LOCUS       NM_053521               4896 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 5 member 7 (Slc5a7), mRNA.
ACCESSION   NM_053521 XM_346846
VERSION     NM_053521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4896)
  AUTHORS   Lin,M., Hu,G., Wang,Z., Yu,B. and Tan,W.
  TITLE     Activation of the High-Affinity Choline Transporter 1 in the Spinal
            Cord Relieves Stress-Induced Hyperalgesia
  JOURNAL   Dig Dis Sci 68 (6), 2414-2426 (2023)
   PUBMED   36808325
  REMARK    GeneRIF: Activation of the High-Affinity Choline Transporter 1 in
            the Spinal Cord Relieves Stress-Induced Hyperalgesia.
REFERENCE   2  (bases 1 to 4896)
  AUTHORS   Han,S., Yang,S.H., Kim,J.Y., Mo,S., Yang,E., Song,K.M., Ham,B.J.,
            Mechawar,N., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of cholinergic signaling in the habenula induces
            anhedonia-like behavior
  JOURNAL   Sci Rep 7 (1), 900 (2017)
   PUBMED   28420875
  REMARK    Erratum:[Sci Rep. 2017 Dec 1;7(1):17090. doi:
            10.1038/s41598-017-16991-1.. PMID: 29196669]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4896)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4896)
  AUTHORS   Bauche,S., O'Regan,S., Azuma,Y., Laffargue,F., McMacken,G.,
            Sternberg,D., Brochier,G., Buon,C., Bouzidi,N., Topf,A., Lacene,E.,
            Remerand,G., Beaufrere,A.M., Pebrel-Richard,C., Thevenon,J., El
            Chehadeh-Djebbar,S., Faivre,L., Duffourd,Y., Ricci,F., Mongini,T.,
            Fiorillo,C., Astrea,G., Burloiu,C.M., Butoianu,N., Sandu,C.,
            Servais,L., Bonne,G., Nelson,I., Desguerre,I., Nougues,M.C.,
            Boeuf,B., Romero,N., Laporte,J., Boland,A., Lechner,D.,
            Deleuze,J.F., Fontaine,B., Strochlic,L., Lochmuller,H., Eymard,B.,
            Mayer,M. and Nicole,S.
  TITLE     Impaired Presynaptic High-Affinity Choline Transporter Causes a
            Congenital Myasthenic Syndrome with Episodic Apnea
  JOURNAL   Am J Hum Genet 99 (3), 753-761 (2016)
   PUBMED   27569547
REFERENCE   5  (bases 1 to 4896)
  AUTHORS   Meixner,M., Atanasova,S., Padberg,W. and Grau,V.
  TITLE     Expression of acetylcholine receptors by experimental rat renal
            allografts
  JOURNAL   Biomed Res Int 2014, 289656 (2014)
   PUBMED   25121092
REFERENCE   6  (bases 1 to 4896)
  AUTHORS   Okuda,T., Okamura,M., Kaitsuka,C., Haga,T. and Gurwitz,D.
  TITLE     Single nucleotide polymorphism of the human high affinity choline
            transporter alters transport rate
  JOURNAL   J Biol Chem 277 (47), 45315-45322 (2002)
   PUBMED   12237312
REFERENCE   7  (bases 1 to 4896)
  AUTHORS   Lips,K.S., Pfeil,U., Haberberger,R.V. and Kummer,W.
  TITLE     Localisation of the high-affinity choline transporter-1 in the rat
            skeletal motor unit
  JOURNAL   Cell Tissue Res 307 (3), 275-280 (2002)
   PUBMED   11904763
REFERENCE   8  (bases 1 to 4896)
  AUTHORS   Okuda,T. and Haga,T.
  TITLE     Functional characterization of the human high-affinity choline
            transporter
  JOURNAL   FEBS Lett 484 (2), 92-97 (2000)
   PUBMED   11068039
REFERENCE   9  (bases 1 to 4896)
  AUTHORS   Apparsundaram,S., Ferguson,S.M., George,A.L. Jr. and Blakely,R.D.
