LOCUS       NM_001037544            2129 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 14 (Slc6a14),
            mRNA.
ACCESSION   NM_001037544 XM_233305
VERSION     NM_001037544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Michalec,K., Mysiorek,C., Kuntz,M., Berezowski,V.,
            Szczepankiewicz,A.A., Wilczynski,G.M., Cecchelli,R. and Nalecz,K.A.
  TITLE     Protein kinase C restricts transport of carnitine by amino acid
            transporter ATB(0,+) apically localized in the blood-brain barrier
  JOURNAL   Arch Biochem Biophys 554, 28-35 (2014)
   PUBMED   24823859
  REMARK    GeneRIF: The analyses of brain slices demonstrated ATB(0,+) luminal
            localization in brain capillaries, confirmed by biotinylation
            experiments in an in vitro model of the blood-brain barrier.
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Samluk,L., Czeredys,M., Skowronek,K. and Nalecz,K.A.
  TITLE     Protein kinase C regulates amino acid transporter ATB(0,+)
  JOURNAL   Biochem Biophys Res Commun 422 (1), 64-69 (2012)
   PUBMED   22561015
  REMARK    GeneRIF: The observed regulation of ATB(0,+) by PKC correlates with
            high activity of both proteins reported for cancer cells.
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Uchiyama,T., Fujita,T., Gukasyan,H.J., Kim,K.J., Borok,Z.,
            Crandall,E.D. and Lee,V.H.
  TITLE     Functional characterization and cloning of amino acid transporter
            B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes
  JOURNAL   J Cell Physiol 214 (3), 645-654 (2008)
   PUBMED   17960566
  REMARK    GeneRIF: Rat pneumocytes express ATB(0,+), which may partly
            contribute towards recovering cationic and neutral amino acids from
            alveolar luminal fluid.
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Flach,C.F., Qadri,F., Bhuiyan,T.R., Alam,N.H., Jennische,E.,
            Holmgren,J. and Lonnroth,I.
  TITLE     Differential expression of intestinal membrane transporters in
            cholera patients
  JOURNAL   FEBS Lett 581 (17), 3183-3188 (2007)
   PUBMED   17575980
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   D'Argenio,G., Calvani,M., Casamassimi,A., Petillo,O.,
            Margarucci,S., Rienzo,M., Peluso,I., Calvani,R., Ciccodicola,A.,
            Caporaso,N. and Peluso,G.
  TITLE     Experimental colitis: decreased Octn2 and Atb0+ expression in rat
            colonocytes induces carnitine depletion that is reversible by
            carnitine-loaded liposomes
  JOURNAL   FASEB J 20 (14), 2544-2546 (2006)
   PUBMED   17065219
  REMARK    GeneRIF: The role of carnitine in inflammatory bowel disease
            (IBD)was evaluated using the expression of the carnitine
            transporters OCTN2 and ATB0+, and butyrate metabolism in
            colonocytes in a rat model of IBD.
REFERENCE   8  (bases 1 to 2129)
  AUTHORS   Choudry,H.A., Souba,W.W., Lin,C., Meng,Q., Karinch,A.M., Huang,J.
            and Pan,M.
  TITLE     Stimulation of expression of the intestinal glutamine transporter
            ATB0 in tumor-bearing rats
  JOURNAL   Ann Surg Oncol 13 (12), 1747-1753 (2006)
   PUBMED   17006743
REFERENCE   9  (bases 1 to 2129)
  AUTHORS   Durand,E., Boutin,P., Meyre,D., Charles,M.A., Clement,K., Dina,C.
            and Froguel,P.
  TITLE     Polymorphisms in the amino acid transporter solute carrier family 6
            (neurotransmitter transporter) member 14 gene contribute to
            polygenic obesity in French Caucasians
  JOURNAL   Diabetes 53 (9), 2483-2486 (2004)
   PUBMED   15331564
  REMARK    Erratum:[Diabetes. 2005 Feb;54(2):587]
REFERENCE   10 (bases 1 to 2129)
  AUTHORS   Pan,M., Meng,Q., Choudry,H.A., Karinch,A.M., Lin,C. and Souba,W.W.
