LOCUS       NM_001399232            1400 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 66 member 1 (Slc66a1),
            transcript variant 1, mRNA.
ACCESSION   NM_001399232
VERSION     NM_001399232.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Jezegou,A., Llinares,E., Anne,C., Kieffer-Jaquinod,S., O'Regan,S.,
            Aupetit,J., Chabli,A., Sagne,C., Debacker,C.,
            Chadefaux-Vekemans,B., Journet,A., Andre,B. and Gasnier,B.
  TITLE     Heptahelical protein PQLC2 is a lysosomal cationic amino acid
            exporter underlying the action of cysteamine in cystinosis therapy
  JOURNAL   Proc Natl Acad Sci U S A 109 (50), E3434-E3443 (2012)
   PUBMED   23169667
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3197]
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Liu,B., Du,H., Rutkowski,R., Gartner,A. and Wang,X.
  TITLE     LAAT-1 is the lysosomal lysine/arginine transporter that maintains
            amino acid homeostasis
  JOURNAL   Science 337 (6092), 351-354 (2012)
   PUBMED   22822152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000005.1  156835426-156835473 c
            49-172              JAXUCZ010000005.1  156833749-156833872 c
            173-338             JAXUCZ010000005.1  156832825-156832990 c
            339-468             JAXUCZ010000005.1  156829085-156829214 c
            469-556             JAXUCZ010000005.1  156828548-156828635 c
            557-699             JAXUCZ010000005.1  156828067-156828209 c
            700-792             JAXUCZ010000005.1  156827799-156827891 c
            793-992             JAXUCZ010000005.1  156826958-156827157 c
            993-1400            JAXUCZ010000005.1  156825590-156825997 c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1400
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /note="solute carrier family 66 member 1"
                     /db_xref="GeneID:362642"
                     /db_xref="RGD:1311627"
     exon            1..48
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..172
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..338
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1260
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PQ-loop repeat-containing protein 2; lysosomal amino acid
                     transporter 1 homolog; PQ loop repeat containing 2"
                     /codon_start=1
                     /product="lysosomal amino acid transporter 1 homolog
                     isoform 1"
                     /protein_id="NP_001386161.1"
                     /db_xref="GeneID:362642"
                     /db_xref="RGD:1311627"
                     /translation="MVWRTLVASNFSTCPNGSIQWIWDVFGECAQDGWDEASVALGLV
                     SIFCFAASTFPQYIKACKTGNMDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTYTA
                     VYYVLADLLMLTLYFHYKFKKQPSLLSAPINSVLLFILGTVCITPLLSSTDPVAVPRE
                     GFRGRTLLSVEPGNKPFTKKEVVGFVIGSASSVLYLLSRLPQIRTNFVRQSTQGISYS
                     LFALVMLGNTLYGLSVLLKNPEVGQSEGSYLLHHLPWLVGSLGVLLLDTIVSFKASWC
                     TEAMMLMLPQSESRSSQADPTAALPGRSDTAATGLGLGGGLGLWAWLPPLHTWPSDRS
                     RVGTGLELACAMPGHTSQVYDSCPRSL"
     exon            339..468
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..556
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..699
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..792
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..992
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1400
                     /gene="Slc66a1"
                     /gene_synonym="Pqlc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggctcc gatcctgaag ctgagagcgg ctgtggatct ttgagctggt tgtcacatac
       61 tcagagtgac cacaatagga actctgtgca ggtggcaagg aactgagagg acccctttct
      121 tcctgctctt ccacccagcc atactctggc ttgggctgtg gcttccttgc agccatggtc
      181 tggaggacac tggtcgccag caacttttcc acctgcccca atggctctat ccagtggatc
      241 tgggatgtgt ttggtgaatg tgcccaggat ggctgggatg aggccagcgt ggccctgggc
      301 ttggtctcca ttttctgctt tgctgcgtct acctttcccc agtacatcaa agcctgcaag
      361 acaggcaaca tggaccaggc cctgtcactg tggttcctgc tgggctggat cggtggagac
      421 tcctgcaacc tcattggttc ctttctggca gaccagctac ccctgcagac ctacacggct
      481 gtgtattatg tcctggccga ccttttgatg ctgacactgt acttccacta caagttcaag
      541 aagcagccct ctctgttgtc tgccccaatc aattctgtgc tcttgttcat cttggggacg
      601 gtgtgcatca caccactgtt gagcagcact gatcctgtgg ctgtccccag ggaaggcttc
      661 agggggcgga cgctcctgtc tgtggagcca ggcaataagc ccttcacaaa gaaggaggtc
      721 gtcggttttg tcattggctc cgcctccagc gtgctgtacc tgctctcaag gctgccgcag
      781 attcgcacca atttcgtacg gcagtcaacc caaggcattt cctactcgct gtttgcactg
      841 gtgatgctgg ggaacacgct atatgggctc agtgtgctgc tcaaaaaccc cgaggtgggc
      901 cagagtgagg gcagctatct gctgcaccac ctgccctggc tcgtgggcag cctgggagtg
      961 ctcctgcttg acaccattgt atccttcaaa gcttcctggt gtacagaagc catgatgctg
     1021 atgctgcctc agagcgagag ccgctcctcc caagctgacc ccacagctgc cctcccagga
     1081 aggagtgata ctgccgccac tggactgggc ctaggaggtg gcctgggact ctgggcctgg
     1141 ctgcctcccc tccacacctg gccttcagac aggtctagag ttggcacagg tctggagttg
     1201 gcgtgtgcta tgccgggaca tacctctcag gtatatgaca gctgtccgag gagcctctag
     1261 ggcaccccag aagacggtgt ggcctcctcc caatcaaact acctcaatct gactatgtac
     1321 tcctggctac atcatagctg ggggacccag ggttgtccct ctgactgggc acaacctagt
     1381 aaatagtacc ttccagctgg
//
