LOCUS       NM_133623               2028 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 13 (Slc6a13),
            mRNA.
ACCESSION   NM_133623
VERSION     NM_133623.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Zhou,Y., Holmseth,S., Guo,C., Hassel,B., Hofner,G., Huitfeldt,H.S.,
            Wanner,K.T. and Danbolt,N.C.
  TITLE     Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and
            SLC6A13) gene in mice leads to changes in liver and brain taurine
            contents
  JOURNAL   J Biol Chem 287 (42), 35733-35746 (2012)
   PUBMED   22896705
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Ikeda,S., Tachikawa,M., Akanuma,S., Fujinawa,J. and Hosoya,K.
  TITLE     Involvement of gamma-aminobutyric acid transporter 2 in the hepatic
            uptake of taurine in rats
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 303 (3), G291-G297 (2012)
   PUBMED   22678999
  REMARK    GeneRIF: results suggest that GAT2 is responsible for taurine
            transport from the circulating blood to hepatocytes predominantly
            in the periportal region.
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Tachikawa,M., Ikeda,S., Fujinawa,J., Hirose,S., Akanuma,S. and
            Hosoya,K.
  TITLE     gamma-Aminobutyric acid transporter 2 mediates the hepatic uptake
            of guanidinoacetate, the creatine biosynthetic precursor, in rats
  JOURNAL   PLoS One 7 (2), e32557 (2012)
   PUBMED   22384273
  REMARK    GeneRIF: GAT2 makes a major contribution to the sinusoidal GAA
            uptake by periportal hepatocytes, thus regulating creatine
            biosynthesis in the liver
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Nakanishi,T., Fukuyama,Y., Fujita,M., Shirasaka,Y. and Tamai,I.
  TITLE     Carnitine precursor gamma-butyrobetaine is a novel substrate of the
            Na(+)- and Cl(-)-dependent GABA transporter Gat2
  JOURNAL   Drug Metab Pharmacokinet 26 (6), 632-636 (2011)
   PUBMED   21997971
  REMARK    GeneRIF: RGat2-mediated d(3)-GBB uptake was Na(+) and Cl(-)
            dependent.
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Fletcher,E.L., Clark,M.J. and Furness,J.B.
  TITLE     Neuronal and glial localization of GABA transporter
            immunoreactivity in the myenteric plexus
  JOURNAL   Cell Tissue Res 308 (3), 339-346 (2002)
   PUBMED   12107427
  REMARK    GeneRIF: large number of GAT2-immunoreactive structures that
            surrounded neurons within each ganglion of the myenteric plexus.
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Borden,L.A., Smith,K.E., Hartig,P.R., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Molecular heterogeneity of the gamma-aminobutyric acid (GABA)
            transport system. Cloning of two novel high affinity GABA
            transporters from rat brain
  JOURNAL   J Biol Chem 267 (29), 21098-21104 (1992)
   PUBMED   1400419
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M95762.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2028
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /note="solute carrier family 6 member 13"
                     /db_xref="GeneID:171163"
                     /db_xref="RGD:620788"
     exon            1..120
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..327
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1934
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /note="solute carrier family 6 (neurotransmitter
                     transporter, GABA), member 13; solute carrier family 6
                     (neurotransmitter transporter), member 13"
                     /codon_start=1
                     /product="sodium- and chloride-dependent GABA transporter
                     2"
                     /protein_id="NP_598307.1"
                     /db_xref="GeneID:171163"
                     /db_xref="RGD:620788"
                     /translation="MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLS
                     VAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGIT
                     AWRKICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTE
                     NCVEFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWII
                     CYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDP
                     QVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFS
                     ILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQF
                     VCVESLVTALVDMYPRVFRKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYA
                     ASGMCLLFVAIFESLCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATF
                     LFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSIYKLRTLKGPLRERLRQ
                     LVCPAEDLPQKSQPELTSPATPMTSLLRLTELESNC"
     exon            328..462
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..603
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..688
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..821
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..956
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1060
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1185
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1298
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1436
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1539
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1640
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1811
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2028
                     /gene="Slc6a13"
                     /gene_synonym="GAT-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcgaac acaagcgcat ccggtagaac ggaaagaaca ggaattgcag agtgacttca
       61 agtctccata cgatttacta cccgggtgac ggcagtgact cgacagagta gcggctgcag
      121 gtgggatgga taacagggtc tcgggaacga ccagtaatgg agagacaaag ccagtgtgtc
      181 cagtcatgga gaaggtggag gaagacggta ccttggaacg ggagcaatgg accaacaaga
      241 tggagttcgt actgtcagtg gcgggagaga tcattggctt aggcaacgtc tggaggtttc
      301 cctatctctg ctacaagaac gggggaggtg ccttctttat tccctacctc atcttcctat
      361 ttacctgtgg cattcctgtc ttcttcctgg agacagcgct tggccagtac accaaccagg
      421 gaggcatcac agcctggagg aaaatctgtc ccatcttcga gggcatcggc tatgcctcac
      481 agatgatcgt cagccttctc aatgtctact acatcgttgt cctggcctgg gccctcttct
      541 acctcttcag cagcttcacc actgacctcc cctggggtag ctgcagccac gagtggaata
      601 cagaaaactg tgtggagttc cagaaaacca acaattccct gaatgtgact tctgagaatg
      661 ccacatcccc tgtcatcgag ttctgggaga ggcgagtcct gaagatctca gatggcatcc
      721 agcacctggg gtccctgcgc tgggagctgg tcctgtgcct cctgcttgcc tggatcatct
      781 gctatttctg catctggaaa ggggtcaagt ccacaggcaa ggtggtgtac ttcacagcta
      841 ctttccctta cctcatgctg gtggtcctgt tgatccgagg agtaacactg cctggagcag
      901 cccagggaat tcagttttac ctgtacccca acatcacacg tctgtgggat ccccaggtgt
      961 ggatggatgc gggcacccag atcttcttct cctttgccat ctgcctgggg tgcctcacgg
     1021 ccctgggcag ctacaacaag taccacaaca actgctacag ggactgcgtc gccctttgca
     1081 ttctcaacag cagcaccagc ttcgtggccg ggtttgccat cttctccatc ctgggcttca
     1141 tgtctcagga gcagggcgta cccatatctg aggttgctga atcaggccct ggcctggcat
     1201 tcatcgccta ccctcgagct gtggtgatgt tacctttctc gcctttgtgg gcctgctgtt
     1261 tcttcttcat ggtggttctc ctgggactag acagccagtt tgtgtgtgta gaaagcctcg
     1321 tgacagcgct ggtggacatg tatccccggg tgttccgtaa gaagaaccgg agggagattc
     1381 tcatcctcat cgtgtctgtc gtctctttct tcatcgggct cattatgctc acagagggcg
     1441 gcatgtacgt gttccagctc ttcgactact atgcggccag tggcatgtgt cttctctttg
     1501 tggccatctt tgagtccctc tgtgtggctt gggtttacgg agccagccgc ttctatgaca
     1561 acattgaaga tatgattggg tacaagccgt ggcctcttat caaatactgt tggctctttt
     1621 tcacgccagc tgtgtgcctg gcaaccttcc tgttctccct gatcaaatac acgccactga
     1681 cctacaacaa gaagtacaca tatccatggt ggggggatgc cctggggtgg ctcctagctc
     1741 tgtcctccat ggtctgcatt cctgcctgga gcatctacaa gctcaggact ctcaagggcc
     1801 cactcagaga gagacttcgc cagctcgtgt gcccggctga agaccttccc cagaagagcc
     1861 aaccagagct gacttctcca gcgacaccga tgacgtccct cctcaggctc acagaactgg
     1921 agtctaactg ctagggacga ggcctttgac acacctgcga gtctgtctgt ggggacagct
     1981 acagacacag agggcagaac cacccctccg tgctggggca gagagaca
//
