LOCUS       NM_130746               3065 bp    mRNA    linear   ROD 22-OCT-2024
DEFINITION  Rattus norvegicus solute carrier family 5 member 6 (Slc5a6),
            transcript variant 1, mRNA.
ACCESSION   NM_130746
VERSION     NM_130746.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Uchida,Y., Ito,K., Ohtsuki,S., Kubo,Y., Suzuki,T. and Terasaki,T.
  TITLE     Major involvement of Na(+) -dependent multivitamin transporter
            (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human
            brain capillary endothelial cells
  JOURNAL   J Neurochem 134 (1), 97-112 (2015)
   PUBMED   25809983
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Ghosal,A., Lambrecht,N., Subramanya,S.B., Kapadia,R. and Said,H.M.
  TITLE     Conditional knockout of the Slc5a6 gene in mouse intestine impairs
            biotin absorption
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (1), G64-G71 (2013)
   PUBMED   23104561
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Nabokina,S.M., Subramanian,V.S. and Said,H.M.
  TITLE     Comparative analysis of ontogenic changes in renal and intestinal
            biotin transport in the rat
  JOURNAL   Am J Physiol Renal Physiol 284 (4), F737-F742 (2003)
   PUBMED   12620923
  REMARK    GeneRIF: Expression of SMVT is developmentally regulated in jejunal
            epithelial brush border membranes
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Chatterjee,N.S., Rubin,S.A. and Said,H.M.
  TITLE     Molecular characterization of the 5' regulatory region of rat
            sodium-dependent multivitamin transporter gene
  JOURNAL   Am J Physiol Cell Physiol 280 (3), C548-C555 (2001)
   PUBMED   11171574
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Chatterjee,N.S., Kumar,C.K., Ortiz,A., Rubin,S.A. and Said,H.M.
  TITLE     Molecular mechanism of the intestinal biotin transport process
  JOURNAL   Am J Physiol 277 (4), C605-C613 (1999)
   PUBMED   10516089
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Prasad,P.D., Wang,H., Kekuda,R., Fujita,T., Fei,Y.J., Devoe,L.D.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning and functional expression of a cDNA encoding a mammalian
            sodium-dependent vitamin transporter mediating the uptake of
            pantothenate, biotin, and lipoate
  JOURNAL   J Biol Chem 273 (13), 7501-7506 (1998)
   PUBMED   9516450
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_130746.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN14984041
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000006.1  31040400-31040443
            45-231              JAXUCZ010000006.1  31040608-31040794
            232-291             JAXUCZ010000006.1  31043170-31043229
            292-802             JAXUCZ010000006.1  31044494-31045004
            803-868             JAXUCZ010000006.1  31045312-31045377
            869-920             JAXUCZ010000006.1  31045662-31045713
            921-988             JAXUCZ010000006.1  31046254-31046321
            989-1143            JAXUCZ010000006.1  31046564-31046718
            1144-1284           JAXUCZ010000006.1  31046931-31047071
            1285-1414           JAXUCZ010000006.1  31047246-31047375
            1415-1503           JAXUCZ010000006.1  31047888-31047976
            1504-1616           JAXUCZ010000006.1  31048275-31048387
            1617-1684           JAXUCZ010000006.1  31048685-31048752
            1685-1771           JAXUCZ010000006.1  31049622-31049708
            1772-1950           JAXUCZ010000006.1  31049836-31050014
            1951-2054           JAXUCZ010000006.1  31050213-31050316
            2055-2170           JAXUCZ010000006.1  31050520-31050635
            2171-3065           JAXUCZ010000006.1  31050777-31051671
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..3065
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /note="solute carrier family 5 member 6"
                     /db_xref="GeneID:170551"
                     /db_xref="RGD:69648"
     exon            1..44
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            45..231
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            232..291
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            292..802
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..2317
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /note="Na(+)-dependent multivitamin transporter; solute
                     carrier family 5 (sodium-dependent vitamin transporter),
                     member 6; solute carrier family 5 (sodium/multivitamin and
                     iodide cotransporter), member 6"
                     /codon_start=1
                     /product="sodium-dependent multivitamin transporter"
                     /protein_id="NP_570102.1"
                     /db_xref="GeneID:170551"
                     /db_xref="RGD:69648"
                     /translation="MTVASTAAPSYTTSDTNRVISTFSVVDYVVFGLLLVLSLVIGLY
                     HACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGGPAEIYRFGTQYWFLG
                     CSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFIFQMVVYMGVAL
                     YAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLIMFLGQLVVII
                     VGAAKVGGLGHVWAVASQHGLISGIELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQ
                     VQRYLSSHSEKAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYKKYSMSPQQEQAAPDQ
                     LVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLTET
                     RAIMLSRSLAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLFCLGMFFPCA
                     NPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAAASPPLNGSSSFLPSNLTVATVTTLMP
                     STLSKPTGLQQFYSLSYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSLNPGTIYPVLPK
                     LLALLPLSCQKRLCWRSHNQDIPVVTNLFPEKMGNGALQDSRDKERMAEDGLVHQPCS
                     PTYIVQETSL"
     exon            803..868
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            869..920
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            921..988
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1143
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1284
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1414
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1503
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1616
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1684
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1771
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1950
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2054
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2170
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..3065
                     /gene="Slc5a6"
                     /gene_synonym="SMVT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgccacg tgtggagaga agggaaaaac tgagccgaga gaggggggga aaaaaccaat
       61 gctgatttcg gaaagaacga aggaacttcg gtagccctgg ccgaaccacc gacgcaagga
      121 aggtagcgct tccgcagagc ggcagcagtt ctgactggag gggcgctcgc tgggagagac
      181 ccatcacacc taaggggaca gctattgctc tgggtgacga ctcctaaaaa gagaatcggt
      241 gcctctacct ctccacgtag ctctgcttca gaacggggat tgcttctcca gctccccctg
      301 gaccatgcca ctgggtggaa gaggaacgct gagaggctga gcgaggaacc agctaggtga
      361 caactcagag cccaggagta ccaagtcact gtaaagcata ggcaccgtga ggatgactgt
      421 ggcgagcact gcggctccct cctatacaac ctcagacacc aaccgggtta tttccacctt
      481 ttctgttgtg gactatgtgg tgtttggcct gttgctggtt ctctcccttg tcattgggct
      541 ctatcatgct tgccgcggct ggggccgcca tactgttggt gagctgctga tggcagaccg
      601 aaaaatgggc tgccttcctg tggcactgtc cttgctggcc accttccagt cagctgtggc
      661 gatccttggg ggaccagctg agatctaccg atttggaacc cagtattggt tcctggggtg
      721 ctcctacttc ctggggcttc tgatccctgc tcacatcttc atccctgtct tctaccgcct
      781 gcatcttacc agcgcctatg agtacctaga gctccgcttc aataaagcag tccggatctg
      841 tgggactgtg accttcatct ttcagatggt ggtctacatg ggagtggctc tctatgcacc
      901 gtccctggcc ctcaatgcag tgactggatt tgatctatgg ctgtcagtcc tggccctagg
      961 aattgtctgc aacatctaca ctgcactggg tgggctgaag gctgtcatct ggacagatgt
     1021 gttccaaacg ttgatcatgt tcctagggca gctggtggtt atcattgtag gagcggccaa
     1081 agtgggcggc ttggggcatg tatgggctgt ggcttcccag catggcctca tctctgggat
     1141 tgagctggat cctgacccct ttgtacgtca tactttctgg actttggcct ttggcggcgt
     1201 cttcatgatg ctctccttgt atggagtgaa tcaggctcag gtgcagcgct acctcagttc
     1261 ccactcagag aaggctgctg tgctctcctg ctatgcagtg ttcccttgcc agcaagtggc
     1321 cctctgcatg agctgcctca ttggtctggt catgtttgcc tattataaga aatatagtat
     1381 gagcccccaa caagagcaag cagcccctga ccagttagtc ctctattttg tgatggacct
     1441 cctgaaagac atgccagggc tgcccgggct cttcgttgct tgcctcttca gtggatctct
     1501 cagcaccata tcctccgcat tcaattcact ggccactgtc acaatggaag acctgatcca
     1561 gccctggttc cctcagttga ctgaaacccg ggccatcatg ctctctcgaa gccttgcctt
     1621 tgcctatggg ctagtttgcc tgggaatggc ctatgtttcc tctcatctgg gatcagtgct
     1681 ccaggcagca ctcagcatct ttggcatggt tggagggcca ctgctgggac tcttctgcct
     1741 tgggatgttc tttccgtgtg ccaaccctct tggtgccatt gtaggcctgt tgacgggact
     1801 caccatggcc ttctggattg gcattgggag catagtaagc aggatgagtt ctgctgcagc
     1861 atcccctccc cttaatggat ccagctcctt cctgcccagc aatctaactg tcgccactgt
     1921 gaccaccctg atgccttcta ccctgtccaa gcccacagga ctgcagcagt tctattccct
     1981 gtcctattta tggtacagtg cgcacaactc caccacagtc attgcagtgg gcctgattgt
     2041 cagtctgctc actgggggaa tgcggggccg gtccctgaac cctggcacca tttaccctgt
     2101 gttgccaaag ctccttgcac tcctgccctt atcctgccag aagcggcttt gctggagaag
     2161 ccacaaccag gatatccctg tggtcaccaa cctgtttcca gagaagatgg ggaacggagc
     2221 gctgcaggac agcagagaca aagagaggat ggctgaagat ggccttgtcc atcagccatg
     2281 cagccccacc tacattgtcc aagagacgtc cctgtgacct gtgacggacc tctcactgca
     2341 gagcagtggc cagagatact ctggagtgca gagctgagtc actgcatgag ttccgcagca
     2401 ctggggtgga tgacctagct cacagcaaag gaccttgatc tttaatgttt caccgccgtg
     2461 ggagctgtcg catgcaaggg acagacagtt tttccttatc ccttgccagt cttcttttag
     2521 gatcaggttt gcaaggtaca gaatcaagca cacgtgggga aatatactga ggaaagggtg
     2581 gcttttgatt aagtgaccag ggttctttgg ggtgaatagg aacatttctt acaactcccc
     2641 ttgagcaagt ttggcaggat tgaccagctc cagcatttag catgaagtcc tcagccctct
     2701 ggtgattccc tcactctcat gtcaacctgg gttatctcaa gccagtgtgg gcctgtggtc
     2761 ttcaggttct ctgtaagact caagtctcct ctcattctac ctacctctgt ttgtgagagg
     2821 gaggctttgg agcgcttggg tctcagcact tagtgcatct acttggtgta tagaccctcg
     2881 ctctcttcag gtggtacatg agagacaggt cctcaccagg acctcttatg cagtgtgcta
     2941 tcctctaaac tcctaagcta ggccaccctg gtgtcattct gtcatctgtg caattcttat
     3001 ttcctttggg agtttcctcc tcatgcattt tgttcctagg gaataaaaat agccattaga
     3061 cctga
//
