LOCUS       NM_013033               2522 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus solute carrier family 5 member 1 (Slc5a1), mRNA.
ACCESSION   NM_013033 XM_346469
VERSION     NM_013033.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Chai,Q., Meng,Z., Lu,D., Zhang,Z., Liu,M. and Wu,W.
  TITLE     Intermittent high glucose induces pyroptosis of rat H9C2
            cardiomyocytes via sodium-glucose cotransporter 1
  JOURNAL   Mol Cell Biochem 476 (6), 2479-2489 (2021)
   PUBMED   33608832
  REMARK    GeneRIF: Intermittent high glucose induces pyroptosis of rat H9C2
            cardiomyocytes via sodium-glucose cotransporter 1.
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Kartinah,N.T., Fadilah,F., Ibrahim,E.I. and Suryati,Y.
  TITLE     The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like
            Peptide-1 via SGLT-1 and GLPR in DM Rats
  JOURNAL   Biomed Res Int 2019, 8724824 (2019)
   PUBMED   31828140
  REMARK    GeneRIF: this study also aims to determine the active ingredients
            of H. sabdariffa (Hib) that interact with sodium-glucose
            cotransporter-1 (SGLT-1) so that it can increase GLP-1 secretion in
            the ileum and interact with GLP-1 receptors (GLP-1R) in the
            pancreas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Erokhova,L., Horner,A., Ollinger,N., Siligan,C. and Pohl,P.
  TITLE     The Sodium Glucose Cotransporter SGLT1 Is an Extremely Efficient
            Facilitator of Passive Water Transport
  JOURNAL   J Biol Chem 291 (18), 9712-9720 (2016)
   PUBMED   26945065
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Kanwal,A., Nizami,H.L., Mallapudi,S., Putcha,U.K., Mohan,G.K. and
            Banerjee,S.K.
  TITLE     Inhibition of SGLT1 abrogates preconditioning-induced
            cardioprotection against ischemia-reperfusion injury
  JOURNAL   Biochem Biophys Res Commun 472 (2), 392-398 (2016)
   PUBMED   26920054
  REMARK    GeneRIF: Present study indicated that inhibition of SGLT1 by
            phlorizin abrogated the beneficial effect of
            ischemic-preconditioning and for the first time, provides evidence
            that SGLT1 plays a crucial role in ischemic preconditioning-induced
            cardioprotection.
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Oliveira,T.L., Candeia-Medeiros,N., Cavalcante-Araujo,P.M.,
            Melo,I.S., Favaro-Pipi,E., Fatima,L.A., Rocha,A.A., Goulart,L.R.,
            Machado,U.F., Campos,R.R. and Sabino-Silva,R.
  TITLE     SGLT1 activity in lung alveolar cells of diabetic rats modulates
            airway surface liquid glucose concentration and bacterial
            proliferation
  JOURNAL   Sci Rep 6, 21752 (2016)
   PUBMED   26902517
  REMARK    GeneRIF: SGLT1 activity in lung alveolar cells of diabetic rats
            modulates airway surface liquid glucose concentration and bacterial
            proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Lambotte,S., Veyhl,M., Kohler,M., Morrison-Shetlar,A.I.,
            Kinne,R.K., Schmid,M. and Koepsell,H.
  TITLE     The human gene of a protein that modifies Na(+)-D-glucose
            co-transport
  JOURNAL   DNA Cell Biol 15 (9), 769-777 (1996)
   PUBMED   8836035
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   Martin,M.G., Turk,E., Lostao,M.P., Kerner,C. and Wright,E.M.
  TITLE     Defects in Na+/glucose cotransporter (SGLT1) trafficking and
            function cause glucose-galactose malabsorption
  JOURNAL   Nat Genet 12 (2), 216-220 (1996)
   PUBMED   8563765
REFERENCE   8  (bases 1 to 2522)
  AUTHORS   Lee,W.S., Kanai,Y., Wells,R.G. and Hediger,M.A.
