LOCUS       NM_053715               2451 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus solute carrier family 5 member 3 (Slc5a3), mRNA.
ACCESSION   NM_053715
VERSION     NM_053715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2451)
  AUTHORS   Barrese V, Stott JB, Baldwin SN, Mondejar-Parreno G and Greenwood
            IA.
  TITLE     SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial
            Contractility Through the Modulation of Vascular Kv7 Channels
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (10), 2468-2480 (2020)
   PUBMED   32787517
  REMARK    GeneRIF: SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates
            Arterial Contractility Through the Modulation of Vascular Kv7
            Channels.
REFERENCE   2  (bases 1 to 2451)
  AUTHORS   Edamatsu M, Kondo Y and Ando M.
  TITLE     Differential localizations of the myo-inositol transporters HMIT
            and SMIT1 in the cochlear stria vascularis
  JOURNAL   Neurosci Lett 674, 88-93 (2018)
   PUBMED   29551423
  REMARK    GeneRIF: Results indicate that H(+)/myo-inositol cotransporter
            (HMIT) is expressed in marginal cells and basal cells of the stria
            vascularis, while Na(+)/myo-inositol cotransporter 1 (SMIT1)
            expression is enriched in basal cells. Study speculates that HMIT
            and SMIT1 may play important roles in the homeostasis of cochlear
            fluids.
REFERENCE   3  (bases 1 to 2451)
  AUTHORS   Manville RW, Neverisky DL and Abbott GW.
  TITLE     SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical
            Interaction with the Pore
  JOURNAL   Biophys J 113 (3), 613-626 (2017)
   PUBMED   28793216
REFERENCE   4  (bases 1 to 2451)
  AUTHORS   Li SYT, Cheng STW, Zhang D and Leung PS.
  TITLE     Identification and Functional Implications of Sodium/Myo-Inositol
            Cotransporter 1 in Pancreatic beta-Cells and Type 2 Diabetes
  JOURNAL   Diabetes 66 (5), 1258-1271 (2017)
   PUBMED   28202581
  REMARK    GeneRIF: Myo-inositol transporter SMIT1 is required to maintain a
            stable phosphoinositide pool in beta-cells in order that
            phosphoinositide remains available despite its rapid turnover.
REFERENCE   5  (bases 1 to 2451)
  AUTHORS   Andronic J, Shirakashi R, Pickel SU, Westerling KM, Klein T, Holm
            T, Sauer M and Sukhorukov VL.
  TITLE     Hypotonic activation of the myo-inositol transporter SLC5A3 in
            HEK293 cells probed by cell volumetry, confocal and
            super-resolution microscopy
  JOURNAL   PLoS One 10 (3), e0119990 (2015)
   PUBMED   25756525
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2451)
  AUTHORS   Berry GT, Wu S, Buccafusca R, Ren J, Gonzales LW, Ballard PL,
            Golden JA, Stevens MJ and Greer JJ.
  TITLE     Loss of murine Na+/myo-inositol cotransporter leads to brain
            myo-inositol depletion and central apnea
  JOURNAL   J Biol Chem 278 (20), 18297-18302 (2003)
   PUBMED   12582158
REFERENCE   7  (bases 1 to 2451)
  AUTHORS   Eladari D, Chambrey R, Pezy F, Podevin RA, Paillard M and Leviel F.
  TITLE     pH dependence of Na+/myo-inositol cotransporters in rat thick limb
            cells
  JOURNAL   Kidney Int 62 (6), 2144-2151 (2002)
   PUBMED   12427139
  REMARK    GeneRIF: Basolateral Na+-MI cotransporter activity is maximal at
            physiological pH values of MTAL cells and interstitium, and a
            powerful modulation of the transporter activity may be exerted by
            pHe and pHi.
REFERENCE   8  (bases 1 to 2451)
  AUTHORS   Aihara N, Imamura N, Kimura T, Yamada K, Hida H, Nishino H, Ueda T
            and Shimada S.
