LOCUS       NM_022590               2254 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 5 member 2 (Slc5a2), mRNA.
ACCESSION   NM_022590
VERSION     NM_022590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Yang,H., Wang,Q., Zhang,P., Cheng,K., Li,H., Wang,H., Cai,M.,
            Ming,Y. and Zhao,Y.
  TITLE     Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold
            ischemia injury
  JOURNAL   Biochem Biophys Res Commun 646, 96-102 (2023)
   PUBMED   36708596
  REMARK    GeneRIF: Preliminary mechanism of inhibitor of SGLT2 in fatty liver
            cold ischemia injury.
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Kravtsova,O., Bohovyk,R., Levchenko,V., Palygin,O., Klemens,C.A.,
            Rieg,T. and Staruschenko,A.
  TITLE     SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na+
            transport in Dahl SS rats
  JOURNAL   Am J Physiol Renal Physiol 322 (6), F692-F707 (2022)
   PUBMED   35466690
  REMARK    GeneRIF: SGLT2 inhibition effect on salt-induced hypertension,
            RAAS, and Na(+) transport in Dahl SS rats.
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Katsurada,K., Nandi,S.S., Sharma,N.M. and Patel,K.P.
  TITLE     Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose
            Cotransporter 2) in Heart Failure: Role of Renal Nerves
  JOURNAL   Circ Heart Fail 14 (12), e008365 (2021)
   PUBMED   34789005
  REMARK    GeneRIF: Enhanced Expression and Function of Renal SGLT2
            (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal
            Nerves.
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Pruett,J.E., Torres Fernandez,E.D., Everman,S.J., Vinson,R.M.,
            Davenport,K., Logan,M.K., Ye,S.A., Romero,D.G. and Yanes
            Cardozo,L.L.
  TITLE     Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a
            Rat Model of Polycystic Ovary Syndrome
  JOURNAL   Int J Mol Sci 22 (5), 2576 (2021)
   PUBMED   33806551
  REMARK    GeneRIF: Impact of SGLT-2 Inhibition on Cardiometabolic
            Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Chae,H., Augustin,R., Gatineau,E., Mayoux,E., Bensellam,M.,
            Antoine,N., Khattab,F., Lai,B.K., Brusa,D., Stierstorfer,B.,
            Klein,H., Singh,B., Ruiz,L., Pieper,M., Mark,M., Herrera,P.L.,
            Gribble,F.M., Reimann,F., Wojtusciszyn,A., Broca,C., Rita,N.,
            Piemonti,L. and Gilon,P.
  TITLE     SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its
            inhibition does not directly affect glucagon and insulin secretion
            in rodents and humans
  JOURNAL   Mol Metab 42, 101071 (2020)
   PUBMED   32896668
  REMARK    GeneRIF: SGLT2 is not expressed in pancreatic alpha- and
            beta-cells, and its inhibition does not directly affect glucagon
            and insulin secretion in rodents and humans.
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Calado,J., Soto,K., Clemente,C., Correia,P. and Rueff,J.
  TITLE     Novel compound heterozygous mutations in SLC5A2 are responsible for
            autosomal recessive renal glucosuria
  JOURNAL   Hum Genet 114 (3), 314-316 (2004)
   PUBMED   14614622
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Bautista,R., Manning,R., Martinez,F., Avila-Casado Mdel,C.,
            Soto,V., Medina,A. and Escalante,B.
  TITLE     Angiotensin II-dependent increased expression of Na+-glucose
            cotransporter in hypertension
  JOURNAL   Am J Physiol Renal Physiol 286 (1), F127-F133 (2004)
   PUBMED   14506074
  REMARK    GeneRIF: in renovascular hypertension, angiotensin II induced SGLT2
            via the AT1 receptor, which was evidenced at both the functional
            and expression levels, probably contributing to increased
            absorption of Na+ and thereby to the development of hypertension.
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   van den Heuvel,L.P., Assink,K., Willemsen,M. and Monnens,L.
  TITLE     Autosomal recessive renal glucosuria attributable to a mutation in
            the sodium glucose cotransporter (SGLT2)
  JOURNAL   Hum Genet 111 (6), 544-547 (2002)
   PUBMED   12436245
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Wright,E.M.
  TITLE     Renal Na(+)-glucose cotransporters
  JOURNAL   Am J Physiol Renal Physiol 280 (1), F10-F18 (2001)
   PUBMED   11133510
  REMARK    Review article
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   You,G., Lee,W.S., Barros,E.J., Kanai,Y., Huo,T.L., Khawaja,S.,
            Wells,R.G., Nigam,S.K. and Hediger,M.A.
  TITLE     Molecular characteristics of Na(+)-coupled glucose transporters in
            adult and embryonic rat kidney
  JOURNAL   J Biol Chem 270 (49), 29365-29371 (1995)
   PUBMED   7493971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U29881.1, AB070850.1 and AB070976.1.