  TITLE     The high affinity Na+/glucose cotransporter. Re-evaluation of
            function and distribution of expression
  JOURNAL   J Biol Chem 269 (16), 12032-12039 (1994)
   PUBMED   8163506
REFERENCE   9  (bases 1 to 2522)
  AUTHORS   Turk,E., Zabel,B., Mundlos,S., Dyer,J. and Wright,E.M.
  TITLE     Glucose/galactose malabsorption caused by a defect in the
            Na+/glucose cotransporter
  JOURNAL   Nature 350 (6316), 354-356 (1991)
   PUBMED   2008213
REFERENCE   10 (bases 1 to 2522)
  AUTHORS   Wiley,L.M., Lever,J.E., Pape,C. and Kidder,G.M.
  TITLE     Antibodies to a renal Na+/glucose cotransport system localize to
            the apical plasma membrane domain of polar mouse embryo blastomeres
  JOURNAL   Dev Biol 143 (1), 149-161 (1991)
   PUBMED   1702069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D16101.1.
            
            On Apr 13, 2007 this sequence version replaced NM_013033.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16101.1, U03120.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132264,
                                           SAMD00132270 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2522
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /note="solute carrier family 5 member 1"
                     /db_xref="GeneID:25552"
                     /db_xref="RGD:3713"
     exon            1..304
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2167
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /note="high affinity sodium-glucose cotransporter;
                     Na(+)/glucose cotransporter 1; Solute carrier family 5,
                     member alpha 1 (Na+/glucose cotransporter); solute carrier
                     family 5 (sodium/glucose cotransporter), member 1"
                     /codon_start=1
                     /product="sodium/glucose cotransporter 1"
                     /protein_id="NP_037165.1"
                     /db_xref="GeneID:25552"
                     /db_xref="RGD:3713"
                     /translation="MDSSTLSPAVTATDAPIQSYERIRNAADISVIVIYFVVVMAVGL
                     WAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFE
                     WNALVFVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISA
                     DIFSGAIFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFIL
                     TGFAFREVGGYEAFMDKYMKAIPTLVSDGNITVKEECYTPRADSFHIFRDPITGDMPW
                     PGLIFGLSILALWYWCTDQVIVQRCLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGMI
                     SRILYTDKIACVLPSECKKYCGTPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMS
                     SLTSIFNSASTLFTMDIYTKIRKGASEKELMIAGRLFILVLIGISIAWVPIVQSAQSG
                     QLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGFLIGISRMITEFAYGT
                     GSCMEPSNCPKIICGVHYLYFAIILFAISVVTVLVISLLTKPIPDVHLYRLCWSLRNS
                     TEERIDLDAGEEEPVEEDPKDTIEIDAEAPQKEKGCFRKAYDLFCGLDQDKGPKMTKE
                     EEEAMKLKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA"
     exon            305..376
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            377..481
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            482..541
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            542..646
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            647..752
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            753..833
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1054
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1190
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1298
