LOCUS       NM_172321               3569 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 15 (Slc6a15),
            mRNA.
ACCESSION   NM_172321
VERSION     NM_172321.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3569)
  AUTHORS   Zaia,K.A. and Reimer,R.J.
  TITLE     Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled
            Neutral Amino Acid Transport
  JOURNAL   J Biol Chem 284 (13), 8439-8448 (2009)
   PUBMED   19147495
  REMARK    GeneRIF: The substrate profile of the NTT4/XT1-dependent activity
            is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15),
            including a submillimolar apparent affinity for proline and leucine
            and a low millimolar apparent affinity for glutamine.
REFERENCE   2  (bases 1 to 3569)
  AUTHORS   Drgonova,J., Liu,Q.R., Hall,F.S., Krieger,R.M. and Uhl,G.R.
  TITLE     Deletion of v7-3 (SLC6A15) transporter allows assessment of its
            roles in synaptosomal proline uptake, leucine uptake and behaviors
  JOURNAL   Brain Res 1183, 10-20 (2007)
   PUBMED   17931606
REFERENCE   3  (bases 1 to 3569)
  AUTHORS   Takanaga,H., Mackenzie,B., Peng,J.B. and Hediger,M.A.
  TITLE     Characterization of a branched-chain amino-acid transporter SBAT1
            (SLC6A15) that is expressed in human brain
  JOURNAL   Biochem Biophys Res Commun 337 (3), 892-900 (2005)
   PUBMED   16226721
REFERENCE   4  (bases 1 to 3569)
  AUTHORS   Uhl,G.R., Kitayama,S., Gregor,P., Nanthakumar,E., Persico,A. and
            Shimada,S.
  TITLE     Neurotransmitter transporter family cDNAs in a rat midbrain
            library: 'orphan transporters' suggest sizable structural
            variations
  JOURNAL   Brain Res Mol Brain Res 16 (3-4), 353-359 (1992)
   PUBMED   1363329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000185.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_172321.4.
            
            On Feb 10, 2021 this sequence version replaced NM_172321.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               JACYVU010000185.1  21183576-21183953
            379-693             JACYVU010000185.1  21205592-21205906
            694-851             JACYVU010000185.1  21209693-21209850
            852-978             JACYVU010000185.1  21210202-21210328
            979-1160            JACYVU010000185.1  21211830-21212011
            1161-1271           JACYVU010000185.1  21219200-21219310
            1272-1513           JACYVU010000185.1  21222778-21223019
            1514-1706           JACYVU010000185.1  21223122-21223314
            1707-1899           JACYVU010000185.1  21226269-21226461
            1900-2059           JACYVU010000185.1  21227739-21227898
            2060-2222           JACYVU010000185.1  21234790-21234952
            2223-3569           JACYVU010000185.1  21236273-21237619
FEATURES             Location/Qualifiers
     source          1..3569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..3569
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /note="solute carrier family 6 member 15"
                     /db_xref="GeneID:282712"
                     /db_xref="RGD:628664"
     exon            1..378
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            379..693
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2594
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /note="orphan sodium- and chloride-dependent
                     neurotransmitter transporter NTT73; transporter v7-3;
                     solute carrier family 6 (neurotransmitter transporter),
                     member 15; orphan transporter v7-3; solute carrier family
                     6 (neutral amino acid transporter), member 15"
                     /codon_start=1
                     /product="sodium-dependent neutral amino acid transporter
                     B(0)AT2"
                     /protein_id="NP_758824.1"
                     /db_xref="GeneID:282712"
                     /db_xref="RGD:628664"
                     /translation="MPKNSKVVKRDLDDDVIESVKDLLSNEDSVEDVSKKSELIVDVQ
                     EEKDTDAEDGSEVDDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLP
                     YLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNV
                     IIGWTLFYFSQSFQQPLPWDQCPLVKNASHTYIEPECEKSSATTYYWYREALAISSSI
                     SESGGLNWKMTGCLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLN
                     GSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDA
                     VLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKTGNVSWDVIPRH
                     INLSAVTAEDYHVVYDIIQKVKEEEFAVLHLKACQIEDELNKAVQGTGLAFIAFTEAM
                     THFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPVVDTFKVRKEILTVICCLLAFCI
                     GLMFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFLEDLTDMLGFAPS
                     KYYYYMWKYISPLMLVTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFS
                     LMVLAILPVPVVFVIRRCNLIDDSSGNLASVTYKRGRVLKEPVNLDGDDASLIHGKIP
                     SEMSSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADMPDMPESDL"
     exon            694..851
