LOCUS       NM_024372               1935 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 6 member 11 (Slc6a11),
            mRNA.
ACCESSION   NM_024372
VERSION     NM_024372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Augier,E., Barbier,E., Dulman,R.S., Licheri,V., Augier,G., Domi,E.,
            Barchiesi,R., Farris,S., Natt,D., Mayfield,R.D., Adermark,L. and
            Heilig,M.
  TITLE     A molecular mechanism for choosing alcohol over an alternative
            reward
  JOURNAL   Science 360 (6395), 1321-1326 (2018)
   PUBMED   29930131
  REMARK    GeneRIF: Expression of the gamma-aminobutyric acid (GABA)
            transporter GAT-3 was selectively decreased within the amygdala of
            alcohol-choosing rats, whereas a knockdown of this transcript
            reversed choice preference of rats that originally chose a sweet
            solution over alcohol.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Chazalon,M., Paredes-Rodriguez,E., Morin,S., Martinez,A.,
            Cristovao-Ferreira,S., Vaz,S., Sebastiao,A., Panatier,A.,
            Boue-Grabot,E., Miguelez,C. and Baufreton,J.
  TITLE     GAT-3 Dysfunction Generates Tonic Inhibition in External Globus
            Pallidus Neurons in Parkinsonian Rodents
  JOURNAL   Cell Rep 23 (6), 1678-1690 (2018)
   PUBMED   29742425
  REMARK    GeneRIF: glial GAT-3 transporters are downregulated while neuronal
            GAT-1 function remains normal in dopamine-depleted rodents.
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Boddum,K., Jensen,T.P., Magloire,V., Kristiansen,U., Rusakov,D.A.,
            Pavlov,I. and Walker,M.C.
  TITLE     Astrocytic GABA transporter activity modulates excitatory
            neurotransmission
  JOURNAL   Nat Commun 7, 13572 (2016)
   PUBMED   27886179
  REMARK    GeneRIF: Increases in GAT-3 activity result in astrocytic Na+
            accumulation and a consequent increase in astrocytic Ca2+ through
            Na+/Ca2+ exchange, leading to the astrocytic release of
            ATP/adenosine.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Melone,M., Ciappelloni,S. and Conti,F.
  TITLE     Plasma membrane transporters GAT-1 and GAT-3 contribute to
            heterogeneity of GABAergic synapses in neocortex
  JOURNAL   Front Neuroanat 8, 72 (2014)
   PUBMED   25120439
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Weingarten,J., Lassek,M., Mueller,B.F., Rohmer,M., Lunger,I.,
            Baeumlisberger,D., Dudek,S., Gogesch,P., Karas,M. and Volknandt,W.
  TITLE     The proteome of the presynaptic active zone from mouse brain
  JOURNAL   Mol Cell Neurosci 59, 106-118 (2014)
   PUBMED   24534009
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Fletcher,E.L., Clark,M.J. and Furness,J.B.
  TITLE     Neuronal and glial localization of GABA transporter
            immunoreactivity in the myenteric plexus
  JOURNAL   Cell Tissue Res 308 (3), 339-346 (2002)
   PUBMED   12107427
  REMARK    GeneRIF: a small proportion of inhibitory motor neurons and at
            least some putative intrinsic primary afferent neurons within the
            rat gastrointestinal tract express GAT3.
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Ribak,C.E., Tong,W.M. and Brecha,N.C.
  TITLE     GABA plasma membrane transporters, GAT-1 and GAT-3, display
            different distributions in the rat hippocampus
  JOURNAL   J Comp Neurol 367 (4), 595-606 (1996)
   PUBMED   8731228
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Liu,Q.R., Lopez-Corcuera,B., Mandiyan,S., Nelson,H. and Nelson,N.
  TITLE     Molecular characterization of four pharmacologically distinct
            gamma-aminobutyric acid transporters in mouse brain [corrected]
  JOURNAL   J Biol Chem 268 (3), 2106-2112 (1993)
   PUBMED   8420981
  REMARK    Erratum:[J Biol Chem 1993 Apr 25;268(12):9156]
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Borden,L.A., Smith,K.E., Hartig,P.R., Branchek,T.A. and
            Weinshank,R.L.
  TITLE     Molecular heterogeneity of the gamma-aminobutyric acid (GABA)
            transport system. Cloning of two novel high affinity GABA
            transporters from rat brain
  JOURNAL   J Biol Chem 267 (29), 21098-21104 (1992)
   PUBMED   1400419
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Clark,J.A., Deutch,A.Y., Gallipoli,P.Z. and Amara,S.G.
  TITLE     Functional expression and CNS distribution of a
            beta-alanine-sensitive neuronal GABA transporter
  JOURNAL   Neuron 9 (2), 337-348 (1992)
   PUBMED   1497897
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M95763.1.