  TITLE     Molecular cloning of a human, hemicholinium-3-sensitive choline
            transporter
  JOURNAL   Biochem Biophys Res Commun 276 (3), 862-867 (2000)
   PUBMED   11027560
REFERENCE   10 (bases 1 to 4896)
  AUTHORS   Okuda,T., Haga,T., Kanai,Y., Endou,H., Ishihara,T. and Katsura,I.
  TITLE     Identification and characterization of the high-affinity choline
            transporter
  JOURNAL   Nat Neurosci 3 (2), 120-125 (2000)
   PUBMED   10649566
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030947.1, SRR26360176.1529150.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN14984021
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000009.1  7953343-7953509     c
            168-401             JAXUCZ010000009.1  7951813-7952046     c
            402-515             JAXUCZ010000009.1  7947004-7947117     c
            516-671             JAXUCZ010000009.1  7946153-7946308     c
            672-820             JAXUCZ010000009.1  7940868-7941016     c
            821-964             JAXUCZ010000009.1  7934765-7934908     c
            965-1118            JAXUCZ010000009.1  7930286-7930439     c
            1119-1336           JAXUCZ010000009.1  7927934-7928151     c
            1337-4896           JAXUCZ010000009.1  7922693-7926252     c
FEATURES             Location/Qualifiers
     source          1..4896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..4896
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /note="solute carrier family 5 member 7"
                     /db_xref="GeneID:85426"
                     /db_xref="RGD:69270"
     exon            1..167
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..401
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1966
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /note="CHT; hemicholinium-3-sensitive choline transporter;
                     solute carrier family 5 (choline transporter), member 7;
                     solute carrier family 5 (sodium/choline cotransporter),
                     member 7"
                     /codon_start=1
                     /product="high affinity choline transporter 1"
                     /protein_id="NP_445973.2"
                     /db_xref="GeneID:85426"
                     /db_xref="RGD:69270"
                     /translation="MPFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIV
                     GGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFF
                     AKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVD
                     VNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFT
                     AVHAKYQSPWLGTIESIEVYTWLDNFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFL
                     AAFGCLVMALPAICIGAIGASTDWNQTAYGFPDPKTKEEADMILPIVLQYLCPVYISF
                     FGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASA
                     TAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGG
                     EPYLYLQPLIFYPGYYPDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLP
                     PKLDIFDAVVSRHSEENMDKTILVRNENIKLNELAPVKPRQSLTLSSTFTNKEALLDV
                     DSSPEGSGTEDNLQ"
     exon            402..515
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..671
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..820
