgagggg cagttgatgg catcctgcac atgttcactc
     1321 ctaagctgga caagatgctg gacccccagg tgtggcggga ggcagccacg caggtcttct
     1381 tcgccctggg gctgggcttt ggaggtgtca tcgccttttc cagctacaac aaacaggaca
     1441 ataactgcca cttcgatgct gccttggtgt ccttcatcaa cttcttcacc tccgtgttgg
     1501 ccaccctcgt ggtgtttgca gtgctgggtt tcaaagctaa catcatgaat gagaagtgtg
     1561 tggtcgagaa tgctgagaaa attctagggt acctcaactc caatgtcttg agccgggacc
     1621 tcatcccacc ccacgtcaac ttctctcacc tgaccaccaa ggactactca gagatgtaca
     1681 atgtcatcat gactgttaag gagaagcagt tctcagccct gggcctggat ccttgcctcc
     1741 tggaggatga gctggacaag tctgtgcagg gcacaggcct ggccttcatc gccttcactg
     1801 aggccatgac acatttcccg gcctctccgt tctggtcggt catgttcttc ctgatgctca
     1861 tcaacctggg cctgggcagt atgattggga ccatggcagg aatcaccaca cctatcatcg
     1921 acaccttcaa ggtgcccaag gagatgttca cagtgggctg ctgtgtcttt gcattcttcg
     1981 tggggctatt gttcgtccag cgctccggaa actactttgt caccatgttt gatgactatt
     2041 cggccaccct gccactcacc gtcatcgtca tccttgagaa catcgctgtg gcctggattt
     2101 acggaaccaa gaagtttatg caggagctga cagagatgct gggcttccga ccgtaccgat
     2161 tctatttcta catgtggaag tttgtgtctc cactgtgcat ggctgtcctc accacagcca
     2221 gcatcatcca gctgggggtg tcacccccag gctacagtgc ctggattaag gaggaggccg
     2281 ccgagcgcta cttgtacttc cccaattggg ccatggcact gctgatcacc ctcattgctg
     2341 tggcaaccct gcctatccct gtggtgttca tcctgaggca cttccacctg ctctctgatg
     2401 gttccaacac cctctccgtg tcctacaaga agggccgcat gatgaaggac atctccaacc
     2461 tggaggagaa cgatgagaca cgcttcatcc tcagcaaggt gcccagtgag gcaccctccc
     2521 ccatgcccac ccaccgctcc tatctggggc ctggcagcac atcacccttg gagagcagca
     2581 gtcaccccaa tggacgatac gggagcggct acctcttggc cagcacccct gagtcagagc
     2641 tgtgaccaca gctccaccct gcctgcctcc cctcaatacc cacctgccca cttggccggg
     2701 cctgttctct tcctccatgg tggccaccag acccaggcca gtccaaggat tgaggatctg
     2761 tcctgccttg ttccccaccc aagtcccggc agacttccta cctatgagca ggggactggg
     2821 gacagttcag tccctattcc aggcccccaa cccatgtaac tttttgagaa ctcttgccaa
     2881 gttgcagcca tgtaaccaca acaatcccag tatgggggga cttcaagtgg gcactttagg
     2941 tgtcacctcc tcttctccct gtaaaaccta tcacttgctg ttcttgggtt tcagggaggg
     3001 tccatttgtg ccactggtca atgtggtggt ggacagaggc ttcagggctg agggtgcagg
     3061 aggtggacgt tagcccagcc catcataaga acagggctca ttgtcctgtc taacccagcc
     3121 aggctgctcg tgagctaaga tagggatagg gacgcgtggg tcaggactcg ggctttgctt
     3181 tggcaggagg tatatgggat ctcctcaatt ctgtcctatg agaaaggcag agccctctca
     3241 ggcttaagca tgaacgctgg cattgaaaga aatgaatcca gttggctcat ggagtctttg
     3301 aatgttcctg tttaccccaa caggggcaaa gaggggtata ttcttgatcc tgcccgagag
     3361 catagtgatg gggtcacttt aactagggtt tagccatttt tcaatctttg ctatccaacc
     3421 tggagccagg ggtggtggtc tttgcctctg tcccagagag aaaagggcac agtgcaagat
     3481 gaggttccca gagcacaatt tgcaggttcc cagcacaatc tagatggttt ggagcacaag
     3541 agaaacaatc ttccgcacct cacctggagc ttgattttct ctttagtggc agcttctccc
     3601 ctggaatgag ggttcctgga gttcagaggt atgccaccag gagcccttgt ttctaaggaa
     3661 agacaggtaa actcactgcc cccttgggct gccactcact ctccttgttg cacaagcaca
     3721 gccaccagtg tgcacatcgt gaagacacct tggaaacctt ccccaaactt ccctagcctg
     3781 tccagagaaa tggcacaggc aattctgggc aggaaagagc ctctggtctt aggttccaag
