LOCUS       NM_001191987            1902 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 5 member 8 (Slc5a8), mRNA.
ACCESSION   NM_001191987 XM_576209
VERSION     NM_001191987.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Nikiforov,A., Kulikova,V. and Ziegler,M.
  TITLE     The human NAD metabolome: Functions, metabolism and
            compartmentalization
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 284-297 (2015)
   PUBMED   25837229
  REMARK    Review article
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Ohkubo,M., Ohta,K., Inoue,K. and Yuasa,H.
  TITLE     Nicotinate uptake by two kinetically distinct Na/-dependent
            carrier-mediated transport systems in the rat small intestine
  JOURNAL   Drug Metab Pharmacokinet 27 (2), 255-262 (2012)
   PUBMED   22123132
  REMARK    GeneRIF: A high affinity type of SMCT1-like transporter,
            additionally in operation in the ileum, is involved in the
            transport of nicotinate.
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Borthakur,A., Anbazhagan,A.N., Kumar,A., Raheja,G., Singh,V.,
            Ramaswamy,K. and Dudeja,P.K.
  TITLE     The probiotic Lactobacillus plantarum counteracts
            TNF-{alpha}-induced downregulation of SMCT1 expression and function
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 299 (4), G928-G934 (2010)
   PUBMED   20671196
  REMARK    GeneRIF: Efficacy of LP or their secreted soluble factors to
            stimulate SMCT1 expression and function and to counteract the
            inhibitory effects of TNF-alpha on butyrate absorption could have
            potential therapeutic value.
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Miyauchi,S., Gopal,E., Babu,E., Srinivas,S.R., Kubo,Y.,
            Umapathy,N.S., Thakkar,S.V., Ganapathy,V. and Prasad,P.D.
  TITLE     Sodium-coupled electrogenic transport of pyroglutamate
            (5-oxoproline) via SLC5A8, a monocarboxylate transporter
  JOURNAL   Biochim Biophys Acta 1798 (6), 1164-1171 (2010)
   PUBMED   20211600
  REMARK    GeneRIF: Sodium-coupled electrogenic transport of pyroglutamate
            (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Gopal,E., Fei,Y.J., Sugawara,M., Miyauchi,S., Zhuang,L., Martin,P.,
            Smith,S.B., Prasad,P.D. and Ganapathy,V.
  TITLE     Expression of slc5a8 in kidney and its role in Na(+)-coupled
            transport of lactate
  JOURNAL   J Biol Chem 279 (43), 44522-44532 (2004)
   PUBMED   15322102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_576209.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.17664.1,
                                           SRR26643295.27702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               JAXUCZ010000007.1  25160280-25160630
            352-417             JAXUCZ010000007.1  25167217-25167282
            418-469             JAXUCZ010000007.1  25169065-25169116
            470-537             JAXUCZ010000007.1  25176143-25176210
            538-692             JAXUCZ010000007.1  25177145-25177299
            693-833             JAXUCZ010000007.1  25178274-25178414
            834-963             JAXUCZ010000007.1  25179700-25179829
            964-1052            JAXUCZ010000007.1  25181827-25181915
            1053-1165           JAXUCZ010000007.1  25183408-25183520
            1166-1233           JAXUCZ010000007.1  25185446-25185513
            1234-1320           JAXUCZ010000007.1  25191899-25191985
            1321-1526           JAXUCZ010000007.1  25192803-25193008
            1527-1630           JAXUCZ010000007.1  25197180-25197283
            1631-1710           JAXUCZ010000007.1  25200483-25200562
            1711-1902           JAXUCZ010000007.1  25200994-25201185
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1902
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /note="solute carrier family 5 member 8"
                     /db_xref="GeneID:500820"
                     /db_xref="RGD:1564146"
     CDS             1..1836
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /note="solute carrier family 5 (iodide transporter),
                     member 8; solute carrier family 5 (sodium/monocarboxylate
                     cotransporter), member 8"
                     /codon_start=1
                     /product="sodium-coupled monocarboxylate transporter 1"
                     /protein_id="NP_001178916.1"
                     /db_xref="GeneID:500820"