  TITLE     Stimulation of intestinal glutamine absorption in chronic metabolic
            acidosis
  JOURNAL   Surgery 136 (2), 127-134 (2004)
   PUBMED   15300171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001037544.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ969954.1, EF494736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000021.1  117144926-117145081
            157-322             JAXUCZ010000021.1  117146094-117146259
            323-454             JAXUCZ010000021.1  117148616-117148747
            455-619             JAXUCZ010000021.1  117150478-117150642
            620-758             JAXUCZ010000021.1  117151524-117151662
            759-891             JAXUCZ010000021.1  117153988-117154120
            892-1032            JAXUCZ010000021.1  117155662-117155802
            1033-1261           JAXUCZ010000021.1  117159391-117159619
            1262-1387           JAXUCZ010000021.1  117162087-117162212
            1388-1506           JAXUCZ010000021.1  117164379-117164497
            1507-1606           JAXUCZ010000021.1  117165071-117165170
            1607-1716           JAXUCZ010000021.1  117165453-117165562
            1717-1884           JAXUCZ010000021.1  117166592-117166759
            1885-2129           JAXUCZ010000021.1  117168128-117168372
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..2129
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /note="solute carrier family 6 member 14"
                     /db_xref="GeneID:298340"
                     /db_xref="RGD:1561810"
     exon            1..156
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2031
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /note="neutral cationic amino acid transporter B0,+;
                     solute carrier family 6 (neurotransmitter transporter),
                     member 14; colonic system B0+ amino acid transporter;
                     solute carrier family 6 (amino acid transporter), member
                     14"
                     /codon_start=1
                     /product="sodium- and chloride-dependent neutral and basic
                     amino acid transporter B(0+)"
                     /protein_id="NP_001032633.1"
                     /db_xref="GeneID:298340"
                     /db_xref="RGD:1561810"
                     /translation="MDRLKCPSFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSD
                     YLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASL
                     GPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANCSSSW
                     ADDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQLPSEQYWDK
                     VTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLI
                     LLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSY
                     NKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIA
                     YPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITL
                     GCCLILFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDI
                     EMMIGAKRWLFWLWWRACWFVITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWC
                     MIIFCIIWIPIMAIIKIVRAEGNILQRIIKCCRPASNWGPYLEKHRGERYKDMAEPAK
                     ETDHEIPTISGTRKPE"
     exon            157..322
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            323..454
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            455..619
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            620..758
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            759..891
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1032
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1261
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1387
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1506
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1606
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1716
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1884
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2129
                     /gene="Slc6a14"
                     /gene_synonym="Atb0+"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcacttt gggaggtagc aacgggggag tgtgcacctg ccaacgtcaa gctcagccag
       61 actgtgagaa gaggcgaggc gaaggcacgc caagggagcg agtgaaccat ggacagattg
      121 aagtgcccga gcttcttcaa gtgcagacag aaggagaaag tgacagcttc atctgagaac
      181 ttccatgttg gtgaaaatga tgaaaatcag gagcgtggta actggtccaa aaaatcagat
      241 tatcttcttt ccatggttgg ctatgcagtg ggattgggca acgtgtggcg attcccttac
      301 ctgacctaca ccaatggtgg aggtgctttc ttgataccct atgcaattat gctagcattg
      361 gctggcttgc ctttgttctt ccttgaatgt tcactgggac aatttgctag cttaggtcca
      421 gtttcagttt ggaggatttt gccactgttt caaggtgtgg gaatcacgat ggtcctgata
      481 tccatttttg tgacaattta ttataatgtc atcattgcct acagtcttta ctacttattt
      541 gcttcttttc aaagtgtact gccatgggct aattgttctt cttcttgggc agacgataac
      601 tgtagcagac aaccaatagt aactggctgt cgtgtgagca cagacacagg aggagacatg
      661 tttatgaata taagctgggt aaatagcaac aacttcacct gcttgaatgg tagtgaagtt
      721 tttcggccag gacaacttcc cagtgaacag tattgggata aagtgacgct tcggaggtca
      781 agtggaatgg atgaaactgg cgtaattgtg tggtacttag cactttgcct tcttctagct
      841 tggatcatag ttggagcagc actatttaaa ggaatcaaat cctctggcaa ggtggtatat
      901 tttacagctc ttttcccgta tgtggtcctt ctcattctac taatacgagg tgcaactttg
      961 gagggtgcat caaaaggcat ttcatattac attggagcac agtcaaattt tacaaaactc
     1021 agagaagctg aggtttggaa ggatgctgcc actcagatat tttattccct ttctgtggct
     1081 tggggtggcc tagtggctct gtcatcttac aacaagttca acaacaactg ttactctgat
     1141 gccattatag tttgcttgac caactgcctc actagtgtgt ttgctggatt cgccattttt
     1201 tctattctgg gacacatggc tcatatatcc ggaaaggaag tctctcaagt tgtaaaatca
     1261 ggatttgact tggcattcat tgcttatccg gaagcactag ctcaactccc aggtggtcca
     1321 ttctggtcca tattattttt cttcatgctt ttaacattgg gtctggattc tcaatttgct
     1381 tctattgaaa caatcacaac aacaattcaa gatttgtttc ccaaagcaat gaaacgcatg
     1441 agggttccta taactttggg atgctgcttg attttgtttc tccttggtct cgtctgtgtg
     1501 actcaggctg gaatttactg ggttcatttg attgatcact tctgtgctgg atgggggatc
     1561 ttaattgctg ccatcttgga aattgcagga atcatctgga tttatggagg aaataggttc
     1621 attgaagata tagaaatgat gattggagca aaaagatggc tattctggct ttggtggaga
     1681 gcttgttggt ttgtcatcac tcctatactg ttgtctgcaa ttctagtctg gtcactggtg
     1741 aaatttcaca gacctaatta tgctgatatt ccatatcctg actggggagt cgctctcgga
     1801 tggtgtatga ttattttctg cattatttgg ataccaatta tggcgatcat aaaaatagtt
     1861 cgggctgaag gaaacatcct tcagcgtatc ataaaatgct gtagaccagc ttcaaactgg
     1921 ggtccatacc tggaaaaaca tcgtggagag agatataaag acatggctga acctgcaaag
     1981 gagactgacc acgaaatacc tactattagt ggcactagaa aaccagaatg agatgtcact
     2041 tttgaaaata tcgaattgtt ctataatgtg attttgtaga gtagggggaa tttttaattt
     2101 atttgtatgt taatcaacta gggggatgt
//