     3841 ggagatactg agcatggcag tgtccctgac ctcctttcaa ggcttgccta ggagaagagc
     3901 tgcttcagag cagcctgtga ggattcagga gctgacctga gaagcacagt atctctctgc
     3961 agtatcacct tagagagatg ggtgtatgga catatatgct tggctgactg gagtggacag
     4021 atggatgggt gggtggatgg ggtcaccata actagggttt agtcatttct caatctcctc
     4081 tatccaacct ggagcaggct cagtggtcat acacacatac atacatacct acatacatac
     4141 atacgtacgt acgtacacac acacacacac acacacacac acacacacac acacacacac
     4201 acacaccctg gagcgagcca ggtgcagcgg tcttacacac acacacacac acacacacac
     4261 acacacacac agacagacac ggtttctatc tttgaaagtt ctggtaggca ggaacagacc
     4321 ggggcacctt ccagaggctc ctgggttatt tttgtggtcc aaatttttct cagtactgag
     4381 agggacggtc taggcccaga tgtccaccta ttgctcctaa gcctactggt tacctccctc
     4441 cctagccgga gaggcctatc ctctcagcct gccatctctc cttttcctaa gttccacaca
     4501 ccttctctca cttctagcct ttctggtccc acccatccta gtatttaagg tgagagggag
     4561 atgagctttt ggggcatggc accccatcat cggcccctca cctgacaaca cctcctcgct
     4621 ggccccatgc ctagtcccaa gcagaattag aaaacaggaa aaccaggccc tagcagagac
     4681 tccactatct ctactcctcc ccacatgcta tttctattgt acattcaatc tgtacatgtg
     4741 ggtgtaaatg ctgtgaaatg acaaacccaa tattatactg tggctggtgg actatttcca
     4801 tcctcagtgc tgtacagatc tattttcatt gtatatttga tatattttta attttgtagc
     4861 gtggctgggc caggccccag cctgtgagcc tgcagtgagt gggggagggg gagccgagct
     4921 ggagctgctg gtttatgcat tgtgggctct gtagtgtgtg ttgtagcctt ttgccatagg
     4981 ccagaccctg tcctggctac atctttgctg tgagttgggc ataggaccca gagctctgtg
     5041 gttttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttac attcgttggt gtgagtgcat
     5101 aaggtgctga tctgtgacac cgccccccac ccagtgttca tcaccttctg aagacttagt
     5161 gtcttcctct cagctctgtg ggtgaggtct caggaccggc gcttctaaga aacactagct
     5221 gtgggaaaag gcacatgttt cctgcaggtg actcaccctc atttcacctt tgatggggag
     5281 gagggccttg ggtgagggaa aagcccccag atttattttc cagtcaacct tctgttgttc
     5341 acactggagt catgacgtct taggcagaca gtaccgggtt tcttaggaag aaggcatctc
     5401 tctgcccttt agtcctgcat ttgtccttga aaaagtcctg agtactcaga aagcggcagc
     5461 tgcttcttag acctctgttg actcctcgga agagacgaag taggctcacc tgaccattga
     5521 agaccaggcc cagcttctga ggaggagctg gaaatgaggg ctgggtctct aagtctttgc
     5581 ccagggtccc tactgccact ggttggtgct gcccatacgg tacctgccag gaggcgaggg
     5641 gtttctgtgg ctatgagtca atagagttgg ggcagtgcag aggtacacct aagggttcct
     5701 gttttgcctg ctcttagctc caatcaccaa cttcttgctc agggagcctt cagctctctt
     5761 catggagcag caagaagcct gaggttctta ggttcggtgg taggggagac ctgaggtaca
     5821 gagggtaggg gagacctgag gtgcagaggg atggtagata gggttggctt ccgccattaa
     5881 gcaataaatc ttcagaggct gctgctgcca ggaaatgccc tccagaggca gtgtgtatga
     5941 gccctgaggc tgtgagccag gccccttaca ggtctgcagt attaccaggc agggactgcc
     6001 cttcttccct tccttaccgc catccctccc ccaactatag tatgcccact gtgaaaagag
     6061 acgtgagatc aagcaggttg tatacacctg actctgtgtg cccctgggtc cctcttctta
     6121 ggtctggatt acggggagct gggggaggag ggcccagggt catttctcat gagaagttct
     6181 gctttgtaca gaccttaaag acataccagg cagtcacttc ctgtccagac acacattcag
     6241 aacagttaaa gttcgcgtgt cttggactaa tcagtgctct gggtcagcat cgctgagccc
     6301 aggagaggag atgaggcatt gtcaccccag agcccccact tcctctcccc taccctggtg
     6361 tacaataaag tatctgttct tagca
//