            
            On Nov 1, 2005 this sequence version replaced NM_022590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-816               U29881.1           1-816
            817-823             AB070850.1         952-958
            824-866             U29881.1           824-866
            867-960             AB070850.1         1002-1095
            961-1635            U29881.1           961-1635
            1636-2016           AB070976.1         1415-1795
            2017-2254           U29881.1           2017-2254
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2254
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /note="solute carrier family 5 member 2"
                     /db_xref="GeneID:64522"
                     /db_xref="RGD:620217"
     exon            1..125
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2018
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /note="low affinity sodium-glucose cotransporter;
                     Na(+)/glucose cotransporter 2; low affinity Na-dependent
                     glucose transporter (SGLT2); solute carrier family 5
                     (sodium/glucose cotransporter), member 2"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 2"
                     /protein_id="NP_072112.2"
                     /db_xref="GeneID:64522"
                     /db_xref="RGD:620217"
                     /translation="MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFR
                     TNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALF
                     VVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSG
                     AVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAF
                     HEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGDLPWPA
                     LLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISR
                     ILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSL
                     ASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQL
                     FDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGS
                     CVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISLCTAPIPQKHLHRLVFSLRHSKE
                     EREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSP
                     PPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA"
     exon            126..197
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..302
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..467
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..573
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..654
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..884
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1020
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1128
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1279
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1448
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1664
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1794
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2254
                     /gene="Slc5a2"
                     /gene_synonym="Sglt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaatgga gggacacgta gaggaaggct ctgaacttgg ggagcagaag gtcctgattg
       61 ataatcctgc tgacattctg gtcattgccg cgtatttcct gctggtcatt ggtgttggct
      121 tgtggtctat gttcagaacc aatagaggca cagttggtgg ctacttcttg gcaggacgga
      181 gcatggtgtg gtggccggtt ggagcctctc tgttcgccag caacatcggc agcggtcatt
      241 ttgtgggcct ggcggggact ggtgcagcaa gtggcttggc cgtggctgga tttgagtgga
      301 atgcgctctt tgtggtgttg ctcctcggct ggctcttcgt gcctgtgtat ctgaccgccg
      361 gagtgattac catgcctcag tacctccgca agcgctttgg tgggcgccgt attcgcctct
      421 acctgtccgt gctctcgctt tttttgtaca ttttcaccaa gatctcggtg gatatgttct
      481 ccggagcagt attcattcaa caggccctgg gctggaacat ttacgcttct gtcatcgcac
      541 tcttgggcat caccatgatt tatactgtga caggagggct ggcggcactg atgtacacag
      601 acactgtgca gaccttcgtc attcttgccg gggccttcat cctcactggt tatgctttcc
      661 atgaagtggg cgggtactca ggtctcttcg acaaatacct gggagcagtg acttcactga
      721 cggtgtccaa ggatccagct gttggcaaca tctccagcac ctgctatcag ccgaggcccg
      781 actcctatca cctgctgcgt gaccctgtga caggagacct gccgtggcct gcgctgcttc
      841 tggggcttac cattgtctca ggctggtact ggtgcagtga ccaggtaatt gtgcagcgct
      901 gcctggctgg aaagaatctg actcacatca aggctggatg catcctgtgt ggttacctga
      961 agctgatgcc catgttcctc atggtcatgc caggcatgat tagccgcatt ctttacccag
     1021 atgaggtggc ctgtgtggta cctgaggtgt gtaagcgggt gtgtggcact gaggtgggct
     1081 gctctaacat cgcctaccca cggcttgttg tgaagctcat gcccaatggt ctgcgtggac
     1141 tcatgctggc agtcatgctg gccgccctca tgtcttctct agcgtccatc tttaacagca
     1201 gcagcacact cttcaccatg gatatctaca cacgcctgcg gcctcgggcg ggtgataggg
     1261 agctgctgct ggttggaagg ctttgggtgg tgttcattgt ggcagtgtcc gtggcttggc
     1321 tgccagtggt gcaggcagca cagggcggcc agctcttcga ttacattcag tctgtctcca
     1381 gctacctggc gcctccagtg tccgctgtct ttgtgctggc actctttgtg ccccgtgtta
     1441 atgagaaggg tgctttctgg ggactcattg ggggcctgct gatgggccta gctcgtctca
     1501 tacccgagtt cttctttggc acgggcagct gtgtgcgacc ctctgcatgc ccagccatct
     1561 tctgccgggt acactacctc tacttcgcca tcattctctt cttctgctcc ggcttcctca
     1621 cactcgcaat ctccctgtgc accgcaccca tccctcagaa gcatctccac cgcctggttt
     1681 tcagtctccg gcacagcaag gaggagcggg aggatctgga tgctgaagag ttagagggtc
     1741 cagcccctcc tcctgtgcag aacgggtgcc aggaatgtgc aatggggatt gaagaggtcc
     1801 agtccccagc tccaggcctg ctccgccagt gcttgctctg gttctgtggg atgagcaaga
     1861 gtgggtcagg gagtcctcca cccactaccg aggaggtggc tgcaaccacc aggcggctag
     1921 aggacatcag tgaggatccc agctgggccc gagtagtcaa cctcaatgcc ctgctcatga
     1981 tgactgtggc tgtgttcctc tggggctttt atgcataaag tcaagtgtgt tggttaccat
     2041 gagttgcaac cagggcatgt ctgagcctca tgaaaagtga gggtgaagaa cttgtagtgg
     2101 atcccagaaa agggcaaaaa tacggcagga aggaactggt tcccttcctc tttacctggg
     2161 gtccagtcca tttgattggt tgtcacttcc cacaagatgg tggccaattt gtcatagatg
     2221 tttgcctatg caaaaataaa gctgcccttc taac
//
