LOCUS       NM_001037198            2246 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 52 member 3 (Slc52a3),
            mRNA.
ACCESSION   NM_001037198 XM_230720
VERSION     NM_001037198.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Long,L., Pang,X.X., Lei,F., Zhang,J.S., Wang,W., Liao,L.D.,
            Xu,X.E., He,J.Z., Wu,J.Y., Wu,Z.Y., Wang,L.D., Lin,D.C., Li,E.M.
            and Xu,L.Y.
  TITLE     SLC52A3 expression is activated by NF-kappaB p65/Rel-B and serves
            as a prognostic biomarker in esophageal cancer
  JOURNAL   Cell Mol Life Sci 75 (14), 2643-2661 (2018)
   PUBMED   29428966
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   Kubo,Y., Yahata,S., Miki,S., Akanuma,S.I. and Hosoya,K.I.
  TITLE     Blood-to-retina transport of riboflavin via RFVTs at the inner
            blood-retinal barrier
  JOURNAL   Drug Metab Pharmacokinet 32 (1), 92-99 (2017)
   PUBMED   27964953
  REMARK    GeneRIF: The function and inhibition profile suggested the
            involvement of Slc52a3 in riboflavin transport at the inner BRB,
            and this is supported by expression and knockdown analysis of
            rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells.
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Subramanian,V.S., Ghosal,A., Subramanya,S.B., Lytle,C. and
            Said,H.M.
  TITLE     Differentiation-dependent regulation of intestinal vitamin B(2)
            uptake: studies utilizing human-derived intestinal epithelial
            Caco-2 cells and native rat intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 304 (8), G741-G748 (2013)
   PUBMED   23413253
  REMARK    GeneRIF: Intestinal riboflavin uptake process undergoes
            differentiation-dependent upregulation and suggest that this is
            mediated (at least in part) via transcriptional mechanisms of Rft1
            and Rft2.
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Nabokina,S.M., Subramanian,V.S. and Said,H.M.
  TITLE     Effect of clinical mutations on functionality of the human
            riboflavin transporter-2 (hRFT-2)
  JOURNAL   Mol Genet Metab 105 (4), 652-657 (2012)
   PUBMED   22273710
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Fujimura,M., Yamamoto,S., Murata,T., Yasujima,T., Inoue,K.,
            Ohta,K.Y. and Yuasa,H.
  TITLE     Functional characteristics of the human ortholog of riboflavin
            transporter 2 and riboflavin-responsive expression of its rat
            ortholog in the small intestine indicate its involvement in
            riboflavin absorption
  JOURNAL   J Nutr 140 (10), 1722-1727 (2010)
   PUBMED   20724488
  REMARK    GeneRIF: results indicate that riboflavin transporter 2(RFT2) is a
            transporter involved in the epithelial uptake of riboflavin in the
            small intestine for its nutritional utilization
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Yao,Y., Yonezawa,A., Yoshimatsu,H., Masuda,S., Katsura,T. and
            Inui,K.
  TITLE     Identification and comparative functional characterization of a new
            human riboflavin transporter hRFT3 expressed in the brain
  JOURNAL   J Nutr 140 (7), 1220-1226 (2010)
   PUBMED   20463145
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Green,P., Wiseman,M., Crow,Y.J., Houlden,H., Riphagen,S., Lin,J.P.,
            Raymond,F.L., Childs,A.M., Sheridan,E., Edwards,S. and
            Josifova,D.J.
  TITLE     Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with
            deafness, is caused by mutations in c20orf54
  JOURNAL   Am J Hum Genet 86 (3), 485-489 (2010)
   PUBMED   20206331
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Yamamoto,S., Inoue,K., Ohta,K.Y., Fukatsu,R., Maeda,J.Y.,
            Yoshida,Y. and Yuasa,H.
  TITLE     Identification and functional characterization of rat riboflavin
            transporter 2
  JOURNAL   J Biochem 145 (4), 437-443 (2009)
   PUBMED   19122205
  REMARK    GeneRIF: RFT2 may play a role in the intestinal absorption of
            riboflavin.
REFERENCE   9  (bases 1 to 2246)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099097.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_001037198.2.