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1449
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1618
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1834
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1943
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2522
                     /gene="Slc5a1"
                     /gene_synonym="SGLT1; SGLT1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcccgac ggtgcggtgc agcgcagcag cccaggggcc cagcgttcct gccgcgcagc
       61 ccctccgtcg cggttcccct ccctcggggc tgatcattaa ctcaaaagca gtataaggag
      121 tgagtggccc cggtgagccg gtgagccgga gggactcgtc gccaccgcca tggacagtag
      181 caccttgagc cccgctgtta ctgccaccga tgcacccatc cagtcctatg agcgcattcg
      241 caatgcggct gacatatcag tcatcgtcat ctacttcgtg gtggtgatgg ctgtcgggct
      301 gtgggccatg ttttccacta atcgtgggac tgttggaggc ttcttcctgg caggccgaag
      361 tatggtgtgg tggccgattg gagcctctct ctttgccagt aacatcggaa gtggtcactt
      421 tgtggggctg gcgggcacag gagcagccgc aggcattgcc atgggtggct tcgaatggaa
      481 cgccttggtg ttcgtggtcg tgctggggtg gctttttgtc cctatttaca tcaaggctgg
      541 ggtggtgacg atgccggagt atctgcggaa gcgatttgga ggcaagcgga tccagatcta
      601 cctttccgtt ctgtccctgc tcctctacat ctttaccaag atctcagcag acatcttctc
      661 tggggctata ttcatcaatc tggccttggg cctggatata tacctggcca ttttcatcct
      721 gctggccatc accgcccttt acaccatcac agggggactg gcagcagtaa tttacacaga
      781 caccttgcag actgcgatca tgctggtggg atcttttatc ctgactgggt ttgctttccg
      841 agaagtagga gggtatgagg ccttcatgga taagtacatg aaagctattc caactttggt
      901 ttctgatgga aacataaccg tcaaagaaga atgttacaca cccagggccg actcgttcca
      961 catattccga gaccccatta cgggggacat gccatggcct gggctcatct tcggcctgtc
     1021 catcctcgcc ctgtggtact ggtgtacgga tcaggtcatt gtgcagcgat gcctctcggc
     1081 caagaacatg tctcacgtga aggctggctg taccctgtgt ggctatctga agctactgcc
     1141 tatgttcctc atggtgatgc ccggaatgat cagccggatt ctatacacag acaaaatcgc
     1201 ctgtgtcctc ccctcagaat gtaagaaata ctgcggcacc ccagtgggct gtaccaacat
     1261 cgcctaccca acactggtgg tggaactcat gcctaacgga cttcgaggcc tgatgctgtc
     1321 cgtcatgatg gcttccctca tgagctcctt gacctccatc ttcaacagcg ccagtactct
     1381 cttcaccatg gacatctaca ccaagatccg gaagggtgca tcggagaagg agctcatgat
     1441 tgcaggaagg ttgttcatcc tcgtgctgat tggcatcagc attgcctggg tgcccattgt
     1501 gcagtctgcc caaagcgggc agctctttga ctacatccag tccatcacca gttacctggg
     1561 gccacccatt gcagccgtct tcctgctggc tattttctgc aagagagtca atgaaccggg
     1621 agccttctgg ggactgattc tcggcttcct gattggaatc tcccgtatga tcactgagtt
     1681 tgcctacgga actggaagct gcatggagcc cagcaactgc cccaagatca tctgcggggt
     1741 ccactatctg tactttgcca tcatcctctt cgctatcagc gtcgtcaccg tcttggtcat
     1801 ctccctcctc accaagccca tcccagacgt gcacctgtac cgtctgtgct ggagtctacg
     1861 taacagcaca gaagagcgca tcgacctgga tgcaggagag gaggagcccg tcgaggagga
     1921 ccctaaagat accattgaaa tagatgcaga agccccccag aaggagaagg ggtgcttcag
     1981 gaaggcatat gacctgttct gtgggctgga ccaggataaa ggaccgaaga tgactaagga
     2041 agaggaggaa gctatgaagc tgaagatgac ggacacttcc gagaagccct tgtggaggac
     2101 agtggtgaac atcaacggca tcatcctcct ggcagtggct gtcttctgcc acgcctattt
     2161 tgcctgaacc ccgccttctg ggggtagact tggcgactct ggagttgtta tttcccacta
     2221 gaccccgcca ctctgtagtg gtaaggggaa actggccagt tgtaaatttt actcattcgg
     2281 ataaaagatg tataagtgtg attatagact tgcttgagga aaatgattac cctgctgtga
     2341 atttatgcct gtgaaaccag tgtgccacac tcatccatca caccagagct ttggagtgac
     2401 gttgactcag atgtagaaaa agtcataccg agacacagag gccctgtgtt gtctgtctca
     2461 ggtacgtcca gcgtgtaact attgtttata attcttaaat actatttttt aaaattgtgg
     2521 tc
//