            
            On Jun 10, 2007 this sequence version replaced NM_024372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95763.1, M95738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1935
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /note="solute carrier family 6 member 11"
                     /db_xref="GeneID:79213"
                     /db_xref="RGD:628737"
     exon            1..253
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1896
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /note="GAT-3; solute carrier family 6 (neurotransmitter
                     transporter), member 11; GABA transporter GAT-3; solute
                     carrier family 6 (neurotransmitter transporter, GABA),
                     member 11"
                     /codon_start=1
                     /product="sodium- and chloride-dependent GABA transporter
                     3"
                     /protein_id="NP_077348.1"
                     /db_xref="GeneID:79213"
                     /db_xref="RGD:628737"
                     /translation="MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHE
                     RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLE
                     TALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTE
                     LPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGN
                     LRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEG
                     IKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCC
                     LNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWAT
                     LFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVML
                     TEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIK
                     WCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFI
                     KLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKE
                     THF"
     exon            254..388
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            389..529
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            530..620
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..753
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..888
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..992
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1117
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1230
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1368
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1471
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1572
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1743
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1935
                     /gene="Slc6a11"
                     /gene_synonym="Gabt4; Gat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagggcgg ccatgactgc ggagcaagcg ctgcccctgg gcaacgggaa ggcggccgag
       61 gaggcgcgag ggtccgaggc gctgggcggc ggcggcgggg gcgcggcggg gacgcgcgag
      121 gcgcgcgaca aggcggtcca cgagcgcggt cactggaaca acaaggtgga gttcgtgttg
      181 agcgtagcgg gagagatcat cggtctgggc aacgtgtggc gcttccccta cctgtgctac
      241 aagaacggcg gaggggcatt cctgattcct tacgtggtgt ttttcatctg ctgtggaatc
      301 cccgtcttct tcctggaaac ggctctgggg cagttcacga gcgagggcgg catcacgtgc
      361 tggaggagag tctgtccttt atttgaaggc atcggctatg caacacaggt gatcgaggcg
      421 catctcaatg tctactacat catcatcctg gcgtgggcca tcttctactt aagcaactgc
      481 ttcaccaccg agctcccctg ggccacctgt gggcatgagt ggaacacaga gaaatgtgtg
      541 gagttccaga agctgaactt cagcaactac agtcatgtgt ccctgcagaa cgcaacctcc
      601 ccggtcatgg agttctggga acgccgggtc ttggctatat ctgatggcat tgaacacatc
      661 gggaacctcc gatgggagct ggcactgtgt ctcctggcgg cttggaccat ctgctacttc
      721 tgcatctgga agggtacgaa gtcaactgga aaggtcgtgt atgtcactgc aaccttcccc
      781 tacatcatgc tgctgatcct cctgatccga ggggtcacgt tgccgggtgc ctcggaaggc
      841 atcaagttct acctgtaccc tgacctctcc cggctctctg atccacaggt gtgggtggat
      901 gctgggacgc agatcttttt ctcctatgcc atctgcctgg gctgcctgac cgctctgggg
      961 agttacaaca actataacaa caactgctac agggactgta ttatgctctg ctgtctgaac
     1021 agtggcacca gcttcgtggc tgggtttgct atcttctcag tcctgggctt catggcgtac
     1081 gagcagggcg tgcctattgc tgaggtggca gaatcaggtc ctggactggc tttcatcgcc
     1141 taccccaagg ctgtcactat gatgcccctg tccccattgt gggccaccct gttcttcatg
     1201 atgctcatct tcctgggcct ggacagtcag tttgtgtgtg tggagagcct tgtgacagcc
     1261 gtggttgaca tgtaccccaa ggtcttccgg cggggctacc ggcgagaact gctcatcctg
     1321 gccctgtcca ttgtctctta tttcctaggc ctggtgatgc tgacagaggg aggcatgtac
     1381 attttccagc tttttgactc atacgccgcc agtggcatgt gcttgctctt cgtggccatc
     1441 tttgagtgtg tctgcatcgg ctgggtgtat ggaagtaaca ggttctatga caatattgag
     1501 gacatgattg gataccggcc actgtcactc atcaagtggt gctggaaagt tgtgacccct
     1561 gggatctgtg cgggcatctt catcttcttt ctggtcaagt acaagccgct caagtacaac
     1621 aatgtgtaca catatcctgc ttggggctac ggcattggct ggctcatggc tctgtcctcc
     1681 atgctgtgca tcccgctctg gatcttcatc aagctgtgga agacagaggg caccctgccc
     1741 gagaaattac agaagttgac agtccccagc gctgatctga aaatgagggg caagcttggg
     1801 gccagcccac ggatggtgac cgttaatgac tgtgaggcca aggtcaaagg cgacggtacc
     1861 atctctgcca tcacagagaa ggagacgcac ttctgatccc cgccagccac ttggatgtgt
     1921 ctccagcctt ccttc
//