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            852..978
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1160
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1271
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1513
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1706
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1899
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2059
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2222
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..3569
                     /gene="Slc6a15"
                     /gene_synonym="Ntt73"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatacacac acgcacgcac acacacacat gcacacacac acactcacat aacacacaca
       61 cacacacaca cacgcacaca cacacacaca cacacacaca cacacacaca cacacacgcg
      121 cgcgcgcgcg cgcgcgcgcg cgccccagga aacaaacgcc agcatcccgt gcaatatcct
      181 ggcacacaca ggcgctcacg agtttctcgg tgccagcttg caggacagcg actcccgaaa
      241 ccaagcctgc ccttggcaag ctttctctgg tctccagaca gctcctctgc ggcctcccgc
      301 accatcacct ggatccgacc ctttcgccac ctaggaacct ggaagctcta aaaggtgctg
      361 gctcaagaag caccagaggt tgtctttaag aagagtaatt tccaatgcct aagaatagca
      421 aagtagtaaa gagagatttg gatgatgatg tcattgaatc tgtcaaagac ctcctgtcca
      481 atgaagactc agtggaagat gtttctaaga agagcgaact aattgttgat gttcaagaag
      541 agaaagatac agatgctgaa gatggatctg aagttgatga tgaaaggcca gcttggaaca
      601 gtaagctgca atacatcctg gcgcaagttg gattttctgt aggtctgggg aatgtgtggc
      661 ggttcccata cctctgccaa aagaatggcg gtggtgcata tcttttgcca tatttaatac
      721 tacttctggt gataggaatt ccactcttct tcttggaact ttctgtgggt caaagaattc
      781 ggagaggcag catcggggtt tggaattaca taagccctaa actgggtggg attggattcg
      841 caagctgtgt agtgtgctat tttgtggctc tctactacaa tgtcatcatt ggctggacat
      901 tgttttactt ttctcagtct tttcaacaac ctctcccttg ggatcaatgc cccctggtga
      961 aaaacgcatc tcatacttat attgagccag aatgtgaaaa aagttctgcc accacttatt
     1021 actggtaccg ggaagcactg gctatcagca gctccatctc tgaaagtggg ggcttaaact
     1081 ggaagatgac tggctgcctg ctggctgcct gggtcatggt ttgtctggcc atgatcaaag
     1141 gcattcagtc ctctggaaaa atcatgtatt ttagttctct gttcccctac gtggtactta
     1201 tatgcttcct aataagatct ctccttttaa atggttcaat tgatggcatc cgacacatgt
     1261 tcacccctaa gcttgaaatg atgctggagc ccaaggtttg gagagaggca gcgactcaag
     1321 tcttctttgc cttgggtttg ggatttggtg gagtcatcgc gttttccagt tacaacaaga
     1381 gagacaacaa ctgccacttc gacgctgtcc tcgtgtcttt tatcaacttt ttcacttcag
     1441 tcctggcaac actggtggtg ttcgcagttc tggggttcaa agccaatatc gtaaatgaaa
     1501 agtgcatttc acaaaattct gagatgatct tgaaactttt gaaaacggga aacgttagtt
     1561 gggatgtcat tccccgtcac atcaaccttt cagctgtcac tgcggaagat tatcatgtag
     1621 tttacgacat cattcaaaaa gtgaaggagg aggagtttgc tgttctccat ctcaaagcct
     1681 gtcaaattga ggatgagcta aataaagctg tgcagggcac tggcttggct ttcattgcct
     1741 ttacagaggc catgacacat tttcctgcat ctcccttctg gtcagtgatg tttttcctca
     1801 tgctgataaa tctcgggctc ggcagcatgt ttggaaccat tgaaggaatc atcactcctg
     1861 ttgtggacac attcaaagtg aggaaggaaa tactcaccgt tatctgttgc ctcctagcat
     1921 tttgtatcgg cttgatgttt gtgcagcgct ctggaaatta cttcgttaca atgtttgatg
     1981 attattctgc cacattgcct ctgttaatcg tggtcatctt ggagaatatt gctgtaagct
     2041 tcgtttacgg catagataag tttctagaag acctaacaga catgttagga tttgctccaa
     2101 gcaaatatta ctattacatg tggaaataca tttctcctct aatgctagta acattgttaa
     2161 tagctagcat tgtgaatatg ggattaagtc ctccgggata taatgcatgg atcaaggaga
     2221 aggcatccga agaatttctg agctacccga tgtgggggat ggtggtctgt ttctctctga
     2281 tggtgctggc tatacttcct gtcccagtcg ttttcgtcat tcgtcgctgc aacctcatag
     2341 atgatagttc tggtaacttg gcctctgtga cctataagag aggaagagtc ctgaaagaac
     2401 ccgtgaactt agacggagat gatgcaagcc tcattcacgg aaagatacca agtgaaatgt
     2461 cgtctccaaa ttttggtaaa aatatctatc gaaaacagag tggttctccg accctggaca
     2521 ctgctcccaa tggacgctat gggattgggt atttgatggc agatatgcca gatatgcccg
     2581 agtctgactt gtagctgagt gaaagcaaag ggttgagctt ggttcatttt tatcaatgag
     2641 cattggttct actatgagaa gcagtgagct tcacttgtca caaggtgatc tcaggtgtcc
     2701 atagccgcca tctttaatct caacagttta agacagttcc agaagagcaa tcctcagttt
     2761 acaattacaa agtaacaatt gcagacaaag cttacattga ctggggtcct attttgccag
     2821 gattttttta aaaagcactt tgacatactt tcaagtattt ctatctctta aaaaaaaggt
     2881 gttacctcag tttctaatag tttccggatt taatattatt ggcgatttga aaaaaaaatc
     2941 cctgttatat cttacaattc ataattttgc cttcggagta agttccagta ttaccatgaa
     3001 cagttgtgtg tgagcgggtg cttttcagca cattgccatg agtacgttct gtagatagcc
     3061 tgtacttatc tttggtagca ttgaaacctt aggcacttag ttggagaaaa cttcaaagta
     3121 ttttcttata tgatagccgt ctagagcaat agtattaaag agtaaaaagg cactgatggt
     3181 ggatgagagg ttaagtccag atgtgatcga gggtttcctg gagtggccat atattttgtg
     3241 taaaataggt gtgtgcaaat gattgaaggg actctcgaga attatgcaga ctgcattttt
     3301 cttatgccgt gtgcctaata aacctactta atatttattg tggttttgag atcacttata
     3361 gtatatttat ataatatact tgcaatgtat agagatgcgc atcaggactc ttaagtgctg
     3421 gtttgaaaac ttgaagcaag atagcatctg atttcatatg tttctgtttt gcttcatttt
     3481 atgcaaatac gaattctttt ttttaagtga ttgttaaaac tgtatggcat tacattttaa
     3541 cctacaaata aacgaagttt aacaatggt
//