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..964
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1118
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1336
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..4896
                     /gene="Slc5a7"
                     /gene_synonym="Cht1; rCHT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttttcca atacccgaat tgattgatcg cctcgcccca cggagacctc agcgagctcc
       61 ttgtcggcac cctccactca cctcgcgcct ccctccctcg ctgtcccaca cagctccgta
      121 ctggggggga cacccggacc cctaaatcag ctccgggtga cgccaagaag atttgatgaa
      181 gtagccctct gtggaaggat cttcacggta ccctaaataa aaaatgcctt tccatgtaga
      241 aggactagta gcgattatcc tgttctacct tcttatattt ctggttggaa tatgggctgc
      301 atggaaaacc aaaaacagcg gtaatgcaga agaacgcagc gaagccatca tagttggggg
      361 ccgagacatt ggtttgttgg ttggtggttt taccatgaca gccacctggg ttggaggagg
      421 ttacatcaac gggacagctg aagcagttta tgggccaggt tgtggtctag cttgggctca
      481 ggcacccatt ggatattctc tgagtctgat tttaggtggc ctgttttttg caaaacctat
      541 gcgttctaag ggatatgtga ctatgttaga cccgtttcaa cagatctatg gaaagcgcat
      601 gggtgggctg ctgttcatcc ctgcactgat gggagagatg ttctgggctg cagcgatttt
      661 ctctgcatta ggggctacca tcagcgtaat cattgatgtg gatgtgaaca tatcggtcat
      721 tgtctccgca ctcattgcca ttctttatac cctcgtggga gggctctact ctgtggcata
      781 tactgatgtt gtacagctat tctgcatttt tataggattg tggatcagtg tcccatttgc
      841 cctgtcacat cctgcagtca ccgacattgg attcactgct gtgcatgcta aataccagag
      901 tccctggctg ggaaccattg aatcaattga agtctacacc tggcttgata attttctgtt
      961 gttgatgctg ggtggaatac catggcaagc ctacttccag agggtcctct cttcatcgtc
     1021 agcgacctat gctcaggtgc tgtccttcct ggcagctttt gggtgcctgg tgatggctct
     1081 accagccata tgcattgggg ccattggagc ctccacagac tggaaccaaa ctgcatatgg
     1141 gtttccagat cccaagacca aggaggaagc agacatgatt ctcccgattg ttctacagta
     1201 cctctgccct gtgtacattt ccttctttgg gcttggtgct gtttctgctg ctgtcatgtc
     1261 ctcggctgac tcatccatcc tatcagcaag ttccatgttt gctcggaata tctaccagct
     1321 ttccttcaga caaaatgcat cagacaagga aattgtgtgg gtcatgagga tcactgtgtt
     1381 tgtgtttgga gcatctgcaa cagccatggc cttgctcacg aagactgtgt atgggctctg
     1441 gtacctgagc tctgaccttg tctacatcat catcttccca cagctgctct gtgtactctt
     1501 catcaaagga accaacactt atggggcagt tgctggttat atttttggac ttttcctgag
     1561 aattaccgga ggagagccat atctatactt gcagccctta atcttctacc ctggttatta
     1621 ccctgacaag aatggtatat acaatcagag gttcccattt aaaactctct ccatggttac
     1681 ctcattcttt accaacattt gtgtttccta tctagccaag tatctatttg aaagtggaac
     1741 cttgcctcca aaattagata tatttgatgc tgttgtctca aggcacagtg aagagaacat
     1801 ggacaagacc attctagtca gaaatgaaaa catcaaatta aatgaacttg cacctgtaaa
     1861 gcctcgacag agcctaaccc tcagttcaac tttcaccaat aaagaggctc tccttgatgt
     1921 tgattccagt ccagagggat ctgggactga agataactta caatgacccc atgtaaaata
     1981 tacagaacag ggcattgctg tagggtaata ctgggaaaaa ggtttggagc atatcttata
     2041 catgttacaa tataaatgtt tgaggaaaaa agtttttcag aaataagata ttatggatga
     2101 gttcagaaaa ataacaattg cacagtgagg cagaagcaag cgtgaaggca acagctttat
     2161 ttctcatcgt agcacttttc attttgaata gctttgttaa gcacataaaa atgcataaag
     2221 ccccagccaa agaaagtggc caaatattat ttatctttat tatggaagga aggaatattt