            
            On Nov 18, 2005 this sequence version replaced XM_230720.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2246
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /note="solute carrier family 52 member 3"
                     /db_xref="GeneID:311536"
                     /db_xref="RGD:1304644"
     exon            1..585
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1410
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /note="riboflavin transporter 2"
                     /codon_start=1
                     /product="solute carrier family 52, riboflavin
                     transporter, member 3"
                     /protein_id="NP_001032275.1"
                     /db_xref="GeneID:311536"
                     /db_xref="RGD:1304644"
                     /translation="MAFLTHLLVCVFGMGSWVAINGLWVELPLLVTKLPEGWYLPSYL
                     TVVIQLANTGPLLVTLMHRFRPGCLSEVPVIFLILCVGTTACILLAFLWSMTSWIQGR
                     QHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLLPALVALVQG
                     SGITTCVNVTETPGTTLNPVTTMETSITQRTLSPSLTPLTWHLESRYLAPRFSPLLFF
                     LLLSFLMGCCLVAFFLLQRQPWGRQGSIEDLLHSQVTLHSIKPRDTEDTGSVGAPVSS
                     PGKGSVEVSVASLRPAQLAFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATL
                     SSVASPLACFLPIFLPNRSLLFLGVLTVLGTGFGTYNMAMAAMSPCPILQGHWGGEVL
                     IVLSWMLFVACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLKL
                     FSSADYCSLDCSA"
     exon            586..1073
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1197
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..2222
                     /gene="Slc52a3"
                     /gene_synonym="Rft2; RGD1304644; rRFT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcccaggc tgcccacaat ggccttcctg acacacctgc tggtctgcgt ctttggcatg
       61 ggctcctggg tggccatcaa tgggctctgg gtggagctgc ccctgctggt gaccaagttg
      121 cccgagggct ggtacttgcc ctcttaccta actgtggtca tccaactggc caacacaggc
      181 cccctcctag tcaccctgat gcatcgcttc cgacccggct gcctgtctga ggtgcccgtg
      241 atcttcctta tcctgtgtgt aggcacaact gcctgcatcc tcctagcctt cctgtggagt
      301 atgacctcct ggatacaggg tagacagcat agtgtggcct tcatcgtcct caccttcttc
      361 ctggccctgg tggattgtac ttcctctgtc accttcttgc ccttcatgag ccagctgccc
      421 acgtactatc ttaccacctt ctttataggc gaggggctca gtggcctcct gcctgcactg
      481 gtggcccttg tccaaggctc aggtatcacc acctgtgtca atgtcacgga gacaccaggt
      541 accaccttga accctgtgac cactatggag acttccatca ctcagagaac ccttagccct
      601 tccctgacgc ccctcacctg gcacctggag agccgctacc tggccccacg cttctcgcca
      661 ctgctcttct tcttactgct ctccttcctg atgggctgct gcctggtcgc cttcttcctc
      721 ctgcagcggc agccctgggg acggcaaggc tccatagagg acctcctcca ctcccaggtc
      781 accctgcact cgatcaaacc acgtgacaca gaggacaccg gctcagtggg cgcccctgtg
      841 agcagcccag gcaagggatc agtggaagtc agtgtagctt cactccgccc agcccagctg
      901 gccttcatct actccgtggt agcctttgtc aatgcgctca ccaatggtgt tctgccctca
      961 gtgcagacct actcctgcct gccttatggg cctgttgcct accatctgtc tgccaccctc
     1021 agctccgtgg ccagccccct cgcctgcttc ctccccatct tcctgcctaa caggtcgctg
     1081 ttattcctgg gggtgctcac agtgttgggg actggctttg ggacctacaa tatggccatg
     1141 gctgctatga gcccctgccc catcctgcag ggtcactggg gtggagaagt ccttatcgtg
     1201 ctctcctgga tgctgtttgt agcctgtctc agctatgtca aggtgatgct gggtgtgatc
     1261 ttgcgtgatc ggagtcgcag cgccctcttg tggtgtgggg cagcagtgca gctgggctct
     1321 ctgattggtg ccctgctcat gttcccgctg gttaatgtac tgaaactctt ctcatctgct
     1381 gactactgca gcctggactg ctcagcctag gctcgcctgg ccaccacagg acaccaggta
     1441 cccccattgc tgaagttaaa agccagaaga gcccagagac acaaagggta acaacccttt
     1501 gccctactac ccccacccca accaacccca atcccacatg gtcacagatc tgggtttggg
     1561 gagcagcaag gctaggcctg agctttttaa cacaatgacc tcctcccaac ctggagtttc
     1621 acagtgcagc ccctccccca accctgtgac ccagtgcgtt tgagctgcag tcttcattct
     1681 cagtctttgg agagatccgg tttgtagcga tcagctggag gcagcctaag gatgttaggg
     1741 gaagatccct ggaagattaa gctgcccctt gcttactgtg agaccttggg gaagtctctt
     1801 tactctctag gcctctgctc attaaaggag ggctgtagta aacagccttt cgcttgtagg
     1861 cttaggcatc taacaggttc tcctgaactc tctcctctgt ggacacactt cttaatacaa
     1921 cctggaggtg atcagaggac ttgtgcagga ccctacctcc atccctcttc tacatcccaa
     1981 gcctgttggt cctgggtccc agtacagccc tctgccttcc ctgtctccta ggatggtgag
     2041 acactgagag gagttggggt gggggggcct gcatctgaga gtaatcacgc ctccccccag
     2101 acacatagtg gccagtgagg acctcagagg ggtggctcag gcagaatgag tttcatctgt
     2161 aattattact ttgttttgca ttttgttcct ttttataaaa attaaagctg tctgtgcttt
     2221 caaaaaaaaa aaaaaaaaaa aaaaaa
//