                     /db_xref="RGD:1564146"
                     /translation="MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKD
                     FLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFGVTYFFVVVISAEV
                     FLPVFYRLGITSTYEYLELRFNRFIRLCGTVLFIVQTILYTGIVIYAPALALNQVTGF
                     DLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQGGINTIL
                     SDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTIYGVNQSQVQRYISCKSRLHA
                     KLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVDQLMPYLVLDILKNY
                     PGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLY
                     GALCIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLAGF
                     AVSLWVGIGAQLYPPLPERTLPLSLETHGCNSTHNGTDWMSTTEMPFSTSAFQIHDVE
                     RSALMDNWYSLSYLYFSTIGTLTTLLVGILISLATGGRKQNLDPRFLLTKQDFLSNFD
                     VFKKKTHVLNYKMHPVEDGGTDNPAFNHVELNFPDHSGKINGTRL"
     exon            1..351
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            352..417
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            418..469
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            470..537
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            538..692
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            693..833
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            834..963
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1052
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1165
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1233
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1320
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1526
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1630
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1710
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1902
                     /gene="Slc5a8"
                     /gene_synonym="RGD1564146"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacgctt cgcgggacat cggcagcttt gtggtgtggg actacgtggt gttcgcaggc
       61 atgctgctca tctcggcggc catcggcatc tattacgcct tcgcgggggg cggccagcag
      121 acctccaagg actttctgat gggcggccgc agtatgagcg ctgtgcctgt ggctctgtcc
      181 ctcaccgcca gcttcatgtc cgctgtcact gtcctgggca cccccgccga ggtctaccgt
      241 tttggggcga tattcagcat ctttggcgtc acttactttt ttgtagtggt tatcagcgcg
      301 gaggtcttcc ttccggtgtt ctatagactc gggatcacca gcacctacga gtatttggag
      361 ctcagattta atcgattcat tcgtctctgt ggcacagtcc tcttcatcgt tcaaacaatt
      421 ctgtacactg ggattgtgat ttatgcccct gctctggctt tgaatcaagt tacaggattt
      481 gatctgtggg gcgcagtggt ggccacaggg gtggtctgca cattctactg cacactgggt
      541 ggtcttaaag cagtcgtctg gacagatgtt tttcaagtcg ggatcatggt ggctggattt
      601 gcatccgtga ttatacaggc ttccataact caaggtggca tcaatacgat tttaagtgac
      661 gcttccaatg gtggaagatt aaacttctgg aattttaatc ctaacccttt gcaaagacac
      721 acgttctgga caattatcgt cggagggact tttacatgga ccaccatcta tggtgtcaac
      781 cagtcccaag tgcagagata tatttcctgt aaaagcagac tccatgcaaa actgtctctc
      841 tatgtcaacc ttgtgggcct ctgggtgatc ctcatctgct ccgtgttctg tgggcttgcc
      901 ctgtactcca gataccatga ctgtgatccc tggacatcta agaaagtgtc agaagttgac
      961 cagcttatgc cttatttggt gctggacatt ttgaaaaatt atcctggtgt tcccggactt
     1021 tttgtggcct gtgcttacag tgggacatta agcacggtgt cttccagcat caatgccttg
     1081 gcagcagtca ctgtggaaga tctcatcaaa cctcgcttca agtctctctc agagaagtct
     1141 ctgtcttgga tttctcaagg aatgagtgtg ctgtacggag ctttgtgcat cgggatggct
     1201 gctgtggcct cgctgatggg agccttgtta caggcagcac ttagcatatt tggcatggtt
     1261 ggtggaccac ttctgggctt gttttctttg ggcatcttgg tccccttcgc caactctgtg
     1321 ggagcctttg ccggtctgtt ggccggattt gccgtttctt tatgggtagg aatcggagcc
     1381 cagctttatc ctccacttcc tgagagaacc ttaccattgt cccttgaaac ccatggctgt
     1441 aacagcacgc acaacgggac agactggatg tcaaccacag agatgccatt ttctactagc
     1501 gctttccaga tacacgacgt ggaaaggagt gcactgatgg acaattggta ttcattatca
     1561 tatctgtact tcagtaccat tggaaccctg acaacgttgc tggtggggat tcttatcagt
     1621 ttagcaacag gaggaagaaa acagaactta gacccccgat tcttactaac caaacaggac
     1681 tttttatcca attttgatgt ttttaagaaa aagactcatg ttttaaacta taaaatgcat
     1741 cctgtggaag acggtggaac tgataacccg gccttcaacc acgtggagct gaacttccca
     1801 gaccacagtg gcaagatcaa tgggactcgc ttgtgaagct tctccagggc tggatgctgt
     1861 tgtataatgt ctggtttttt tttattatta aaaaacatgt tt
//