     2281 attaaagagt ccattggaag gagattggat ggtcccgatc attttcactg gcgaatgcac
     2341 tggataacag attaattact acaacatgga ggttatgcgt gtattcacgg tcactactgt
     2401 gaaggatgca gtgggttagc cagtacactt ttccccatgg gtaggttgtc tggctctccc
     2461 ataatcttaa ctatggcatt tacccatttt tcaaggtgtg ctttcttacc cttttttgcc
     2521 atctagcatg tgtactctct ccattcatcc ctccatctat ctatccctcc ttctttctac
     2581 actctctcct ttcttctgct ctttcccttt cactcccttt ctcccttctc tttatctctt
     2641 tatattttgt ttctgtgagg ggctggaact ctattacagg gccttgcaca tgctaagtaa
     2701 gagctctcct actgagctac attgcaacct cacaataatt tattttttta gtaatatcgt
     2761 acattattct aagcacaagc aacacaacaa tatcttattt aatagtgaca tttttatgtg
     2821 aaaatgatag aaaacagagt ttatgttgga gtaagataga agcactgagc cctttaagtg
     2881 tgaccacagt tgctatatgc tcaaagagaa gggtccaaaa ccaagcatga aatggttgtt
     2941 gggcagcatt acagcaataa gtcaagaaga aaaggaaaag aaggagaaga agaaaaacgg
     3001 atttctgtct ccagctttta tacattaaat gttgttacac attataaata taatgtcttg
     3061 gcttatcttc taagagtatt ggaggcaaag ttgagccata tataaagtgt ggtttctgtc
     3121 taacatctgt tacaagtgcc acctgcttca tcagcatgca ttcgacgcat atttattacc
     3181 agcagttccc aaataactct ctgagaaact gggaaacaaa ccctgcttac ttttggacat
     3241 ccaataatgt aagagtttag tgctaaggat ctactcttga cacttttcca cataagccat
     3301 ttttagggac tggacagatc accacaagtg tgtatattga ttttcaaatg taatagaaaa
     3361 caaaaagtaa aaacaagtca tagaagaagc catcattttt aatgtctttt gtgtacatgg
     3421 atttcaggag gtcaatcatt aaatgtaatt ttgcttttct ttgtagcatt cagaattaca
     3481 tataaaactt gtgccaccaa accctagaat tctttttata agttacagtt attatctctt
     3541 aaagcatcac atttggaact cctttcttta aaaaggatga cttaaaaatt cctactgtga
     3601 cttttaaaat gtaaaattaa ataattttac atattgtaat gtcctatttt tcaggattgt
     3661 ctcaatcctt aaaccacttt actgatttgt gtatgtacgt aaggaagaga attcatttac
     3721 cctccagttt atctcagaat cagctcacta gctatggagt agttatggaa attatggagt
     3781 ctgagatgtt caaacatggt gtgagaaaag agtcaaagga aaaaagaaaa cacagataaa
     3841 aaagtagtaa actttgtact tgaaaatcta ctagtgacaa tgatgaaatt tctggtaaac
     3901 atggtatttc agatgcacaa agtcttccaa cagagacaaa agagaaactt ttgcccaact
     3961 catgatcttc catgagattg ttgaggtata tgcttgcatt aggaacatca cagaacctca
     4021 ctcacactag atctcacagc gaagcaggtt cctttcacag acattacact ttgtaatgct
     4081 cttagtcaac aactgtccaa ctaagcttaa aatatttaaa gtatcataat agcaaaaatg
     4141 agagaagaat cccaagatat ttatttatgc atactcttga atggaattcc ccatgatttc
     4201 caagaaagag atgatgcttc aaggtatatt ggattggaga catctctaaa ttattccaga
     4261 ttcaagcagc agacctcatt ttcaaatccc caatgaaatc aaaataaccc aaatgtttca
     4321 gcctcttgct tgggaagtaa tacatgtgga tagcatttga gcaagatagg agtttcactc
     4381 ctatatatta acaatgattg tgctatgttt cttaggtaat ttgtgttcct ctccatgtgt
     4441 tcagaacatc aagcttgtag ctggaacgat atgttaacaa gctgtcaaat gctcagtgcc
     4501 aaaatccaat ttcattgtta tacttacaag taatgaattt tatgtgcata ttatatgaat
     4561 gtaagcttga aatgaatgca tttaatattt aatataatgt atattgaaaa tgtcatttgt
     4621 aaataatgaa ttagcattat attttaaaca taaatcatca tttccctttt tgtccttcta
     4681 caaaatttgc tctggtatcc tatgtaacgt ataataagtt tgttataatg tatgttggct
     4741 actgcataga caaatgcata gaattgttcc aaaacttata tttttatctg tcaaaatgtt
     4801 atacaaaatt atacagaaat aagtagattt acaagtacac atgtatgtgt tcaaatgtaa
     4861 tgatactgta ttaaattatt ccattgcaat tcaaaa
//