  TITLE     Intracerebral hemorrhage upregulates Na(+)/myo-inositol
            cotransporter in the rat brain
  JOURNAL   Neurosci Lett 327 (1), 21-24 (2002)
   PUBMED   12098491
  REMARK    GeneRIF: Intracerebral hemorrhage upregulates Na(+)/myo-inositol
            cotransporter in the rat brain.
REFERENCE   9  (bases 1 to 2451)
  AUTHORS   Lubrich B, Spleiss O, Gebicke-Haerter PJ and van Calker D.
  TITLE     Differential expression, activity and regulation of the
            sodium/myo-inositol cotransporter in astrocyte cultures from
            different regions of the rat brain
  JOURNAL   Neuropharmacology 39 (4), 680-690 (2000)
   PUBMED   10728889
REFERENCE   10 (bases 1 to 2451)
  AUTHORS   Hager K, Hazama A, Kwon HM, Loo DD, Handler JS and Wright EM.
  TITLE     Kinetics and specificity of the renal Na+/myo-inositol
            cotransporter expressed in Xenopus oocytes
  JOURNAL   J Membr Biol 143 (2), 103-113 (1995)
   PUBMED   7537337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA513484.1, AY231162.1 and BE116021.1.
            
            On Nov 23, 2005 this sequence version replaced NM_053715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               CA513484.1         10-685
            677-1926            AY231162.1         618-1867
            1927-2451           BE116021.1         1-525               c
FEATURES             Location/Qualifiers
     source          1..2451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2451
                     /gene="Slc5a3"
                     /gene_synonym="Smit"
                     /note="solute carrier family 5 member 3"
                     /db_xref="GeneID:114507"
                     /db_xref="RGD:621530"
     exon            1..2447
                     /gene="Slc5a3"
                     /gene_synonym="Smit"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2216
                     /gene="Slc5a3"
                     /gene_synonym="Smit"
                     /note="solute carrier family 5 (inositol transporters),
                     member 3; solute carrier family 5 (sodium/myo-inositol
                     cotransporter), member 3"
                     /codon_start=1
                     /product="sodium/myo-inositol cotransporter"
                     /protein_id="NP_446167.2"
                     /db_xref="GeneID:114507"
                     /db_xref="RGD:621530"
                     /translation="MRAVLETADIAIVALYFVLVMCIGFFAMWKSNRSTVSGYFLAGR
                     SMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYI
                     RSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYV
                     SVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMMKVGGFEEVKRRYM
                     LASPNVASILLTHNLSNTNSCMVHPKADALKMLRDPTDEDVPWPGFILGQTPASVWYW
                     CADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFVDDIACINPE
                     HCMQVCGSRAGCSNIAYPRLVMELVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTL
                     DVYKLLRNNASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTP
                     PVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAIRLILAFTYRAPECDQPDNRPSFIKD
                     IHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTVVTKESCSQKDEPYK
                     MQEKSILRCSENSEVVSHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEA
                     ETPVDAYSNGQAALMGERAREKETESRSRYWKFIDWFCGFKSRSLSKRSLRDSMDEEA
                     VCLQMLEETPRVRVILNIGLFAVCSLGIFMFVYFSL"
ORIGIN      
        1 aagtattaaa aagctggaca cttctgtcat tcggacattt ttactcacaa gttcccagaa
       61 tgagggctgt gctggagaca gcagacattg ccatagtggc cctgtatttt gtcctggtca
      121 tgtgcattgg tttctttgcc atgtggaaat ctaatagaag cactgtgagt ggatacttcc
      181 tggccgggcg ctctatgacc tgggtggcca ttggtgcctc tctgtttgtg agcaatattg
      241 ggagtgaaca cttcattggg ctggcaggat ctggagcagc cagtggattt gcagtgggcg
      301 catgggagtt caatgccttg ctgctcttgc aacttctggg atgggttttc atccctattt
      361 acatccgctc aggggtgtac accatgcctg aatatttgtc caagaggttc ggtggccata
      421 ggattcaggt ctattttgcg gccttgtccc tgctcctcta tatcttcacc aagctctcgg
      481 tggatctgta ctcaggggcc ctctttatcc aggagtcctt gggttggaac ctttatgtgt
      541 ctgtcatcct gctcattggc atgactgctc tgctgaccgt cactggaggc cttgttgcag
      601 tgatctacac agacactctc caggctctgc tcatgatcat tggggcactg acacttatgg
      661 ttattagcat gatgaaggtt ggagggtttg aggaagttaa gagaaggtac atgttggcct
      721 cacccaatgt tgcttccatt ttgttgacac acaacctttc caacacaaat tcttgtatgg
      781 tgcatcctaa ggcagatgcc ctaaagatgt tgagagatcc aacagatgaa gacgtcccat
      841 ggcctggatt cattcttggg cagaccccag cctcggtatg gtactggtgt gctgaccaag
      901 tcatcgtgca gagggttcta gcagccaaaa acattgctca tgccaaaggt tctactctga
      961 tggctggctt cttgaagctc ctaccaatgt ttatcatagt cgtacccgga atgatttcca
     1021 ggatactgtt tgttgatgat atagcttgca tcaacccaga acactgcatg caagtgtgtg
     1081 gaagcagagc tgggtgctcc aatattgctt acccacgcct ggtgatggag ttggttcccg
     1141 tgggccttcg gggcctgatg atggcagtga tgattgcagc tctgatgagc gacttggact
     1201 ccatctttaa cagcgccagt accatattca ccctcgatgt gtacaagctt ctccgcaaca
     1261 atgcaagctc gcgggaactg atgattgtgg gcaggatatt tgtggctttt atggttgtca
     1321 tcagcatagc atgggtgcca attattgtgg agatgcaagg aggccaaatg tacctttata
     1381 tccaggaggt ggcggattat ctgacccctc cggtggcggc cctcttcctt ctggcaattt
     1441 tctggaaacg ttgcaatgag caaggggctt tctatggtgg aatggcaggt tttgttcttg
     1501 gagctatccg tttgatactg gctttcacct accgtgctcc tgagtgtgac caacctgata
     1561 acaggcccag cttcatcaaa gacatccatt atatgtatgt ggctacagca ttattttgga
     1621 tcacaggact cattactgta attgttagtc ttctcacacc acctcccacg aaggatcaga
     1681 ttcgtaccac taccttttgg tcaaaaaaga ctgtggtgac gaaggagagt tgctctcaga
     1741 aagacgaacc atataaaatg caagagaaga gtattctgcg atgcagtgag aatagtgaag
     1801 tcgtcagcca cactattccc aatgggaagt ctgaagacag cattaagggg ctccaacctg
     1861 aagacgttaa tctgctggtg acatgccgag aggagggcaa cccagtggct tccatgggtc
     1921 attcagaagc agaaacacca gtagatgctt attccaatgg gcaagcagct ctcatgggtg
     1981 agagagcgcg agagaaggaa acagaaagta gaagccggta ttggaagttc atagactggt
     2041 tttgtggctt taaaagtaga agcctgagca agaggagcct cagagactcg atggacgagg
     2101 aggccgtttg tttgcagatg ttagaggaga ccccacgagt cagagtgatc ctaaacattg
     2161 gactttttgc tgtgtgttca ctcgggattt tcatgtttgt ttatttctcc ttatgaactt
     2221 atggatatgg tgagatactt aaaaaaaaaa caaaacaaaa catggtcttt gaaaacaaaa
     2281 atgtaactgc tgcagctctc aggcattgtt tacgctgaag gttttagcca aattctactt
     2341 agcagaaaaa tcatctattt gcaagactat tttcccagag atggaggaaa agtaaatctg
     2401 caacttatct gaaacaaagc agaatgaatt gtgcaaaaaa aaaaaaaaaa a
//
